Human immunodeficiency virus: Mutations in the viral protease that confer resistance to saquinavir increase the dissociation rate constant of the protease-saquinavir complex

Journal of Biological Chemistry

Volumn 271, Issue 52, 1996, Pages 33231-33235

  Maschera, Barbara ^b   Darby, Graham ^b   Palú, Giorgio ^c   Wright, Lois L ^a   Tisdale, Margaret ^b   Myers, Richard ^b   Blair, Edward D ^b   Furfine, Eric S ^a  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; PROTEINASE; SAQUINAVIR; VIRUS ENZYME;

ARTICLE; BINDING AFFINITY; CATALYSIS; DRUG PROTEIN BINDING; ENZYME BINDING; ENZYME KINETICS; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; PRIORITY JOURNAL;

ANTIVIRAL AGENTS; CARBAMATES; DRUG RESISTANCE, MICROBIAL; HIV PROTEASE; HIV PROTEASE INHIBITORS; HUMANS; INDINAVIR; ISOQUINOLINES; KINETICS; MUTAGENESIS; NELFINAVIR; RITONAVIR; SAQUINAVIR; SULFONAMIDES; SULFONIC ACIDS;

EID: 0030468331     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.52.33231     Document Type: Article

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