Renal and ocular hemodynamic effects of insulin

Diabetes

Volumn 46, Issue 11, 1997, Pages 1868-1874

  Schmetterer, Leopold ^a,b   Müller, Markus ^a   Fasching, Peter ^a   Diepolder, Carmen ^a   Gallenkamp, Antje ^a   Zanaschka, Gabriele ^a   Findl, Oliver ^a   Strenn, Karin ^a   Mensik, Christa ^a   Tschernko, Edda ^a   Eichler, Hans Georg ^a   Wolzt, Michael ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOHIPPURIC ACID; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NORADRENALIN; PLACEBO; POTASSIUM CHLORIDE; RECOMBINANT HUMAN INSULIN;

ADULT; ARTICLE; BLOOD FLOW VELOCITY; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOPPLER ECHOGRAPHY; DRUG EFFECT; EYE BLOOD FLOW; EYE FUNDUS; GLUCOSE BLOOD LEVEL; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY BLOOD FLOW; KIDNEY PLASMA FLOW; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VASODILATATION;

EID: 9844249100     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.11.1868     Document Type: Article

References (52)

1. Yagi S, Takata S, Kiyokawa H, Yamamoto M, Noto Y, Ikeda T, Hattori N: Effects of insulin on vasoconstrictive responses to norepinephrine and angiotensin II in rabbit femoral artery and vein. Diabetes 37:1064-1067, 1988
2. Feldman RD, Bierbrier GS: Insulin-mediated vasodilation: impairment with increased blood pressure and body mass. Lancet 342:707-709, 1993
3. Andersen EA, Hoffman RP, Balon TW, Sinkey CA, Mark AL: Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans. J Clin Invest 87:2246-2252, 1991
4. Vollenweider P, Tappy L, Randin D, Schneiter E, Jequier E, Nicod P, Scherrer U: Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans. J Clin Invest 92:147-154, 1992
5. Baron AD, Brechtel G: Insulin differentially regulates systemic and skeletal muscle vascular resistance. Am J Physiol 265:E61-E67, 1993
6. Scherrer U, Randin D, Vollenweider P, Vollenweider L, Nicod P: Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest 94:2511-2515, 1994
7. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD: Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. J Clin Invest 94:1172-1179, 1994
8. Baron AD: The coupling of glucose metabolism and perfusion in human skeletal muscle. Diabetes 45 (Suppl. 1):S105-S109, 1996
9. Calver A, Collier J, Vallance P: Nitric oxide and the control of human vascular tone in health and disease. Eur J Med 2:48-53, 1993
10. Palmer RMJ, Rees DD, Ashton DS, Moncada S: L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem Biophys Res Commun 153:1251-1256, 1988
11. Rees DD, Palmer MJ, Schulz R, Hodson HF, Moncada S: Characterisation of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 101:746-752, 1990
12. Laakso M, Edelman SV, Brechtel G, Baron AD: Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes 41:1076-1083, 1992
13. Deussen A, Sonntag M, Vogel R: L-arginine derived nitrous oxide: a major determinant of uveal blood flow. Exp Eye Res 57:129-134, 1993
14. Mann RM, Riva CE, Stone RA, Barnes GE, Cranstoun S: Nitric oxide and choroidal blood flow regulatioa Invest Ophthalmol Vis Sci 36:925-930, 1995
15. Schmetterer L, Krejcy K, Kastner J, Wolzt M, Gouya G, Flndl O, Lexer F, Breiteneder H, Fercher AF, Eichler HG: The effect of systemic nitric oxide-synthase inhibition on ocular fundus pulsations in man. Exp Eye Res 64:305-312, 1997
16. Chen C, Mitchell KD, Navar LG: Role of endothelium-derived nitric oxide in the renal hemodynamic response to amino acid infusion. Am J Physiol 263:510-516, 1992
17. Naess PA, Kirkeboen KA, Christensen G, Kiil F. Inhibition of renal nitric oxide synthesis with NG-monomethyl-L-arginine and NG-nitro-L-arginine. Am J Physiol 262:939-942, 1992
18. Wolzt M, Schmetterer L, Ferber W, Artner E, Mensik C, Eichler HG, Krejcy K: Effect of nitric oxide-synthase inhibition on renal hemodynamics in man: reversal by L-arginine. Am J Physiol 272:178-182, 1997
19. De Fronzo RA, Tobin JD, Andress R: Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223, 1979
20. Fasching P, Ratheiser K, Waldhäusl W, Rohac M, Osterrode W, Nowotny P, Vlerhapper H: Metabolic effects of fish-oil supplementation in patients with impaired glucose tolerance. Diabetes 40:583-589, 1991
21. Schmetterer L, Lexer F, Unfried C, Sattmann H, Fercher AF: Topical measurement of fundus pulsations. Opt Eng 34:711-716, 1995
22. Fercher AF, Hitzenberger CK, Drexler W, Kamp G, Sattmann H: In vivo optical coherence tomography. Am J Ophthalmol 116:113-114, 1993
23. Drexler W, Hitzenberger CK, Satmann H, Fercher AF: Measurement of the thickness of fundus layers by partial coherence tomography. Opt Eng 34:701-710, 1995
24. Schmetterer L, Wolzt M, Salomon A, Rheinberger A, Unfried C, Zanaschka G, Fercher A: The effect of isoproterenol, phenylephrine and sodium nitroprusside on fundus pulsations in healthy volunteers. Br J Ophthalmol 80:217-223, 1996
25. Schmetterer L, Strenn K, Findl O, Breiteneder H, Graselli U, Agneter E, Eichler HG, Wolzt M: Effects of antiglaucoma drugs on ocular hemodynamics in healthy volunteers. Clin Pharmacol Ther 43:501-508, 1997
