Functional role of nitric oxide in regulation of ocular blood flow

European Journal of Pharmacology

Volumn 374, Issue 2, 1999, Pages 161-174

  Koss, Michael C ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Eye; Nitric oxide (NO); Nitric oxide (NO) synthase; Ocular blood flow; Ocular pathophysiology; Vascular physiology

Indexed keywords

ACETYLCHOLINE; BRADYKININ; CALCITONIN; DIPYRIDAMOLE; ENDOTHELIN 1; GLYCERYL TRINITRATE; GUANYLATE CYCLASE; GUANYLATE CYCLASE INHIBITOR; HISTAMINE; ISOSORBIDE DINITRATE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N(G) NITROARGININE; N(G) NITROARGININE METHYL ESTER; NEUROPEPTIDE; NITRIC ACID DERIVATIVE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; NITROPRUSSIDE SODIUM; NORADRENALIN; PROSTAGLANDIN; PROSTAGLANDIN D2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; SUBSTANCE P; UNINDEXED DRUG; VASODILATOR AGENT; VASOPRESSIN;

AUTOREGULATION; DOG; ENZYME LOCALIZATION; EYE BLOOD FLOW; EYE DISEASE; GLAUCOMA; HUMAN; IMMUNOHISTOCHEMISTRY; INTRAOCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MONKEY; MOUSE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RABBIT; RAT; RETINA ISCHEMIA; REVIEW; UVEITIS; VASODILATATION;

EID: 0032996235     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00242-3     Document Type: Article

References (200)

1. Abran D., Varma D.R., Chemtob S. Regulation of prostanoid vasomotor effects and receptors in choroidal vessels of newborn pigs. Am. J. Physiol. 272:1997;R995-R1001.
2. Adachi K., Fujita Y., Morizane C., Akaike A., Ueda M., Satoh M., Masai H., Kashii S., Honda Y. Inhibition of NMDA receptors and nitric oxide synthase reduces ischemic injury of the retina. Eur. J. Pharmacol. 350:1998;53-57.
3. Alder V.A., Su E.N., Yu D.Y., Cringle S.J. Oxygen reactivity of the feline isolated ophthalmociliary artery. Invest. Ophthalmol. Vis. Sci. 34:1993;49-57.
4. Alder V.A., Su E.N., Yu D.Y., Cringle S.J., Yu P.K. Diabetic retinopathy: early functional changes. Clin. Exp. Pharmacol. Physiol. 24:1997;785-788.
5. Allen J.B., McGahan M.C., Ferrell J.B., Adler K.B., Fleisher L.N. Nitric oxide synthase inhibitors exert differential time-dependent effects on LPS-induced uveitis. Exp. Eye Res. 62:1996;21-28.
6. Alm, A., 1992. Ocular circulation. In: Hart, W.M. (Ed.), Adler's Physiology of the Eye: Clinical Application. Mosby-Year Book, St. Louis, MO, pp. 198-227.
7. Alm P., Uvelius B., Ekstrom J., Holmqvist B., Larsson B., Andersson K.E. Nitric oxide synthase-containing neurons in rat parasympathetic, sympathetic and sensory ganglia: a comparative study. Histochem. J. 27:1995;819-831.
8. Andersson S.E. Glibenclamide and L-NG-nitro-arginine methyl ester modulate the ocular and hypotensive effects of calcitonin gene-related peptide. Eur. J. Pharmacol. 224:1992;89-91.
9. 2α-induced ocular hyperemia. Exp. Eye Res. 59:1994;401-408.
10. Azuma H., Masuda H., Sato J., Niwa K., Tokoro T. A possible role of endogenous inhibitor for nitric oxide synthesis in the bovine ciliary muscle. Exp. Eye Res. 64:1997;823-830.
11. Bakken I.J., Vincent M.B., Sjaavaag I., White L.R. Vasodilation in porcine ophthalmic artery: peptide interaction with acetylcholine and endothelial dependence. Neuropeptides. 29:1995;69-75.
12. Becquet F., Courtois Y., Goureau O. Nitric oxide in the eye: multifaceted roles and diverse outcomes. Surv. Ophthalmol. 42:1997;71-82.
13. Behar-Cohen F.F., Goureau O., D'Hermies F., Courtois Y. Decreased intraocular pressure induced by nitric oxide donors is correlated to nitrite production in the rabbit eye. Invest. Ophthalmol. Vis. Sci. 37:1996;1711-1715.
14. Behar-Cohen F.F., Savoldelli M., Parel J.M., Goureau O., Thillaye-Goldenberg B., Courtois Y., Pouliquen Y., de Kozak Y. Reduction of corneal edema in endotoxin-induced uveitis after application of L-NAME as nitric oxide synthase inhibitor in rats by iontophoresis. Invest. Ophthalmol. Vis. Sci. 39:1998;897-904.
15. Bellot J.L., Palmero M., Garcia-Cabanes C., Espi R., Hariton C., Orts A. Additive effect of nitric oxide and prostaglandin-E2 synthesis inhibitors in endotoxin-induced uveitis in the rabbit. Inflammation Res. 45:1996;203-208.
16. Bellot J.L., Palmero M., Alcoriza N., Blanco A., Garcia-Cabanes C., Hariton C., Orts A. Concomitant treatment with a 5-lipoxygenase inhibitor improves the anti-inflammatory effect of the inhibition of nitric oxide synthase during the early phase of endotoxin-induced uveitis in the rabbit. Ophthalmic Res. 29:1997;227-236.
17. Benedito S., Prieto D., Nielsen P.J., Nyborg N.C.B. Histamine induces endothelium-dependent relaxation of bovine retinal arteries. Invest. Ophthalmol. Vis. Sci. 32:1991;32-38.
