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0030079560
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Mapping vertebrate embryos
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of special interest. A clear and succinct comparison of gastrulation in different vertebrate embryos.
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Tam PPL, Quinlan GA. Mapping vertebrate embryos. of special interest Curr Biol. 6:1996;104-106 A clear and succinct comparison of gastrulation in different vertebrate embryos.
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Curr Biol
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Tam, P.P.L.1
Quinlan, G.A.2
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2
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0029120563
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Diversification of cardiomyogenic cell lineages during early heart development
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Yutzey KE, Bader D. Diversification of cardiomyogenic cell lineages during early heart development. Circ Res. 77:1995;216-219.
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Circ Res
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Yutzey, K.E.1
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Regionalisation of cell fate and morphogenetic movement of mesoderm during mouse gastrulation
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Parameswaran M, Tam PPL. Regionalisation of cell fate and morphogenetic movement of mesoderm during mouse gastrulation. Dev Genet. 17:1995;16-28.
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Parameswaran, M.1
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0030926093
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The allocation of epiblast cells to the embryonic heart and other mesodermal lineages: The role of ingression and tissue movement during gastrulation
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of special interest. Heterotopic and heterochronic transplantation of transgenically labelled grafts are used to investigate the developmental potency of epiblast cells. Cells in a posterior distal cell location that subsequently give rise to cardiac mesoderm retain a broad developmental potency even after ingression through the streak and migration to an anterior proximal position. Epiblast cells will contribute to differentiated cardiac tissue without having undergone ingression or migration if directly transplanted to this location.
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Tam PP, Parameswaran M, Kinder SJ, Weinberger RP. The allocation of epiblast cells to the embryonic heart and other mesodermal lineages: the role of ingression and tissue movement during gastrulation. of special interest Development. 124:1997;1631-1642 Heterotopic and heterochronic transplantation of transgenically labelled grafts are used to investigate the developmental potency of epiblast cells. Cells in a posterior distal cell location that subsequently give rise to cardiac mesoderm retain a broad developmental potency even after ingression through the streak and migration to an anterior proximal position. Epiblast cells will contribute to differentiated cardiac tissue without having undergone ingression or migration if directly transplanted to this location.
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Development
, vol.124
, pp. 1631-1642
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Tam, P.P.1
Parameswaran, M.2
Kinder, S.J.3
Weinberger, R.P.4
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5
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0030578423
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The fate diversity of mesodermal cells within the heart field during chicken early embryogenesis
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Cohen Gould L, Mikawa T. The fate diversity of mesodermal cells within the heart field during chicken early embryogenesis. Dev Biol. 177:1996;265-273.
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Dev Biol
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Cohen Gould, L.1
Mikawa, T.2
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0027943780
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Cardiovascular development in the zebrafish. II. Endocardial progenitors are sequestered within the heart field
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Lee RK, Stainier DY, Weinstein BM, Fishman MC. Cardiovascular development in the zebrafish. II. Endocardial progenitors are sequestered within the heart field. Development. 120:1994;3361-3366.
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Lee, R.K.1
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Weinstein, B.M.3
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7
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0028941267
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QCE-6: A clonal cell line with cardiac myogenic and endothelial cell potentials
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Eisenberg CA, Bader D. QCE-6: a clonal cell line with cardiac myogenic and endothelial cell potentials. Dev Biol. 167:1995;469-481.
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Eisenberg, C.A.1
Bader, D.2
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8
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0030034945
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Establishment of the mesodermal cell line QCE-6. A model system for cardiac cell differentiation
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Eisenberg CA, Bader DM. Establishment of the mesodermal cell line QCE-6. A model system for cardiac cell differentiation. Circ Res. 78:1996;205-216.
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Circ Res
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Eisenberg, C.A.1
Bader, D.M.2
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9
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0031057963
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Wnt-11 is expressed in early avain mesoderm and required for the differentiation of the quail mesoderm cell line QCE-6
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Eisenberg CA, Gourdie RG, Eisenberg LM. Wnt-11 is expressed in early avain mesoderm and required for the differentiation of the quail mesoderm cell line QCE-6. Development. 124:1997;525-536.
