메뉴 건너뛰기




Volumn 14, Issue 1, 1999, Pages 1-9

Molecular approaches to achieving control of gene expression by drug intervention at the transcriptional level

Author keywords

Antitumour drugs; DNA bending; Protein DNA complexes; Transcriptional control

Indexed keywords

CELL NUCLEUS RECEPTOR; CISPLATIN; DNA; RACHELMYCIN;

EID: 0032911152     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (27)

References (51)
  • 4
    • 0023145547 scopus 로고
    • The molecular genetics of cancer
    • Bishop J.M. (1987) The molecular genetics of cancer. Science, 235, 305.
    • (1987) Science , vol.235 , pp. 305
    • Bishop, J.M.1
  • 5
    • 0026010995 scopus 로고
    • Molecular themes in oncogenesis
    • Bishop J.M. (1991) Molecular themes in oncogenesis. Cell, 64, 235.
    • (1991) Cell , vol.64 , pp. 235
    • Bishop, J.M.1
  • 8
    • 0030013203 scopus 로고    scopus 로고
    • Biochemistry and structural biology of transcription factor II D (TFIID)
    • Burley S.K., Roeder R.G. (1996) Biochemistry and structural biology of transcription factor II D (TFIID) Annual Reviews in Biochemistry, 65, 769.
    • (1996) Annual Reviews in Biochemistry , vol.65 , pp. 769
    • Burley, S.K.1    Roeder, R.G.2
  • 9
    • 0028206145 scopus 로고
    • Effects of minor groove binding drugs on the interaction of TATA box binding protein and TFIIA with DNA
    • Chiang S.Y., Welch J., Rauscher F.J. III, Beerman T.A. (1994) Effects of minor groove binding drugs on the interaction of TATA box binding protein and TFIIA with DNA. Biochemistry, 33, 7033.
    • (1994) Biochemistry , vol.33 , pp. 7033
    • Chiang, S.Y.1    Welch, J.2    Rauscher F.J. III3    Beerman, T.A.4
  • 11
    • 0029009684 scopus 로고
    • 2+ complex on DNA: A new paradigm for the structure of a drug-DNA complex and implications for the structure of the quinolone bacterial gyrase-DNA complex
    • 2+ complex on DNA: a new paradigm for the structure of a drug-DNA complex and implications for the structure of the quinolone bacterial gyrase-DNA complex. Journal of Medicinal Chemistry, 3, 498.
    • (1995) Journal of Medicinal Chemistry , vol.3 , pp. 498
    • Fan, J.Y.1    Sun, D.2    Yu, H.3    Kerwin, S.M.4    Hurley, L.H.5
  • 12
    • 0030707763 scopus 로고    scopus 로고
    • Will genetics really revolutionize the drug discovery process?
    • Gelbert L.M., Gregg R.E. (1997) Will genetics really revolutionize the drug discovery process? Current Opinions in Biotechnology, 8, 669.
    • (1997) Current Opinions in Biotechnology , vol.8 , pp. 669
    • Gelbert, L.M.1    Gregg, R.E.2
  • 13
    • 0031979354 scopus 로고    scopus 로고
    • Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA
    • Good L., Nielsen P.E. (1998) Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA. Nature Biotechnology, 16, 355.
    • (1998) Nature Biotechnology , vol.16 , pp. 355
    • Good, L.1    Nielsen, P.E.2
  • 14
    • 0030037074 scopus 로고    scopus 로고
    • Molecular details of the structure of a psorospermin-DNA covalent/intercalation complex and associated DNA sequence selectivity
    • Hansen M., Lee S.J., Cassady J.M., Hurley L.H. (1996) Molecular details of the structure of a psorospermin-DNA covalent/intercalation complex and associated DNA sequence selectivity. Journal of the Americal Chemical Society, 24, 5553.
    • (1996) Journal of the Americal Chemical Society , vol.24 , pp. 5553
    • Hansen, M.1    Lee, S.J.2    Cassady, J.M.3    Hurley, L.H.4
  • 15
    • 0039121646 scopus 로고
    • Control of gene expression by oligodeoxynucleotides covalently linked to intercalating agents and nucleic acid-cleaving reagents
    • Cohen J.S. (ed.), CRC Press: Boca Raton, FL
    • Helénè C., Toulmé J.J. (1989) Control of gene expression by oligodeoxynucleotides covalently linked to intercalating agents and nucleic acid-cleaving reagents. In Topics in Molecular and Structural Biology. Oligonucleotides: Antisense Inhibitors of Gene Expression. Cohen J.S. (ed.), p. 137. CRC Press: Boca Raton, FL.
