Conformational change in human DNA repair enzyme O6-methylguanine-DNA methyltransferase upon alkylation of its active site by SN1 (indirect- acting) and SN2 (direct-acting) alkylating agents: Breaking a 'salt-link'?

Biochemistry

Volumn 35, Issue 38, 1996, Pages 12259-12266

  Oh, Hue Kian ^a   Teo, Alvin K C ^a   Ali, Rahmen B ^a   Lim, Allan ^a   Ayi, Teck Choon ^a   Yarosh, D B ^b   Li, Benjamin F L ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b AGI Dermatics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O BENZYLGUANINE; ALKYLATING AGENT; GUANINE DERIVATIVE; METHYL IODIDE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MONOCLONAL ANTIBODY; PROTEINASE;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA ALKYLATION; DNA REPAIR; ENZYME ACTIVE SITE; ENZYME DEGRADATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ALKYLATING AGENTS; AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; BINDING SITES; BLOTTING, WESTERN; CELLS, CULTURED; CYSTEINE; DNA REPAIR; EPITOPE MAPPING; GUANINE; HUMANS; HYDROCARBONS, IODINATED; METHYLTRANSFERASES; MOLECULAR SEQUENCE DATA; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; POINT MUTATION; PRECIPITIN TESTS; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; SERINE ENDOPEPTIDASES;

MAMMALIA;

EID: 0029760175     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9603635     Document Type: Article

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