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Volumn 5, Issue 2, 1999, Pages 166-171

Leptin, polycystic ovaries and polycystic ovary syndrome

Author keywords

Insulin resistance; Leptin; Obesity; Polycystic ovary syndrome

Indexed keywords

INSULIN; LEPTIN; NEUROPEPTIDE Y;

EID: 0032903024     PISSN: 13554786     EISSN: None     Source Type: Journal    
DOI: 10.1093/humupd/5.2.166     Document Type: Review
Times cited : (42)

References (70)
  • 1
    • 0025882204 scopus 로고
    • Insulin resistance of puberty: A defect restricted to peripheral glucose metabolism
    • Amiel, S.A., Caprio, S., Sherwin, R.S. et al. (1991) Insulin resistance of puberty: a defect restricted to peripheral glucose metabolism. J. Clin. Endocrinol. Metab., 72, 277-282.
    • (1991) J. Clin. Endocrinol. Metab. , vol.72 , pp. 277-282
    • Amiel, S.A.1    Caprio, S.2    Sherwin, R.S.3
  • 2
    • 0031306926 scopus 로고    scopus 로고
    • Oocyte influences on early development: The regulatory proteins leptin and STAT3 are polarized in mouse and human oocytes and differentially distributed within the cell of the preimplantation stage embryo
    • Antczak, M. and Van Blerkdom, J. (1997) Oocyte influences on early development: the regulatory proteins leptin and STAT3 are polarized in mouse and human oocytes and differentially distributed within the cell of the preimplantation stage embryo. Mol. Hum. Reprod., 3, 1067-1086.
    • (1997) Mol. Hum. Reprod. , vol.3 , pp. 1067-1086
    • Antczak, M.1    Van Blerkdom, J.2
  • 3
    • 0028889654 scopus 로고
    • Metabolic features of polycystic ovary syndrome are found in adolescent girls with hyperandrogenism
    • Apter, D., Butzow, T., Laughlin, G.A. and Yen, S.S. (1995) Metabolic features of polycystic ovary syndrome are found in adolescent girls with hyperandrogenism. J. Clin. Endocrinol. Metab., 80, 2966-2973.
    • (1995) J. Clin. Endocrinol. Metab. , vol.80 , pp. 2966-2973
    • Apter, D.1    Butzow, T.2    Laughlin, G.A.3    Yen, S.S.4
  • 4
    • 0030698381 scopus 로고    scopus 로고
    • Inappropriate gonadotropin secretion in polycystic ovary syndrome: Influence of adiposity
    • Arroyo, A., Laughlin, G.A., Morales, A.J. and Yen, S.S. (1997) Inappropriate gonadotropin secretion in polycystic ovary syndrome: influence of adiposity. J. Clin. Endocrinol. Metab., 82, 3728-3733.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 3728-3733
    • Arroyo, A.1    Laughlin, G.A.2    Morales, A.J.3    Yen, S.S.4
  • 5
    • 0029047506 scopus 로고
    • Polycystic ovary syndrome: The spectrum of the disorder in 1741 patients
    • Balen, A.H., Conway, G.S., Kaltsas, G. et al. (1995) Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients. Hum. Reprod., 10, 2107-2111.
    • (1995) Hum. Reprod. , vol.10 , pp. 2107-2111
    • Balen, A.H.1    Conway, G.S.2    Kaltsas, G.3
  • 6
    • 0029953957 scopus 로고    scopus 로고
    • Leptin is a metabolic signal to the reproductive system
    • Barash, I.A., Cheung, C.C., Weigle, D.S. et al. (1996) Leptin is a metabolic signal to the reproductive system. Endocrinology, 137, 3144-3147.
    • (1996) Endocrinology , vol.137 , pp. 3144-3147
    • Barash, I.A.1    Cheung, C.C.2    Weigle, D.S.3
  • 7
    • 0029671107 scopus 로고    scopus 로고
    • The android woman - A risky condition
    • Bjorntorp, P. (1996) The android woman - a risky condition. J. Intern. Med., 239, 105-110.