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Development
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Eisenberg, C.A.1
Gourdie, R.G.2
Eisenberg, L.M.3
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0029873444
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Formation and early morphogenesis of endocardial endothelial precursor cells and the role of endoderm
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Sugi Y, Markwald RR. Formation and early morphogenesis of endocardial endothelial precursor cells and the role of endoderm. Dev Biol. 175:1996;66-83.
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Dev Biol
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Sugi, Y.1
Markwald, R.R.2
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11
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0028810741
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Cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages
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Stainier DY, Weinstein BM, Detrich HW, Zon LI, Fishman MC. Cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages. Development. 121:1995;3141-3150.
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Development
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Stainier, D.Y.1
Weinstein, B.M.2
Detrich, H.W.3
Zon, L.I.4
Fishman, M.C.5
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12
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0031040497
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The zebrafish gene cloche acts upstream of a flk-1 homologue to regulate endothelial cell differentiation
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Liao W, Bisgrove BW, Sawyer H, Hug B, Bell B, Peters K, Grunwald DJ, Stainier DY. The zebrafish gene cloche acts upstream of a flk-1 homologue to regulate endothelial cell differentiation. Development. 124:1997;381-389.
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Development
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Liao, W.1
Bisgrove, B.W.2
Sawyer, H.3
Hug, B.4
Bell, B.5
Peters, K.6
Grunwald, D.J.7
Stainier, D.Y.8
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13
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0029083928
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Diversification of cardiomyogenic cell lineages in vitro
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Yutzey K, Gannon M, Bader D. Diversification of cardiomyogenic cell lineages in vitro. Dev Biol. 170:1995;531-541.
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Dev Biol
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Yutzey, K.1
Gannon, M.2
Bader, D.3
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14
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12644276397
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Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo
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of special interest. See annotation [15].
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Stainier DY, Fouquet B, Chen JN, Warren KS, Weinstein BM, Meiler SE, Mohideen MA, Neuhauss SC, Solnica-Krezel L, Schier AF, et al. Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. of special interest Development. 123:1996;285-292 See annotation [15].
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Development
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Stainier, D.Y.1
Fouquet, B.2
Chen, J.N.3
Warren, K.S.4
Weinstein, B.M.5
Meiler, S.E.6
Mohideen, M.A.7
Neuhauss, S.C.8
Solnica-Krezel, L.9
Schier, A.F.10
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15
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12644311273
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Mutations affecting the cardiovascular system and other internal organs in zebrafish
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of special interest. This paper and [14] describe the results of two large-scale mutagenesis screens in zebrafish to identify genes involved in the formation and function of the cardiovascular system. A large number of mutant phenotypes are described and, although none of the mutated genes have been identified, this promises to be a rich source of novel genes involved in the cardiogenic process.
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Chen JN, Haffter P, Odenthal J, Vogelsang E, Brand M, van Eeden FJ, Furutani Seiki M, Granato M, Hammerschmidt M, Heisenberg CP, et al. Mutations affecting the cardiovascular system and other internal organs in zebrafish. of special interest Development. 123:1996;293-302 This paper and [14] describe the results of two large-scale mutagenesis screens in zebrafish to identify genes involved in the formation and function of the cardiovascular system. A large number of mutant phenotypes are described and, although none of the mutated genes have been identified, this promises to be a rich source of novel genes involved in the cardiogenic process.
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(1996)
Development
, vol.123
, pp. 293-302
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Chen, J.N.1
Haffter, P.2
Odenthal, J.3
Vogelsang, E.4
Brand, M.5
Van Eeden, F.J.6
Furutani Seiki, M.7
Granato, M.8
Hammerschmidt, M.9
Heisenberg, C.P.10
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16
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0029872137
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The polyclonal origin of myocyte lineages
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of special interest. A review of heart formation (based on studies of the chick embryo) that emphasises the origin and role of distinct myocardial and endocardial lineages, as assessed by retroviral lineage labelling.
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Mikawa T, Fischmann DA. The polyclonal origin of myocyte lineages. of special interest Annu Rev Physiol. 58:1996;509-521 A review of heart formation (based on studies of the chick embryo) that emphasises the origin and role of distinct myocardial and endocardial lineages, as assessed by retroviral lineage labelling.
