Modulation of human T-lymphocyte functions by the consumption of carotenoid-rich vegetables

British Journal of Nutrition

Volumn 82, Issue 5, 1999, Pages 383-389

  Watzl, Bernhard ^a   Bub, Achim ^a   Brandstetter, Birgit R ^b   Rechkemmer, Gerhard ^a  

^a FEDERAL RESEARCH INSTITUTE OF NUTRITION AND FOOD   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Carotenoids; Cytokines; T lymphocytes; Vegetable consumption

Indexed keywords

CAROTENOID; CONCANAVALIN A; CYTOKINE; INTERLEUKIN 2; INTERLEUKIN 4;

ADULT; ARTICLE; BLOOD ANALYSIS; CARROT; CELL PROLIFERATION; CONTROLLED STUDY; DIET; HELPER CELL; HUMAN; HUMAN EXPERIMENT; IMMUNE SYSTEM; LYMPHOCYTE PROLIFERATION; MALE; MONONUCLEAR CELL; NORMAL HUMAN; SPINACH; T LYMPHOCYTE; TOMATO; VEGETABLE;

DAUCUS CAROTA; LYCOPERSICON ESCULENTUM; SPINACIA OLERACEA;

EID: 0032710872     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1017/s0007114599001634     Document Type: Article

References (38)