    • (1996) J. Intern. Med. , vol.239 , pp. 105-110
    • Bjorntorp, P.1
  • 8
    • 85047677586 scopus 로고    scopus 로고
    • Clinical review 90. Leptin and clinical medicine: A new piece in the puzzle of obesity
    • Bray, G.A. and York, D.A. (1997) Clinical review 90. Leptin and clinical medicine: a new piece in the puzzle of obesity. J. Clin. Endocrinol. Metab., 82, 2771-2776.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 2771-2776
    • Bray, G.A.1    York, D.A.2
  • 9
    • 0029795322 scopus 로고    scopus 로고
    • Serum immunoreactive leptin concentrations in women with polycystic ovary syndrome
    • Brzechffa, P.R., Jakimiuk, A.J., Agarwal, S.K. et al. (1996) Serum immunoreactive leptin concentrations in women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 81, 4166-4169.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 4166-4169
    • Brzechffa, P.R.1    Jakimiuk, A.J.2    Agarwal, S.K.3
  • 10
    • 0031154904 scopus 로고    scopus 로고
    • Leptin is normal in PCOS; an editorial about three 'negative' papers
    • Caro, J.F. (1997) Leptin is normal in PCOS; an editorial about three 'negative' papers. J. Clin. Endocrinol. Metab., 82, 1685-1686.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 1685-1686
    • Caro, J.F.1
  • 11
    • 0030900628 scopus 로고    scopus 로고
    • Circulating leptin concentrations in polycystic ovary syndrome: Relation to anthropometric and metabolic parameters
    • Chapman, I.M., Wittert, G.A. and Norman, R.J. (1997) Circulating leptin concentrations in polycystic ovary syndrome: relation to anthropometric and metabolic parameters. Clin. Endocrinol., 46, 175-181.
    • (1997) Clin. Endocrinol. , vol.46 , pp. 175-181
    • Chapman, I.M.1    Wittert, G.A.2    Norman, R.J.3
  • 12
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • Chehab, F.F., Lim, M.E. and Lu, R. (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genet., 12, 318-320.
    • (1996) Nature Genet. , vol.12 , pp. 318-320
    • Chehab, F.F.1    Lim, M.E.2    Lu, R.3
  • 13
    • 0030028959 scopus 로고    scopus 로고
    • Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
    • Chua, S.C.J., Chung, W.K., Wu-Peng, X.S. et al. (1996) Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science, 271, 994-996.
    • (1996) Science , vol.271 , pp. 994-996
    • Chua, S.C.J.1    Chung, W.K.2    Wu-Peng, X.S.3
  • 14
    • 0030957207 scopus 로고    scopus 로고
    • Cellular insulin resistance in adipocytes from obese polycystic ovary syndrome subjects involves adenosine modulation of insulin sensitivity
    • Ciaraldi, T.P., Morales, A.J., Hickman, M.G. et al. (1997) Cellular insulin resistance in adipocytes from obese polycystic ovary syndrome subjects involves adenosine modulation of insulin sensitivity. J. Clin. Endocrinol. Metab., 82, 1421-1425.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 1421-1425
    • Ciaraldi, T.P.1    Morales, A.J.2    Hickman, M.G.3
  • 15
    • 0030007116 scopus 로고    scopus 로고
    • Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction
    • Cioffi, J.A., Shafer, A.W., Zupancic, T.J. et al. (1996) Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nature Med., 2, 585-589.
    • (1996) Nature Med. , vol.2 , pp. 585-589
    • Cioffi, J.A.1    Shafer, A.W.2    Zupancic, T.J.3
  • 16
    • 0031157855 scopus 로고    scopus 로고
    • The expression of leptin and its receptors in pre-ovulatory human follicles
    • Cioffi, J.A., Van Blerkom, J., Antczak, M. et al. (1997) The expression of leptin and its receptors in pre-ovulatory human follicles. Mol. Hum. Reprod., 3, 467-472.
    • (1997) Mol. Hum. Reprod. , vol.3 , pp. 467-472
    • Cioffi, J.A.1    Van Blerkom, J.2    Antczak, M.3
  • 17
    • 0344450708 scopus 로고    scopus 로고
    • A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
    • Clement, K., Vaisse, C., Lahlou, N. et al. (1998) A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature, 392, 398-401.
