메뉴 건너뛰기




Volumn 11, Issue 2, 1997, Pages 78-87

Blood-cerebrospinal fluid barrier dysfunction for high molecular weight proteins in alzheimer disease and major depression: Indication for disease subsets

Author keywords

Albumin ratio; Alzheimer disease; Blood brain barrier; Blood CSF barrier; IgG ratio; Immunoactivation; Major depression

Indexed keywords

IMMUNOGLOBULIN G; PROTEIN; SERUM ALBUMIN;

EID: 0342683872     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002093-199706000-00004     Document Type: Article
Times cited : (54)

References (72)
  • 1
    • 0020616406 scopus 로고
    • Albumin and immunoglobulin in plasma and cerebrospinal fluid, and blood-cerebrospinal fluid barrier function in patients with dementia of Alzheimer type and multi-infarct dementia
    • Alafuzoff I, Adolfsson R, Bucht G, Winbald B. Albumin and immunoglobulin in plasma and cerebrospinal fluid, and blood-cerebrospinal fluid barrier function in patients with dementia of Alzheimer type and multi-infarct dementia. J Neurol Sci 1983;60:465-72.
    • (1983) J Neurol Sci , vol.60 , pp. 465-472
    • Alafuzoff, I.1    Adolfsson, R.2    Bucht, G.3    Winbald, B.4
  • 4
    • 0022552302 scopus 로고
    • Avenues for entry of peripherally administered protein to the central nervous system in the mouse, rat and squirrel monkey
    • Balin BJ, Broadwell RD, Salcman M, El-Kalliny M. Avenues for entry of peripherally administered protein to the central nervous system in the mouse, rat and squirrel monkey. J Comp Neurol 1986;251:260-80.
    • (1986) J Comp Neurol , vol.251 , pp. 260-280
    • Balin, B.J.1    Broadwell, R.D.2    Salcman, M.3    El-Kalliny, M.4
  • 5
    • 0027304432 scopus 로고
    • Neuropathologische, immunologische und psychobiologische Aspekte der Alzheimer Demenz
    • Bauer J, Berger M. Neuropathologische, immunologische und psychobiologische Aspekte der Alzheimer Demenz. Fortschr Neurol Psychiatr 1993;61:225-40.
    • (1993) Fortschr Neurol Psychiatr , vol.61 , pp. 225-240
    • Bauer, J.1    Berger, M.2
  • 8
    • 0014481056 scopus 로고
    • Junctions between intimately opposed cell membranes in the vertebrate brain
    • Brightman MW, Reese TS. Junctions between intimately opposed cell membranes in the vertebrate brain. J Cell Biol 1969;40:648-77.
    • (1969) J Cell Biol , vol.40 , pp. 648-677
    • Brightman, M.W.1    Reese, T.S.2
  • 9
    • 0021249811 scopus 로고
    • Immunoglobulin and other proteins in the cerebrospinal fluid of patients with Alzheimer's disease
    • Chapel HM, Esiri MM, Wilcock GK. Immunoglobulin and other proteins in the cerebrospinal fluid of patients with Alzheimer's disease. J Clin Pathol 1984;37:697-9.
    • (1984) J Clin Pathol , vol.37 , pp. 697-699
    • Chapel, H.M.1    Esiri, M.M.2    Wilcock, G.K.3
  • 10
    • 0018862804 scopus 로고
    • Serum immunoglobulins and cognitive status in the elderly. I. A population study
    • Cohen D, Eisdorfer C. Serum immunoglobulins and cognitive status in the elderly. I. A population study. Br J Psychiatry 1980;136:33-9.
    • (1980) Br J Psychiatry , vol.136 , pp. 33-39
    • Cohen, D.1    Eisdorfer, C.2
  • 11
    • 0026476657 scopus 로고
    • Cervical lymphatics, the blood-brain-barrier and the immunoreactivity of the brain: A new view
    • Cserr HF, Knopf PM. Cervical lymphatics, the blood-brain-barrier and the immunoreactivity of the brain: a new view. Immunol Today 1992; 13(12):507-12.