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(1996)
Annu Rev Physiol
, vol.58
, pp. 509-521
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Mikawa, T.1
Fischmann, D.A.2
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17
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0030025948
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Heart formative factor(s) is localized in the anterior endoderm of early Xenopus neurula
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Tonegawa A, Moriya M, Tada M, Nishimatsu S, Katagiri C, Ueno N. Heart formative factor(s) is localized in the anterior endoderm of early Xenopus neurula. Rouxs Arch Dev Biol. 205:1996;282-289.
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Rouxs Arch Dev Biol
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Tonegawa, A.1
Moriya, M.2
Tada, M.3
Nishimatsu, S.4
Katagiri, C.5
Ueno, N.6
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18
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0029583152
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Induction of avian cardiac myogenesis by anterior endoderm
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Schultheiss TM, Xydas S, Lassar AB. Induction of avian cardiac myogenesis by anterior endoderm. Development. 121:1995;4203-4214.
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Development
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Schultheiss, T.M.1
Xydas, S.2
Lassar, A.B.3
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19
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0028912639
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An inductive role for the endoderm in Xenopus cardiogenesis
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Nascone N, Mercola M. An inductive role for the endoderm in Xenopus cardiogenesis. Development. 121:1995;515-523.
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(1995)
Development
, vol.121
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Nascone, N.1
Mercola, M.2
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0029049445
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Initiation of cardiac differentiation occurs in the absence of anterior endoderm
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Gannon M, Dader D. Initiation of cardiac differentiation occurs in the absence of anterior endoderm. Development. 121:1995;2439-2450.
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Development
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Gannon, M.1
Dader, D.2
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0030601343
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The allocation of epiblast cells to ectodermal and germ-line lineage is influenced by the position of the cells in the gastrulating mouse embryo
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Tam PPL, Zhou SX. The allocation of epiblast cells to ectodermal and germ-line lineage is influenced by the position of the cells in the gastrulating mouse embryo. Dev Biol. 178:1996;124-132.
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Dev Biol
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Tam, P.P.L.1
Zhou, S.X.2
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22
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0031018002
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A role for bone morphogenetic proteins in the induction of cardiac myogenesis
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of outstanding interest. The authors of this elegant paper identify the signalling molecules BMP-2 and BMP-4 as positive inducers of cardiac fate in chick. They propose a general model involving the induction of a cardiogenic field in the anterior mesoderm by anterolateral endoderm and subsequent specification of cardiac precursors by BMPs.
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Schultheiss TM, Burch JB, Lassar AB. A role for bone morphogenetic proteins in the induction of cardiac myogenesis. of outstanding interest Genes Dev. 11:1997;451-462 The authors of this elegant paper identify the signalling molecules BMP-2 and BMP-4 as positive inducers of cardiac fate in chick. They propose a general model involving the induction of a cardiogenic field in the anterior mesoderm by anterolateral endoderm and subsequent specification of cardiac precursors by BMPs.
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(1997)
Genes Dev
, vol.11
, pp. 451-462
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Schultheiss, T.M.1
Burch, J.B.2
Lassar, A.B.3
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24
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0031055346
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Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos
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Dudley AT, Robertson EJ. Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos. Dev Dyn. 208:1997;349-362.
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(1997)
Dev Dyn
, vol.208
, pp. 349-362
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Dudley, A.T.1
Robertson, E.J.2
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25
-
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0030601359
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Combined BMP-2 and FGF-4 but neither factor alone induces cardiogenesis in non-precardiac embryonic mesoderm
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Lough N, Barron M, Brogley M, Sugi Y, Bolender DL, Zhu X. Combined BMP-2 and FGF-4 but neither factor alone induces cardiogenesis in non-precardiac embryonic mesoderm. Dev Biol. 178:1996;198-202.
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Dev Biol
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Lough, N.1
Barron, M.2
Brogley, M.3
Sugi, Y.4
Bolender, D.L.5
Zhu, X.6
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26
-
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0029775569
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Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spermann's organiser
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of special interest. The cerberus gene was identified in a screen for organiser-specific genes. From the onset of gastrulation, it is expressed in the anterior endoderm which lies adjacent to the precardiac mesoderm. The authors report duplication of head structures, including heart, in response to ectopic cerberus expression.
