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Volumn 5, Issue 9, 1999, Pages 387-392

The p53 family: Same response, different signals?

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

EID: 0032793756     PISSN: 13574310     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-4310(99)01545-2     Document Type: Review
Times cited : (64)

References (67)
  • 1
    • 0030812331 scopus 로고    scopus 로고
    • Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
    • Kaghad M.et al. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell. 90:1997;809-819.
    • (1997) Cell , vol.90 , pp. 809-819
    • Kaghad, M.1
  • 2
    • 0032161624 scopus 로고    scopus 로고
    • P63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
    • Yang A.et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell. 2:1998;305-316.
    • (1998) Mol. Cell , vol.2 , pp. 305-316
    • Yang, A.1
  • 3
    • 0031874340 scopus 로고    scopus 로고
    • A new human p53 homologue
    • Trink B.et al. A new human p53 homologue. Nat. Med. 4:1998;747-748.
    • (1998) Nat. Med. , vol.4 , pp. 747-748
    • Trink, B.1
  • 4
    • 0031852337 scopus 로고    scopus 로고
    • Cloning and functional analysis of human p51, which structurally and functionally resembles p53
    • Osada M.et al. Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nat. Med. 4:1998;839-843.
    • (1998) Nat. Med. , vol.4 , pp. 839-843
    • Osada, M.1
  • 5
    • 0031766482 scopus 로고    scopus 로고
    • Cloning and chromosomal mapping of the human p53-related KET gene to chromosome 3q27 and its murine homolog Ket to mouse chromosome 16
    • Augustin M., Bamberger C., Paul D., Schmale H. Cloning and chromosomal mapping of the human p53-related KET gene to chromosome 3q27 and its murine homolog Ket to mouse chromosome 16. Mamm. Genome. 9:1998;899-902.
    • (1998) Mamm. Genome , vol.9 , pp. 899-902
    • Augustin, M.1    Bamberger, C.2    Paul, D.3    Schmale, H.4
  • 6
    • 0032581326 scopus 로고    scopus 로고
    • A second p53-related protein, p73L, with high homology to p73
    • Senoo M.et al. A second p53-related protein, p73L, with high homology to p73. Biochem. Biophys. Res. Commun. 248:1998;603-607.
    • (1998) Biochem. Biophys. Res. Commun. , vol.248 , pp. 603-607
    • Senoo, M.1
  • 7
    • 0033510901 scopus 로고    scopus 로고
    • Characterization of an autoantigen associated with chronic ulcerative stomatitis: The CUSP autoantigen is a member of the p53 family
    • (in press)
    • Lee, L.A. et al. Characterization of an autoantigen associated with chronic ulcerative stomatitis: the CUSP autoantigen is a member of the p53 family, J. Invest. Dermatol. (in press).
    • J. Invest. Dermatol.
    • Lee, L.A.1
  • 8
    • 0031464286 scopus 로고    scopus 로고
    • P53CP, a putative p53 competing protein that specifically binds to the consensus p53 DNA binding sites: A third member of the p53 family?
    • Bian J., Sun Y. p53CP, a putative p53 competing protein that specifically binds to the consensus p53 DNA binding sites: a third member of the p53 family? Proc. Natl. Acad. Sci. U. S. A. 94:1997;14753-14758.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 14753-14758
    • Bian, J.1    Sun, Y.2
  • 9
    • 0032499528 scopus 로고    scopus 로고
    • Non-p53 p53RE binding protein, a human transcription factor functionally analogous to p53
    • Zeng X., Levine A.J., Lu H. Non-p53 p53RE binding protein, a human transcription factor functionally analogous to p53. Proc. Natl. Acad. Sci. U. S. A. 95:1998;6681-6686.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 6681-6686
    • Zeng, X.1    Levine, A.J.2    Lu, H.3
  • 10
    • 0030030975 scopus 로고    scopus 로고
    • The human tumour suppressor gene p53 is alternatively spliced in normal cells
    • Flaman J.M.et al. The human tumour suppressor gene p53 is alternatively spliced in normal cells. Oncogene. 12:1996;813-818.
    • (1996) Oncogene , vol.12 , pp. 813-818
    • Flaman, J.M.1
  • 11
    • 0030796188 scopus 로고    scopus 로고
    • Differential expression of the regularly spliced wild-type p53 and its COOH-terminal alternatively spliced form during epidermal differentiation
    • Rehberger P.A.et al. Differential expression of the regularly spliced wild-type p53 and its COOH-terminal alternatively spliced form during epidermal differentiation. Cell Growth Differ. 8:1997;851-860.
