Oocyte influences on early development: The regulatory proteins leptin and STAT3 are polarized in mouse and human oocytes and differentially distributed within the cells of the preimplantation stage embryo

Molecular Human Reproduction

Volumn 3, Issue 12, 1997, Pages 1067-1086

  Antczak, Michael ^a   Van Blerkom, Jonathan ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b Reproductive Genetics Center   (United States)

Author keywords

Embryonic development; Leptin; Maternal inheritance; Polarity; STAT3

Indexed keywords

CARRIER PROTEIN; CELL SURFACE RECEPTOR; DNA BINDING PROTEIN; LEPTIN; LEPTIN RECEPTOR; PROTEIN; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN; STAT3 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ANIMAL; ARTICLE; BLASTOCYST; C57BL MOUSE; CELL POLARITY; CYTOLOGY; EMBRYO DEVELOPMENT; FEMALE; GENETICS; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; ISOLATION AND PURIFICATION; METABOLISM; MORULA; MOUSE; OBESITY; OOCYTE; OVARY FOLLICLE; PHYSIOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; ZYGOTE;

ANIMALS; BLASTOCYST; CARRIER PROTEINS; CELL POLARITY; DNA-BINDING PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; EMBRYONIC DEVELOPMENT; FEMALE; HUMANS; LEPTIN; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; MORULA; OBESITY; OOCYTES; OVARIAN FOLLICLE; PREGNANCY; PROTEINS; RECEPTORS, CELL SURFACE; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; ZYGOTE;

EID: 0031306926     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: 10.1093/molehr/3.12.1067     Document Type: Article

References (45)

