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0029805706
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The new genomics: Global views of biology
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of oustanding interest. A comprehensive commentary on the future direction of genomics research. Fundamental changes in experimental paradigms and technology are described for the analysis of DNA, RNA and protein sequences. The affect of new genomic technologies on society are also discussed.
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Lander ES. The new genomics: global views of biology. of oustanding interest Science. 274:1996;536-539 A comprehensive commentary on the future direction of genomics research. Fundamental changes in experimental paradigms and technology are described for the analysis of DNA, RNA and protein sequences. The affect of new genomic technologies on society are also discussed.
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Lander, E.S.1
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Positional cloning moves from perditional to traditional
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Collins FS. Positional cloning moves from perditional to traditional. Nat Genet. 9:1995;347-350.
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Nat Genet
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Collins, F.S.1
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XREF database at the National Center for Biotechnology Information on the World Wide Web URL: of special interest
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XREF database at the National Center for Biotechnology Information on the World Wide Web URL: http://www.ncbi.nlm.nih.gov/XREFdb/m of special interest.
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4
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85030306648
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A comprehensive commentary on the future of genomics research. Fundamental changes in experimental paradigms and technology are described for the analysis of DNA, RNA and protein sequences. The affect of new genomic technologies on society are also discussed.
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A comprehensive commentary on the future of genomics research. Fundamental changes in experimental paradigms and technology are described for the analysis of DNA, RNA and protein sequences. The affect of new genomic technologies on society are also discussed.
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The genomics gamble
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of special interest. A recent analysis of the impact of genomics in the pharmaceutical and biotechnology sectors.
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Cohen J. The genomics gamble. of special interest Science. 275:1997;767-772 A recent analysis of the impact of genomics in the pharmaceutical and biotechnology sectors.
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Cohen, J.1
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Morell V. Life's last domain. Nature. 273:1996;1043-1045.
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Nature
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Morell, V.1
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Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii
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Bult CJ, White O, Olsen GJ, Zhou L, Fleischmann RD, Sutton GG, Blake JA, FitzGerald LM, Clayton RA, Gocayne JD, et al. Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii. Science. 273:1996;1058-1073.
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Bult, C.J.1
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Sutton, G.G.6
Blake, J.A.7
Fitzgerald, L.M.8
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0031000180
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The first genome from the third domain of life
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of special interest. Analysis of several sequenced genomes was performed to group genes from different organisms by function (orthologue analysis). The use of comparative genomics to identify gene function and biological pathways is highlighted.
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Clayton RA, White O, Ketchum KA, Venter JC. The first genome from the third domain of life. of special interest Nature. 387:1997;459-462 Analysis of several sequenced genomes was performed to group genes from different organisms by function (orthologue analysis). The use of comparative genomics to identify gene function and biological pathways is highlighted.
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Nature
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Clayton, R.A.1
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Big time for small genomes
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Koonin EV. Big time for small genomes. Genome Res. 7:1997;418-421.
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0029653518
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Whole-genome random sequencing and assembly of Haemophilus influenzae Rd
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Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 269:1995;496-512.
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Kerlavage, A.R.6
Bult, C.J.7
Tomb, J.F.8
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0029059785
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Bacterial genome sequence bagged
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Nowak R. Bacterial genome sequence bagged. Science. 269:1995;468-470.
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Nowak, R.1
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The complete genome sequence of Escherichia coli K-12
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Blattner FR, Plunkett G III, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, et al. The complete genome sequence of Escherichia coli K-12. Science. 277:1997;1453-1462.
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Blattner, F.R.1
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Glasner, J.D.8
Rode, C.K.9
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13
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0030835739
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The complete genome sequence of the gastric pathogen Helicobacter pylori
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of special interest. The sequencing and analysis of the genome of a major pathogen is presented. Also see Dolittle 1997 [13] for a discussion of the impact of this paper.
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Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, et al. The complete genome sequence of the gastric pathogen Helicobacter pylori. of special interest Nature. 388:1997;539-547 The sequencing and analysis of the genome of a major pathogen is presented. Also see Dolittle 1997 [13] for a discussion of the impact of this paper.