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Bouwmeester T, Kim S-H, Sasai Y, Lu B, De Robertis EM. Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spermann's organiser. of special interest Nature. 382:1996;595-601 The cerberus gene was identified in a screen for organiser-specific genes. From the onset of gastrulation, it is expressed in the anterior endoderm which lies adjacent to the precardiac mesoderm. The authors report duplication of head structures, including heart, in response to ectopic cerberus expression.
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(1996)
Nature
, vol.382
, pp. 595-601
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Bouwmeester, T.1
Kim, S.-H.2
Sasai, Y.3
Lu, B.4
De Robertis, E.M.5
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27
-
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0030587603
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NK-2 homeobox genes and heart development
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of outstanding interest. This review emphasises the extraordinary similarities in the molecular mechanisms of heart formation in vertebrates and dorsal vessel formation in Drosophila.
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Harvey RP. NK-2 homeobox genes and heart development. of outstanding interest Dev Biol. 178:1996;203-216 This review emphasises the extraordinary similarities in the molecular mechanisms of heart formation in vertebrates and dorsal vessel formation in Drosophila.
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(1996)
Dev Biol
, vol.178
, pp. 203-216
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Harvey, R.P.1
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28
-
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0029955134
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Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia
-
of special interest. This paper addresses the function of then frog homologue of Nkx2-5 by overexpression in Xenopus embryos. Although ectopic expression of cardiac differentiation markers is not detected, a general increase in heart size is seen when XNkx2.5 is expressed in cells that normally form part of the heart field.
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Cleaver OB, Patterson KD, Krieg PA. Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia. of special interest Development. 122:1996;3549-3556 This paper addresses the function of then frog homologue of Nkx2-5 by overexpression in Xenopus embryos. Although ectopic expression of cardiac differentiation markers is not detected, a general increase in heart size is seen when XNkx2.5 is expressed in cells that normally form part of the heart field.
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(1996)
Development
, vol.122
, pp. 3549-3556
-
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Cleaver, O.B.1
Patterson, K.D.2
Krieg, P.A.3
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29
-
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0030465318
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Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation
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of special interest. A description of the cloning of the zebrafish Nkx2-5 homologue and its expression pattern. The function of nkx2.5 is addressed by overexpression in embryos, the effects of which are more dramatic than that in Xenopus [28], with a general increase in heart size, as well as an occasional ectopic expression of cardiac differentiation markers.
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Chen JN, Fishman MC. Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. of special interest Development. 122:1996;3809-3816 A description of the cloning of the zebrafish Nkx2-5 homologue and its expression pattern. The function of nkx2.5 is addressed by overexpression in embryos, the effects of which are more dramatic than that in Xenopus [28], with a general increase in heart size, as well as an occasional ectopic expression of cardiac differentiation markers.
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(1996)
Development
, vol.122
, pp. 3809-3816
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Chen, J.N.1
Fishman, M.C.2
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30
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0029090829
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Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx2-5
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Lyons I, Parsons L, Hartley L, Li R, Andrews JE, Robb L, Harvey RP. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx2-5. Genes Dev. 9:1995;1654-1666.
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Genes Dev
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Lyons, I.1
Parsons, L.2
Hartley, L.3
Li, R.4
Andrews, J.E.5
Robb, L.6
Harvey, R.P.7
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31
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0028863326
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Tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx2.3, a second vertebrate homologue of tinman
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Evans SM, Yan W, Murillo MP, Ponce J, Papalopulu N. tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specification, may be represented by a family of genes in vertebrates: XNkx2.3, a second vertebrate homologue of tinman. Development. 121:1995;3889-3899.
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Development
, vol.121
, pp. 3889-3899
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Evans, S.M.1
Yan, W.2
Murillo, M.P.3
Ponce, J.4
Papalopulu, N.5
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32
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0029984771
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Chick Nkx-2.3 represents a novel family member of vertebrate homologues to the Drosophila homeobox gene tinman: Differential expression of cNKx-2.3 and cNKx-2.5 during heart and gut development
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Buchberger A, Pabst O, Brand T, Seidl K, Arnold HH. Chick Nkx-2.3 represents a novel family member of vertebrate homologues to the Drosophila homeobox gene tinman: differential expression of cNKx-2.3 and cNKx-2.5 during heart and gut development. Mech Dev. 56:1996;151-163.
