Endothelium-dependent vasodilation in the uvea of hypertensive and normotensive rats

Current Eye Research

Volumn 17, Issue 2, 1998, Pages 189-196

  Granstam, E ^a   Granstam, S O ^a   Fellstrom B ^a   Lind, L ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Blood flow; Endothelin; Hypertension; Nitric oxide; Rat; Uvea

Indexed keywords

ACETYLCHOLINE; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN; ENDOTHELIN A RECEPTOR ANTAGONIST; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; VASOCONSTRICTOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM; EYE BLOOD FLOW; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; UVEA; VASCULAR RESISTANCE; VASODILATATION;

ACETYLCHOLINE; ANIMALS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HYPERTENSION; MALE; MICROSPHERES; NITRIC OXIDE; NITROPRUSSIDE; OMEGA-N-METHYLARGININE; PEPTIDES, CYCLIC; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTORS, ENDOTHELIN; REGIONAL BLOOD FLOW; UVEA; VASCULAR RESISTANCE; VASODILATION;

EID: 0031907531     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/ceyr.17.2.189.5609     Document Type: Article

References (42)

1. Yanagisawa, M. and Masaki, T. (1989) Molecular biology and biochemistry of the endothelins. Trends Pharmacol. Sci. 10, 374-378.
2. Lüscher, T. F. and Noll, G. (1995) The endothelium as a regulator of vascular tone and growth. In The Endothelium in Cardiovascular Disease (Ed. Lüscher, T. F.). Pp. 1-24. Springer Verlag, Berlin.
3. Yao, K., Tschudi, M., Flammer, J. and Lüscher, T. F. (1991) Endothelium-dependent regulation of vascular tone of the porcine ophthalmic artery. Invest. Ophthalmol. Vis. Sci. 32, 1791-1798.
4. Haefliger, I. O., Flammer, J. and Lüscher, T. F. (1992) Nitric oxide and endothelin-1 are important regulators of human ophthalmic artery. Invest. Ophthalmol. Vis. Sci. 33, 2340-2343.
5. Meyer, P., Flammer, J. and Lüscher, T. F. (1993) Endothelium-dependent regulation of the ophthalmic microcirculation in the perfused porcine eye: role of nitric oxide and endothelins. Invest. Ophthalmol. Vis. Sci. 34, 3614-3621.
6. Nyborg, N. C. B., Prieto, D., Benedito, S. and Nielsen, P. J. (1991) Endothelin-1-induced contraction of bovine retinal small arteries is reversible and abolished by nitren-dipine. Invest. Ophthalmol. Vis. Sci. 32, 27-31.
7. Deussen, A., Sonntag, M. and Vogel, R. (1993) L-arginine-derived nitric oxide: a major determinant of uveal blood flow. Exp. Eye Res. 57, 129-134.
8. Mann, R. M., Riva, C. E., Stone, R. A., Barnes, G. E. and Cranstoun, S. D. (1995) Nitric oxide and choroidal blood flow regulation. Invest. Ophthalmol. Vis. Sci, 36, 925-930.
9. Hayreh, S. S., Servais, G. E. and Virdi, P. S. (1989) Retinal arteriolar changes in malignant arterial hypertension. Ophthalmologica, 198, 178-196.
10. Tso, M. O. M. and Jampol, L. M. (1982) Pathophysiology of hypertensive retinopathy. Ophthalmology, 89, 1132-1145.
11. Linder, L., Kiowski, W., Bühler, F. R. and Lüscher, T. F. (1990) Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo: blunted response in essential hypertension. Circulation, 81, 1762-1767.
12. Panza, J. A., Casino, P. R., Kilcoyne, C. M. and Quyyumi, A. A. (1993) Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension. Circulation, 87, 1468-1474.
13. Dohi, Y., Thiel, M. A., Bühler, F. R. and Lüscher, T. F. (1990) Activation of endothelial L-arginine pathway in resistance arteries: effect of age and hypertension. Hypertension, 15, 170-179.
14. Lüscher, T. F. (1990) Imbalance of endothelium-derived relaxing and contrating factors. A new concept in hypertension? Am. J. Hypertens. 3, 317-330.
15. G-monomethyl-L-arginine-induced pressor response at developmental and established stages in spontaneously hypertensive rats. J. Pharmacol. Exp. Ther. 259, 52-57.
16. Sawada, Y., Sakamaki, T., Nakamura, T., Sato, K., Ono, Z. and Murata, K. (1994) Release of nitric oxide in response to acetylcholine is unaltered in spontaneously hypertensive rats. J. Hypertens. 12, 745-750.
17. Cockcroft, J. R., Chowienczyk, P. J., Benjamin, N. and Ritter, J. M. (1994) Preserved endothelium-dependent vasodilatation in patients with essential hypertension. N. Engl. J. Med. 330, 1036-1040.