18. Benedito S., Prieto D., Nielsen P.J., Nyborg N.C.B. Role of the endothelium in acetylcholine-induced relaxation and spontaneous tone of bovine isolated retinal small arteries. Exp. Eye Res. 52:1991;575-579.
19. Bergua A., Mayer B., Neuhuber W.L. Nitrergic and VIPergic neurons in the choroid and ciliary ganglion of the duck Anis carina. Anat. Embryol. (Berlin). 193:1996;239-248.
20. Bonne C., Muller A., Villain M. Free radicals in retinal ischemia. Gen. Pharmacol. 30:1998;275-280.
21. Bouzas E.A., Donati G., Pournaras C.J. Distribution and regulation of the optic nerve head tissue PO2. Surv. Ophthalmol. 42:1997;S27-S34. Suppl. 1.
22. Bredt D.S., Hwang P.M., Snyder S.H. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature. 347:1990;768-770.
23. Brown S.M., Jampol L.M. New concepts of regulation of retinal vessel tone. Arch. Ophthalmol. 114:1996;199-204.
24. Buckley C.H., Hadoke P.W., O'Brien C.J. Use of isolated ocular arteries in vitro to define the pathology of vascular changes in glaucoma. Br. J. Ophthalmol. 81:1997;599-607.
25. Buckley C.H., Hadoke P.W.F., O'Brien C.J. Role of the endothelium in modulating functional responses of isolated bovine anterior ciliary arteries to vasoconstrictor agonists. Br. J. Ophthalmol. 82:1998;826-829.
26. Buerk D.G., Riva C.E. Vasomotion and spontaneous low-frequency oscillations in blood flow and nitric oxide in cat optic nerve head. Microvasc. Res. 55:1998;103-112.
27. + ion changes during flicker stimuli in cat optic nerve head. Invest. Ophthalmol. Vis. Sci. 36:1995;2216-2227.
28. Buerk D.G., Riva C.E., Cranstoun S.D. Nitric oxide has a vasodilatory role in cat optic nerve head during flicker stimuli. Microvasc. Res. 52:1996;13-26.
29. Buerk D.G., Atochin D.N., Riva C.E. Simultaneous tissue PO2, nitric oxide, and laser Doppler blood flow measurements during neuronal activation of optic nerve. Adv. Exp. Med. Biol. 454:1998;159-164.
30. Chakravarthy U., Stitt A.W., McNally J., Bailie J.R., Hoey E.M., Duprex P. Nitric oxide synthase activity and expression in retinal capillary endothelial cells and pericytes. Curr. Eye Res. 14:1995;285-294.
31. Chen Z., Gu Q., Kaufman P.L., Cynader M.S. Histochemical mapping of NADPH-diaphorase in monkey and human eyes. Curr. Eye Res. 17:1998;370-379.
32. Chiou G.C., Liu S.X., Li B.H., Chiang C.H., Varma R.S. Ocular hypotensive effects of L-arginine and its derivatives and their actions on ocular blood flow. J. Ocul. Pharmacol. Ther. 11:1995;1-10.
33. Cuthbertson S., Jackson B., Toledo C., Fitzgerald M.E., Shih Y.F., Zagvazdin Y., Reiner A. Innervation of orbital and choroidal blood vessels by the pterygopalatine ganglion in pigeons. J. Comp. Neurol. 386:1997;422-442.
34. Darius S., Wolf G., Huang P.L., Fishman M.C. Localization of NADPH-diaphorase/nitric oxide synthase in the rat retina: an electron microscopic study. Brain Res. 690:1995;231-235.
35. Dawson T.M., Bredt D.S., Fotuhi M., Hwang P.M., Snyder S.H. Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc. Natl. Acad. Sci. USA. 88:1991;7797-7801.
36. Delaey C., Van de Voorde J. The effect of NO donors on bovine retinal small arteries and posterior ciliary arteries. Invest. Ophthalmol. Vis. Sci. 39:1998;1642-1646.
37. Deussen A., Sonntag M., Vogel R. L-arginine-derived nitric oxide: a major determinant of uveal blood flow. Exp. Eye Res. 57:1993;129-134.
38. Do Carmo A., Lopes C., Santos M., Proenca R., Cunha-Vaz J., Carvalho A.P. Nitric oxide synthase activity and L-arginine metabolism in the retinas from streptozotocin-induced diabetic rats. Gen. Pharmacol. 30:1998;319-324.
39. Donati G., Pournaras C.J., Munoz J.L., Poitry S., Poitry-Yamate C.L., Tsacopoulos M. Nitric oxide controls arteriolar tone in the retina of the miniature pig. Invest. Ophthalmol. Vis. Sci. 36:1995;2228-2237.
40. Donati G., Pournaras C.J., Pizzolato G.P., Tsacopoulos M. Decreased nitric oxide production accounts for secondary arteriolar constriction after retinal branch vein occlusion. Invest. Ophthalmol. Vis. Sci. 38:1997;1450-1457.
41. Donati G., Pournaras C.J., Tsacopoulos M. Effect of nitroprusside on arteriolar constriction after retinal branch vein occlusion. Invest. Ophthalmol. Vis. Sci. 39:1998;1910-1917.
42. Feelisch M. The use of nitric oxide donors in pharmacological studies. Naunyn-Schmiedeberg's Arch. Pharmacol. 358:1998;113-122.
43. Fischer A.J., Stell W.K. Nitric oxide synthase-containing cells in the retina, pigmented epithelium, choroid, and sclera of the chick eye. J. Comp. Neurol. 405:1999;1-14.
44. Flugel C., Tamm E.R., Mayer B., Lutjen-Drecoll E. Species differences in choroidal vasodilative innervation: evidence for specific intrinsic nitrergic and VIP-positive neurons in the human eye. Invest. Ophthalmol. Vis. Sci. 35:1994;592-599.