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Mech Dev
, vol.56
, pp. 151-163
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Buchberger, A.1
Pabst, O.2
Brand, T.3
Seidl, K.4
Arnold, H.H.5
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33
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0030899175
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The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- And postnatal mouse development
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Pabst O, Schneider A, Brand T, Arnold HH. The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development. Dev Dyn. 209:1997;29-35.
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Dev Dyn
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Pabst, O.1
Schneider, A.2
Brand, T.3
Arnold, H.H.4
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34
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0030589617
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A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm
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Lee KH, Xu Q, Breitbart RE. A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm. Dev Biol. 180:1996;722-731.
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Dev Biol
, vol.180
, pp. 722-731
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Lee, K.H.1
Xu, Q.2
Breitbart, R.E.3
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35
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0030926451
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Homeodomain factor Nkx2-5 controls left/right asymmetric expression of the bHLH gene eHand during murine heart development
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Biben C, Harvey RP. Homeodomain factor Nkx2-5 controls left/right asymmetric expression of the bHLH gene eHand during murine heart development. Genes Dev. 11:1997;1357-1369.
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(1997)
Genes Dev
, vol.11
, pp. 1357-1369
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Biben, C.1
Harvey, R.P.2
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36
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0029549692
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A subsclass of bHLH proteins required for cardiac morphogenesis
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Srivastava D, Cserjesi P, Olson EN. A subsclass of bHLH proteins required for cardiac morphogenesis. Science. 270:1995;1995-1999.
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(1995)
Science
, vol.270
, pp. 1995-1999
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Srivastava, D.1
Cserjesi, P.2
Olson, E.N.3
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37
-
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0030903857
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Regulation of cardiac mesoderm and neural crest development by the bHLH transcription factor, dHAND
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of special interest. A description of the phenotype of mice homozygous for a targeted interruption of the dHAND gene. These mice have a defect in heart tube looping, though not as severe as that reported for Nkx2-5 [30] or MEF2-C [42], and an apparent lack of the right ventricle.
-
Srivastava D, Thomas T, Lin Q, Kirby ML, Brown D, Olson EN. Regulation of cardiac mesoderm and neural crest development by the bHLH transcription factor, dHAND. of special interest Nat Genet. 16:1997;154-160 A description of the phenotype of mice homozygous for a targeted interruption of the dHAND gene. These mice have a defect in heart tube looping, though not as severe as that reported for Nkx2-5 [30] or MEF2-C [42], and an apparent lack of the right ventricle.
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(1997)
Nat Genet
, vol.16
, pp. 154-160
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Srivastava, D.1
Thomas, T.2
Lin, Q.3
Kirby, M.L.4
Brown, D.5
Olson, E.N.6
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38
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0029896641
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An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and established an anterior-posterior gradient of expression
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Ross RS, Navankasattusas S, Harvey RP, Chien KR. An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and established an anterior-posterior gradient of expression. Development. 122:1996;1799-1809.
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Development
, vol.122
, pp. 1799-1809
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Ross, R.S.1
Navankasattusas, S.2
Harvey, R.P.3
Chien, K.R.4
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39
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0031029447
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CARP, a cardiac ankyrin repeat protein is downstream in the Nkx2-5 homeobox gene pathway
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Zou Y, Evans S, Chen J, Kuo H-C, Harvey RP, Chien KR. CARP, a cardiac ankyrin repeat protein is downstream in the Nkx2-5 homeobox gene pathway. Development. 124:1997;793-804.
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Development
, vol.124
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Zou, Y.1
Evans, S.2
Chen, J.3
Kuo, H.-C.4
Harvey, R.P.5
Chien, K.R.6
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40
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0031033603
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D-mef2 is a target for tinman activation during Drosophila heart development
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of special interest. Shows that D-mef2 expression in the developing Drosophila heart requires an enhancer element containing two tinman-binding sites, both of which are essential for enhancer function in cardiac muscle cells. Ectopic tinman expression can activate the enhancer outside the cardiac lineage.