    • (1997) Cell Growth Differ. , vol.8 , pp. 851-860
    • Rehberger, P.A.1
  • 12
    • 0031056054 scopus 로고    scopus 로고
    • The murine C′-terminally alternatively spliced form of p53 induces attenuated apoptosis in myeloid cells
    • Almog N.et al. The murine C′-terminally alternatively spliced form of p53 induces attenuated apoptosis in myeloid cells. Mol. Cell. Biol. 17:1997;713-722.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 713-722
    • Almog, N.1
  • 13
    • 0032476743 scopus 로고    scopus 로고
    • Two new p73 splice variants, gamma and delta, with different transcriptional activity
    • De Laurenzi V.et al. Two new p73 splice variants, gamma and delta, with different transcriptional activity. J. Exp. Med. 188:1998;1763-1768.
    • (1998) J. Exp. Med. , vol.188 , pp. 1763-1768
    • De Laurenzi, V.1
  • 14
    • 0029972806 scopus 로고    scopus 로고
    • P53: Puzzle and paradigm
    • Ko L.J., Prives C. p53: puzzle and paradigm. Genes Dev. 10:1996;1054-1072.
    • (1996) Genes Dev. , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 15
    • 0032557649 scopus 로고    scopus 로고
    • Identification of a novel p53 functional domain that is necessary for mediating apoptosis
    • Zhu J., Zhou W., Jiang J., Chen X. Identification of a novel p53 functional domain that is necessary for mediating apoptosis. J. Biol. Chem. 273:1998;13030-13036.
    • (1998) J. Biol. Chem. , vol.273 , pp. 13030-13036
    • Zhu, J.1    Zhou, W.2    Jiang, J.3    Chen, X.4
  • 16
    • 0030864137 scopus 로고    scopus 로고
    • Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity
    • Candau R.et al. Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity. Oncogene. 15:1997;807-816.
    • (1997) Oncogene , vol.15 , pp. 807-816
    • Candau, R.1
  • 17
    • 0030448650 scopus 로고    scopus 로고
    • Identification of a novel p53 functional domain that is necessary for efficient growth suppression
    • Walker K.K., Levine A.J. Identification of a novel p53 functional domain that is necessary for efficient growth suppression. Proc. Natl. Acad. Sci. U. S. A. 93:1996;15335-15340.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 15335-15340
    • Walker, K.K.1    Levine, A.J.2
  • 18
    • 0031414301 scopus 로고    scopus 로고
    • The Li-Fraumeni syndrome: An inherited susceptibility to cancer
    • Evans S.C., Lozano G. The Li-Fraumeni syndrome: an inherited susceptibility to cancer. Mol. Med. Today. 3:1997;390-395.
    • (1997) Mol. Med. Today , vol.3 , pp. 390-395
    • Evans, S.C.1    Lozano, G.2
  • 19
    • 0028303752 scopus 로고
    • Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
    • Lin J., Chen J., Elenbaas B., Levine A.J. Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev. 8:1994;1235-1246.
    • (1994) Genes Dev. , vol.8 , pp. 1235-1246
    • Lin, J.1    Chen, J.2    Elenbaas, B.3    Levine, A.J.4
  • 20
    • 0031564952 scopus 로고    scopus 로고
    • Tumour-suppressor genes. Killer in search of a motive?
    • Clurman B., Groudine M. Tumour-suppressor genes. Killer in search of a motive? Nature. 389:1997;122-123.
    • (1997) Nature , vol.389 , pp. 122-123
    • Clurman, B.1    Groudine, M.2
  • 21
    • 0032053793 scopus 로고    scopus 로고
    • Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers
    • Nomoto S.et al. Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers. Cancer Res. 58:1998;1380-1383.
    • (1998) Cancer Res. , vol.58 , pp. 1380-1383
    • Nomoto, S.1
  • 22
    • 0032523842 scopus 로고    scopus 로고
    • Mutation, allelotyping, and transcription analyses of the p73 gene in prostatic carcinoma
    • Takahashi H.et al. Mutation, allelotyping, and transcription analyses of the p73 gene in prostatic carcinoma. Cancer Res. 58:1998;2076-2077.
    • (1998) Cancer Res. , vol.58 , pp. 2076-2077
    • Takahashi, H.1
  • 23
    • 0031766420 scopus 로고    scopus 로고
    • Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines
    • Kovalev S.et al. Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines. Cell Growth Differ. 9:1998;897-903.