    • (1989) Topics in Molecular and Structural Biology. Oligonucleotides: Antisense Inhibitors of Gene Expression , pp. 137
    • Helénè, C.1    Toulmé, J.J.2
  • 16
    • 0028136464 scopus 로고
    • Specific inhibition of formation of transcription complexes by a calicheamicin oligosaccharide: A paradigm for the development of transcriptional antagonists
    • Ho S.N., Boyer S.H., Schreiber S.L., Danishefsky S.J., Crabtree G.R. (1994) Specific inhibition of formation of transcription complexes by a calicheamicin oligosaccharide: a paradigm for the development of transcriptional antagonists. Proceedings of the National Academy of Sciences, USA, 91, 9203.
    • (1994) Proceedings of the National Academy of Sciences, USA , vol.91 , pp. 9203
    • Ho, S.N.1    Boyer, S.H.2    Schreiber, S.L.3    Danishefsky, S.J.4    Crabtree, G.R.5
  • 17
    • 0024478054 scopus 로고
    • p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor
    • Hudziak R.M., Lewis G.D., Winget M., Fendly B.M., Shepard H.M., Ullrich A. (1989) p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor. Molecular and Cellular Biology, 9, 1165.
    • (1989) Molecular and Cellular Biology , vol.9 , pp. 1165
    • Hudziak, R.M.1    Lewis, G.D.2    Winget, M.3    Fendly, B.M.4    Shepard, H.M.5    Ullrich, A.6
  • 18
    • 0024463685 scopus 로고
    • DNA and associated targets for drug design
    • Hurley L.H. (1989) DNA and associated targets for drug design. Journal of Medicinal Chemistry, 32, 2027.
    • (1989) Journal of Medicinal Chemistry , vol.32 , pp. 2027
    • Hurley, L.H.1
  • 19
    • 0027483012 scopus 로고
    • Co-crystal structure of TBP recognizing the minor groove of a TATA element
    • Kim J.L., Nikolov D.B., Burley S.K. (1993) Co-crystal structure of TBP recognizing the minor groove of a TATA element. Nature, 365, 520.
    • (1993) Nature , vol.365 , pp. 520
    • Kim, J.L.1    Nikolov, D.B.2    Burley, S.K.3
  • 20
    • 0032484105 scopus 로고    scopus 로고
    • Topoisomerase II site-directed alkylation of DNA by psorospermin and its effect on topoisomerase II-mediated DNA cleavage
    • Kwok Y., Hurley L.H. (1998) Topoisomerase II site-directed alkylation of DNA by psorospermin and its effect on topoisomerase II-mediated DNA cleavage. Journal of Biological Chemistry, 49, 33020.
    • (1998) Journal of Biological Chemistry , vol.49 , pp. 33020
    • Kwok, Y.1    Hurley, L.H.2
  • 21
    • 0032506135 scopus 로고    scopus 로고
    • Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites
    • Kwok Y., Zeng Q., Hurley L.H. (1998) Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites. Proceedings of the National Academy of Sciences, USA, 95, 13531.
    • (1998) Proceedings of the National Academy of Sciences, USA , vol.95 , pp. 13531
    • Kwok, Y.1    Zeng, Q.2    Hurley, L.H.3
  • 24
    • 1842411320 scopus 로고    scopus 로고
    • Crystal structure of the nucleosome core particle at 2.8 Å resolution
    • Luger K., Mader A.W., Richmond R.K., Sargent D.F., Richmond T.J. (1997) Crystal structure of the nucleosome core particle at 2.8 Å resolution. Nature, 389, 251.
    • (1997) Nature , vol.389 , pp. 251
    • Luger, K.1    Mader, A.W.2    Richmond, R.K.3    Sargent, D.F.4    Richmond, T.J.5
  • 27
    • 0026341239 scopus 로고
    • Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide
    • Nielsen P.E., Egholm M., Berg R.H., Buchardt O. (1991) Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science, 254, 1497.
    • (1991) Science , vol.254 , pp. 1497
    • Nielsen, P.E.1    Egholm, M.2    Berg, R.H.3    Buchardt, O.4
  • 28
    • 0028075767 scopus 로고
    • Sequence-specific transcription arrest by peptide nucleic acid bound to the DNA template strand
    • Nielsen P.E., Egholm M., Buchardt O. (1994) Sequence-specific transcription arrest by peptide nucleic acid bound to the DNA template strand. Gene, 149, 139.