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Nature
, vol.388
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Tomb, J.F.1
White, O.2
Kerlavage, A.R.3
Clayton, R.A.4
Sutton, G.G.5
Fleischmann, R.D.6
Ketchum, K.A.7
Klenk, H.P.8
Gill, S.9
Dougherty, B.A.10
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A bug with excess gastric avidity
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Dolittle RF. A bug with excess gastric avidity. Nature. 388:1997;515-516.
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Nature
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Dolittle, R.F.1
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15
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8544240102
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Overview of the yeast genome
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of special interest. A summary of the genes, and their potential function, identified from sequencing the yeast genome. This reference includes a comprehensive list of World Wide Web sites to access yeast genome data.
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Mewes HW, Albermann K, Bähr M, Frishman D, Gleissner A, Hani J, Heumann K, Kleine K, Maieri A, Oliver SG, et al. Overview of the yeast genome. of special interest Nature. 387:1997;7-8 A summary of the genes, and their potential function, identified from sequencing the yeast genome. This reference includes a comprehensive list of World Wide Web sites to access yeast genome data.
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Nature
, vol.387
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Mewes, H.W.1
Albermann, K.2
Bähr, M.3
Frishman, D.4
Gleissner, A.5
Hani, J.6
Heumann, K.7
Kleine, K.8
Maieri, A.9
Oliver, S.G.10
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16
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85030304485
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Multipurpose Automated Genome Project Investigation Environment (MAGPIE) on World Wide Web URL:
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Multipurpose Automated Genome Project Investigation Environment (MAGPIE) on World Wide Web URL: http://www.mcs.anl.gov/home/gaasterl/magpie.html.
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17
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85030300481
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Entrez Genome Division at the National Center for Biotechnology Information (NCBI) on World Wide Web URL:
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Entrez Genome Division at the National Center for Biotechnology Information (NCBI) on World Wide Web URL: http://www.ncbi.nlm.nih.gov/Entrez/Genome/org.html.
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18
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85030304296
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The Institute for Genomic Research (TIGR) Microbial database on World Wide Web URL:
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The Institute for Genomic Research (TIGR) Microbial database on World Wide Web URL: http://www.tigr.org/tdb/mdb/mdb.html.
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Gambling on a shortcut to genome sequencing
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Roberts L. Gambling on a shortcut to genome sequencing. Science. 252:1991;1618-1619.
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Science
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Roberts, L.1
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16144364414
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Generation and analysis of 280,000 human expressed sequence tags
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The Washington University/Merck expressed sequenced tag (EST) database represents one of the largest public databases of EST sequences, and contains 319,311 EST sequences. A complete description of source of the cDNA clones, the generation of the EST sequences, and analysis of the data for 280,000 sequences from 22 different cDNA libraries (from 12 different tissues and three developmental states) is provided. Essential reading for scientists searching this EST database.
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Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, et al. Generation and analysis of 280,000 human expressed sequence tags. Genome Res. 6:1996;807-828 The Washington University/Merck expressed sequenced tag (EST) database represents one of the largest public databases of EST sequences, and contains 319,311 EST sequences. A complete description of source of the cDNA clones, the generation of the EST sequences, and analysis of the data for 280,000 sequences from 22 different cDNA libraries (from 12 different tissues and three developmental states) is provided. Essential reading for scientists searching this EST database.
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Genome Res
, vol.6
, pp. 807-828
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Hillier, L.D.1
Lennon, G.2
Becker, M.3
Bonaldo, M.F.4
Chiapelli, B.5
Chissoe, S.6
Dietrich, N.7
Dubuque, T.8
Favello, A.9
Gish, W.10
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21
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85030306416
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Unigene unique human gene sequence collection at the National Center for Biotechnology Information on World Wide Web URL:
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Unigene unique human gene sequence collection at the National Center for Biotechnology Information on World Wide Web URL: http://www.ncbi.nlm.nih.gov/UniGene/index.html.
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22
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0030218045
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Gene expression in normal and disease states - Identification of therapeutic targets
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Fannon MR. Gene expression in normal and disease states - identification of therapeutic targets. Trends Biotechnol. 14:1996;294-298.