    • (1998) Cell Growth Differ. , vol.9 , pp. 897-903
    • Kovalev, S.1
  • 24
    • 0032953808 scopus 로고    scopus 로고
    • Mutational and expression analysis of the p73 gene in melanoma cell lines
    • Tsao H., Zhang X., Majewski P., Haluska F.G. Mutational and expression analysis of the p73 gene in melanoma cell lines. Cancer Res. 59:1999;172-174.
    • (1999) Cancer Res. , vol.59 , pp. 172-174
    • Tsao, H.1    Zhang, X.2    Majewski, P.3    Haluska, F.G.4
  • 25
    • 0032100611 scopus 로고    scopus 로고
    • Activation of p73 silent allele in lung cancer
    • Mai M.et al. Activation of p73 silent allele in lung cancer. Cancer Res. 58:1998;2347-2349.
    • (1998) Cancer Res. , vol.58 , pp. 2347-2349
    • Mai, M.1
  • 26
    • 0032191602 scopus 로고    scopus 로고
    • Loss of imprinting and allele switching of p73 in renal cell carcinoma
    • Mai M.et al. Loss of imprinting and allele switching of p73 in renal cell carcinoma. Oncogene. 17:1998;1739-1741.
    • (1998) Oncogene , vol.17 , pp. 1739-1741
    • Mai, M.1
  • 27
    • 0033611565 scopus 로고    scopus 로고
    • P73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent
    • Ichimiya S.et al. p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent. Oncogene. 18:1999;1061-1066.
    • (1999) Oncogene , vol.18 , pp. 1061-1066
    • Ichimiya, S.1
  • 28
    • 0032938712 scopus 로고    scopus 로고
    • Infrequent somatic mutations of the p73 gene in various human cancers
    • Han S.et al. Infrequent somatic mutations of the p73 gene in various human cancers. Eur. J. Surg. Oncol. 25:1999;194-198.
    • (1999) Eur. J. Surg. Oncol. , vol.25 , pp. 194-198
    • Han, S.1
  • 29
    • 0032191393 scopus 로고    scopus 로고
    • Tumor surveillance via the ARF-p53 pathway
    • Sherr C.J. Tumor surveillance via the ARF-p53 pathway. Genes Dev. 12:1998;2984-2991.
    • (1998) Genes Dev. , vol.12 , pp. 2984-2991
    • Sherr, C.J.1
  • 30
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang Y., Xiong Y., Yarbrough W.G. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell. 92:1998;725-734.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 31
    • 0031030325 scopus 로고    scopus 로고
    • Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF
    • Quelle D.E., Cheng M., Ashmun R.A., Sherr C.J. Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF. Proc. Natl. Acad. Sci. U. S. A. 94:1997;669-673.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 669-673
    • Quelle, D.E.1    Cheng, M.2    Ashmun, R.A.3    Sherr, C.J.4
  • 32
    • 0032951530 scopus 로고    scopus 로고
    • P73 function is inhibited by tumor-derived p53 mutants in mammalian cells
    • Di Como C.J., Gaiddon C., Prives C. p73 function is inhibited by tumor-derived p53 mutants in mammalian cells. Mol. Cell. Biol. 19:1999;1438-1449.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1438-1449
    • Di Como, C.J.1    Gaiddon, C.2    Prives, C.3
  • 33
    • 0033594491 scopus 로고    scopus 로고
    • P63 is a p53 homologue required for limb and epidermal morphogenesis
    • Mills A.A.et al. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature. 398:1999;708-713.
    • (1999) Nature , vol.398 , pp. 708-713
    • Mills, A.A.1
  • 34
    • 0033594485 scopus 로고    scopus 로고
    • P63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
    • Yang A.et al. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature. 398:1999;714-718.
    • (1999) Nature , vol.398 , pp. 714-718
    • Yang, A.1
  • 35
    • 0027109075 scopus 로고
    • P53, guardian of the genome
    • Lane D.P. p53, guardian of the genome. Nature. 358:1992;15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 36
    • 0032192140 scopus 로고    scopus 로고
    • The complexity of p53 modulation: Emerging patterns from divergent signals
    • Giaccia A.J., Kastan M.B. The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev. 12:1998;2973-2983.