45. Flugel-Koch C., Kaufman P., Lutjen-Drecoll E. Association of a choroidal ganglion cell plexus with the fovea centralis. Invest. Ophthalmol. Vis. Sci. 35:1994;4268-4272.
46. Funk R.H., Mayer B., Worl J. Nitrergic innervation and nitrergic cells in arteriovenous anastomoses. Cell Tissue Res. 277:1994;477-484.
47. Furchgott R.F., Zawadzki J.V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 288:1980;373-376.
48. Geyer O., Almog J., Lupu-Meiri M., Lazar M., Oron Y. Nitric oxide synthase inhibitors protect rat retina against ischemic injury. FEBS Lett. 374:1995;399-402.
49. Geyer O., Podos S.M., Mittag T. Nitric oxide synthase activity in tissues of the bovine eye. Graefe's Arch. Clin. Exp. Ophthalmol. 235:1997;786-793.
50. Gidday J.M., Zhu Y. Nitric oxide does not mediate autoregulation of retinal blood flow in newborn pig. Am. J. Physiol. Heart Circ. Physiol. 269:1995;H1065-H1072.
51. Gidday J.M., Zhu Y. Endothelium-dependent changes in retinal blood flow following ischemia. Curr. Eye Res. 17:1998;798-807.
52. Goh Y., Hotehama Y., Mishima H.K. Characterization of ciliary muscle relaxation induced by various agents in cats. Invest. Ophthalmol. Vis. Sci. 36:1995;1188-1192.
53. Goldstein I.M., Ostwald P., Roth S. Nitric oxide: a review of its role in retinal function and disease. Vision Res. 36:1996;2979-2994.
54. Goureau O., Jeanny J.C., Becquet F., Hartmann M.P., Courtois Y. Protection against light-induced retinal degeneration by an inhibitor of NO synthase. NeuroReport. 5:1993;233-236.
55. Goureau O., Bellot J., Thillaye B., Courtois Y., de Kozak Y. Increased nitric oxide production in endotoxin-induced uveitis. Reduction of uveitis by an inhibitor of nitric oxide synthase. J. Immunol. 154:1995;6518-6523.
56. Granstam E., Wang L., Bill A. Vascular effects of endothelin-1 in the cat; modification by indomethacin and L-NAME. Acta Physiol. Scand. 148:1993;165-176.
57. Granstam E., Granstam S.O., Fellström B., Lind L. Endothelium-dependent vasodilation in the uvea of hypertensive and normotensive rats. Curr. Eye Res. 17:1998;189-196.
58. Griffith, O.W., Gross, S.S., 1996. Inhibitors of nitric oxide synthases. In: Feelisch, M., Stamler, J.S. (Eds.), Methods in Nitric Oxide Research. Wiley, New York, NY, pp. 187-220.
59. Grunwald J.E., DuPont J., Dreyer E.B. Effect of chronic nitrate treatment on retinal vessel caliber in open-angle glaucoma. Am. J. Ophthalmol. 123:1997;753-758.
60. Haefliger, I.O., Flammer, J., 1998. Nitric Oxide and Endothelin in the Pathogenesis of Glaucoma. Lippincott-Ravin, Philadelphia, PA.
61. Haefliger I.O., Flammer J., Luscher T.F. Nitric oxide and endothelin-1 are important regulators of human ophthalmic artery. Invest. Ophthalmol. Vis. Sci. 33:1992;2340-2343.
62. Haefliger I.O., Flammer J., Luscher T.F. Heterogeneity of endothelium-dependent regulation in ophthalmic and ciliary arteries. Invest. Ophthalmol. Vis. Sci. 34:1993;1722-1730.
63. Haefliger I.O., Meyer P., Flammer J., Luscher T.F. The vascular endothelium as a regulator of the ocular circulation: a new concept in ophthalmology? Surv. Ophthalmol. 39:1994;123-132.
64. Haefliger I.O., Zschauer A., Anderson D.R. Relaxation of retinal pericyte contractile tone through the nitric oxide-cyclic guanosine monophosphate pathway. Invest. Ophthalmol. Vis. Sci. 35:1994;991-997.
65. Haefliger I.O., Chen Q., Anderson D.R. Effect of oxygen on relaxation of retinal pericytes by sodium nitroprusside. Graefe's Arch. Clin. Exp. Ophthalmol. 235:1997;388-392.
66. Hangai M., Yoshimura N., Hiroi K., Mandai M., Honda Y. Inducible nitric oxide synthase in retinal ischemia-reperfusion injury. Exp. Eye Res. 63:1996;501-509.
67. Hangai M., Miyamoto K., Hiroi K., Tujikawa A., Ogura Y., Honda Y., Yoshimura N. Roles of constitutive nitric oxide synthase in postischemic rat retina. Invest. Ophthalmol. Vis. Sci. 40:1999;450-458.
68. Hangai M., Yoshimura N., Hiroi K., Mandai M., Honda Y. Role of nitric oxide during the initial phase of reperfusion after retinal ischemia in the rat. Ophthalmic Res. 31:1999;16-23.
69. Hardy P., Nuyt A.M., Abran D., St-Louis J., Varma D.R., Chemtob S. Nitric oxide in retinal and choroidal blood flow autoregulation in newborn pigs: interactions with prostaglandins. Pediatr. Res. 39:1996;487-493.
70. Hardy P., Peri K.G., Lahaie I., Varma D.R., Chemtob S. Increased nitric oxide synthesis and action preclude choroidal vasoconstriction to hyperoxia in newborn pigs. Circ. Res. 79:1996;504-511.
