Suppression of nitric oxide generated by inflammatory microphages by calcitonin gene-related peptide in aqueous humor

Investigative Ophthalmology and Visual Science

Volumn 39, Issue 8, 1998, Pages 1372-1378

  Taylor, Andrew W ^a   Yee, David G ^a   Streilein, J Wayne ^a  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTIGEN; CALCITONIN GENE RELATED PEPTIDE; CYTOKINE; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; NEUROPEPTIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; AQUEOUS HUMOR; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOBLOTTING; IMMUNOREGULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; T LYMPHOCYTE;

ANIMALS; AQUEOUS HUMOR; CALCITONIN GENE-RELATED PEPTIDE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNE TOLERANCE; IMMUNOBLOTTING; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MYCOBACTERIUM TUBERCULOSIS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RABBITS; T-LYMPHOCYTES;

EID: 0031779801     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Cousins SW, Trattler WB, Streiletn JW. Immune privilege and suppression of immunogenic inflammation in the anterior chamber of the eye. Curr Eye Res. 1991;10:287-297.
2. Niederkorn JY, Benson JL, Mayhew E. Efferent blockade of delayed-type hypersensitivity responses in the anterior chamber of the eye. Reg Immunol. 1991;3:349-354.
3. Streilein JW, Takeuchi M, Taylor AW. Immune privilege, T-cell tolerance, and tissue-restricted autoimmunity. Hum Immunol. 1997;52:138-143.
4. Kaiser C, Ksander B, Streilein J. Inhibition of lymphocyte proliferation by aqueous humor. Reg Immunol. 1989;2:42-49.
5. Streilein JW. Ocular immune privilege in the immunosuppressive intraocular microenvironment. Ocul Immunol Inflamm. 1995;3: 139-143.
6. Knisely TL, Hosoi J, Nazareno R, Grandstein RD. The presence of biologically significant concentrations of glucocorticoids but little or no cortisol binding globulin with aqueous humor: relevance to immune privilege in the anterior chamber of the eye. Invest Ophthalmol Vis Sci. 1994;35:3711-3723.
7. Apte RS, Niederkorn JY. Isolation and characterization of a unique natural killer cell inhibitory factor present in the anterior chamber of the eye J Immunol. 1996;156:2667-2673
8. Cousins SW, McCabe MM, Danielpour D, Streilein JW. Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor. Invest Ophthalmol Vis Sci. 1991;32:33-43.
9. Granstein R, Staszewski R, Knisely TL, et al. Aqueous humor contains transforming growth factor-β and a small (<3500 daltons) inhibitor of thymocyte proliferation. J Immunol. 1990;144:3021-3026.
10. Jampel HD, Roche N, Stark WJ, Roberts AB. Transforming growth factor-β in human aqueous humor. Curr Eye Res. 1990;9:963-969.
11. Taylor AW, Streilein JW, Cousins SW. Vasoactive intestinal peptide (vasoactive intestinal peptide) contributes to the immunosuppressive activity of normal aqueous humor. J Immunol. 1994;153: 1080-1086.
12. Taylor A, Streilein J, Cousins S. Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humor. Curr Eye Res. 1992;11:1199-1206.
13. Taylor AW. Neuroimmunomodulation in immune privilege: role of neuropeptides in ocular immunosuppression. Neuroimmunomodulation. 1996;3:195-204.
14. Stone RA, McGlinn AM. Calcitonin gene-related peptide immunoreactive nerves in human and rhesus monkey eyes. Invest Ophthalmol Vis Sci. 1988;29:305-310.
15. Terenghi G, Polak JM, Ghatei MA, et al. Distribution and origin of calcitonin gene-related peptide (CGRP) immunoreactivity in the sensory innervation of the mammalian eye. J Comp Neurol. 1985; 233:506-516.
16. Rosenfeld MG, Amara SG, Evans RM. Alternative RNA processing: determining neuronal phenotype. Science. 1984;225:1315-1320.
17. Asahina A, Moro O, Hosoi J, et al. Specific induction of cAMP in langerhans cells by calcitonin gene-related peptide: relevance to functional effects. Proc Natt Acad Sci USA. 1995;92:8323-8327.
18. Asahina A, Hosoi J, Biessert S, Stratigos A, Granstein RD. Inhibition of the induction of delayed-type and contact hypersensitivity by calcitonin gene-related peptide. J Immunol. 1995;154:3056-3061.