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Gajewski K, Kim Y, Lee YM, Olson EN, Schulz RA. D-mef2 is a target for tinman activation during Drosophila heart development. of special interest EMBO J. 16:1997;515-522 Shows that D-mef2 expression in the developing Drosophila heart requires an enhancer element containing two tinman-binding sites, both of which are essential for enhancer function in cardiac muscle cells. Ectopic tinman expression can activate the enhancer outside the cardiac lineage.
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EMBO J
, vol.16
, pp. 515-522
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Gajewski, K.1
Kim, Y.2
Lee, Y.M.3
Olson, E.N.4
Schulz, R.A.5
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41
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0029584055
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Cardiac myogenesis: Overexpression of Xcsx2 or XMEF2A in whole Xenopus embryos induces the precocious expression of the XMHCα gene
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Fu Y, Izumo S. Cardiac myogenesis: overexpression of Xcsx2 or XMEF2A in whole Xenopus embryos induces the precocious expression of the XMHCα gene. Rouxs Arch Dev Biol. 205:1995;198-202.
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Rouxs Arch Dev Biol
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Fu, Y.1
Izumo, S.2
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42
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0030911475
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Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF-2C
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Lin Q, Schwarz J, Bucana C, Olson EN. Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF-2C. of special interest Science. 276:1997;1404-1407 Mice homozygous for a null mutation of MEF-2C have a severe heart tube looping defect and lack a right ventricle. Although most markers of cardiac differentiation are normal, GATA-4 is downregulated.
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GATA-4/5/6: A subfamily of three transcription factors transcribed in the developing heart and gut
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Evans, T.6
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44
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Over-expression of GATA-6 in Xenopus embryos blocks differentiation of heart precursors
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Gove C, Walmsley M, Nijjar S, Bertwistle D, Guille M, Partington G, Bomford A, Patient R. Over-expression of GATA-6 in Xenopus embryos blocks differentiation of heart precursors. EMBO J. 16:1997;355-368.
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The Xenopus GATA-4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis
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Jiang Y, Evans T. The Xenopus GATA-4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis. Dev Biol. 174:1996;258-270.
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Morrisey EE, Ip HS, Tang Z, Lu MM, Parmacek MS. GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development. Dev Biol. 183:1997;21-36.
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GATA4 transcription factor is required for ventral morphogenesis and heart tube formation
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Kuo CT, Morrisey EE, Anandappa R, Sigrist K, Lu MM, Parmacek MS, Soudais C, Leiden JM. GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. of special interest Genes Dev. 11:1997;1048-1060 See annotation [49].
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Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis
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of special interest. This paper and [48] both describe the effects of GATA-4 knockout in the mouse. Although cardiogenesis appears to occur, as measured by the presence of markers of terminal cardiac differentiation, a gross defect in embryonic folding prevents heart tube fusion and causes a generalized disruption of the ventral body pattern.
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Molkentin JD, Lin Q, Duncan SA, Olson EN. Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. of special interest Genes Dev. 11:1997;1061-1072 This paper and [48] both describe the effects of GATA-4 knockout in the mouse. Although cardiogenesis appears to occur, as measured by the presence of markers of terminal cardiac differentiation, a gross defect in embryonic folding prevents heart tube fusion and causes a generalized disruption of the ventral body pattern.
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51
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Activation of the cardiac alpha-actin promoter depends upon serum response factor, tinman homologue, Nkx-2.5, and intact serum response elements
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Chen CY, Croissant J, Majesky M, Topouzis S, McQuinn T, Frankovsky MJ, Schwartz RJ. Activation of the cardiac alpha-actin promoter depends upon serum response factor, tinman homologue, Nkx-2.5, and intact serum response elements. Dev Gen. 19:1996;119-130.
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of outstanding interest. In addition to discussing the early events of cardiac specification, this review also covers later steps in morphogenesis - such as chamber formation - that are beyond the scope of our own review.
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Fishman MC, Chien KR. Fashioning the vertebrate heart: earliest embryonic decisions. of outstanding interest Development. 124:1997;2099-2117 In addition to discussing the early events of cardiac specification, this review also covers later steps in morphogenesis - such as chamber formation - that are beyond the scope of our own review.
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Development
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Fishman, M.C.1
Chien, K.R.2
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