71. Hardy P., Varma D.R., Chemtob S. Control of cerebral and ocular blood flow autoregulation in neonates. Pediatr. Clin. North Am. 44:1997;137-152.
72. Hardy P., Abran D., Hou X., Lahaie I., Peri K.G., Asselin P., Varma D.R., Chemtob S. A major role for prostacyclin in nitric oxide-induced ocular vasorelaxation in the piglet. Circ. Res. 83:1998;721-729.
73. Harino S., Nishimura K., Kitanishi K., Suzuki M., Reinach P. The role of nitric oxide in autoregulation of blood flow to decreased perfusion pressure in the cat retina. J. Ocul. Pharmacol. Ther. 15(4):1999;. in press.
74. Hashitani H., Windle A., Suzuki H. Neuroeffector transmission in arterioles of the guinea-pig choroid. J. Physiol. (London). 510:1998;209-223.
75. Haufschild T., Nava E., Meyer P., Flammer J., Luscher T.F., Haefliger I.O. Spontaneous calcium-independent nitric oxide synthase activity in porcine ciliary processes. Biochem. Biophys. Res. Commun. 222:1996;786-789.
76. Hessemer V., Schmidt K.G. Influence of the vasodilator drug isosorbide dinitrate on ocular circulation. Arch. Ophthalmol. 115:1997;324-327.
77. Hill C.E., Gould D.J. Modulation of sympathetic vasoconstriction by sensory nerves and nitric oxide in rat irideal arterioles. J. Pharmacol. Exp. Ther. 273:1995;918-926.
78. Hiraki S., Zhang X.Y., Hayasaka S. Effects of a nitric oxide synthase inhibitor on prostaglandin-induced aqueous flare elevation in pigmented rabbits. Ophthalmic Res. 28:1996;260-264.
79. Hoey S., Grabowski P.S., Ralston S.H., Forrester J.V., Liversidge J. Nitric oxide accelerates the onset and increases the severity of experimental autoimmune uveoretinitis through an IFN-gamma-dependent mechanism. J. Immunol. 159:1997;5132-5142.
80. Hope B.T., Michael G.J., Knigge K.M., Vincent S.R. Neuronal NADPH diaphorase is a nitric oxide synthase. Proc. Natl. Acad. Sci. USA. 88:1991;2811-2814.
81. Huxlin K.R. NADPH-diaphorase expression in neurons and glia of the normal adult rat retina. Brain Res. 692:1995;195-206.
82. Huxlin K.R., Bennett M.R. NADPH diaphorase expression in the rat retina after axotomy - a supportive role for nitric oxide. Eur. J. Neurosci. 7:1995;2226-2239.
83. Iadecola C. Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci. 20:1997;132-139.
84. Ignarro L.J., Buga G.M., Wood K.S., Byrns R.E., Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. USA. 84:1987;9265-9269.
85. Jacot J.L., O'Neill J.T., Scandling D.M., West S.D., McKenzie J.E. Nitric oxide modulation of retinal, choroidal, and anterior uveal blood flow in newborn piglets. J. Ocul. Pharmacol. Ther. 14:1998;473-489.
86. Jacquemin E., de Kozak Y., Thillaye B., Courtois Y., Goureau O. Expression of inducible nitric oxide synthase in the eye from endotoxin-induced uveitis rats. Invest. Ophthalmol. Vis. Sci. 37:1996;1187-1196.
87. Kamikawatoko S., Tokoro T., Ishida A., Masuda H., Hamasaki H., Sato J., Azuma H. Nitric oxide relaxes bovine ciliary muscle contracted by carbachol through elevation of cyclic GMP. Exp. Eye Res. 66:1998;1-7.
88. Kelly P.A.T., Buckley C.H., Ritchie I.M., O'Brien C. Possible role for nitric oxide releasing nerves in the regulation of ocular blood flow in the rat. Br. J. Ophthalmol. 82:1998;1199-1202.
89. Kitamura Y., Okamura T., Kani K., Toda N. Nitric oxide-mediated retinal arteriolar and arterial dilatation induced by substance P. Invest. Ophthalmol. Vis. Sci. 34:1993;2859-2865.
90. Koch K.W., Lambrecht H.G., Haberecht M., Redburn D., Schmidt H.H. Functional coupling of a Ca2+/calmodulin-dependent nitric oxide synthase and a soluble guanylyl cyclase in vertebrate photoreceptor cells. EMBO J. 13:1994;3312-3320.
91. Koistinaho J., Swanson R.A., de Vente J., Sagar S.M. NADPH-diaphorase (nitric oxide synthase)-reactive amacrine cells of rabbit retina: putative target cells and stimulation by light. Neuroscience. 57:1993;587-597.
92. Kondo M., Wang L., Bill A. Vascular responses in retina and optic nerve to L-NAME, a nitric oxide blocker, and flickering light in monkeys. Invest. Ophthalmol. Vis. Sci. 36:1995;S116.
93. Kondo M., Wang L., Bill A. The role of nitric oxide in hyperaemic response to flicker in the retina and optic nerve in cats. Acta Ophthalmol. Scand. 75:1997;232-235.
94. Koss M.C. Effect of inhibition of NO synthesis on basal ocular blood flow and reperfusion after ischemia. Invest. Ophthalmol. Vis. Sci. 37:1996;S842.
95. Koss M.C. Role of nitric oxide in maintenance of basal anterior choroidal blood flow in rats. Invest. Ophthalmol. Vis. Sci. 39:1998;559-564.
96. Koss M.C. Effect of nitric oxide synthesis inhibition on post-occlusive choroidal blood flow in rats. J. Ocul. Pharmacol. Ther. 15:1999;. in press.