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Trends Biotechnol
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Fannon, M.R.1
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23
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10244230901
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A gene map of the human genome
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Schuler GD, Boguski MS, Stewart EA, Stein LD, Gyapay G, Rice K, White RE, Rodriguez-Tome P, Aggarwal A, Bajorek E, et al. A gene map of the human genome. Science. 274:1996;540-546.
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Science
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Schuler, G.D.1
Boguski, M.S.2
Stewart, E.A.3
Stein, L.D.4
Gyapay, G.5
Rice, K.6
White, R.E.7
Rodriguez-Tome, P.8
Aggarwal, A.9
Bajorek, E.10
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24
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0030471309
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It's the genes! EST access to the human genome content
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Gerhold D, Caskey CT. It's the genes! EST access to the human genome content. Bioessays. 18:1996;973-981.
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Bioessays
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Gerhold, D.1
Caskey, C.T.2
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25
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Transgenic rodents in toxicology
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Dayan AD. Transgenic rodents in toxicology. Int J Exp Path. 77:1996;251-256.
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Int J Exp Path
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Dayan, A.D.1
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Transgenic model applications to drug discovery
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Polite HG. Transgenic model applications to drug discovery. Int J Exp Path. 77:1996;257-262.
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Polite, H.G.1
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The role of the genome project in determining gene function: Insights from model organisms
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Miklos GLG, Rubin GM. The role of the genome project in determining gene function: insights from model organisms. Cell. 86:1996;521-529.
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Cell
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Miklos, G.L.G.1
Rubin, G.M.2
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30
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Goffeau A, Barrell BG, Bussy H, Davis RW, Dujon B, Feldman H, Galibert F, Hoheisel JD, Jacq C, Johnston M, et al. Life with 6000 genes. Science. 274:1996;546-567.
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Goffeau, A.1
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Bussy, H.3
Davis, R.W.4
Dujon, B.5
Feldman, H.6
Galibert, F.7
Hoheisel, J.D.8
Jacq, C.9
Johnston, M.10
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31
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0029804246
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Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy
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Shoemaker DD, Lashkari DA, Morris D, Mittmann M, Davis RW. Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy. Nat Genet. 14:1996;450-456.
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Nat Genet
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Shoemaker, D.D.1
Lashkari, D.A.2
Morris, D.3
Mittmann, M.4
Davis, R.W.5
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32
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0030915681
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Positionally cloned human disease genes: Patterns of evolutionary conservation and functional motifs
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Mushegian AR, Bassett DE Jr, Boguski MS, Bork P, Koonin EV. Positionally cloned human disease genes: patterns of evolutionary conservation and functional motifs. Proc Natl Acad Sci USA. 94:1997;5831-5836.
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Proc Natl Acad Sci USA
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Mushegian, A.R.1
Bassett D.E., Jr.2
Boguski, M.S.3
Bork, P.4
Koonin, E.V.5
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33
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0029809862
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Reverse two-hybrid and one-hybrid systems to detect dissociation of protein - Protein and protein - DNA interactions
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Vidal M, Brachmann RK, Fataey A, Harlow E, Boeke JD. Reverse two-hybrid and one-hybrid systems to detect dissociation of protein - protein and protein - DNA interactions. Proc Natl Acad Sci USA. 96:1996;10315-10320.
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Proc Natl Acad Sci USA
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Vidal, M.1
Brachmann, R.K.2
Fataey, A.3
Harlow, E.4
Boeke, J.D.5
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34
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0030738524
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Monitoring protein - Protein interactions in intact eukaryotic cells by β-galactosidase complementation
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Rossi F, Charlton CA, Blau HM. Monitoring protein - protein interactions in intact eukaryotic cells by β-galactosidase complementation. Proc Natl Acad Sci USA. 94:1997;8405-8410.
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(1997)
Proc Natl Acad Sci USA
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Rossi, F.1
Charlton, C.A.2
Blau, H.M.3
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35
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0028910906
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Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men
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Ridker PM, Hennekens CH, Lindpaintner K, Stampfer MJ, Eisenberg PR, Miletich JP. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. N Engl J Med. 332:1995;912-917.