    • (1998) Nature , vol.392 , pp. 398-401
    • Clement, K.1    Vaisse, C.2    Lahlou, N.3
  • 18
    • 0029860791 scopus 로고    scopus 로고
    • Modulation of insulin activities by leptin
    • Cohen, B., Novick, D. and Rubenstein, M. (1996) Modulation of insulin activities by leptin. Science, 274, 1185-1188.
    • (1996) Science , vol.274 , pp. 1185-1188
    • Cohen, B.1    Novick, D.2    Rubenstein, M.3
  • 19
    • 0030915091 scopus 로고    scopus 로고
    • The clinical management of hirsutism
    • Conn, J.J. and Jacobs, H.S. (1997) The clinical management of hirsutism (review). Eur. J. Endocrinol., 136, 339-348.
    • (1997) Eur. J. Endocrinol. , vol.136 , pp. 339-348
    • Conn, J.J.1    Jacobs, H.S.2
  • 20
    • 13344295079 scopus 로고    scopus 로고
    • Serum immunoreactive-leptin concentrations in normal-weight and obese humans
    • Considine, R.V., Sinha, M.K., Heiman, M.L. et al. (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med., 334, 292-295.
    • (1996) N. Engl. J. Med. , vol.334 , pp. 292-295
    • Considine, R.V.1    Sinha, M.K.2    Heiman, M.L.3
  • 21
    • 0025283561 scopus 로고
    • Acanthosis nigricans in obese women with the polycystic ovary syndrome: Disease spectrum not distinct entity
    • Conway, G.S. and Jacobs, H.S. (1990) Acanthosis nigricans in obese women with the polycystic ovary syndrome: disease spectrum not distinct entity. Postgrad. Med. J., 66, 536-538.
    • (1990) Postgrad. Med. J. , vol.66 , pp. 536-538
    • Conway, G.S.1    Jacobs, H.S.2
  • 22
    • 0027135479 scopus 로고
    • Clinical implications of hyperinsulinaemia in women
    • Conway, G.S. and Jacobs, H.S. (1993) Clinical implications of hyperinsulinaemia in women. Clin. Endocrinol., 39, 623-632.
    • (1993) Clin. Endocrinol. , vol.39 , pp. 623-632
    • Conway, G.S.1    Jacobs, H.S.2
  • 23
    • 0030918387 scopus 로고    scopus 로고
    • Leptin: A hormone of reproduction
    • Conway, G.S. and Jacobs, H.S. (1997) Leptin: a hormone of reproduction. Hum. Reprod., 12, 633-635.
    • (1997) Hum. Reprod. , vol.12 , pp. 633-635
    • Conway, G.S.1    Jacobs, H.S.2
  • 24
    • 0025027380 scopus 로고
    • Effects of luteinizing hormone, insulin, insulin-like growth factor-I and insulin-like growth factor small binding protein 1 in the polycystic ovary syndrome
    • Conway, G.S., Jacobs, H.S., Holly, J.M. and Wass, J.A. (1990) Effects of luteinizing hormone, insulin, insulin-like growth factor-I and insulin-like growth factor small binding protein 1 in the polycystic ovary syndrome. Clin. Endocrinol., 33, 593-603.
    • (1990) Clin. Endocrinol. , vol.33 , pp. 593-603
    • Conway, G.S.1    Jacobs, H.S.2    Holly, J.M.3    Wass, J.A.4
  • 25
    • 0026574154 scopus 로고
    • Women with polycystic ovary syndrome wedge resected in 1956 to 1965: A long-term follow-up focusing on natural history and circulating hormones
    • Dahlgren, E., Johansson, S., Lindstedt, G. et al. (1992) Women with polycystic ovary syndrome wedge resected in 1956 to 1965: a long-term follow-up focusing on natural history and circulating hormones. Fertil. Steril., 57, 505-513.
    • (1992) Fertil. Steril. , vol.57 , pp. 505-513
    • Dahlgren, E.1    Johansson, S.2    Lindstedt, G.3
  • 26
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis
    • Dunaif, A. (1997) Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr. Rev., 18, 774-800.
    • (1997) Endocr. Rev. , vol.18 , pp. 774-800
    • Dunaif, A.1
  • 27
    • 0024437305 scopus 로고
    • Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome
    • Dunaif, A., Segal, K.R., Futterweit, W. and Dobrjansky, A. (1989) Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes, 38, 1165-1174.