97. Lam T.T., Tso M.O. Nitric oxide synthase (NOS) inhibitors ameliorate retinal damage induced by ischemia in rats. Res. Commun. Mol. Pathol. Pharmacol. 92:1996;329-340.
98. Lau K.C., So K.F., Tay D., Leung M.C. NADPH-diaphorase neurons in the retina of the hamster. J. Comp. Neurol. 350:1994;550-558.
99. Lepple-Wienhues A., Stahl F., Wiederholt M. Differential smooth muscle-like contractile properties of trabecular meshwork and ciliary muscle. Exp. Eye Res. 53:1991;33-38.
100. Liepe B.A., Stone C., Koistinaho J., Copenhagen D.R. Nitric oxide synthase in Muller cells and neurons of salamander and fish retina. J. Neurosci. 14:1994;7641-7654.
101. Liu S.X., Chiou G.C., Varma R.S. Improvement of retinal functions after ischemia with L-arginine and its derivatives. J. Ocul. Pharmacol. Ther. 11:1995;261-265.
102. Liu S.X., Xuan B.O., Chen Z., Varma R.S., Chiou G.C. Nitric oxide donors: effects of S-nitrosoglutathione and 4-phenyl-3-furoxancarbonitrile on ocular blood flow and retinal function recovery. J. Ocul. Pharmacol. Ther. 13:1997;105-114.
103. Liu R., Flammer J., Luscher T.F., Haefliger I.O. Beta-adrenergic agonist-induced nitrite production in isolated pig ciliary processes. Graefe's Arch. Clin. Exp. Ophthalmol. 236:1998;613-616.
104. Lopez-Costa J.J., Goldstein J., Mallo G., Saavedra J.P. NADPH-diaphorase distribution in the choroid after continuous illumination. NeuroReport. 6:1995;361-364.
105. Lopez-Costa J.J., Goldstein J., Saavedra J.P. Neuronal and macrophagic nitric oxide synthase isoforms distribution in normal rat retina. Neurosci. Lett. 232:1997;155-158.
106. Mandai M., Yoshimura N., Yoshida M., Iwaki M., Honda Y. The role of nitric oxide synthase in endotoxin-induced uveitis: effects of NG-nitro L-arginine. Invest. Ophthalmol. Vis. Sci. 35:1994;3673-3680.
107. Mandai M., Mittag T.W., Kogishi J., Iwaki M., Hangai M., Yoshimura N. Role of nitric oxide synthase isozymes in endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 37:1996;826-832.
108. Mann R.M., Riva C.E., Stone R.A., Barnes G.E., Cranstoun S.D. Nitric oxide and choroidal blood flow regulation. Invest. Ophthalmol. Vis. Sci. 36:1995;925-930.
109. Marin J., Rodriguez-Martinez M.A. Role of vascular nitric oxide in physiological and pathological conditions. Pharmacol. Ther. 75:1997;111-134.
110. Martin W., Villani G.M., Jothianandan D., Furchgott R.F. Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta. J. Pharmacol. Exp. Ther. 232:1985;708-716.
111. Maynard K.I., Chen D., Arango P.M., Ogilvy C.S. Nitric oxide produced during ischemia improves functional recovery in the rabbit retina. NeuroReport. 8:1996;81-85.
112. McMenamin P.G., Crewe J.M. Cellular localisation and dynamics of nitric oxide synthase expression in the rat anterior segment during endotoxin-induced uveitis. Exp. Eye Res. 65:1997;157-164.
113. Meijer F., Ruijter J.M., Van Delft J.L., Van Haeringen N.J. Nitric oxide induces vascular permeability changes in the guinea pig conjunctiva. Eur. J. Pharmacol. 284:1995;61-67.
114. Meijer F., Van Delft J.L., Garrelds I.M., Van Haeringen N.J., Kijlstra A. Nitric oxide plays a role as a mediator of conjunctival edema in experimental allergic conjunctivitis. Exp. Eye Res. 62:1996;359-365.
115. Meyer P., Flammer J., Luscher T.F. Local anesthetic drugs reduce endothelium-dependent relaxations of porcine ciliary arteries. Invest. Ophthalmol. Vis. Sci. 34:1993;2730-2736.
116. Meyer P., Flammer J., Luscher T.F. Endothelium-dependent regulation of the ophthalmic microcirculation in the perfused porcine eye: role of nitric oxide and endothelins. Invest. Ophthalmol. Vis. Sci. 34:1993;3614-3621.
117. Meyer P., Flammer J., Luscher T.F. Effect of dipyridamole on vascular responses of porcine ciliary arteries. Curr. Eye Res. 15:1996;387-393.
118. Moncada S. Nitric oxide in the vasculature: physiology and pathophysiology. Ann. NY Acad. Sci. 811:1997;60-69.
119. Moncada S., Higgs A. The L-arginine-nitric oxide pathway. N. Engl. J. Med. 329:1993;2002-2012.
120. Moncada S., Palmer R.M., Higgs E.A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43:1991;109-142.
121. Moncada S., Higgs A., Furchgott R. International union of pharmacology nomenclature in nitric oxide research. Pharmacol. Rev. 49:1997;137-142.
122. Moore P.K., Wallace P., Gaffen Z., Hart S.L., Babbedge R.C. Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects. Br. J. Pharmacol. 110:1993;219-224.
123. Morizane C., Adachi K., Furutani I., Fujita Y., Akaike A., Kashii S., Honda Y. N(omega)-nitro-L-arginine methyl ester protects retinal neurons against N-methyl-D-aspartate-induced neurotoxicity in vivo. Eur. J. Pharmacol. 328:1997;45-49.
124. Murad F., Ishii K., Forstermann U., Gorsky L., Kerwin J.F. Jr., Pollock J., Heller M. EDRF is an intracellular second messenger and autacoid to regulate cyclic GMP synthesis in many cells. Adv. Second Messenger Phosphoprotein Res. 24:1990;441-448.
