Nitric oxide synthase activity and L-arginine metabolism in the retinas from streptozotocin-induced diabetic rats

General Pharmacology

Volumn 30, Issue 3, 1998, Pages 319-324

  Do Carmo, Anália ^a   Lopes, Celeste ^b   Santos, Maria ^c   Proença, Rui ^a   Cunha Vaz, José ^a   Carvalho, Arsélio P ^c  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Diabetes; Nitric oxide; Retina; Synthase

Indexed keywords

AMINOGUANIDINE; ARGININE; CITRULLINE; GLUTAMINE; NITRIC OXIDE SYNTHASE; ORNITHINE;

AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RETINA; STREPTOZOCIN DIABETES;

ANIMALS; ARGININE; DIABETES MELLITUS, EXPERIMENTAL; MALE; NITRIC OXIDE SYNTHASE; RATS; RATS, WISTAR; RETINA; STREPTOZOCIN;

EID: 0032033590     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(97)00363-7     Document Type: Conference Paper

References (22)

1. Allen J. B., McGahan M. C., Ferrell J. B., Adler K. B., Fleisher L. N. Nitric oxide synthase inhibitors exert differential time-dependent effects on LPS-induced uveitis. Exp. Eye Res. 62:1996;21-28.
2. Bogle R. G., Baydoun A. R., Pearson J. D., Moncada S., Mann G. E. L-arginine transport is increased in macrophages generating nitric oxide. Biochem. J. 284:1992;15-18.
3. Bredt D. S. and Schmidt H. W. (1996) Methods in Nitric Oxide Research. pp. 249-252, Wiley, Chichester.
4. Bredt D. S., Snyder S. H. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc. Natl. Acad. Sci. USA. 86:1989;9030-9033.
5. Brosnan J. T., Man K. W., Hall D. E., Colbourne S. A., Brosnan M. E. Interorgan metabolism of amino acids in streptozotocin diabetic ketoacidotic rat. Am. J. Physiol. 244:1983;E151-E158.
6. Corbett J. A., Mikhael A., Shimizu J., Frederick K., Misko T. P., McDaniel M. L., Kanagawa O., Unanue E. R. Nitric oxide production in islets from nonobese diabetic mice. aminoguanidine-sensitive and resistant stages in the immunological diabetic process Proc. Natl. Acad. Sci. USA. 90:1993;8992-8995.
7. Fernstrom M. H., Volk E. A., Fernstrom J. D., Iuvone M. Effect of tyrosine administration on DOPA accumulation in light- and dark-adapted retinas from normal and diabetic rats. Life Sci. 39:1986;2049-2057.
8. Hangai M., Yoshimura N., Hiroi K., Mandai M., Honda Y. Inducible nitric oxide synthase in retinal ischemia-reperfusion injury. Exp. Eye Res. 63:1996;501-509.
9. Inoguchi T., Battan R., Handler E., Sportsman J. R., Heath W., King G. L. Preferential elevation of protein kinase C isoform βII and diacylglycerol levels in the aorta and heart of diabetic rats. Proc. Natl. Acad. Sci. USA. 89:1992;11059-11063.
10. Jacquemin E., Kozak Y., Thillaye B., Courtois Y., Goureau O. Expression of inducible nitric oxide synthase in the eye from endotoxin-induced uveitis rats. Invest. Ophthalmol. Visual Sci. 37:1996;1187-1196.
11. Kern T. S., Kowluru R. A., Engerman R. L. Abnormalities of retinal metabolism in diabetes or galactosemia. ATPases and glutathione Invest. Ophthalmol. Visual Sci. 35:1994;2962-2967.
12. Kunz D., Mühl H., Walker G., Pfeilschifter J. Two distinct signaling pathways trigger the expression of inducible nitric oxide synthase in rat mesangial cells. Proc. Natl. Acad. Sci. USA. 91:1994;5387-5391.
13. Laszlo F., Evans S. M., Whittle B. J. R. Aminoguanidine inhibits both constitutive and inducible nitric oxide synthase isoforms in rat intestinal microvasculature in vivo. Eur. J. Pharmac. 272:1995;169-175.
14. 3H]arginine transport and nitric oxide synthase in rat brain synaptosomes. Neurosci. Lett.(181):1994;1-2.
15. Misko T. P., Moore W. M., Kasten T. P. Selective inhibition of the inducible nitric oxide synthase by aminoguanidine. Eur. J. Pharmacol. 233:1993;119-125.
16. Santos M. S., Moreno A. J., Carvalho A. P. Relationships between ATP depletion, membrane potential and the release of neurotransmitters in rat nerve terminals. Stroke. 27:1996;941-950.
17. Sen H. A., Campochiaro P. A. Stimulation of cyclic adenosine monophosphate accumulation causes breakdown of the blood-retinal barrier. Invest. Ophthalmol. Visual Sci. 32:1991;2006-2010.
18. Sharma K., Danoff T. M., DePiero A., Ziyadeh F. N. Enhanced expression of inducible nitric oxide synthase in murine macrophages and glomerular mesangial cells by elevated glucose levels. possible mediation by protein kinase C Biochem. Biophys. Res. Commun. 207:1995;80-88.
19. Southan G. J., Szab E. C. Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Biochem. Pharmac. 51:1996;383-394.
20. Tilton R. G., Chang K., Corbett J. A., Misko T. P., Currie M. G., Bora N. S., Kaplan H. J., Williamson J. R. Endotoxin-induced uveitis in the rat is attenuated by inhibition of nitric oxide production. Invest. Ophthalmol. Visual Sci. 35:1994;3278-3288.
21. Vilchis C., Salceda R. Effect of diabetes on levels and uptake of putative amino acid neurotransmitters in rat retina and retinal pigment epithelium. Neurochem. Res. 21:1996;1167-1171.
22. White M. F. The transport of cationic amino acids across the plasma membrane of mammalian cells. Biochim. Biophys. Acta. 822:1985;355-374.