    • (1989) Diabetes , vol.38 , pp. 1165-1174
    • Dunaif, A.1    Segal, K.R.2    Futterweit, W.3    Dobrjansky, A.4
  • 28
    • 0029119085 scopus 로고
    • Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome
    • Dunaif, A., Xia, J., Book, C.B. et al. (1995) Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome. J. Clin. Invest., 96, 801-810.
    • (1995) J. Clin. Invest. , vol.96 , pp. 801-810
    • Dunaif, A.1    Xia, J.2    Book, C.B.3
  • 29
    • 0029795871 scopus 로고    scopus 로고
    • The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome
    • Dunaif, A., Scott, D., Finegood, D. et al. (1996) The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 81, 3299-3306.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 3299-3306
    • Dunaif, A.1    Scott, D.2    Finegood, D.3
  • 30
    • 0030753638 scopus 로고    scopus 로고
    • Endocrine function of neuropeptide Y knockout mice
    • Erickson, J.C., Ahima, R.S., Hollopeter, G. et al. (1997) Endocrine function of neuropeptide Y knockout mice. Regulatory Peptides, 70, 199-202.
    • (1997) Regulatory Peptides , vol.70 , pp. 199-202
    • Erickson, J.C.1    Ahima, R.S.2    Hollopeter, G.3
  • 31
    • 0029095150 scopus 로고
    • Polycystic ovary syndrome
    • Franks, S. (1995) Polycystic ovary syndrome. N. Engl. J. Med., 333, 853-861.
    • (1995) N. Engl. J. Med. , vol.333 , pp. 853-861
    • Franks, S.1
  • 32
    • 0031012588 scopus 로고    scopus 로고
    • The alphabet of weight control
    • Friedman, J.M. (1998) The alphabet of weight control. Nature, 385, 119-120.
    • (1998) Nature , vol.385 , pp. 119-120
    • Friedman, J.M.1
  • 33
  • 34
    • 0029793625 scopus 로고    scopus 로고
    • Gender differences in plasma leptin concentrations
    • Havel, P.J., Kasim-Karakas, S., Dubuc, G.R. et al. (1996) Gender differences in plasma leptin concentrations. Nature Med., 2, 949-950.
    • (1996) Nature Med. , vol.2 , pp. 949-950
    • Havel, P.J.1    Kasim-Karakas, S.2    Dubuc, G.R.3
  • 35
    • 0029907970 scopus 로고    scopus 로고
    • Evidence for leptin binding to proteins in serum of rodents and humans: Modulation with obesity
    • Houseknecht, K.L., Mantzoros, C.S., Kuliawat, R. et al. (1996) Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity. Diabetes, 45, 1638-1643.
    • (1996) Diabetes , vol.45 , pp. 1638-1643
    • Houseknecht, K.L.1    Mantzoros, C.S.2    Kuliawat, R.3
  • 36
    • 0030453726 scopus 로고    scopus 로고
    • Difference in leptin mRNA levels between omental and subcutaneous abdominal adipose tissue from obese humans
    • Hube, F., Lietz, U., Igel, M. et al. (1996) Difference in leptin mRNA levels between omental and subcutaneous abdominal adipose tissue from obese humans. Horm. Metab. Res., 28, 690-693.
    • (1996) Horm. Metab. Res. , vol.28 , pp. 690-693
    • Hube, F.1    Lietz, U.2    Igel, M.3
  • 37
    • 0023296437 scopus 로고
    • Polycystic ovaries and polycystic ovary syndrome
    • Jacobs, H.S. (1987) Polycystic ovaries and polycystic ovary syndrome. Gynecol. Endocrinol., 1, 113-131.
    • (1987) Gynecol. Endocrinol. , vol.1 , pp. 113-131
    • Jacobs, H.S.1
  • 38
  • 39
    • 0030735281 scopus 로고    scopus 로고
    • Expression of functional leptin receptors in the human ovary
    • Karlsson, C., Lindell, K., Svensson, E. et al. (1997) Expression of functional leptin receptors in the human ovary. J. Clin. Endocrinol. Metab., 82, 4144-4148.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 4144-4148
    • Karlsson, C.1    Lindell, K.2    Svensson, E.3
  • 40
    • 0026543775 scopus 로고
    • Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome
    • Kiddy, D.S., Hamilton-Fairley, D., Bush, A. et al. (1992) Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome. Clin. Endocrinol., 36, 105-111.