125. Nakanome Y., Karita K., Izumi H., Tamai M. Two types of vasodilatation in cat choroid elicited by electrical stimulation of the short ciliary nerve. Exp. Eye Res. 60:1995;37-42.
126. Nathan C., Xie Q.W. Regulation of biosynthesis of nitric oxide. J. Biol. Chem. 269:1994;13725-13728.
127. Nathanson J.A. Direct application of a guanylate cyclase activator lowers intraocular pressure. Eur. J. Pharmacol. 147:1988;155-156.
128. Nathanson J.A. Nitrovasodilators as a new class of ocular hypotensive agents. J. Pharmacol. Exp. Ther. 260:1992;956-965.
129. Nathanson J.A., McKee M. Identification of an extensive system of nitric oxide-producing cells in the ciliary muscle and outflow pathway of the human eye. Invest. Ophthalmol. Vis. Sci. 36:1995;1765-1773.
130. Nathanson J.A., McKee M. Alterations of ocular nitric oxide synthase in human glaucoma. Invest. Ophthalmol. Vis. Sci. 36:1995;1774-1784.
131. Neal M., Cunningham J., Matthews K. Selective release of nitric oxide from retinal amacrine and bipolar cells. Invest. Ophthalmol. Vis. Sci. 39:1998;850-853.
132. Neufeld A.H., Hernandez M.R., Gonzalez M. Nitric oxide synthase in the human glaucomatous optic nerve head. Arch. Ophthalmol. 115:1997;497-503.
133. Nilsson S.F. Nitric oxide as a mediator of parasympathetic vasodilation in ocular and extraocular tissues in the rabbit. Invest. Ophthalmol. Vis. Sci. 37:1996;2110-2119.
134. Nishimura K., Riva C.E., Harino S., Reinach P., Cranstoun S.D., Mita S. Effects of endothelin-1 on optic nerve head blood flow in cats. J. Ocul. Pharmacol. Ther. 12:1996;75-83.
135. Nyborg N.C.B., Nielsen P.J. Neurogenic NO accounts for the nonadrenergic noncholinergic vasodilation in human posterior ciliary arteries. Invest. Ophthalmol. Vis. Sci. 35:1994;S1287.
136. O'Brien C., Kelly P.A., Ritchie I.M. Effect of chronic inhibition of nitric oxide synthase on ocular blood flow and glucose metabolism in the rat. Br. J. Ophthalmol. 81:1997;68-71.
137. Oh S.J., Kim I.B., Lee M.Y., Chun M.H., Chung J.W. NOS-like immunoreactive neurons express GABA-like immunoreactivity in rabbit and rat retinae. Exp. Brain Res. 120:1998;109-113.
138. Okamura T., Kitamura Y., Uchiyama M., Toda M., Ayajiki K., Toda N. Canine retinal arterial and arteriolar dilatation induced by nipradilol, a possible glaucoma therapeutic. Pharmacology. 53:1996;302-310.
139. Okamura T., Toda M., Ayajiki K., Toda N. Receptor subtypes involved in relaxation and contraction by arginine vasopressin in canine isolated short posterior ciliary arteries. J. Vasc. Res. 34:1997;464-472.
140. Osborne N.N., Barnett N.L., Herrera A.J. NADPH diaphorase localization and nitric oxide synthetase activity in the retina and anterior uvea of the rabbit eye. Brain Res. 610:1993;194-198.
141. Ostwald P., Goldstein I.M., Pachnanda A., Roth S. Effect of nitric oxide synthase inhibition on blood flow after retinal ischemia in cats. Invest. Ophthalmol. Vis. Sci. 36:1995;2396-2403.
142. Ostwald P., Park S.S., Toledano A.Y., Roth S. Adenosine receptor blockade and nitric oxide synthase inhibition in the retina: impact upon post-ischemic hyperemia and the electroretinogram. Vision Res. 37:1997;3453-3461.
143. Palmer R.M., Ferrige A.G., Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 327:1987;524-526.
144. Park C.S., Pardhasaradhi K., Gianotti C., Villegas E., Krishna G. Human retina expresses both constitutive and inducible isoforms of nitric oxide synthase mRNA. Biochem. Biophys. Res. Commun. 205:1994;85-91.
145. Parks D.J., Cheung M.K., Chan C.C., Roberge F.G. The role of nitric oxide in uveitis. Arch. Ophthalmol. 112:1994;544-546.
146. Perez M.T.R., Larsson B., Alm P., Andersson K.-E., Ehinger B. Localisation of neuronal nitric oxide synthase-immunoreactivity in rat and rabbit retinas. Exp. Brain Res. 104:1995;207-217.
147. Poukens V., Glasgow B.J., Demer J.L. Nonvascular contractile cells in sclera and choroid of humans and monkeys. Invest. Ophthalmol. Vis. Sci. 39:1998;1765-1774.
148. Reiner A., Zagvazdin Y. On the selectivity of 7-nitroindazole as an inhibitor of neuronal nitric oxide synthase. Trends Pharmacol. Sci. 19:1998;348-350.
149. Riva C.E., Harino S., Shonat R.D., Petrig B.L. Flicker evoked increase in optic nerve head blood flow in anesthetized cats. Neurosci. Lett. 128:1991;291-296.
150. Rocha G., Baines M.G., Deschenes J., Duclos A., Antecka E., Di Silvio M. Nitric oxide and transforming growth factor-beta levels during experimental uveitis in the rabbit. Can. J. Ophthalmol. 32:1997;17-24.
151. Rosenbaum J.T., McDevitt H.O., Guss R.B., Egbert P.R. Endotoxin-induced uveitis in rats as a model for human disease. Nature. 286:1980;611-613.