    • (1992) Immunol Today , vol.13 , Issue.12 , pp. 507-512
    • Cserr, H.F.1    Knopf, P.M.2
  • 12
    • 0343875312 scopus 로고
    • Comparisons of protein content of first and second portions of cerebrospinal fluid removed at lumbar puncture
    • Eaton LM. Comparisons of protein content of first and second portions of cerebrospinal fluid removed at lumbar puncture. Proc Staff Meet Mayo Clin 1939;14:661-3.
    • (1939) Proc Staff Meet Mayo Clin , vol.14 , pp. 661-663
    • Eaton, L.M.1
  • 13
    • 0021854780 scopus 로고
    • CSF in Alzheimer's disease. Studies on blood-brain barrier function and intrathecal protein synthesis
    • Elovaara I, Icén A, Palo J, Erkinjuntti T. CSF in Alzheimer's disease. Studies on blood-brain barrier function and intrathecal protein synthesis. J Neurol Sci 1985;70:73-80.
    • (1985) J Neurol Sci , vol.70 , pp. 73-80
    • Elovaara, I.1    Icén, A.2    Palo, J.3    Erkinjuntti, T.4
  • 14
    • 0023640751 scopus 로고
    • Intraneuronal IgG in the central nervous system: Uptake by retrograde axonal transport
    • Fabian RH, Petroff G. Intraneuronal IgG in the central nervous system: uptake by retrograde axonal transport. Neurology 1987;37:1780-4.
    • (1987) Neurology , vol.37 , pp. 1780-1784
    • Fabian, R.H.1    Petroff, G.2
  • 15
    • 0343439517 scopus 로고
    • Progressive fall in protein content of cerebrospinal fluid withdrawn above a tumor of the cauda equina
    • Fabing HD. Progressive fall in protein content of cerebrospinal fluid withdrawn above a tumor of the cauda equina. Arch Neurol Psychiatr 1939:41:373-4.
    • (1939) Arch Neurol Psychiatr , vol.41 , pp. 373-374
    • Fabing, H.D.1
  • 16
    • 0020426739 scopus 로고
    • Differentiation of the humoral immune response in inflammatory diseases of the central nervous system
    • Felgenhauer K. Differentiation of the humoral immune response in inflammatory diseases of the central nervous system. J Neurol 1982;228:223-37.
    • (1982) J Neurol , vol.228 , pp. 223-237
    • Felgenhauer, K.1
  • 17
    • 0000757775 scopus 로고
    • Factors influencing the concentration gradient of protein in cerebrospinal fluid
    • Fishman RA, Ransohoff J, Osserman EF. Factors influencing the concentration gradient of protein in cerebrospinal fluid. J Clin Invest 1958;37:1419-28.
    • (1958) J Clin Invest , vol.37 , pp. 1419-1428
    • Fishman, R.A.1    Ransohoff, J.2    Osserman, E.F.3
  • 18
    • 0016823810 scopus 로고
    • Mini-Mental State: A practical method for grading the cognitive state of patients for the clinician
    • Folstein M, Folstein S, McHugh PR. Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98.
    • (1975) J Psychiatr Res , vol.12 , pp. 189-198
    • Folstein, M.1    Folstein, S.2    McHugh, P.R.3
  • 19
    • 0024335805 scopus 로고
    • Neuron-binding antibodies in Alzheimer's disease and Down's syndrome
    • Franceschi M, Comola M, Nunni R. Neuron-binding antibodies in Alzheimer's disease and Down's syndrome. J Gerontol 1989;44:128-30.
    • (1989) J Gerontol , vol.44 , pp. 128-130
    • Franceschi, M.1    Comola, M.2    Nunni, R.3
  • 21
    • 0024853831 scopus 로고
    • Regional cerebral glucose transport and utilization in Alzheimer's disease
    • Friedland RP, Jagust WJ, Hnesman RH, et al. Regional cerebral glucose transport and utilization in Alzheimer's disease. Neurology 1989;39: 1427-34.