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N Engl J Med
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Ridker, P.M.1
Hennekens, C.H.2
Lindpaintner, K.3
Stampfer, M.J.4
Eisenberg, P.R.5
Miletich, J.P.6
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36
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0030902227
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Population genetics of BRCA1 and BRCA2
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Szabo CI, King MC. Population genetics of BRCA1 and BRCA2. Am J Hum Genet. 60:1997;1013-1020.
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Am J Hum Genet
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Szabo, C.I.1
King, M.C.2
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37
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0030961374
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The extent of genetic variation in the CCR5 gene
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of special interest. Summarizes recent data on genetic variation of the CCR5 chemokine receptor that the HIV virus uses to infect T-lymphocytes. A recent example of genetic variation that has major implications for HIV drug discovery.
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Ansari-Lari MA, Liu XM, Metzker ML, Rut AR, Gibbs RA. The extent of genetic variation in the CCR5 gene. of special interest Nat Genet. 16:1997;221-222 Summarizes recent data on genetic variation of the CCR5 chemokine receptor that the HIV virus uses to infect T-lymphocytes. A recent example of genetic variation that has major implications for HIV drug discovery.
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(1997)
Nat Genet
, vol.16
, pp. 221-222
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Ansari-Lari, M.A.1
Liu, X.M.2
Metzker, M.L.3
Rut, A.R.4
Gibbs, R.A.5
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38
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0028246289
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Light-generated oligonucleotide arrays for rapid DNA sequence analysis
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Pease AC, Solas D, Sullivan EJ, Cronin MT, Holmes CP, Fodor SPA. Light-generated oligonucleotide arrays for rapid DNA sequence analysis. Proc Natl Acad Sci USA. 91:1994;5022-5026.
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(1994)
Proc Natl Acad Sci USA
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Pease, A.C.1
Solas, D.2
Sullivan, E.J.3
Cronin, M.T.4
Holmes, C.P.5
Fodor, S.P.A.6
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39
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0029093770
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Using oligonucleotide probe arrays to access genetic diversity
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Lipshutz RJ, Morris D, Chee M, Hubbell E, Kozal MJ, Shen N, Yang R, Fodor SPA. Using oligonucleotide probe arrays to access genetic diversity. Biotechniques. 19:1995;442-447.
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(1995)
Biotechniques
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Lipshutz, R.J.1
Morris, D.2
Chee, M.3
Hubbell, E.4
Kozal, M.J.5
Shen, N.6
Yang, R.7
Fodor, S.P.A.8
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40
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10244219858
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Accessing genetic information with high-density DNA arrays
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of oustanding interest. An oligonucleotide resequencing array was designed to sequence the human mitochondrial genome, which is approximately 16.6 kb. Using this array it was possible to resequence with 99% accuracy. A scheme to hybridize two samples simultaneously for the identification of polymorphisms is described. The advantages of using oligonucleotide arrays for resequencing are also described.
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Chee M, Yang R, Hubbell E, Berno A, Huang XC, Stern D, Winkler J, Lockhart DJ, Morris MS, Fodor SPA. Accessing genetic information with high-density DNA arrays. of oustanding interest Science. 274:1996;610-614 An oligonucleotide resequencing array was designed to sequence the human mitochondrial genome, which is approximately 16.6 kb. Using this array it was possible to resequence with 99% accuracy. A scheme to hybridize two samples simultaneously for the identification of polymorphisms is described. The advantages of using oligonucleotide arrays for resequencing are also described.
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(1996)
Science
, vol.274
, pp. 610-614
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Chee, M.1
Yang, R.2
Hubbell, E.3
Berno, A.4
Huang, X.C.5
Stern, D.6
Winkler, J.7
Lockhart, D.J.8
Morris, M.S.9
Fodor, S.P.A.10
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41
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0029741063
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The future of genetic studies of complex human diseases
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of oustanding interest. The authors compare the two primary genetic approaches for identifying human disease genes, linkage analysis and association studies. Mathematical models are presented that compare the linkage and association studies and predict the number of families (or sib pairs) and genetic markers required to identify genes using each approach. The analysis presented by the authors highlight how single nucleotide polymorphisms and oligonucleotide array technology will facilitate the identification of human disease genes through association studies.