152. Roth S. Role of nitric oxide in retinal cell death. Clin. Neurosci. 4:1997;216-223.
153. Roufail E., Stringer M., Rees S. Nitric oxide synthase immunoreactivity and NADPH diaphorase staining are co-localised in neurons closely associated with the vasculature in rat and human retina. Brain Res. 684:1995;36-46.
154. Sandell J.H. NADPH diaphorase cells in the mammalian inner retina. J. Comp. Neurol. 238:1985;466-472.
155. Schmetterer L., Findl O., Fasching P., Ferber W., Strenn K., Breiteneder H., Adam H., Eichler H.G., Wolzt M. Nitric oxide and ocular blood flow in patients with IDDM. Diabetes. 46:1997;653-658.
156. 2 responsiveness of cerebral and ocular circulation in humans. Am. J. Physiol. 273:1997;R2005-R2012.
157. Schmetterer L., Krejcy K., Kastner J., Wolzt M., Gouya G., Findl O., Lexer F., Breiteneder H., Fercher A.F., Eichler H.G. The effect of systemic nitric oxide-synthase inhibition on ocular fundus pulsations in man. Exp. Eye Res. 64:1997;305-312.
158. Schmetterer L., Muller M., Fasching P., Diepolder C., Gallenkamp A., Zanaschka G., Findl O., Strenn K., Mensik C., Tschernko E., Eichler H.G., Wolzt M. Renal and ocular hemodynamic effects of insulin. Diabetes. 46:1997;1868-1874.
159. Schuman J.S., Erickson K., Nathanson J.A. Nitrovasodilator effects on intraocular pressure and outflow facility in monkeys. Exp. Eye Res. 58:1994;99-105.
160. Seligsohn E.E., Bill A. Effects of NG-nitro-L-arginine methyl ester on the cardiovascular system of the anaesthetized rabbit and on the cardiovascular response to thyrotropin-releasing hormone. Br. J. Pharmacol. 109:1993;1219-1225.
161. Smith J.R., Hart P.H., Coster D.J., Williams K.A. Mice deficient in tumor necrosis factor receptors p55 and p75, interleukin-4, or inducible nitric oxide synthase are susceptible to endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 39:1998;658-661.
162. Su E.N., Alder V.A., Yu D.Y., Cringle S.J. Adrenergic and nitrergic neurotransmitters are released by the autonomic system of the pig long posterior ciliary artery. Curr. Eye Res. 13:1994;907-917.
163. Su E.N., Yu D.Y., Alder V.A., Cringle S.J., Yu P.K. Direct vasodilatory effect of insulin on isolated retinal arterioles. Invest. Ophthalmol. Vis. Sci. 37:1996;2634-2644.
164. Sun W., Erichsen J.T., May P.J. NADPH-diaphorase reactivity in ciliary ganglion neurons: a comparison of distributions in the pigeon, cat, and monkey. Vis. Neurosci. 11:1994;1027-1031.
165. Tamm E.R., Flugel-Koch C., Mayer B., Lutjen-Drecoll E. Nerve cells in the human ciliary muscle: ultrastructural and immunocytochemical characterization. Invest. Ophthalmol. Vis. Sci. 36:1995;414-426.
166. Taniguchi T., Kawakami H., Sawada A., Iwaki M., Tsuji A., Sugiyama K., Kitazawa Y. Effects of nitric oxide synthase inhibitor on intraocular pressure and ocular inflammation following laser irradiation in rabbits. Curr. Eye Res. 17:1998;308-315.
167. Taylor A.W., Yee D.G., Streilein J.W. Suppression of nitric oxide generated by inflammatory microphages by calcitonin gene-related peptide in aqueous humor. Invest. Ophthalmol. Vis. Sci. 39:1998;1372-1378.
168. Tilton R.G., Chang K., Hasan K.S., Smith S.R., Petrash J.M., Misko T.P., Moore W.M., Currie M.G., Corbett J.A., McDaniel M.L. Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation. Diabetes. 42:1993;221-232.
169. Tilton R.G., Chang K., Corbett J.A., Misko T.P., Currie M.G., Bora N.S., Kaplan H.J., Williamson J.R. Endotoxin-induced uveitis in the rat is attenuated by inhibition of nitric oxide production. Invest. Ophthalmol. Vis. Sci. 35:1994;3278-3288.
170. Tilton R.G., Chang K.C., LeJeune W.S., Stephan C.C., Brock T.A., Williamson J.R. Role for nitric oxide in the hyperpermeability and hemodynamic changes induced by intravenous VEGF. Invest. Ophthalmol. Vis. Sci. 40:1999;689-696.
171. Toda N., Ayajiki K., Yoshida K., Kimura H., Okamura T. Impairment by damage of the pterygopalatine ganglion of nitroxidergic vasodilator nerve function in canine cerebral and retinal arteries. Circ. Res. 72:1993;206-213.
172. Toda N., Kitamura Y., Okamura T. Role of nitroxidergic nerve in dog retinal arterioles in vivo and arteries in vitro. Am. J. Physiol. Heart Circ. Physiol. 266:1994;H1985-H1992.
173. Toda N., Zhang J.X., Ayajiki K., Okamura T. Mechanisms underlying endothelium-independent relaxation by acetylcholine in canine retinal and cerebral arteries. J. Pharmacol. Exp. Ther. 274:1995;1507-1512.
174. Toda N., Kitamura Y., Okamura T. Functional role of nerve-derived nitric oxide in isolated dog ophthalmic arteries. Invest. Ophthalmol. Vis. Sci. 36:1995;563-570.