1. Abdel-Fattah G, Watzl B, Huang DS & Watson RR (1993) Beta-carotene in vitro stimulates tumor necrosis factor alpha and interleukin-1 alpha secretion by human peripheral blood mononuclear cells. Nutrition Research 13, 863-871.
2. Bendich A (1989) Carotenoids and the immune response. Journal of Nutrition 119, 112-115.
3. Bendich A (1991) Beta-carotene and the immune response. Proceedings of the Nutrition Society 50, 263-274.
4. Bendich A (1996) Antioxidant vitamins and human immune responses. Vitamins and Hormones 52, 35-62.
5. Block G, Patterson B & Subar A (1992) Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutrition and Cancer 18, 1-29.
6. Boeing H, Bohlscheid-Thomas S, Voss S, Schneeweiss S & Wahrendorf J (1997) The relative validity of vitamin intakes derived from a food frequency questionnaire compared to 24-hour recalls and biological measurements: results from the EPIC pilot study in Germany. European Prospective Investigation into Cancer and Nutrition. International Journal of Epidemiology 26, Suppl. 1, S82-S90.
7. Bone RA, Landrum JT, Friedes LM, Gomez CM, Kilburn MD, Menendez E, Vidal I & Wang W (1997) Distribution of lutein and zeaxanthin stereoisomers in the human retina. Experimental Eye Research 64, 211-218.
8. Bundesinstitut für gesundheitlichen Verbraucherschutz and Veterinärmedizin (1994) German Food Code and Nutrition Data Base Version II.2. Berlin: Nutri-Science.
9. Burri BJ (1997) Beta-carotene and human health: a review of current research. Nutrition Research 17, 547-580.
10. Chew BP, Wong MW & Wong TS (1996) Effects of lutein from marigold extract on immunity and growth of mammary tumors in mice. Anticancer Research 16, 3689-3694.
11. Clevidence BA, Khachik F, Brown ED, Nair PP, Wiley ER, Prior RL, Cao G, Morel DW, Stone W, Gross M & Kramer T (1997) Human consumption of carotenoid-rich vegetables. In Antioxidant Methodology: in Vivo and in Vitro Concepts, pp. 53-62 [OI Aruoma and SL Cuppett, editors]. Champaign, IL: AOCS Press.
12. Daudu PA, Kelly DS, Taylor PC, Burri BJ & Wu MM (1994) Effect of a low beta-carotene diet on the immune functions of adult women. American Journal of Clinical Nutrition 60, 969-972.
13. Fotouhi N, Meydani M, Santos MS, Meydani SM, Hennekens CH & Gaziano JM (1996) Carotenoid and tocopherol concentrations in plasma, peripheral blood mononuclear cells, and red blood cells after long-term β-carotene supplementation in men. American Journal of Clinical Nutrition 63, 553-558.
14. Gardner EM, Bernstein ED, Dorfman M, Abrutyn E & Murasko DM (1997) The age-associated decline in immune function of healthy individuals is not related to changes in plasma concentrations of β-carotene, retinol, α-tocopherol or zinc. Mechanisms of Aging and Development 94, 55-69.
15. Gerster H (1997) The potential role of lycopene for human health. Journal of the American College of Nutrition 16, 109-126.
16. Hughes DA, Wright AJA, Finglas PM, Peerless ACJ, Bailey AL, Astley SB, Pinder AC & Southon S (1997a) The effect of beta-carotene supplementation on the immune function of blood monocytes from healthy male nonsmokers. Journal of Laboratory and Clinical Medicine 129, 309-317.
17. Hughes DA, Wright AJA, Finglas PM, Peerless ACJ, Bailey AL, Astley SB, Pinder AC & Southon S (1997b) Comparison of effects of beta-carotene and lycopene supplementation on the expression of functionally associated molecules on human monocytes. Biochemical Society Transactions 25, 206S.
18. Iyonouchi H, Sun S, Mizokami M & Gross MD (1996) Effect of various carotenoids on cloned, effector-stage T-helper cell activity. Nutrition and Cancer 26, 313-324.
19. Kazi N, Radvany R, Oldham T, Keshavarzian A, Frommel TO, Libertin C & Mobarhan S (1997) Immunomodulatory effect of beta-carotene on T lymphocyte subsets in patients with resected colonie polyps and cancer. Nutrition and Cancer 28, 140-145.
20. Key TJA, Thorogood M, Appleby PN & Burr ML (1996) Dietary habits and mortality in 11 000 vegetarians and health conscious people: results of a 17 year follow up. British Medical Journal 313, 775-779.
21. Kramer TR & Burri BJ (1997) Modulated mitogenic proliferative responsiveness of lymphocytes in whole-blood cultures after a low-carotene diet and mixed-carotenoid supplementation in women. American Journal of Clinical Nutrition 65, 871-875.
22. Mangels AR, Holden JM, Beecher GR, Forman MR & Lanza E (1993) Carotenoid content of fruits and vegetables: an evaluation of analytic data. Journal of the American Dietetic Association 93, 284-296.
23. Mayne ST (1996) Beta-carotene, carotenoids, and disease prevention in humans. FASEB Journal 10, 690-701.
24. Meydani SN, Santos MS, Ribaya-Mercado JD, Leka L, Han SN & Russell RM (1995a) Effect of β-carotene on the immune response of elderly women. FASEB Journal 9, A170 Abstr.
25. Meydani SN, Wu D, Santos MS & Hayek MG (1995b) Antioxidants and immune response in aged persons: overview of present evidence. American Journal of Clinical Nutrition 62, 1462S-1476S.
26. Moriguchi S, Okishima N, Sumida S, Okamura K, Tatsuya D & Kishino Y (1996) Beta-carotene supplementation enhances lymphocyte proliferation with mitogens in human peripheral blood lymphocytes. Nutrition Research 16, 211-218.
27. Mosmann TR & Sad S (1996) The expanding universe of T-cell subsets: Th1, Th2 and more. Immunology Today 17, 138-146.
28. Müller H, Bub A, Watzl B & Rechkemmer G (1999) Plasma concentrations of carotenoids in healthy volunteers after intervention with carotenoid-rich foods. European Journal of Nutrition 38, 35-44.
29. Ness AR & Powles JW (1997) Fruit and vegetables, and cardiovascular disease: a review. International Journal of Epidemiology 26, 1-13.
30. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens F, Valaris B, Williams JH, Barnhart S & Hammer S (1996) Effects of a combination of beta-carotene and vitamin A on lung cancer and cardiovascular disease. New England Journal of Medicine 334, 1150-1155.
31. Pelz R, Schmidt-Faber B & Heseker H (1998) Die Carotinoidzufuhr in der Nationalen Verzehrsstudie (Carotenoid intake in the German National Food Consumption Survey). Zeitschrift für Ernährungswissenschaft 37, 319-327.
32. Pool-Zobel BL, Bub A, Müller H, Wollowski I & Rechkemmer G (1997) Consumption of vegetables reduces genetic damage in humans: first results of a human intervention trial with carotenoid-rich foods. Carcinogenesis 18, 1847-1850.
33. Ringer TV, DeLoof MJ, Winterrowd GE, Francom SF, Gaylor SK, Ryan JA, Sanders ME & Hughes GS (1991) Beta-carotene's effects on serum lipoproteins and immunologic indices in humans. American Journal of Clinical Nutrition 53, 688-694.
34. Santos MS, Meydani SN, Leka L, Wu D, Fotouhi N, Meydani M, Hennekens CH & Gaziano JM (1996) Natural killer cell activity in elderly men is enhanced by beta-carotene supplementation. American Journal of Clinical Nutrition 64, 772-777.
35. Stahl W & Sies H (1996) Lycopene: a biologically important carotenoid for humans? Archives of Biochemistry and Biophysics 336, 1-9.
36. Steinmetz KA & Potter JD (1991) Vegetables, fruit, and cancer: II. Mechanisms. Cancer Causes and Control 2, 427-442.
37. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. New England Journal of Medicine 330, 1029-1035.
38. Watson RR, Prabhala RH, Plezia PM & Alberts DS (1991) Effects of beta-carotene on lymphocyte subpopulations in elderly humans: evidence for dose-response relationship. American Journal of Clinical Nutrition 53, 90-94.