    • (1994) Gene , vol.149 , pp. 139
    • Nielsen, P.E.1    Egholm, M.2    Buchardt, O.3
  • 30
    • 0026569275 scopus 로고
    • Specific binding of chromosomal protein HMGl to DNA damaged by the anticancer drug cisplatin
    • Pil P.M., Lippard S.J. (1992) Specific binding of chromosomal protein HMGl to DNA damaged by the anticancer drug cisplatin. Science, 256, 234.
    • (1992) Science , vol.256 , pp. 234
    • Pil, P.M.1    Lippard, S.J.2
  • 31
    • 0029838307 scopus 로고    scopus 로고
    • DMA sequence-and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the caribbean tunicate Ecteinascidia turbinata
    • Pommier Y., Kohlhagen G., Bailly C., Waring M., Mazumder A., Kohn K.W. (1996) DMA sequence-and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the caribbean tunicate Ecteinascidia turbinata. Biochemistry, 35, 13303.
    • (1996) Biochemistry , vol.35 , pp. 13303
    • Pommier, Y.1    Kohlhagen, G.2    Bailly, C.3    Waring, M.4    Mazumder, A.5    Kohn, K.W.6
  • 32
    • 0028017791 scopus 로고
    • Signalling targets for the development of cancer drugs
    • Powis G., Workman P. (1994) Signalling targets for the development of cancer drugs. Anti-Cancer Drug Design, 9, 263.
    • (1994) Anti-cancer Drug Design , vol.9 , pp. 263
    • Powis, G.1    Workman, P.2
  • 33
    • 0001685401 scopus 로고
    • The major adduct of the antitumor drug cis-diamminedichloro-platinum(II) with DNA bends the duplex by ~40° toward the major groove
    • Rice J.A., Crothers D.M., Pinto A.L., Lippard S.J. (1988) The major adduct of the antitumor drug cis-diamminedichloro-platinum(II) with DNA bends the duplex by ~40° toward the major groove. Proceedings of the National Academy of Sciences, USA, 85, 4158.
    • (1988) Proceedings of the National Academy of Sciences, USA , vol.85 , pp. 4158
    • Rice, J.A.1    Crothers, D.M.2    Pinto, A.L.3    Lippard, S.J.4
  • 34
    • 0021760689 scopus 로고
    • Structure of the nucleosome core particle at 7 Å resolution
    • Richmond T.J., Finch J.T., Rushton B., Rhodes D., Klug A. (1984) Structure of the nucleosome core particle at 7 Å resolution. Nature, 311, 532.
    • (1984) Nature , vol.311 , pp. 532
    • Richmond, T.J.1    Finch, J.T.2    Rushton, B.3    Rhodes, D.4    Klug, A.5
  • 36
    • 0028838714 scopus 로고
    • Intracellular receptors and signal transducers and activators of transcription superfamilies: Novel targets for small-molecule drug discovery
    • Rosen J., Day A., Jones T.K., Jones E.T., Nadzan A.M., Stein R.B. (1995) Intracellular receptors and signal transducers and activators of transcription superfamilies: novel targets for small-molecule drug discovery. Journal of Medicinal Chemistry, 38, 4855.
    • (1995) Journal of Medicinal Chemistry , vol.38 , pp. 4855
    • Rosen, J.1    Day, A.2    Jones, T.K.3    Jones, E.T.4    Nadzan, A.M.5    Stein, R.B.6
  • 38
    • 0032561788 scopus 로고    scopus 로고
    • Molecular basis for the DNA sequence selectivity of ecteinascidin 736 and 743: Evidence for the dominant role of direct readout via hydrogen bonding
    • Seaman F.C., Hurley L.H. (1998) Molecular basis for the DNA sequence selectivity of ecteinascidin 736 and 743: evidence for the dominant role of direct readout via hydrogen bonding. Journal of the American Chemical Society, 120, 13028.
    • (1998) Journal of the American Chemical Society , vol.120 , pp. 13028
    • Seaman, F.C.1    Hurley, L.H.2
  • 39
    • 0024533317 scopus 로고
    • Mechanism of quinolone inhibition of DNA gyrase. Appearance of unique norfloxacin binding sites in enzyme-DNA complexes
    • Shen L.L., Kohlbrenner W.E., Weigl D., Baranowski J. (1989) Mechanism of quinolone inhibition of DNA gyrase. Appearance of unique norfloxacin binding sites in enzyme-DNA complexes. Journal of Biological Chemistry, 264, 2973.
    • (1989) Journal of Biological Chemistry , vol.264 , pp. 2973