    • (1992) Clin. Endocrinol. , vol.36 , pp. 105-111
    • Kiddy, D.S.1    Hamilton-Fairley, D.2    Bush, A.3
  • 41
    • 0028205364 scopus 로고
    • Sexual dimorphism of age-related changes in whole-body fat distribution in the obese
    • Kotani, K., Tokunaga, K., Fujioka, S. et al. (1994) Sexual dimorphism of age-related changes in whole-body fat distribution in the obese. Int. J. Obes. Related Metab. Disorders, 18, 202-207.
    • (1994) Int. J. Obes. Related Metab. Disorders , vol.18 , pp. 202-207
    • Kotani, K.1    Tokunaga, K.2    Fujioka, S.3
  • 42
    • 0031844422 scopus 로고    scopus 로고
    • Leptin levels in women with polycystic ovary syndrome before and after treatment with diazoxide
    • Krassas, G.E., Kaltsas, T.H., Pontikedes, N. et al. (1998) Leptin levels in women with polycystic ovary syndrome before and after treatment with diazoxide. Eur. J. Endocrinol., 139, 184-189.
    • (1998) Eur. J. Endocrinol. , vol.139 , pp. 184-189
    • Krassas, G.E.1    Kaltsas, T.H.2    Pontikedes, N.3
  • 43
    • 0031156840 scopus 로고    scopus 로고
    • Serum leptin levels in women with polycystic ovary syndrome: The role of insulin resistance/hyperinsulinemia
    • Laughlin, G.A., Morales, A.J. and Yen, S.S. (1997) Serum leptin levels in women with polycystic ovary syndrome: the role of insulin resistance/hyperinsulinemia. J. Clin. Endocrinol. Metab., 82, 1692-1696.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 1692-1696
    • Laughlin, G.A.1    Morales, A.J.2    Yen, S.S.3
  • 45
    • 0026060104 scopus 로고
    • Polycystic ovary syndrome and bulimia
    • McCluskey, S., Evans, C., Lacey, J.H. et al. (1991) Polycystic ovary syndrome and bulimia. Fertil. Steril., 55, 287-291.
    • (1991) Fertil. Steril. , vol.55 , pp. 287-291
    • McCluskey, S.1    Evans, C.2    Lacey, J.H.3
  • 46
    • 0030828831 scopus 로고    scopus 로고
    • Leptin levels and insulin sensitivity in obese and non-obese patients with polycystic ovary syndrome
    • Micic, D., Macut, D., Popovic, V. et al. (1997) Leptin levels and insulin sensitivity in obese and non-obese patients with polycystic ovary syndrome. Gynecol. Endocrinol., 11, 315-320.
    • (1997) Gynecol. Endocrinol. , vol.11 , pp. 315-320
    • Micic, D.1    Macut, D.2    Popovic, V.3
  • 47
    • 70349566593 scopus 로고
    • Diabetes mellitus: A 'thrifty' genotype rendered detrimental by 'progress'
    • Neel, J.V. (1962) Diabetes mellitus: a 'thrifty' genotype rendered detrimental by 'progress'. Am. J. Hum. Genet., 14, 353-362.
    • (1962) Am. J. Hum. Genet. , vol.14 , pp. 353-362
    • Neel, J.V.1
  • 48
    • 0030960289 scopus 로고    scopus 로고
    • Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications
    • Nestler, J.E. (1997) Role of hyperinsulinemia in the pathogenesis of the polycystic ovary syndrome, and its clinical implications. Semin. Reprod. Endocrinol., 15, 111-122.
    • (1997) Semin. Reprod. Endocrinol. , vol.15 , pp. 111-122
    • Nestler, J.E.1
  • 49
    • 0024381472 scopus 로고
    • Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome
    • Nestler, J.E., Barlascini, C.O., Matt, D.W. et al. (1989) Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 68, 1027-1032.
