Involvement of T-box genes Tbx2-Tbx5 in vertebrate limb specification and development

Development

Volumn 125, Issue 13, 1998, Pages 2499-2509

  Gibson Brown, Jeremy J ^a   Agulnik, Sergei I ^b   Silver, Lee M ^b   Niswander, Lee ^c   Papaioannou, Virginia E ^a  

^a New York Presbyterian Columbia University Medical Center   (United States)

^b PRINCETON UNIVERSITY   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Chick; Limb development; Limb identity; T box gene; Tbx2; Tbx3; Tbx4; Tbx5

Indexed keywords

SONIC HEDGEHOG PROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHICK EMBRYO; EMBRYO; FORELIMB; GENE; GENE EXPRESSION; HINDLIMB; LIMB BUD; LIMB DEVELOPMENT; MESENCHYME; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; AVIAN PROTEINS; BODY PATTERNING; CHICK EMBRYO; DNA-BINDING PROTEINS; ECTODERM; EMBRYONIC INDUCTION; EVOLUTION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE LIBRARY; HEDGEHOG PROTEINS; HINDLIMB; LIMB BUD; MESODERM; MICE; MODELS, BIOLOGICAL; PROTEIN BIOSYNTHESIS; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSPLANTATION, HETEROTOPIC; WING;