26. Schmetterer L, Kemmler D, Breiteneder H, Alschinger C, Koppensteiner R, Lexer F, Fercher AF, Eichler HG, Wolzt M: A randomized, placebo-controlled, double blind cross over study of the effect of pentoxifylline on ocular fundus pulsations. Am J Ophthalmol 121:169-176, 1996
27. Gee W: Ocular pneumoplethysmography. Surv Ophthalmol 29:276-292, 1985
28. Langham ME, Tomey K: A clinical procedure for the measurement of the ocular pulse-pressure relationship and the ophthalmic arterial pressure. Exp Eye Res 27:17-25, 1978
29. Langham ME, Farrell RA, O'Brien V, Silver DM, Schilder P: Blood flow in the human eye. Acta Ophthalmol 67 (Suppl. 191):9-13, 1989
30. Schmetterer L, Wolzt M, Lexer F, Alschinger C, Gouya G, Zanaschka G, Fassolt A, Eichler HG, Fercher AF: The effect of hyperoxia and hypercapnia on fundus pulsations in the macular and optic disc region in healthy young volunteers. Exp Eye Res 61:685-690, 1995
31. Schmetterer L, Lexer F, Graselli U, Findl O, Eichler HG, Wolzt M: The effect of different mixtures of O2 and CO2 on ocular fundus pulsations. Exp Eye Res 63:351-355, 1996
32. Lieb WE, Cohen SM, Merton DA, Shields JA, Mitchell DG, Goldberg BB: Color Doppler imaging of the eye and the orbit. Arch Ophthalmol 109:527-531, 1991
33. Schnurr E, Lahme W, Küppers H: Measurement of renal clearance of insulin and PAH in the steady state without urine collection. Clin Nephrol 13:26-29, 1980
34. Kubicek WG, Kottke FJ, Rumos MU, Patterson RP, Witsoe DA, Labree JW, Remole W, Layman TE, Schoening H, Garamella JT: The Minnesota impedance cardiograph-theory and applications. Biomed Eng 9:410-416, 1974
35. De Mey C, Enterling D: Disagreement between standard transthoracic impedance cardiography and the automated transthoracic electrical bioimpedance method in estimating the cardiovascular responses to phenylephrine and isoprenaline in healthy men. Br J Clin Pharmacol 35:349-355, 1993
36. Jilma B, Kastner J, Mensik C, Hildebrand J, Vondrovec B, Krejcy K, Wagner O, Eichler HG: Sex differences in nitric oxide production. Life Sci 58:460-476, 1996
37. Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shineboume EA, Barnes PJ: Increased nitric oxide in exhaled air of asthmatic patients. Lancet 343:1-33-135, 1994
38. Krejcy K, Schmetterer L, Kastner J, Nieszpaur-Los M, Monitzer B, Schütz W, Eichler HG, Kyrle P: Role of nitric oxide in hemostatic system activation in vivo in humans. Arterioscler Thromb Vasc Biol 15:2063-2067, 1995
39. Baron AD, Brechtel G, Johnson A, Fineberg N, Henry DP, Steinberg HO: Interactions between insulin and norepinephrine on blood pressure and insulin sensitivity. J Clin Invest 93:2453-2462, 1994
40. Stenvinkel P, Bolinder J, Alvestrand A: Effects of insulin on renal haemodynamics and the proximal and distal tubular sodium handling in healthy subjects. Diabetologia 35:1042-1048, 1992
41. Norgaard K, Jensen T, Skott P, Thorsteinsson B, Bruun NE, Giese J, Feldt-Rasmussen B: Effects of insulin on renal hemodynamics and sodium handling in normal subjects. Scand J Clin Lab Invest 51:367-376, 1991
42. Schmetterer L, Findl O, Fasching P, Ferber W, Strenn K, Breiteneder H, Adam H, Eichler HG, Wolzt M: NO and ocular blood flow in patients with insulin-dependent diabetes mellitus. Diabetes 46:653-658, 1997
43. Steinberg HO, Brechtel G, Johnson A, Baron A: Insulin mediated endothelium dependent vasodilation is impaired in obesity (Abstract). Diabetes 43:315, 1994
44. Calver A, Collier J, Vallance P: Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. J Clin Invest 90:2548-2554, 1992
45. McVeigh GE, Brennan GM, Johnston GD, McDermott BJ, McGrath LT, Henry WR, Andrews JW, Hayes JR: Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 35:771-776, 1992
46. g-monomethyl-L-arginine in patients with hypertension: the nitric oxide dilator mechanism appears abnormal. J Hypertension 10:1025-1031, 1992
47. Baron AD: Hemodynamic actions of insulin. Am J Physiol 267:E187-E202, 1994
48. Krejcy K, Wolzt M, Kreuzer C, Breiteneder H, Schütz W, Eichler HG, Schmetterer L: Characterisation of angiotensin-II effects on cerebral and ocular circulation by noninvasive methods. Br J Clin Pharmacol 43:501-508, 1997
49. Wolzt M, Schmetterer L, Kastner J, Krejcy K, Zanaschka G, Unfried C, Eichler HG: Short-term drug effects on the signal-averaged electrocardiogram: assessment of intra- and interindividual variability of spectral temporal mapping and time-domain analysis. J Pharmacol Exp 275:1375-1381, 1995
50. Gherezghiher T, Okubo H, Koss C: Choroidal and ciliary blood flow analysis: application of laser Doppler flowmetry in experimental animals. Exp Eye Res. 53:151-156, 1991
51. Lang CC, Rahman AR, Balfour DJ, Struthers AD: Enalapril blunts the antinatriuretic effect of circulating noradrenaline in man. J Hypertens 11:565-571, 1993
52. Stamler JS, Loh E, Roddy M, Currie KE, Creager MA: Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation 89:2035-2040, 1994