    • (1998) Genes Dev. , vol.12 , pp. 2973-2983
    • Giaccia, A.J.1    Kastan, M.B.2
  • 37
    • 0030941458 scopus 로고    scopus 로고
    • P53, the cellular gatekeeper for growth and division
    • Levine A.J. p53, the cellular gatekeeper for growth and division. Cell. 88:1997;323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 38
    • 0031982545 scopus 로고    scopus 로고
    • The p53 network
    • Agarwal M.L.et al. The p53 network. J. Biol. Chem. 273:1998;1-4.
    • (1998) J. Biol. Chem. , vol.273 , pp. 1-4
    • Agarwal, M.L.1
  • 39
    • 0032508608 scopus 로고    scopus 로고
    • Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
    • Canman C.E.et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science. 281:1998;1677-1679.
    • (1998) Science , vol.281 , pp. 1677-1679
    • Canman, C.E.1
  • 40
    • 0031741138 scopus 로고    scopus 로고
    • Viral oncoproteins discriminate between p53 and the p53 homolog p73
    • Marin M.C.et al. Viral oncoproteins discriminate between p53 and the p53 homolog p73. Mol. Cell. Biol. 18:1998;6316-6324.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 6316-6324
    • Marin, M.C.1
  • 41
    • 0032417530 scopus 로고    scopus 로고
    • Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73
    • Higashino F., Pipas J.M., Shenk T. Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73. Proc. Natl. Acad. Sci. U. S. A. 95:1998;15683-15687.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 15683-15687
    • Higashino, F.1    Pipas, J.M.2    Shenk, T.3
  • 42
    • 0031661779 scopus 로고    scopus 로고
    • Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins
    • Roth J.et al. Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins. J. Virol. 72:1998;8510-8516.
    • (1998) J. Virol. , vol.72 , pp. 8510-8516
    • Roth, J.1
  • 43
    • 0032933627 scopus 로고    scopus 로고
    • Distinct regulation of p53 and p73 activity by adenovirus EIA, E1B, and e4orf6 proteins
    • Steegenga W.T.et al. Distinct regulation of p53 and p73 activity by adenovirus EIA, E1B, and e4orf6 proteins. Mol. Cell. Biol. 19:1999;3885-3894.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3885-3894
    • Steegenga, W.T.1
  • 44
    • 0031564954 scopus 로고    scopus 로고
    • P73 is a human p53-related protein that can induce apoptosis
    • Jost C.A., Marin M.C., Kaelin W.G. Jr. p73 is a human p53-related protein that can induce apoptosis. Nature. 389:1997;191-194.
    • (1997) Nature , vol.389 , pp. 191-194
    • Jost, C.A.1    Marin, M.C.2    Kaelin W.G., Jr.3
  • 45
    • 0032533514 scopus 로고    scopus 로고
    • The potential tumor suppressor p73 differentially regulates cellular p53 target genes
    • Zhu J., Jiang J., Zhou W., Chen X. The potential tumor suppressor p73 differentially regulates cellular p53 target genes. Cancer Res. 58:1998;5061-5065.
    • (1998) Cancer Res. , vol.58 , pp. 5061-5065
    • Zhu, J.1    Jiang, J.2    Zhou, W.3    Chen, X.4
  • 46
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumor suppression
    • el-Deiry W.S.et al. WAF1, a potential mediator of p53 tumor suppression. Cell. 75:1993;817-825.
    • (1993) Cell , vol.75 , pp. 817-825
    • El-Deiry, W.S.1
  • 47
    • 0027717617 scopus 로고
    • P21 is a universal inhibitor of cyclin kinases
    • Xiong Y.et al. p21 is a universal inhibitor of cyclin kinases. Nature. 366:1993;701-704.
    • (1993) Nature , vol.366 , pp. 701-704
    • Xiong, Y.1
  • 48
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper J.W.et al. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 75:1993;805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1
  • 49
    • 0033616501 scopus 로고    scopus 로고
    • GADD45 induction of a G2/M cell cycle checkpoint
    • Wang X.W.et al. GADD45 induction of a G2/M cell cycle checkpoint. Proc. Natl. Acad. Sci. U. S. A. 96:1999;3706-3711.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 3706-3711
    • Wang, X.W.1
  • 50
    • 16144362452 scopus 로고    scopus 로고
    • Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway
    • Rouault J.P.et al. Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. Nat. Genet. 14:1996;482-486.
    • (1996) Nat. Genet. , vol.14 , pp. 482-486
    • Rouault, J.P.1
  • 51
    • 0031310665 scopus 로고    scopus 로고
    • 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression
    • Hermeking H.et al. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol. Cell. 1:1997;3-11.
