The werner mutation: Does it lead to a 'public' or 'private' mechanism of aging?

Molecular Medicine

Volumn 3, Issue 6, 1997, Pages 356-358

  Martin, George M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELICASE;

AGING; CELL CYCLE S PHASE; CELL SURVIVAL; CLINICAL FEATURE; GENE MUTATION; HUMAN; PRIORITY JOURNAL; SHORT SURVEY; SKIN FIBROBLAST; TELOMERE; WERNER SYNDROME;

EID: 0030857408     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03401682     Document Type: Short Survey

References (20)

1. Yu C-E, Oshima J, Fu YH, et al. (1996) Positional cloning of the Werner's syndrome gene. Science 272: 258-262.
2. http://www3.ncbi.nlm.nih.gov/omim.
3. Oshima J, Yu CE, Piussan G, et al. (1996) Homozygous and compound heterozygous mutations at the Werner syndrome locus. Hum. Mol. Genet. 5: 1909-1913.
4. Epstein CJ, Martin GM, Schultz, AL, et al. (1966) Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine 45: 177-221.
5. Stadtman ER, Oliver CN. (1991) Metal-catalyzed oxidation of protein. Physiological consequences. J. Biol. Chem. 266: 2005-2008.
6. Cohen JI, Arnett EN, Kolodny AL, et al. (1987) Cardiovascular features of the Werner syndrome. Am. J. Cardiol. 59: 493-495.
7. Goto M, Miller RW, Ishikawa Y, et al. (1996) Excess of rare cancers in Werner syndrome (adult progeria). Cancer Epidemiol. Biomarkers Prev. 5: 239-246.
8. Rose MR. (1991) Evolutionary Biology of Aging. Oxford University Press, New York.
9. Yu CE, Oshima J, Wijsman EM, et al. (1997) Mutations in the concenus helicase domains of the Werner syndrome gene. Am. J. Hum. Genet. 60: 330-341.
10. Martin GM, Sprague CA, Epstein CJ. (1970) Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype. Lab. Invest. 23: 86-92.
11. Oshima J, Campisi J, Tannock TC, et al. (1995) Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors. J. Cell. Physiol. 162: 277-283.
12. Poot M, Hoehn H, Runger TM, et al. (1992) Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines. Exp. Cell Res. 202: 267-273.
13. Schulz VP, Zakian VA, Ogburn CE, et al. (1996) Accelerated loss telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. Hum. Genet. 97: 750-754.
14. Martin GM, Austad SN, Johnson TE. (1996) Genetic analysis of ageing: Role of oxidative damage and environmental stresses. Nat. Genet. 13: 25-34.
15. Hoehn H, Bryant EM, Au K, et al. (1975) Variegated translocation mosaicism in human skin fibroblast cultures. Cytogenet. Cell Genet. 15: 282-298.
16. Salk D, Au K, Hoehn H, et al. (1981) Cytogenetics of Werner's syndrome cultured skin fibroblasts: Variegated translocated mosaicism. Cytogenet. Cell Genet. 30: 92-107.
17. Fukuchi K, Martin GM, Monnat RJ Jr. (1989) Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc. Natl. Acad. Sci. U.S.A. 86: 5893-5897.
18. Fukuchi K, Tanaka K, Kamahara Y, et al. (1990) Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients. Hum. Genet. 84: 249-252.
19. Runger TM, Bauer C, Dekant B, et al. (1994) Hypermutable ligation of plasmid DNA ends in cells from patients with Werner syndrome. J. Invest. Dermatol. 102: 45-48.
20. Ye L, Miki T, Nakura J, et al. (1997) Rapid publication: Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population. Am. J. Med. Genet. 68: 494-498.