    • (1989) Neurology , vol.39 , pp. 1427-1434
    • Friedland, R.P.1    Jagust, W.J.2    Hnesman, R.H.3
  • 22
    • 0018610797 scopus 로고
    • Congophilic microangiopathy in the pathogenesis of Alzheimer's syndrome (presenile dementia)
    • Glenner GG. Congophilic microangiopathy in the pathogenesis of Alzheimer's syndrome (presenile dementia). Med Hypotheses 1979;5: 1231-6.
    • (1979) Med Hypotheses , vol.5 , pp. 1231-1236
    • Glenner, G.G.1
  • 23
    • 0021832282 scopus 로고
    • On causative theories in Alzheimer's disease
    • Glenner GG. On causative theories in Alzheimer's disease. Hum Pathol 1985;16:433-5.
    • (1985) Hum Pathol , vol.16 , pp. 433-435
    • Glenner, G.G.1
  • 24
    • 0022902555 scopus 로고
    • On primal causes in Alzheimer's disease
    • Glenner GG. On primal causes in Alzheimer's disease. Neurobiol Aging 1986;7:506-8.
    • (1986) Neurobiol Aging , vol.7 , pp. 506-508
    • Glenner, G.G.1
  • 25
    • 0019489110 scopus 로고
    • Congophilic angiopathy in the pathogenesis of Alzheimer's degeneration
    • Glenner GG, Henry JH, Fujihara S. Congophilic angiopathy in the pathogenesis of Alzheimer's degeneration. Ann Pathol 1981;2:120-9.
    • (1981) Ann Pathol , vol.2 , pp. 120-129
    • Glenner, G.G.1    Henry, J.H.2    Fujihara, S.3
  • 26
    • 0021207461 scopus 로고
    • Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
    • Glenner GG, Wong CW. Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 1984;122:1131-5.
    • (1984) Biochem Biophys Res Commun , vol.122 , pp. 1131-1135
    • Glenner, G.G.1    Wong, C.W.2
  • 27
    • 0001360461 scopus 로고
    • Brain interleukin 1 and S-100 immunoreactivity are elevated in Down's syndrome and Alzheimer disease
    • Griffin WST, Stanley LC, Ling C, et al. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down's syndrome and Alzheimer disease. Proc Natl Acad Sci USA 1989;86:7611-5.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 7611-7615
    • Griffin, W.S.T.1    Stanley, L.C.2    Ling, C.3
  • 28
    • 0022921664 scopus 로고
    • An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease
    • Hardy JA, Mann DMA, Wester P, Winblad B. An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease. Neurobiol Aging 1986;7:489-502.
    • (1986) Neurobiol Aging , vol.7 , pp. 489-502
    • Hardy, J.A.1    Mann, D.M.A.2    Wester, P.3    Winblad, B.4
  • 31
    • 0017110280 scopus 로고
    • Immuno-electron microscopic localization of immunoglobulins in amyloid fibrils and senile plaques
    • Ishii T, Haga S. Immuno-electron microscopic localization of immunoglobulins in amyloid fibrils and senile plaques. Acta Neuropathol (Berl) 1976;36:243-9.
    • (1976) Acta Neuropathol (Berl) , vol.36 , pp. 243-249
    • Ishii, T.1    Haga, S.2
  • 32
    • 0016849288 scopus 로고
    • Identification of components of immunoglobulins in senile plaques by means of fluorescent antibody technique
    • Ishii T, Haga S, Schimuzu F. Identification of components of immunoglobulins in senile plaques by means of fluorescent antibody technique. Acta Neuropathol (Berl) 1975;32:157-62.
    • (1975) Acta Neuropathol (Berl) , vol.32 , pp. 157-162
    • Ishii, T.1    Haga, S.2    Schimuzu, F.3
  • 33
    • 0024451476 scopus 로고
    • Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease
    • Joachim CL, Mori H, Selkoe DJ. Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease. Nature 1989;341:226-30.