18. Rees, D. D., Palmer, R. M. J. and Moncada, S. (1989) Role of endothelium-derived nitric oxide in the regulation of blood pressure. Proc. Natl. Acad. Sci. USA, 86, 3375-3378.
19. A receptor. Life Sci. 50, 247-255.
20. Kukovetz, W. R., Holzmann, S., Wurm, A. and Pöch, G. (1979) Evidence for cyclic GMP-mediated relaxant effects of nitro-compounds in coronary smooth muscle. Naunyn-Schmiedeberg's Arch. Pharmacol. 310, 129-138.
21. Koskinen, L.-O. D. (1989) Cerebral and peripheral blood flow effects of TRH in the rat: a role of vagal nerves. Peptides, 10, 933-938.
22. Hillerdal, M. (1987) Cochlear blood flow in the rat: a methodological evaluation of the microsphere method. Hearing Res. 27, 27-35.
23. Hillerdal, M., Sperber, G. O. and Bill, A. (1987) The microsphere method for measuring low blood flow: theory and computer simulations applied to findings in the rat cochlea. Acta Physiol. Scand. 130, 229-235.
24. Irinoda, K. (1977) The ocular manifestations of spontaneously hypertensive rat. Jpn. J. Ophthalmol. 21, 125-131.
25. Chandra, S. R. and Friedman, E. (1972) Choroidal blood flow: II. the effects of autonomic agents. Arch. Ophthalmol. 87, 67-69.
26. Riva, C. E., Cranstoun, S. D., Mann, R. M. and Barnes, G. E. (1994) Local choroidal blood flow in the cat by laser doppler flowmetry. Invest. Ophthalmol. Vis. Sci. 35, 608-618.
27. Furchgott, R. F. and Zawadzki, J. V. (1980) The obligatory role of endothelial cells in the relaxation or arterial smooth muscle by acetylcholine. Nature, 288, 373-376.
28. Alm, A. and Bill, A. (1972) The oxygen supply to the retina: II. effects of high intraocular pressure and of increased arterial carbon dioxide tension on uveal and retinal blood flow in cats. Acta Physiol. Scand. 84, 306-319.
29. Bill, A. (1974) Effects of acetazolamide and carotid occlusion on the ocular blood flow in unanesthetized rabbits. Invest. Ophthalmol. 13, 954-958.
30. Chakravarthy, U., Stitt, A. W., McNally, J., Bailie, J. R., Hoey, E. M. and Duprex, P. (1995) Nitric oxide synthase activity and expression in retinal capillary endothelial cells and pericytes. Curr. Eye Res. 14, 285-294.
31. Yamamoto, R., Bredt, D. S., Snyder, S. H. and Stone, R. A. (1993) The localization of nitric oxide synthase in the rat eye and related cranial ganglia. Neuroscience, 54, 189-200.
32. Chakravarthy, U., Douglas, A. J., Bailie, J. R., McKibben, B. and Archer, D. B. (1994) Immunoreactive endothelin distribution in ocular tissues. Invest. Ophthalmol. Vis. Sci. 35, 2448-2454.
33. Arai, H., Hori, S., Aramori, I., Ohkubo, H. and Nakanishi, S. (1990) Cloning and expression of a cDNA encoding an endothelin receptor. Nature, 348, 730-732.
34. Sakurai, T., Yanagisawa, M., Takuwa, Y., Miyazaki, H., Kimura, S., Goto, K. and Masaki, T. (1990) Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature, 348, 732-735.
35. Stitt, A. W., Chakravarthy, U., Gardiner, T. A. and Archer, D. B. (1995) Endothelin-like immunoreactivity and receptor binding in the choroid and retina. Curr. Eye Res. 15, 111-117.
36. B receptors in isolated porcine ophthalmic artery. Acta Physiol. Scand. 157, 245-252.
37. Masaki, T., Kimura, S., Yanagisawa, M. and Goto, K. (1991) Molecular and cellular mechanism of endothelin regulation: implications for vascular function. Circulation, 84, 1457-1468.
38. Granstam, E., Wang, L. and Bill, A. (1993) Vascular effects of endothelin-1 in the cat; modification by indomethcain and L-NAME. Acta Physiol. Scand. 148, 165-176.
39. Alm, A., Bill, A. and Young, F. A. (1973) The effects of pilocarpine and neostigmine on the blood flow through the anterior uvea in monkeys: a study with radioactively labelled microspheres. Exp. Eye Res. 15, 31-36.
40. Kinyoun, J. L. and Kalina, R. E. (1986) Visual loss from choroidal ischemia. Am. J. Ophthalmol. 101, 650-656.
41. MacCumber, M. W., Flower, R. W. and Langham, M. E. (1993) Ischemic hypertensive choroidopathy, fluorescein angiography, indocyanine green videoangiography and measurement of pulsatile blood flow. Arch. Ophthalmol. 111, 704-705.
42. Kishi, S., Tso, M. O. M. and Hayreh, S. S. (1985) Fundus lesions in malignant hypertension I: a pathologic study of experimental hypertensive choroidopathy. Arch. Ophthalmol. 103, 1189-1197.