    • (1989) J. Clin. Endocrinol. Metab. , vol.68 , pp. 1027-1032
    • Nestler, J.E.1    Barlascini, C.O.2    Matt, D.W.3
  • 50
    • 0032565971 scopus 로고    scopus 로고
    • Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome
    • Nestler, J.E., Jakubowicz, D.J., Evans, W.S. and Pasquali, R. (1998) Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome. N. Engl. J. Med., 338, 1876-1880.
    • (1998) N. Engl. J. Med. , vol.338 , pp. 1876-1880
    • Nestler, J.E.1    Jakubowicz, D.J.2    Evans, W.S.3    Pasquali, R.4
  • 51
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Pelleymounter, M.A., Cullen, M.J., Baker, M.B. et al. (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science, 269, 540-543.
    • (1995) Science , vol.269 , pp. 540-543
    • Pelleymounter, M.A.1    Cullen, M.J.2    Baker, M.B.3
  • 52
    • 2042548063 scopus 로고    scopus 로고
    • Mortality of women with polycystic ovary syndrome at long-term follow-up
    • Pierpoint, T., McKeigue, P.M., Isaacs, A.J. et al. (1998) Mortality of women with polycystic ovary syndrome at long-term follow-up. J. Clin. Epidemiol., 51, 581-586.
    • (1998) J. Clin. Epidemiol. , vol.51 , pp. 581-586
    • Pierpoint, T.1    McKeigue, P.M.2    Isaacs, A.J.3
  • 53
    • 0343488760 scopus 로고    scopus 로고
    • Chronobiologic evolution of luteinizing hormone secretion in adolescence: Developmental patterns and speculations on the onset of the polycystic ovary syndrome
    • Porcu, E., Venturoli, S., Longhi, M. et al. (1997) Chronobiologic evolution of luteinizing hormone secretion in adolescence: developmental patterns and speculations on the onset of the polycystic ovary syndrome. Fertil. Steril., 67, 842-848.
    • (1997) Fertil. Steril. , vol.67 , pp. 842-848
    • Porcu, E.1    Venturoli, S.2    Longhi, M.3
  • 54
    • 0031050415 scopus 로고    scopus 로고
    • Relatively low plasma leptin concentrations precede weight gain in Pima Indians
    • Ravussin, E., Pratley, R.E., Maffei, M. et al. (1997) Relatively low plasma leptin concentrations precede weight gain in Pima Indians. Nature Med., 3, 238-240.
    • (1997) Nature Med. , vol.3 , pp. 238-240
    • Ravussin, E.1    Pratley, R.E.2    Maffei, M.3
  • 56
    • 0029816596 scopus 로고    scopus 로고
    • Effects of gender, body composition, and menopause on plasma concentrations of leptin
    • Rosenbaum, M., Nicolson, M., Hirsch, J. et al. (1996) Effects of gender, body composition, and menopause on plasma concentrations of leptin. J. Clin. Endocrinol Metab., 81, 3424-3427.
    • (1996) J. Clin. Endocrinol Metab. , vol.81 , pp. 3424-3427
    • Rosenbaum, M.1    Nicolson, M.2    Hirsch, J.3
  • 57
    • 0031156593 scopus 로고    scopus 로고
    • Serum leptin concentrations in women with polycystic ovary syndrome
    • Rouru, J., Anttila, L., Koskinen, P. et al. (1997) Serum leptin concentrations in women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab., 82, 1697-1700.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 1697-1700
    • Rouru, J.1    Anttila, L.2    Koskinen, P.3
  • 58
    • 0029157428 scopus 로고
    • Transient increase in obese gene expression after food intake or insulin administration
    • Saladin, R., De Vos, P., Guerre-Millo, M. et al. (1995) Transient increase in obese gene expression after food intake or insulin administration. Nature, 377, 527-529.
    • (1995) Nature , vol.377 , pp. 527-529
    • Saladin, R.1    De Vos, P.2    Guerre-Millo, M.3
  • 59
    • 0030689791 scopus 로고    scopus 로고
    • Polycystic ovary syndrome associated with treatment with the anticonvulsant sodium valproate
    • Sharma, S. and Jacobs, H.S. (1997) Polycystic ovary syndrome associated with treatment with the anticonvulsant sodium valproate. Curr. Opin. Obstet. Gynecol., 9, 391-392.