    • (1989) Nature , vol.341 , pp. 226-230
    • Joachim, C.L.1    Mori, H.2    Selkoe, D.J.3
  • 34
    • 0020003188 scopus 로고
    • Immunological indices in the cerebrospinal fluid of patients with presenile dementia of the Alzheimer type
    • Jonker C, Eikelenboom P, Tavenier P. Immunological indices in the cerebrospinal fluid of patients with presenile dementia of the Alzheimer type. Br J Psychiatry 1982;140:44-9.
    • (1982) Br J Psychiatry , vol.140 , pp. 44-49
    • Jonker, C.1    Eikelenboom, P.2    Tavenier, P.3
  • 35
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease A4 protein resembles a cell-surface receptor
    • Kang J, Lemaire HG, Unterbeck A, et al. The precursor of Alzheimer's disease A4 protein resembles a cell-surface receptor. Nature 1987;325:733-6.
    • (1987) Nature , vol.325 , pp. 733-736
    • Kang, J.1    Lemaire, H.G.2    Unterbeck, A.3
  • 36
    • 0023110541 scopus 로고
    • CSF and serum concentrations of albumin and IgG in Alzheimer's disease
    • Kay AD, May C, Papadopoulos NM, et al. CSF and serum concentrations of albumin and IgG in Alzheimer's disease. Neurobiol Aging 1987;8:21-5.
    • (1987) Neurobiol Aging , vol.8 , pp. 21-25
    • Kay, A.D.1    May, C.2    Papadopoulos, N.M.3
  • 38
    • 0021986721 scopus 로고
    • The integrity of the blood-brain barrier in Alzheimer's type and multi-infarct dementia by the study of albumin and IgG in serum and cerebrospinal fluid
    • Leonardi A, Gandolfo C, Arata L, Vecchia R. The integrity of the blood-brain barrier in Alzheimer's type and multi-infarct dementia by the study of albumin and IgG in serum and cerebrospinal fluid. J Neurol Sci 1985;67:253-61.
    • (1985) J Neurol Sci , vol.67 , pp. 253-261
    • Leonardi, A.1    Gandolfo, C.2    Arata, L.3    Vecchia, R.4
  • 40
    • 0016442208 scopus 로고
    • The incidence of cerebral amyloid angiopathy in Alzheimer's disease
    • Mandlybur TI. The incidence of cerebral amyloid angiopathy in Alzheimer's disease. Neurology 1975;25:120-6.
    • (1975) Neurology , vol.25 , pp. 120-126
    • Mandlybur, T.I.1
  • 41
    • 0022414320 scopus 로고
    • The neuropathology of Alzheimer's disease: A review with pathogenetic, aetiological, and therapeutic considerations
    • Mann DMA. The neuropathology of Alzheimer's disease: a review with pathogenetic, aetiological, and therapeutic considerations. Mech Ageing Dev 1985;31:213-55.
    • (1985) Mech Ageing Dev , vol.31 , pp. 213-255
    • Mann, D.M.A.1
  • 43
    • 0025365306 scopus 로고
    • The prevalence of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Down's syndrome and Alzheimer's disease
    • Mann DMA, Jones D, Prinja D, Purkiss MS. The prevalence of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Down's syndrome and Alzheimer's disease. Acta Neuropathol 1990;80:318-27.
    • (1990) Acta Neuropathol , vol.80 , pp. 318-327
    • Mann, D.M.A.1    Jones, D.2    Prinja, D.3    Purkiss, M.S.4
  • 45
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Reports of the NINCDS-ADRDA workgroup under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: reports of the NINCDS-ADRDA workgroup under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-44.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 46
    • 0023869451 scopus 로고
    • Effect of aging on the blood-brain-barrier
    • Mooradian AD. Effect of aging on the blood-brain-barrier. Neurobiol Aging 1988;9:31-9.