    • Shen, L.L.1    Kohlbrenner, W.E.2    Weigl, D.3    Baranowski, J.4
  • 41
    • 37049183697 scopus 로고
    • Human beast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon D.J., Clark G.M., Wong S.G., Levin W.J., Ullrich A., McGuire W.L. (1987) Human beast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science, 235, 177.
    • (1987) Science , vol.235 , pp. 177
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 42
    • 0025891698 scopus 로고
    • DNA looping between sites for transcriptional activation: Self-association of DNA-bound Sp1
    • Su W., Jackson S., Tjian R., Echols H. (1991) DNA looping between sites for transcriptional activation: self-association of DNA-bound Sp1. Genes and Development, 5, 820.
    • (1991) Genes and Development , vol.5 , pp. 820
    • Su, W.1    Jackson, S.2    Tjian, R.3    Echols, H.4
  • 43
    • 0027991994 scopus 로고
    • Cooperative bending of the 21-base-pair repeats of the SV40 viral early promoter by human Sp1
    • Sun D., Hurley L.H. (1994a) Cooperative bending of the 21-base-pair repeats of the SV40 viral early promoter by human Sp1. Biochemistry, 33, 9578.
    • (1994) Biochemistry , vol.33 , pp. 9578
    • Sun, D.1    Hurley, L.H.2
  • 44
    • 0027999874 scopus 로고
    • Binding of Sp1 to the 21-base-pair repeat region of SV40 DNA: Effect of intrinsic and drug-induced DNA bending between GC boxes
    • Sun D., Hurley L.H. (1994b) Binding of Sp1 to the 21-base-pair repeat region of SV40 DNA: effect of intrinsic and drug-induced DNA bending between GC boxes. Gene, 149, 165.
    • (1994) Gene , vol.149 , pp. 165
    • Sun, D.1    Hurley, L.H.2
  • 45
    • 0029328528 scopus 로고
    • TBP binding to the TATA box induces a specific downstream unwinding site that is targeted by pluramycin
    • Sun D., Hurley L.H. (1995) TBP binding to the TATA box induces a specific downstream unwinding site that is targeted by pluramycin. Chemistry and Biology, 2, 457.
    • (1995) Chemistry and Biology , vol.2 , pp. 457
    • Sun, D.1    Hurley, L.H.2
  • 46
    • 0000739713 scopus 로고    scopus 로고
    • Recognition of 16 base pairs in the minor groove of DNA by a pyrrole-imidazol polyamide dimer
    • Trauger J.W., Baird E.E., Dervan P.B. (1998) Recognition of 16 base pairs in the minor groove of DNA by a pyrrole-imidazol polyamide dimer. Journal of the American Chemical Society, 120, 3534.
    • (1998) Journal of the American Chemical Society , vol.120 , pp. 3534
    • Trauger, J.W.1    Baird, E.E.2    Dervan, P.B.3
  • 47
    • 0028227965 scopus 로고
    • Cisplatin-DNA adducts are molecular decoys for the ribosomal RNA transcription factor hUBF (human upstream binding factor)
    • Treiber D.K., Zhai X., Jantzen H.M., Essigmann J.M. (1994) Cisplatin-DNA adducts are molecular decoys for the ribosomal RNA transcription factor hUBF (human upstream binding factor) Proceedings of the National Academy of Sciences, USA, 91, 5672.
    • (1994) Proceedings of the National Academy of Sciences, USA , vol.91 , pp. 5672
    • Treiber, D.K.1    Zhai, X.2    Jantzen, H.M.3    Essigmann, J.M.4
  • 48
  • 50
    • 0031215078 scopus 로고    scopus 로고
    • On the pairing rules for recognition in the minor groove of DNA by pyrroleimidazole polyamides
    • White S., Baird E.E., Dervan P.B. (1997) On the pairing rules for recognition in the minor groove of DNA by pyrroleimidazole polyamides. Chemistry and Biology, 4, 569.
    • (1997) Chemistry and Biology , vol.4 , pp. 569
    • White, S.1    Baird, E.E.2    Dervan, P.B.3
  • 51
    • 0032576722 scopus 로고    scopus 로고
    • Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands
    • White S., Szewczyk J.W., Turner J.M., Baird E.E., Dervan P.B. (1998) Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands. Nature, 391, 468.
    • (1998) Nature , vol.391 , pp. 468
    • White, S.1    Szewczyk, J.W.2    Turner, J.M.3    Baird, E.E.4    Dervan, P.B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.