    • (1997) Curr. Opin. Obstet. Gynecol. , vol.9 , pp. 391-392
    • Sharma, S.1    Jacobs, H.S.2
  • 60
    • 0032508682 scopus 로고    scopus 로고
    • Biological action of leptin as an angiogenic factor
    • Sierra-Honigmann, M.R., Nath, A.K., Murakami, C. et al. (1998) Biological action of leptin as an angiogenic factor. Science, 281, 1683-1686.
    • (1998) Science , vol.281 , pp. 1683-1686
    • Sierra-Honigmann, M.R.1    Nath, A.K.2    Murakami, C.3
  • 62
    • 0030013588 scopus 로고    scopus 로고
    • Life without neuropeptide Y
    • Stephens, T.W. (1998) Life without neuropeptide Y. Nature, 381, 377-378.
    • (1998) Nature , vol.381 , pp. 377-378
    • Stephens, T.W.1
  • 63
    • 0029098589 scopus 로고
    • The role of neuropeptide Y in the antiobesity action of the obese gene product
    • Stephens, T.W., Basinski, M., Bristow, P.K. et al. (1995) The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature, 377, 530-532.
    • (1995) Nature , vol.377 , pp. 530-532
    • Stephens, T.W.1    Basinski, M.2    Bristow, P.K.3
  • 64
    • 0032014836 scopus 로고    scopus 로고
    • A leptin missense mutation associated with hypogonadism and morbid obesity
    • Strobel, A., Issad, T., Camoin, L. et al. (1998) A leptin missense mutation associated with hypogonadism and morbid obesity. Nature Genet., 18, 213-215.
    • (1998) Nature Genet. , vol.18 , pp. 213-215
    • Strobel, A.1    Issad, T.2    Camoin, L.3
  • 65
    • 0017164596 scopus 로고
    • Reproductive hormonal function in the genetically obese (ob/ob) mouse
    • Swerdloff, R.S., Batt, R.A. and Bray, G.A. (1976) Reproductive hormonal function in the genetically obese (ob/ob) mouse. Endocrinology, 98, 1359-1364.
    • (1976) Endocrinology , vol.98 , pp. 1359-1364
    • Swerdloff, R.S.1    Batt, R.A.2    Bray, G.A.3
  • 66
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, OB-R
    • Tartaglia, L.A., Dembski, M., Weng, X. et al. (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell, 83, 1263-1271.
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.A.1    Dembski, M.2    Weng, X.3
  • 67
    • 0030848557 scopus 로고    scopus 로고
    • Contribution of androgens to the gender difference in leptin production in obese children and adolescents
    • Wabitsch, M., Blum, W.F., Muche, R. et al. (1997) Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J. Clin. Invest., 100, 808-813.
    • (1997) J. Clin. Invest. , vol.100 , pp. 808-813
    • Wabitsch, M.1    Blum, W.F.2    Muche, R.3
  • 68
    • 0029795318 scopus 로고    scopus 로고
    • Induction of ovulation with low-dose gonadotropins in polycystic ovary syndrome: An analysis of 109 pregnancies in 225 women
    • White, D.M., Polson, D.W., Kiddy, D. et al. (1996) Induction of ovulation with low-dose gonadotropins in polycystic ovary syndrome: an analysis of 109 pregnancies in 225 women. J. Clin. Endocrinol. Metab., 81, 3821-3824.
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 3821-3824
    • White, D.M.1    Polson, D.W.2    Kiddy, D.3
  • 69
    • 0031046147 scopus 로고    scopus 로고
    • Direct intraovarian effects of leptin: Impairment of the synergistic action of insulin-like growth factor-I on follicle-stimulating hormone-dependent estradiol-17 beta production by rat ovarian granulosa cells
    • Zachow, R.J. and Magoffin, D.A. (1997) Direct intraovarian effects of leptin: impairment of the synergistic action of insulin-like growth factor-I on follicle-stimulating hormone-dependent estradiol-17 beta production by rat ovarian granulosa cells. Endocrinology, 138, 847-850.
    • (1997) Endocrinology , vol.138 , pp. 847-850
    • Zachow, R.J.1    Magoffin, D.A.2
  • 70
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y., Proenca, R., Maffei, M. et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature, 372, 425-432.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3


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