    • (1988) Neurobiol Aging , vol.9 , pp. 31-39
    • Mooradian, A.D.1
  • 47
    • 0025821880 scopus 로고
    • Leakage and neuronal uptake of serum protein in aged and Alzheimer brains: A postmortem phenomenon with antemortem etiology
    • Mori S, Sternberger NH, Herman MM, Sternberger LA. Leakage and neuronal uptake of serum protein in aged and Alzheimer brains: a postmortem phenomenon with antemortem etiology. Lab Invest 1991;64(3):345-51.
    • (1991) Lab Invest , vol.64 , Issue.3 , pp. 345-351
    • Mori, S.1    Sternberger, N.H.2    Herman, M.M.3    Sternberger, L.A.4
  • 48
    • 0342569561 scopus 로고
    • Neuropsychological deficits and other psychiatric symptoms in HIV-1 infected patients
    • Weis S, Hippius H, eds. Seattle, WA: Horgrefe & Huber Publishers
    • Naber D, Perro S, Schielke E, Goebel FD, Hippius H. Neuropsychological deficits and other psychiatric symptoms in HIV-1 infected patients. In: Weis S, Hippius H, eds. HIV-1 infection of the central nervous system. Seattle, WA: Horgrefe & Huber Publishers, 1995.
    • (1995) HIV-1 Infection of the Central Nervous System
    • Naber, D.1    Perro, S.2    Schielke, E.3    Goebel, F.D.4    Hippius, H.5
  • 49
    • 0018913150 scopus 로고
    • Postmortal diffusion of plasma albumin in rat brain
    • Oehmichen M, Gencic M. Postmortal diffusion of plasma albumin in rat brain. Z Rechtsmed 1980;84:113.
    • (1980) Z Rechtsmed , vol.84 , pp. 113
    • Oehmichen, M.1    Gencic, M.2
  • 51
    • 0025341743 scopus 로고
    • Microangiopathy, the vascular basement membrane and Alzheimer's disease
    • Perlmutter LS, ChangChui H. Microangiopathy, the vascular basement membrane and Alzheimer's disease. Brain Res Bull 1990;24:677-86.
    • (1990) Brain Res Bull , vol.24 , pp. 677-686
    • Perlmutter, L.S.1    ChangChui, H.2
  • 53
    • 0342569560 scopus 로고
    • Amyloid angiopathy in Alzheimer's disease
    • Ranalli P, Bergeron C. Amyloid angiopathy in Alzheimer's disease. Ann Neurol 1984;16:119.
    • (1984) Ann Neurol , vol.16 , pp. 119
    • Ranalli, P.1    Bergeron, C.2
  • 54
    • 0012033401 scopus 로고
    • Passage of proteins from blood to CSF - Model for transfer by pores and vesicles
    • Wood JH, ed. New York: Plenum Publishing Corporation
    • Rapoport SI. Passage of proteins from blood to CSF - model for transfer by pores and vesicles. In: Wood JH, ed. Neurobiology of cerebrospinal fluid 2. New York: Plenum Publishing Corporation, 1983:233-45.
    • (1983) Neurobiology of Cerebrospinal Fluid 2 , pp. 233-245
    • Rapoport, S.I.1
  • 55
    • 0018346036 scopus 로고
    • Blood-brain-barrier permeability in senescent rats
    • Rapoport SI, Ohno K, Pettigrew KD. Blood-brain-barrier permeability in senescent rats. J Gerontol 1976;34:162-9.
    • (1976) J Gerontol , vol.34 , pp. 162-169
    • Rapoport, S.I.1    Ohno, K.2    Pettigrew, K.D.3
  • 56
    • 0018949369 scopus 로고
    • The discrimination between blood-CSF barrier dysfunction and inflammatory reaction of the CNS by a recent evaluation graph for the protein profile of the cerebrospinal fluid
    • Reiber H. The discrimination between blood-CSF barrier dysfunction and inflammatory reaction of the CNS by a recent evaluation graph for the protein profile of the cerebrospinal fluid. J Neurol 1990;224:89-99.