19. Nong YH, Titus RG, Ribeiro JMC, Remold HG. Peptides encoded by the calcitonin gene inhibit macrophage function. J Immunol. 1989;143:45-49.
20. Khachatryan A, Guerder S, Palluault F, et al. Targeted expression of the neuropeptide calcitonin gene-related peptide to β cells prevents diabetes in NOD mice. J Immunol. 1997;158:1409-1416.
21. Boudard F, Bastide M. Inhibition of mouse T-cell proliferation by CGRP and vasoactive intestinal peptide: effects of these neuropeptides on IL-2 production and cAMP synthesis. J Neurosci Res. 1991;29:29-41.
22. Kurz B, VonGaudecker B, Kranz A, Krisch B, Mentlein R. Calcitonin gene-related peptide and its receptor in the thymus. Peptides. 1995;16:1497-1503.
23. Hanesch U, Pfrommer U, Grubb BD, Schaible HG. Acute and chronic phases of unilateral inflammation in rat's ankle are associated with an increase in the proportion of calcitonin gene-related peptide-immunoreactive dorsal root ganglion cells. Eur J Neurosci. 1993;5:154-161.
24. Unger WG, Terenghi G, Ghatei MA, et al. Calcitonin gene-related polypeptide as a mediator of the neurogenic ocular injury response. J Ocul Pharmacol. 1985;1:189-199.
25. Wahlestedt C, Beding B, Ekman R, et al. Calcitonin gene-related peptide in the eye: release by sensory nerve stimulation and effects associated with neurogenic inflammation. Regul Pept. 1986;16: 107-115.
26. Wang ZY, Alm P, Håskanson R. The contribution of nitric oxide to endotoxin-inducd ocular inflammation: interaction with sensory nerve fibers. Br J Parmacol. 1996;118:1537-1543.
27. Lorsbach RB, Murphy WJ, Lowenstein CJ, Snyder SH, Russell SW. Expression of nitric oxide synthase gene in mouse macrophages activated for tumor cell killing: molecular basis for synergy between interferon-g and lipopolysaccharide. J Biol Chem. 1993; 268:1908-1913.
28. 15N]nitrate in biological fluids. Analyt Biochem. 1982; 126:131-138.
29. Farrar MA, Schreiber RD. The molecular cell biology of interfer-on-γ and its receptor. Annu Rev Immunol. 1993;11:571-611.
30. MacMicking J, Xie QW, Nathan C. Nitric oxide and macrophage function. Annu Rev Immunol. 1997;15:323-350.
31. Owan I, Ibaraki K. The role of calcitonin gene-related peptide (CGRP) in macrophages: the presence of functional receptors and effects on proliferation and differentiation into osteoclast-like cells. Bone Miner. 1995;24:151-164.
32. Brain SD, Williams TJ, Tippins JR, Mons HR, MacIntyre I. Calcitonin gene-related peptide is a potent vasodilator. Nature. 1985; 313:54-56.
33. Oksala O, Stjernschantz J. Effects of calcitonin gene-related peptide in the eye. Invest Ophthalmol Vis Sci. 1988;29:1006-1011.
34. Krootila K, Uusitalo H, Palkama A. Intraocular and cardiovascular effects of calcitonin gene-related peptide (CGRP)-I and -II in the rabbit. Invest Ophthalmol Vis Sci. 1991;32:3084-3090.
35. Förstermann U, Gath I, Schwanz P, Closs EI, Kleinert H. Isoforms of nitric oxide synthase: properties, distribution and expressional control. Biochem Pharmacol. 1995;50:1321-1332.
36. Stuehr DJ, Cho HJ, Kwon NS, Weise MF, Nathan CF. Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein. Proc Natl Acad Sci USA. 1991;88:7773-7777.
37. Mandai M, Mittag TW, Kogishi J, et al. Role of nitric oxide synthase isozymes in endotoxin-induced uveitis. Invest Ophthalmol Vis Sci. 1996;37:826-832.
38. Xie QW, Cho HJ, Calaycay J, et al. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science. 1992;256:225-228.
39. Back KJ, Thiel BA, Lucas S, Stuehr DJ. Macrophage nitric oxide synthase subunits: purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme. J Biol Chem. 1993;268:21120-21129.
40. Ghosh DK, Stuehr DJ. Macrophage NO synthase: characterization of isolated oxygenase and reductase domains revels a head-to-head subunit interaction. Biochem 1995;34:801-807.
41. Albakri QA, Stuehr DJ. Intracellular assembly of inducible NO synthase is limited by nitric oxide-mediated changes in heme insertion and availability. J Biol Chem. 1996;271:5414-5421.