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Risch N, Merikangas K. The future of genetic studies of complex human diseases. of oustanding interest Science. 273:1996;1516-1517 The authors compare the two primary genetic approaches for identifying human disease genes, linkage analysis and association studies. Mathematical models are presented that compare the linkage and association studies and predict the number of families (or sib pairs) and genetic markers required to identify genes using each approach. The analysis presented by the authors highlight how single nucleotide polymorphisms and oligonucleotide array technology will facilitate the identification of human disease genes through association studies.
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(1996)
Science
, vol.273
, pp. 1516-1517
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Risch, N.1
Merikangas, K.2
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42
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0030861903
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The use of a genetic map of biallelic markers in linkage studies
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of special interest. Compares single nucleotide polymorphisms to more conventional genetic markers and the impact of single nucleotide polymorphism markers on future genetic studies.
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Kruglyak L. The use of a genetic map of biallelic markers in linkage studies. of special interest Nat Genet. 17:1997;21-24 Compares single nucleotide polymorphisms to more conventional genetic markers and the impact of single nucleotide polymorphism markers on future genetic studies.
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(1997)
Nat Genet
, vol.17
, pp. 21-24
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Kruglyak, L.1
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43
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0031057682
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High throughput parallel analysis of hundreds of patient samples for more than 100 mutations in multiple disease genes
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Shuber AP, Michalowsky LA, Nass GS, Skoletsky J, Hire LM, Kotsopoulos SK, Phipps MF, Barberio DM, Klinger KW. High throughput parallel analysis of hundreds of patient samples for more than 100 mutations in multiple disease genes. Hum Mol Genet. 6:1997;337-347.
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(1997)
Hum Mol Genet
, vol.6
, pp. 337-347
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Shuber, A.P.1
Michalowsky, L.A.2
Nass, G.S.3
Skoletsky, J.4
Hire, L.M.5
Kotsopoulos, S.K.6
Phipps, M.F.7
Barberio, D.M.8
Klinger, K.W.9
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44
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0029913452
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Mutation detection with MutH, MutL, and MutS mismatch repair proteins
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Smith J, Modrich P. Mutation detection with MutH, MutL, and MutS mismatch repair proteins. Proc Natl Acad Sci USA. 93:1996;4374-4379.
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(1996)
Proc Natl Acad Sci USA
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, pp. 4374-4379
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Smith, J.1
Modrich, P.2
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45
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0031035007
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Polymorphisms in drug-metabolizing enzymes: What is their clinical relevance and why do they exist?
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of outstanding interest. An excellent review of pharmacogenetics and the affect of genetic variation on drug metabolizing enzymes. Also see Puga 1997 [45] for additional information on genetic variation in drug metabolizing enzymes.
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Nebert DW. Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist? of outstanding interest Am J Hum Genet. 60:1997;284-295 An excellent review of pharmacogenetics and the affect of genetic variation on drug metabolizing enzymes. Also see Puga 1997 [45] for additional information on genetic variation in drug metabolizing enzymes.
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(1997)
Am J Hum Genet
, vol.60
, pp. 284-295
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Nebert, D.W.1
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46
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0030935831
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Genetic polymorphisms in human drug-metabolizing enzymes: Potential uses of reverse genetics to identify genes of toxicological relevance
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Puga A, Nebert DW, McKinnon RA, Menon AG. Genetic polymorphisms in human drug-metabolizing enzymes: potential uses of reverse genetics to identify genes of toxicological relevance. Crit Rev Toxicol. 27:1997;199-222.
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Crit Rev Toxicol
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Puga, A.1
Nebert, D.W.2
McKinnon, R.A.3
Menon, A.G.4
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47
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0031038038
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Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
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of outstanding interest. One of the largest and most comprehensive pharmacogenetics studies published. This work highlights the large number of different types of genetic variants that are known to occur in drug metabolizing enzymes. This study is a good example of the complexity and technical challenges of future pharmacogenetic studies.
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of outstanding interest. This work highlights the application of bioinformatics and genetic analysis to compound screening and drug discovery.
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