Features of immunological investigations in elderly;Besonderheiten immunologischer untersuchungsergebnisse im alter

Zeitschrift fur Gerontologie und Geriatrie

Volumn 30, Issue 3, 1997, Pages 220-225

  Rink, L ^a   Seyfarth, M ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Ageing; Cytokines; Immunoglobulins; Immunosenescence; Lymphocyte subsets

Indexed keywords

ACUTE PHASE PROTEIN; ALPHA 2 MACROGLOBULIN; AUTOANTIBODY; C REACTIVE PROTEIN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA; ZINC;

AGED; ARTICLE; B LYMPHOCYTE; CHRONIC DISEASE; IMMUNE SYSTEM; IMMUNOGLOBULIN BLOOD LEVEL; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTOPENIA; MONOCLONAL IMMUNOGLOBULINEMIA; NATURAL KILLER CELL; NEUTROPHIL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

AGED; AGED, 80 AND OVER; AGING; CYTOKINES; FEMALE; HUMANS; IMMUNE TOLERANCE; IMMUNOGLOBULINS; IMMUNOLOGIC TESTS; LYMPHOCYTE COUNT; MALE; REFERENCE VALUES;

EID: 0030743302     PISSN: 0044281X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Burns EA, Lum LG, L'Hommedieu G, Goodwin JS (1993) Specific humoral immunity in the elderly: in vivo and in vitro response to vaccination. J Gerontol 28:B231-B236
2. Cakman I, Kirchner H, Rink L (1997) Reconstitution of interferon-α production by zinc-supplementation of leukocyte cultures of elderly individuals. J Interferon Cytokine Res (im Druck)
3. Cakman I, Rohwer J, Schütz RM, Kirchner H, Rink L (1996) Dysregulation between TH1 and TH2 T cell subpopulations in the elderly. Mech Ageing Dev 87:197-209
4. Fagiolo U, Cossarizza A, Scala E, Fanales-Belasio E, Ortolani C, Cozzi E, Monti D, Franceschi C, Paganelli R (1993) Increased cytokine production in mononuclear cells of healthy elderly people. Eur J Immunol 23:2375-2378
5. Ford PM (1986) The immunology of ageing. Clin Rheum Dis 12:1-10
6. Franceschi C, Monti D, Sansoni P, Cossarizza A (1995) The immunology of exceptional individuals: the lesson of centenarians. Immunol Today 16:12-16
7. Gillis S, Kozak R, Durante M, Weksler ME (1981) Immunological studies of aging. Decreased production of and response to T cell growth factor by lymphocytes from aged humans. J Clin Invest 67:937-942
8. Ligthart GJ, Corberand JX, Fournier C, Galanaud P, Hijmans W, Kennes B, Müller-Hermelink HK, Steinmann GG (1984) Admission criteria for immunogerontological studies in man: the SENIEUR-protocol. Mech Ageing Dev 28:47-55
9. Ligthart GJ, Corberand JX, Geertzen HG, Meinders AE, Knook DL, Hijmans W (1990) Necessity of the assessment of health status in human immunogerontological studies: evaluation of the SENIEUR protocol. Mech Ageing Dev 55:89-105
10. Ligthart GJ, Radl J, Corberand JX, van Nieuwkoop JA, van Staalduinen GJ, van Helmond DJ, Hijmans W (1990) Monoclonal gammopathies in human aging: increased occurrence with age and correlation with health status. Mech Agein Dev 52:243-253
11. Menzel EJ, Zlabinger GJ, Dunky A, Steffen C (1988) Autoimmunity and T-cell subpopulations in old age. Arch Gerontol Geriatr 249-260
12. Michie CA, McLean A, Alcock C, Beverley PC (1992) Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature 360:264-265
13. Murasko DM, Weiner P, Kaye D (1987) Decline in mitogen induced proliferation of lymphocytes with increasing age. Clin Exp Immunol 70:440-448
14. Paganelli R, Quinti I, Fagiolo U, Cossarizza A, Ortolani C, Guerra E, Sansoni P, Pucillo LP, Cozzi E, Bertollo L, Monti D, Franceschi C (1992) Changes in circulating B cells and immunoglobulin classes and subclasses in a healthy aged population. Clin Exp Immunol 90:351-354
15. Paganelli R, Scala E, Rosso R, Cossarizza A, Bertollo L, Barbieri D, Fabrizi A, Lusi EA, Fagiolo U, Franceschi C (1996) A shift to TH0 cytokine production by CD4+ cells in human longevity: studies on two healthy centenarians. Eur J Immunol 26: 2030-2034
16. Pawelec G, Adibzadeh M, Pohla H, Schaudt K (1995) Immunosenescence: ageing of the immune system. Immunol Today 16:420-422
17. Posnett DN, Sinha R, Kabak S, Russo C (1994) Clonal populations of T cells in normal elderly humans: the T cells equivalent to "benign monoclonal gammapathy". J Exp Med 179:609-618
18. Saltzman RL, Peterson PK (1987) Immunodeficiency of the elderly. Rev Infect Dis 9:1127-1139
19. Sansoni P, Cossarizza A, Brianti V, Fagnoni F, Snelli G, Monti D, Marcato A, Passeri G, Ortolani C, Forti E, Fagiolo U, Passeri M, Franceschi C (1993) Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians. Blood 82: 2767-2773
20. Sindermann J, Kruse A, Frercks HJ, Schütz RM, Kirchner H (1993) Investigations of the lymphokine system in elderly individuals. Mech Ageing Dev 70:149-159
21. Staiano-Coico L, Darzynkiewicz Z, Melamed MR, Weksler ME (1984) Immunological studies of aging. IX. Impaired proliferation of T lymphocytes detected in elderly humans by flow cytometry. J Immunol 132:1788-1792
22. Xu X, Beckman I, Ahern M, Bradley (1993) A comprehensive analysis of peripheral blood lymphocytes in healthy aged humans by flow cytometry 71:549-557