    • (1997) Mol. Cell , vol.1 , pp. 3-11
    • Hermeking, H.1
  • 52
    • 0030611095 scopus 로고    scopus 로고
    • Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
    • Peng C.Y.et al. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science. 277:1997;1501-1505.
    • (1997) Science , vol.277 , pp. 1501-1505
    • Peng, C.Y.1
  • 53
    • 0028335717 scopus 로고
    • Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
    • Miyashita T.et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 9:1994;1799-1805.
    • (1994) Oncogene , vol.9 , pp. 1799-1805
    • Miyashita, T.1
  • 54
    • 0030930366 scopus 로고    scopus 로고
    • A model for p53-induced apoptosis
    • Polyak K.et al. A model for p53-induced apoptosis. Nature. 389:1997;300-305.
    • (1997) Nature , vol.389 , pp. 300-305
    • Polyak, K.1
  • 55
    • 0032510136 scopus 로고    scopus 로고
    • Involvement of p85 in p53-dependent apoptotic response to oxidative stress
    • Yin Y.et al. Involvement of p85 in p53-dependent apoptotic response to oxidative stress. Nature. 391:1998;707-710.
    • (1998) Nature , vol.391 , pp. 707-710
    • Yin, Y.1
  • 56
    • 0027244853 scopus 로고
    • The p53-mdm-2 autoregulatory feedback loop
    • Wu X., Bayle J.H., Olson D., Levine A.J. The p53-mdm-2 autoregulatory feedback loop. Genes Dev. 7:1993;1126-1132.
    • (1993) Genes Dev. , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4
  • 57
    • 0032185124 scopus 로고    scopus 로고
    • P300/MDM2 complexes participate in MDM2-mediated p53 degradation
    • Grossman S.R.et al. p300/MDM2 complexes participate in MDM2-mediated p53 degradation. Mol. Cell. 2:1998;405-415.
    • (1998) Mol. Cell , vol.2 , pp. 405-415
    • Grossman, S.R.1
  • 58
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • Honda R., Tanaka H., Yasuda H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420:1997;25-27.
    • (1997) FEBS Lett. , vol.420 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 59
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • Kubbutat M.H., Jones S.N., Vousden K.H. Regulation of p53 stability by Mdm2. Nature. 387:1997;299-303.
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.1    Jones, S.N.2    Vousden, K.H.3
  • 60
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt Y., Maya R., Kazaz A., Oren M. Mdm2 promotes the rapid degradation of p53. Nature. 387:1997;296-299.
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 61
    • 0027325132 scopus 로고
    • Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
    • Oliner J.D.et al. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature. 362:1993;857-860.
    • (1993) Nature , vol.362 , pp. 857-860
    • Oliner, J.D.1
  • 62
    • 0032961828 scopus 로고    scopus 로고
    • MDM2 suppresses p73 function without promoting p73 degradation
    • Zeng X.et al. MDM2 suppresses p73 function without promoting p73 degradation. Mol. Cell. Biol. 19:1999;3257-3266.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3257-3266
    • Zeng, X.1
  • 63
    • 0033602462 scopus 로고    scopus 로고
    • Inactivation of the p53 homologue p73 by the mdm2-oncoprotein
    • Dobbelstein M., Wienzek S., Konig C., Roth J. Inactivation of the p53 homologue p73 by the mdm2-oncoprotein. Oncogene. 18:1999;2101-2106.
    • (1999) Oncogene , vol.18 , pp. 2101-2106
    • Dobbelstein, M.1    Wienzek, S.2    Konig, C.3    Roth, J.4
  • 64
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower L.A.et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature. 356:1992;215-221.
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1
  • 65
    • 0033600234 scopus 로고    scopus 로고
    • The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
    • Gong J.et al. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. Nature. 399:1999;806-809.
    • (1999) Nature , vol.399 , pp. 806-809
    • Gong, J.1
  • 66
    • 0033600240 scopus 로고    scopus 로고
    • Interaction of c-Abl and p73a and their collaboration to induce apoptosis
    • Agami R.et al. Interaction of c-Abl and p73a and their collaboration to induce apoptosis. Nature. 399:1999;809-813.
    • (1999) Nature , vol.399 , pp. 809-813
    • Agami, R.1
  • 67
    • 0033600235 scopus 로고    scopus 로고
    • P73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
    • Yuan Z-M.et al. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature. 399:1999;814-817.
    • (1999) Nature , vol.399 , pp. 814-817
    • Yuan, Z.-M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.