Structural insight into a quinolone-topoisomerase II-DNA complex. Further evidence for a 2:2 quinobenzoxazine-Mg2+ self-assembly model formed in the presence of topoisomerase II

Journal of Biological Chemistry

Volumn 274, Issue 24, 1999, Pages 17226-17235

  Kwok, Yan ^a   Zeng, Qingping ^a   Hurley, Laurence H ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3 AMINO 1 PYRROLIDINYL) 2 FLUORO 4 OXO 4H QUINO[8,1A,1 B,C][1,4]BENZOXAZINE 5 CARBOXYLIC ACID; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); MAGNESIUM; NORFLOXACIN; PSOROSPERMIN; QUINOLONE DERIVATIVE; SPERMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; BINDING SITE; DNA CLEAVAGE; DNA DRUG COMPLEX; DRUG STRUCTURE; ENZYME SUBSTRATE COMPLEX; INTERCALATION COMPLEX; PRIORITY JOURNAL; STOICHIOMETRY;

ANTINEOPLASTIC AGENTS; BASE PAIR MISMATCH; BASE SEQUENCE; BINDING SITES; BINDING, COMPETITIVE; DNA; DNA TOPOISOMERASES, TYPE II; HYDROGEN-ION CONCENTRATION; INTERCALATING AGENTS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; NORFLOXACIN; OXAZINES; QUINOLONES; ULTRAVIOLET RAYS; XANTHENES; XANTHONES;

EID: 0033546394     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.24.17226     Document Type: Article

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