175. Toda N., Toda M., Ayajiki K., Okamura T. Monkey central retinal artery is innervated by nitroxidergic vasodilator nerves. Invest. Ophthalmol. Vis. Sci. 37:1996;2177-2184.
176. Toda M., Okamura T., Azuma I., Toda N. Modulation by neurogenic acetylcholine of nitroxidergic nerve function in porcine ciliary arteries. Invest. Ophthalmol. Vis. Sci. 38:1997;2261-2269.
177. Toda M., Ayajiki K., Okamura T., Azuma I., Toda N. Desmopressin-induced dog ciliary artery relaxation. Eur. J. Pharmacol. 344:1998;197-201.
178. Toda N., Toda M., Ayajiki K., Okamura T. Cholinergic nerve function in monkey ciliary arteries innervated by nitroxidergic nerve. Am. J. Physiol. Heart Circ. Physiol. 274:1998;H1582-H1589.
179. Van Gelderen E.M., Den Boer M.O., Saxena P.R. NG-nitro L-arginine methyl ester: systemic and pulmonary haemodynamics, tissue blood flow and arteriovenous shunting in the pig. Naunyn-Schmiedeberg's Arch. Pharmacol. 348:1993;417-423.
180. Vanhoutte P.M., Miller V.M. Heterogeneity of endothelium-dependent responses in mammalian blood vessels. J. Cardiovasc. Pharmacol. 7:1985;S12-S23. Suppl. 3.
181. Venturini C.M., Knowles R.G., Palmer R.M., Moncada S. Synthesis of nitric oxide in the bovine retina. Biochem. Biophys. Res. Commun. 180:1991;920-925.
182. Veriac S., Tissie G., Bonne C. Oxygen free radicals adversely affect the
183. Vincent S.R., Hope B.T. Neurons that say NO. Trends Neurosci. 15:1992;108-113.
184. Vorwerk C.K., Hyman B.T., Miller J.W., Husain D., Zurakowski D., Huang P.L., Fishman M.C., Dreyer E.B. The role of neuronal and endothelial nitric oxide synthase in retinal excitotoxicity. Invest. Ophthalmol. Vis. Sci. 38:1997;2038-2044.
185. Wang Z.Y., Hakanson R. Role of nitric oxide (NO) in ocular inflammation. Br. J. Pharmacol. 116:1995;2447-2450.
186. Wang R.F., Podos S.M. Effect of the topical application of nitroglycerin on intraocular pressure in normal and glaucomatous monkeys. Exp. Eye Res. 60:1995;337-339.
187. Wang Y., Okamura T., Toda N. Mechanisms of acetylcholine-induced relaxation in dog external and internal ophthalmic arteries. Exp. Eye Res. 57:1993;275-281.
188. Wang Y., Okamura T., Toda N. Mechanisms of histamine-induced relaxation in external and internal ophthalmic arteries. Invest. Ophthalmol. Vis. Sci. 34:1993;41-48.
189. Wang Z.Y., Alm P., Hakanson R. The contribution of nitric oxide to endotoxin-induced ocular inflammation: interaction with sensory nerve fibres. Br. J. Pharmacol. 118:1996;1537-1543.
190. Wang Z.Y., Waldeck K., Grundemar L., Hakanson R. Ocular inflammation induced by electroconvulsive treatment: contribution of nitric oxide and neuropeptides mobilized from C-fibres. Br. J. Pharmacol. 120:1997;1491-1496.
191. Wiederholt M., Sturm A., Lepple-Wienhues A. Relaxation of trabecular meshwork and ciliary muscle by release of nitric oxide. Invest. Ophthalmol. Vis. Sci. 35:1994;2515-2520.
192. Wiencke A.K., Nilsson H., Nielsen P.J., Nyborg N.C. Nonadrenergic noncholinergic vasodilation in bovine ciliary artery involves CGRP and neurogenic nitric oxide. Invest. Ophthalmol. Vis. Sci. 35:1994;3268-3277.
193. Wu G.S., Zhang J., Rao N.A. Peroxynitrite and oxidative damage in experimental autoimmune uveitis. Invest. Ophthalmol. Vis. Sci. 38:1997;1333-1339.
194. Yamamoto R., Bredt D.S., Dawson T.M., Snyder S.H., Stone R.A. Enhanced expression of nitric oxide synthase by rat retina following pterygopalatine parasympathetic denervation. Brain Res. 631:1993;83-88.
195. Yamamoto R., Bredt D.S., Snyder S.H., Stone R.A. The localization of nitric oxide synthase in the rat eye and related cranial ganglia. Neuroscience. 54:1993;189-200.
196. Yanagiya N., Akiba J., Kado M., Yoshida A., Kono T., Iwamoto J. Transient corneal edema induced by nitric oxide synthase inhibition. Nitric Oxide. 1:1997;397-403.
197. Yao K., Tschudi M., Flammer J., Lüscher T.F. Endothelium-dependent regulation of vascular tone of the porcine ophthalmic artery. Invest. Ophthalmol. Vis. Sci. 32:1991;1791-1798.
198. Zagvazdin Y.S., Fitzgerald M.E., Sancesario G., Reiner A. Neural nitric oxide mediates Edinger-Westphal nucleus evoked increase in choroidal blood flow in the pigeon. Invest. Ophthalmol. Vis. Sci. 37:1996;666-672.
199. Zhu P., Beny J.L., Flammer J., Luscher T.F., Haefliger I.O. Relaxation by bradykinin in porcine ciliary artery. Role of nitric oxide and K(+)-channels. Invest. Ophthalmol. Vis. Sci. 38:1997;1761-1767.
200. Zschauer A., Uusitalo H., Brayden J.E. Role of endothelium and hyperpolarization in CGRP-induced vasodilation of rabbit ophthalmic artery. Am. J. Physiol. 263:1992;H359-H365.