EID: 0031903568     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Agulnik, S. I., Garvey, N., Hancock, S., Ruvinsky, I., Chapman, D. L., Agulnik, I., Bollag, R., Papaioannou, V. E. and Silver, L. M. (1996). Evolution of mouse T-box genes by tandem duplication and cluster dispersion. Genetics 144, 249-254.
2. Bamshad, M., et al. (1997). Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome. Nature Genetics 16, 311-315.
3. Basson, C. T., et al. (1997). Mutations in human TBX5 cause limb and cardiac malformations in Holt-Oram syndrome. Nature Genetics 15, 30-35.
4. Cairns, J. M. and Saunders, J. W. Jr. (1954). The influence of embryonic mesoderm on the regional specification of epidermal derivatives in the chick. J. Exp. Zool. 127, 221-248.
5. Carroll, R. L. (1988). Vertebrate Paleontology and Evolution. New York: W. H. Freeman.
6. Chan, D. C., Laufer, E., Tabin, C. and Leder, P. (1995). Polydactylous limbs in Strong 's Luxoid mice result from ectopic polarizing activity. Development 121, 1971-1978.
7. Chang, D. T., Lopez, A.. Kessler, D. P. V., Chiang, C., Simandl, B. K., Zhao, R., Seldin, M. F., Fallon, J. F. and Beachy, P. A. (1994). Products, genetic linkage and limb patterning activity of a murine hedgehog gene. Development 120, 3339-3353.
8. Chapman, D. L., Garvey, N., Hancock, S., Alexiou, M., Agulnik, S. I., Gibson-Brown, J. J., Cebra-Thomas, J., Bollag, R. J., Silver, L. M. and Papaioannou, V. E. (1996). Expression of the T-box family genes. Tbx1-Tbx5, during early mouse development. Dev. Dynam. 206, 379-390.
9. Charité, J., de Graff, W., Shen, S. and Deschamps, J. (1994). Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures. Cell 78, 589-601.
10. Church, G. M. and Gilbert, W. (1984). Genomic sequencing. Proc. Natl. Actid. Sci. USA 81, 1991-1995.
11. Cohn, M. J., Izpisúa-Belmonte, J. C., Abud, H., Heath, J. K. and Tickle, C. (1995). Fibroblast growth factors induce additional limb development from the flank of chick embryos. Cell 80, 739-746.
12. Cohn, M. J., Patel, K., Krumlauf, R., Wilkinson, D. G., Clarke, J. D. W. and Tickle, C. (1997). Hox9 genes and vertebrate limb specification. Nature 387, 97-101.
13. Crossley, P. H., Minowada, G., MacArthur, C. A. and Martin, G. R. (1996). Roles for FGF8 in the induction, initiation, and maintenance of chick limb development. Cell 84, 127-136.
14. Dollé, P., Dierich, A., LeMeur, M., Schimmang, T., Schuhbaur, B., Chambon, P. and Duboule, D. (1993). Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell 75, 431-441.
15. Genetics Computer Group. (1989). The Wisconsin GCG Package. Maryland Biotechnology Institute, Madison, WI.
16. Gibson-Brown, J. J., Agulnik, S. I., Chapman, D. L., Alexiou, M., Garvey, N., Silver, L. M. and Papaioannou, V. E. (1996). Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity. Mech. Dev. 56, 93-101.
17. Gibson-Brown, J. J., Agulnik, S. I., Silver, L. M. and Papaioannou, V. E. (1998). Expression of T-box genes Tbx2-Tbx5 during chick organogenesis. Mech. Dev. (in press).
18. Goff, D. J. and Tabin, C. J. (1997). Analysis of Hoxd-13 and Hoxd-11 misexpression in chick limb buds reveals that Hox genes affect both bone condensation and growth. Development 124, 627-636.
19. Hamburger, V. (1938). Morphogenetic and axial self-differentiation of transplanted limb primordia of 2-day chick embryos. J. Exp. Zool, 177, 379-400.
20. Hamburger, V. and Hamilton, H. L. (1951 ). A series of normal stages in the development of the chick embryo. J. Morphol. 88, 49-92.
21. Hamburger, V. and Hamilton, H. L. (1992). A series of normal stages in the development of the chick embryo. Dev. Dynam. 195, 231-272.
22. Holland, P. W. H., Garcia-Fernàndez, J., Williams, N. A. and Sidow, A. (1994). Gene duplications and the origins of vertebrate development. Development 1994 Supplement, 125-133.
23. Kopp, A. and Duncan, I. (1997). Control of cell fate and polarity in the adult abdominal segments of Drosophila by optomotor-blind. Development 124, 3715-3726.
24. Li, Q. Y., et al. (1997). Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family. Nature Genetics 15, 21-29.
25. MacCabe, J. A., Errick, J. and Saunders, J. W. Jr. (1974). Ectodermal control of the dorso-ventral axis in the leg bud of the chick embryo. Dev. Biol. 39, 69-82.
26. Mahmood, R., Bresnick, J., Hornbruch, A., Mahoney, C., Morton, N., Colquhoun, K., Martin, P., Lumsden, A., Dickson, C. and Mason, I. (1995). A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth. Curr. Biol. 5, 797-806.
27. Maisey, J. G. (1996). Discovering Fossil Fishes. New York: Henry Holt.
28. Michaud, J. L., Lapointe, F. and Le Douarin, N. M. (1997). The dorsoventral polarity of the presumptive limb is determined by signals produced by the somites and by the lateral somatopleure. Development 124, 1453-1463.
29. Nelson, C. E., Morgan, B. A., Burke, A. C., Laufer, E., DiMambro, E., Murtaugh, L. C., Gonzales, E., Tessarollo, L., Parada, L. F. and Tabin, C. (1996). Analysis of Hox gene expression in the chick limb bud. Development 122, 1449-1466.