    • (1990) J Neurol , vol.224 , pp. 89-99
    • Reiber, H.1
  • 57
    • 0020051891 scopus 로고
    • Variation in immunoglobulin G and albumin concentrations during lumbar CSF removal: A reappraisal
    • Rice GPA, Armstrong H, Ebers GC. Variation in immunoglobulin G and albumin concentrations during lumbar CSF removal: a reappraisal. Neurology 1982;32:893-4.
    • (1982) Neurology , vol.32 , pp. 893-894
    • Rice, G.P.A.1    Armstrong, H.2    Ebers, G.C.3
  • 58
    • 0018887732 scopus 로고
    • Pathologic verification of ischemic score in differentiation of dementias
    • Rosen WG, Terry RD, Fuld PA, Katzman R, Peck A. Pathologic verification of ischemic score in differentiation of dementias. Ann Neurol 1980;7:486-8.
    • (1980) Ann Neurol , vol.7 , pp. 486-488
    • Rosen, W.G.1    Terry, R.D.2    Fuld, P.A.3    Katzman, R.4    Peck, A.5
  • 59
    • 0020958398 scopus 로고
    • Integrity of blood-brain-barrier to peroxidase in senescent mice
    • Rudick RA, Buell SJ. Integrity of blood-brain-barrier to peroxidase in senescent mice. Neurobiol Aging 1983;4:283-7.
    • (1983) Neurobiol Aging , vol.4 , pp. 283-287
    • Rudick, R.A.1    Buell, S.J.2
  • 60
    • 0028287247 scopus 로고
    • TI: Elevated cerebrospinal fluid protein in men with unipolar or bipolar depression
    • Samuelson SD, Winokur G, Pitts AF. TI: elevated cerebrospinal fluid protein in men with unipolar or bipolar depression. Biol Psychiatry 1994;35(8):539-44.
    • (1994) Biol Psychiatry , vol.35 , Issue.8 , pp. 539-544
    • Samuelson, S.D.1    Winokur, G.2    Pitts, A.F.3
  • 61
    • 0023125913 scopus 로고
    • Examination of blood-brain barrier permeability in dementia of the Alzheimer type with *68Ga* EDTA and positron emission tomography
    • Schlageter NL, Carson RE, Rapoport SI. Examination of blood-brain barrier permeability in dementia of the Alzheimer type with *68Ga* EDTA and positron emission tomography. J Cereb Blood Flow Metab 1987;7:1-8.
    • (1987) J Cereb Blood Flow Metab , vol.7 , pp. 1-8
    • Schlageter, N.L.1    Carson, R.E.2    Rapoport, S.I.3
  • 62
    • 0027367764 scopus 로고
    • Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease
    • Selkoe DJ. Physiological production of the β-amyloid protein and the mechanism of Alzheimer's disease. Trends Neurosci 1993;16:403-8.
    • (1993) Trends Neurosci , vol.16 , pp. 403-408
    • Selkoe, D.J.1
  • 63
    • 0028269027 scopus 로고
    • Central nervous system IgG synthesis rates in Alzheimer's disease: Possible differences in early onset and late onset subgroups
    • Small GW, Rosenthal M, Tourtelotte WW. Central nervous system IgG synthesis rates in Alzheimer's disease: possible differences in early onset and late onset subgroups. Alzheimer Dis Assoc Disord 1994; 8:29-37.
    • (1994) Alzheimer Dis Assoc Disord , vol.8 , pp. 29-37
    • Small, G.W.1    Rosenthal, M.2    Tourtelotte, W.W.3
  • 64
    • 0018194577 scopus 로고
    • Immunocytochemical localization of plasma proteins in neuronal perikarya
    • Sparrow JR. Immunocytochemical localization of plasma proteins in neuronal perikarya. Neurosci Lett 1978;8:335-9.