1. Abdel-Rahman, B., Fiddler, M., Rappolee, D. and Pergament, E. (1995) Expression of transcription regulating genes in human preimplantation embryos. Hum. Reprod., 10, 2787-2792.
2. Antczak, M., Van Blerkom, J. and Clark, A (1997) A novel mechanism of VEGF, leptin, and TGFβ2 sequestration in a subpopulation of human ovarian follicle cells. Hum. Reprod., 12, 2226-2234.
3. Baumann, H., Morella, K., White, D. et al. (1996) The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc. Natl. Acad. Sci. USA, 93, 8374-8378.
4. Bennett, B., Solar, G., Yuan, J. et al. (1996) A role for leptin and its cognate receptor in hematopoiesis. Curr. Biol., 6, 1170-1180.
5. Chehab, F., Lom, M., and Lu, R. (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genet., 12, 318-320.
6. Chehab, F., Mounzih, K., Ronghua, L. and Lim, M. (1997) Early onset of reproductive function in normal female mice treated with leptin. Science, 257, 88-90.
7. Cioffi, J., Van Blerkom, J., Antczak, M. et al. (1997) The expression of leptin and its receptors in preovulatory human follicles. Mol. Hum. Reprod., 3, 467-172.
8. Coleman, D. (1978) Obese and diabetes: two mutant genes causing diabetes-obesity syndrome in mice. Diabetologia, 14, 141-148.
9. Conway, G. and Jacobs, H. (1997) Leptin: a hormone of reproduction. Hum. Reprod., 12, 633-635.
10. Dale, B., Tosti, E. and Iaccarino, M. (1995) Is the plasma membrane of the human oocyte reorganized following fertilisation and early cleavage? Zygote, 3, 31-36.
11. Darnell, J., Kerr, I. and Stark, G. (1994) Jak-STAT pathways and transcriptional activation in response to IFN's and other extracellular signaling proteins. Science, 264, 1415-1421.
12. Edwards, R.G. and Beard, H.K. (1997) Oocyte polarity and cell determination in early mammalian embryos. Mol. Hum. Reprod., 3, 863-905.
13. Erbach, G., Lawitts, J., Papaioannou, V. and Biggers, J. (1994) Differential growth of the mouse preimplantation embryo in chemically defined medium. Biol. Reprod., 50, 1027-1033.
14. Gardner, R. (1996) Can developmentally significant spatial patterning of the egg be discontinuous in mammals? Hum. Reprod. Update, 2, 3-27.
15. Gardner, R. (1997) The early blastocyst is bilaterally symmetrical and its axis of symmetry is aligned with the animal-vegetal axis of the zygote in the mouse. Development, 124, 289-301.
16. Ghilardi, N., Ziegler, S., Wiestner, A. et al. (1996) Defective STAT signaling by the leptin receptor in diabetic mice. Proc. Natl. Acad. Sci. USA, 93, 6231-6235.
17. Graham, C. and Deussen, Z. (1978) Features of cell lineage in preimplantation mouse development. J. Embryol. Exp. Morphol., 48, 53-72.
18. Gulyas, B. (1975) A re-examination of cleavage patterns in eutherian mammalian eggs: rotation of blastomere pairs during second cleavage of the rabbit. J. Exp. Zool., 193, 235-248.
19. Hamilton, B., Paglia, D., Kwan, A. and Deitel, M. (1995) Increased obese mRNA expression in omental fat cells from massively obese humans. Nature Med., 1, 953-956.
20. Handyside, A. and Johnson, M. (1978) Temporal and spatial patterns of the synthesis of tissue-specific polypeptides in the preimplantation mouse embryo. J. Embryol. Exp. Morphol., 44, 191-199.
21. Hummel, K. (1957) Transplantation of ovaries in the obese mouse. Anat. Rec., 128, 569-577.
22. Johnson, M. and Ziomek, C. (1981a) The foundation of two distinct cell lineages within the mouse morula. Cell, 24, 71-80.
23. Johnson, M. and Ziomek, C. (1981b) Induction of polarity in mouse 8-cell blastomeres; specificity, geometry and stability. J. Cell Biol., 91, 303-308
24. Lee, H.-G., Proenca, R., Montez, K. et al. (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature, 379, 632-635.
25. Longo, F. and Chen, D. (1985) Development of cortical polarity in mouse eggs: involvement of the meiotic apparatus. Dev. Biol., 107, 382-394.
26. Lonnqvist, F., Amer, P., Nordfors, L. and Schalling, M. (1995) Overexpression of the obese (ob) gene in adipose tissues of human subjects. Nature Med., 1, 950-953.
27. Maro, B., Johnson, M., Webb, M., and Flach, G. (1986) Mechanism of polar body formation in mouse oocytes: an interaction between chromosomes, the cytoskeleton and the plasma membrane. J. Embryol. Exp. Morphol., 92, 11-32.
28. Palmieri, S., Peter, W., Heike, H. and Scholer, H. (1994) Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev. Biol., 166, 259-267.
29. Payne, D., Flaherty, S., Barry, M., and Matthews, C. (1997) Observations on polar body extrusion and pronuclear formation in human oocytes using time-lapse cinematography. Hum. Reprod., 12, 532-541.
30. Santello, L., Alikani, M., Talansky, B. et al. (1992) Is the human oocyte plasma membrane polarized? Hum. Reprod., 7, 999-1003.
31. Scholer, H., Dressler, G., Balling, R. et al. (1990) Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J., 9, 2185-2195.
32. Schultz, R., Letourneau, G., and Wasserman, P. (1979) Program of early development in the mammal: changes in the patterns and absolute rates of tubulin and total protein synthesis during oocyte growth in the mouse. Dev. Biol., 73, 120-133.
33. Schultz, R., Montgomery, R. and Balanoff, J. (1983) Regulation of mouse oocyte meiotic maturation: Implications of a decrease in oocyte cAMP and protein dephosphorylation in commitment to resume meiosis. Dev. Biol., 97, 264-273
34. Smithberg, M. and Runner, M. (1957) Pregnancy induced in genetically sterile mice. J Hered., 48, 97-100.
35. Takeda, K., Noguchi, K., Shi, W. et al. (1997) Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl. Acad. Sci. USA, 94, 3801-3804.
36. Tartaglia, L., Dembski, M., Weng, X. et al. (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell, 1263-1271.
37. Vaissee, C., Halaas, J., Horvath, C. et al. (1996) Leptin activation of STAT3 in the hypothalamus of wild type and ob/ob mice but not db/db mice. Nature Genet., 14, 95-97.
38. Van Blerkom, J. (1981) Structural relationship and posttranslational modification of stage-specific proteins synthesized during early preimplantation development in the mouse. Proc. Natl. Acad. Sci. USA, 78, 7629-7633.
39. Van Blerkom, J. (1985) Posttranslational modification of proteins during resumption of arrested meiosis and early embryogenesis in the mammal. In Veneziale, C. (ed.), Control of Cell Growth and Proliferation. Van Norstrand, Reinhold Co, New York, USA, pp. 67-86.
40. Van Blerkom, J. and Bell, H. (1986) Regulation of development in the fully grown mouse oocyte: chromosome mediated temporal and spatial differentiation of the cytoplasm and plasma membrane. J. Embryol. Exp. Morphol., 93, 213-238.
41. Van Blerkom, J., Barton, S. and Johnson, M. (1975) Molecular differentiation in the preimplantation mouse embryo. Nature, 259, 319-321.
42. Van Blerkom, J., Davis, P., Merriam, J. and Sinclair, J. (1995) Nuclear and cytoplasmic dynamics of sperm penetration, pronuclear formation and microtubule organization during fertilization and early preimplantation development in the human. Hum. Reprod. Update, 1, 429-461.
43. Wilson, I., Bolton, E., and Cuttler, R. (1972) Preimplantation differentiation in the mouse egg as revealed by microinjection of vital markers. J. Embryol. Exp. Morphol., 27, 467-479.
44. Zhang, Y., Proenca, R., Maffei, M. et al. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature, 372, 425-432
45. Ziomek, C. and Johnson, M (1982) The roles of phenotype and position in guiding the fate of 16-cell mouse blastomeres. Dev. Biol., 91, 440-447.