30. Niswander, L. (1997). Limb mutants: what can they tell us about normal limb development? Curr. Opin. Gen. Dev. 7, 530-536.
31. Ohuchi, H., Nakagawa, T., Yamauchi, M., Ohata, T., Yoshioka, H., Kuwana, T., Mima, T., Mikawa, T., Nohno, T. and Noji, S. (1995). An additional limb can be induced from the flank of the chick embryo by FGF4. Biochem. Biophys. Res. Commun. 209, 809-816.
32. Ohuchi, H., et al. (1997). The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ecrodennal factor. Development 124, 2235-2244.
33. Ohuchi, H., Takeuchi, J., Yoshioka, H., Ishimaru, Y., Ogura, K., Takahashi, N., Ogura, T. and Noji, S. (1998). Correlation of wing-leg identity in ectopic FGF-induced chimeric limbs with the differential expression of chick Tbx5 and Tbx4. Development 125, 51-60.
34. Papaioannou, V. E. and Silver, L. M. (1998). The T-box gene family. BioEssays 20, 9-19.
35. Pautou, M.-P. (1977). Dorso-ventral axis determination of chick limb bud development. In Vertebrate Limb and Somite Morphogenesis (ed. D. A. Ede, J. R. Hinchcliffe, and M. Balls), pp. 257-266. Cambridge: Cambridge University Press.
36. Rancourt, D. E., Tsuzuki, T. and Capecchi, M. R. (1995). Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. Genes Dev. 9, 108-122.
37. Ranson, M., Tickle, C., Mahon, K. A. and Mackem, S. (1995). Gnot1, a member of a new homeobox gene subfamily, is expressed in a dynamic, region-specific domain along the proximodistal axis of the developing limb. Mech. Dev. 51, 17-30.
38. Riddle, R. D., Johnson, R. L., Laufer, E. and Tabin, C. (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75, 1401-1416.
39. Rowe, D. A. and Fallon, J. F. (1981). The effect of removing posterior apical ectodermal ridge of the chick wing and leg on pattern formation. J. Embryol. Exp. Morphol. 65 (Supplement), 309-325.
40. Ruvinsky, I. and Silver, L. M. (1997). Newly identified paralog groups on mouse chromosome 5 and 11 reveal the age of a T-box cluster duplication. Genomics 40, 262-266.
41. Saunders, J. W. Jr. (1948). The proximo-distal sequence of origin of the parts of the chick wing and the role of the ectoderm. J. Exp. Zool. 108, 363-404.
42. Saunders, J. W. Jr. and Gasseling, M. T. (1968). Ectodermal-mesenchymal interactions in the origin of limb symmetry. In Epithelial-mesenchymal Interactions (ed. R. Fleischmajer and R. E. Billingham), pp. 78-97. Baltimore: Williams and Wilkins.
43. Saunders, J. W. Jr., Cairns, J. M. and Gasseling, M. T. (1957). The role of the apical ridge of ectoderm in the differentiation of the morphological structure and inductive specificity of limb parts in the chick. J. Morphol. 101, 57-88.
44. Saunders, J. W. Jr., Gasseling, M. T. and Cairns, J. M. (1959). The differentiation of prospective thigh mesoderm beneath the apical ectodermal ridge of the wing bud in the chick embryo. Dev. Biol. 1, 281-301.
45. Schinzel, A., Illig, R. and Prader, A. (1987). The ulnar-mammary syndrome: an autosomal dominant pleiotropic gene. Clin. Genet. 32, 160-168.
46. Schulte-Merker, S. and Smith, J. C. (1995). Mesoderm formation in response to Brachyury requires FGF signalling. Curr. Biol. 5, 62-67.
47. Shubin, N., Tabin, C. and Carroll, S. (1997). Fossils, genes and the evolution of animal limbs. Nature 388, 639-648.
48. Sunimerbell, D., Lewis, J. H. and Wolpert, L. (1973). Positional information in chick limb morphogenesis. Nature 244, 492-495.
49. Tickle, C. (1993). Chick limb buds. In Essential Developmental Biology: A Practical Approach (ed. C. D. Stern and P. W. H. Holland), pp. 119-125. Oxford: IRL Press.
50. Tickle, C. (1995). Vertebrate limb development. Curr. Opin. Gen. Dev. 5, 478-484.
51. Tickle, C. (1996). Genetics and limb development. Der. Genet, 19, 1-8.
52. Tickle, C., Summerbell, D. and Wolpert, L. (1975). Positional signalling and specification of digits in chick limb morphogenesis. Nature 254, 199-202.
53. Vogel, A., Rodriguez, C. and Izpisúa-Belmonte, J. (1996). Involvement of FGF8 in initiation, outgrowth and patterning of the vertebrate limb. Development 122, 1737-1750.
54. Wilkinson, D. G. (1992). Whole mount in situ hybridization of vertebrate embryos. In In Situ Hybridization: A Practical Approach (ed. D. G. Wilkinson, Ed.), pp. 75-84. Oxford: IRL Press.
55. Xu, X., Weinstein, M., Li, C., Naski, M., Cohen, R. I., Ornitz, D. M., Leder, P. and Deng, C. (1998). Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development 125, 753-765.
56. Yang, Y. and Niswander, L. (1995). Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: dorsal signals regulate anteroposterior patterning. Cell 80, 939-947.
57. Yokouchi, Y., Nakazato, S., Yamamoto, M., Goto, Y., Kameda, T., Iba, H. and Kuroiwa, A. (1995). Misexpression of Hoxa-13 induces cartilage homeotic transformation and changes cell adhesiveness in chick limb buds. Genes Dev. 9, 2509-2522.
58. Zwilling, E. (1955). Ectoderm-mesoderm relationship in the development of the chick embryo limb bud. J. Exp. Zool. 128, 423-441.