    • (1978) Neurosci Lett , vol.8 , pp. 335-339
    • Sparrow, J.R.1
  • 65
    • 0343875310 scopus 로고
    • Variation in immunoglobulin G index and synthesis rate during lumbar CSF removal
    • Stein DP, Rudick RA. Variation in immunoglobulin G index and synthesis rate during lumbar CSF removal. Neurology 1986;36(Suppl 1):255.
    • (1986) Neurology , vol.36 , Issue.1 SUPPL. , pp. 255
    • Stein, D.P.1    Rudick, R.A.2
  • 66
    • 0023109592 scopus 로고
    • Amyloid beta protein gene: cDNA, mRNA distribution and genetic linkage near the Alzheimer locus
    • Tanzi RE, Gusella JF, Watkins PC, et al. Amyloid beta protein gene: cDNA, mRNA distribution and genetic linkage near the Alzheimer locus. Science 1987;235:880-4.
    • (1987) Science , vol.235 , pp. 880-884
    • Tanzi, R.E.1    Gusella, J.F.2    Watkins, P.C.3
  • 67
    • 0017592811 scopus 로고
    • Principles of albumin and IgG analyses in neurological disorders. 1. Establishment of reference values
    • Tibbling G, Link H, Ohman S. Principles of albumin and IgG analyses in neurological disorders. 1. Establishment of reference values. Scand J Clin Lab Invest 1977;37:385-90.
    • (1977) Scand J Clin Lab Invest , vol.37 , pp. 385-390
    • Tibbling, G.1    Link, H.2    Ohman, S.3
  • 68
    • 0014851803 scopus 로고
    • Observations on the brains of demented old people
    • Tomlinson BE, Blessed G, Roth M. Observations on the brains of demented old people. J Neurol Sci 1970;11:205-42.
    • (1970) J Neurol Sci , vol.11 , pp. 205-242
    • Tomlinson, B.E.1    Blessed, G.2    Roth, M.3
  • 69
    • 0023025655 scopus 로고
    • The blood brain barrier in Alzheimer's disease
    • Vinters HV, Pardridge WM. The blood brain barrier in Alzheimer's disease. Can J Neurol Sci 1986;13:446-8.
    • (1986) Can J Neurol Sci , vol.13 , pp. 446-448
    • Vinters, H.V.1    Pardridge, W.M.2
  • 70
    • 0017844247 scopus 로고
    • Protein fractions of lumbar, cisternal, and ventricular cerebrospinal fluid: Separate areas of references
    • Weisner B, Bernhardt W. Protein fractions of lumbar, cisternal, and ventricular cerebrospinal fluid: separate areas of references. J Neurol Sci 1978;37:205-14.
    • (1978) J Neurol Sci , vol.37 , pp. 205-214
    • Weisner, B.1    Bernhardt, W.2
  • 71
    • 0020348267 scopus 로고
    • Evidence for blood-brain barrier changes in senile dementia of the Alzheimer type (SAD)
    • Sinex FM, Merril CR, eds. New York: New York Academy of Sciences
    • Wisniewski HM, Kozlowski PB. Evidence for blood-brain barrier changes in senile dementia of the Alzheimer type (SAD). In: Sinex FM, Merril CR, eds. Alzheimer's disease, Down s syndrome and aging. Annals of the New York Academy of Sciences, vol. 396. New York: New York Academy of Sciences, 1982:119-29.
    • (1982) Alzheimer's Disease, Down s Syndrome and Aging. Annals of the New York Academy of Sciences , vol.396 , pp. 119-129
    • Wisniewski, H.M.1    Kozlowski, P.B.2
  • 72
    • 0024238679 scopus 로고
    • Protein gradients in the cerebrospinal fluid and the calculation of intracerebral IgG synthesis
    • Wurster U. Protein gradients in the cerebrospinal fluid and the calculation of intracerebral IgG synthesis. J Neuroimmunol 1988;20:233-5.
    • (1988) J Neuroimmunol , vol.20 , pp. 233-235
    • Wurster, U.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.