Modulated mitogenic proliferative responsiveness of lymphocytes in whole-blood cultures after a low-carotene diet and mixed-carotenoid supplementation in women

American Journal of Clinical Nutrition

Volumn 65, Issue 3, 1997, Pages 871-875

  Kramer, Tim R ^a,c   Burri, Betty J ^b  

^a BELTSVILLE HUMAN NUTRITION RESEARCH CENTER   (United States)

^b W Human Nutrition Research Center   (United States)

^c AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

carotenoids; mitogenic responsiveness; phytohemagglutinin; T lymphocyte proliferation; whole blood cultures; Carotene

Indexed keywords

CAROTENE; CAROTENOID; PHYTOHEMAGGLUTININ;

ARTICLE; CANCER RISK; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DOSE RESPONSE; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; LYMPHOCYTE PROLIFERATION; MITOGENESIS; NORMAL HUMAN; RISK ASSESSMENT;

EID: 0031039659     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/65.3.871     Document Type: Article

References (30)

1. Rogers AE, Longnecker MP. Biology of disease. Dietary and nutritional influences on cancer: a review of epidemiologic and experimental data. Lab Invest 1988;59:729-59.
2. Micozzi MS. Foods, micronutrients, and reduction of human cancer. In: Moon TE, Micozzi MS, eds. Nutrition and cancer prevention. New York: Marcel Dekker, Inc. 1989:213-41.
3. Dorgan JF, Schatzkin A. Antioxidant micronutrients in cancer prevention. Hematol Oncol Clin North Am 1991;5:433-68.
4. Ziegler RG. A review of epidemiological evidence that carotenoids reduce the risk of cancer. J Nutr 1989;119:116-22.
5. Gridley G, McLaughlin JK, Block G, et al. Diet and oral and pharyngeal cancer among blacks. Nutr Cancer 1990;14:219-25.
6. Steinmetz KA, Potter JD. Vegetables, fruit, and cancer. I. Epidemiology. Cancer Causes Control 1991;2:325-57.
7. Steinmetz KA, Potter JD. Vegetables, fruit, and cancer. II. Mechanism. Cancer Causes Control 1991;2:427-42.
8. Block G, Patterson B, Subar A. Fruits, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 1992;18:1-29.
9. Steinmetz KA, Potter JD. Food-group consumption and colon cancer in the Adelaide case-control study. I. Vegetables and fruit. Int J Cancer 1993;53:711-9.
10. Bendich A, Olson JA. Biological actions of carotenoids. FASEB J 1989;3:1927-32.
11. Baker KR, Meydani M. β-carotene as an antioxidant in immunity and cancer. J Optimal Nutr 1994;3:39-50.
12. Middleton E Jr, Kandaswami C. The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer. In: Harborne JB, ed. The flavonoids: advances in research since 1986. London: Chapman & Hall, 1993:619-52.
13. Berg PA, Daniel PT. Effects of flavonoid compounds on the immune response. In: Cody V, Middleton E Jr, Harborne JB, Beretz A, eds. Plant flavonoids in biology and medicine II: biochemical, cellular, and medicinal properties. New York: Alan R Liss, Inc. 1988:157-71.
14. Bendich A, Shapiro SS. Effect of β-carotene and canthaxanthin on the immune responses of the rat. J Nutr 1986;116:2254-62.
15. Bendich A, β-Carotene and the immune response. Proc Nutr Soc 1991;50:263-74.
16. van Poppel G, Spanhaak S, Ockhuizen T. Effect of β-carotene on immunological indexes in healthy male smokers. Am J Clin Nutr 1993;57:402-7.
17. Moriguchi S, Okishima N, Sumida S, Okamura K, Doi T, Kishino Y. β-Carotene supplementation enhances lymphocyte proliferation with mitogens in human peripheral blood lymphocytes. Nutr Res 1996; 16:211-8.
18. Daudu PA, Kelley DS, Taylor PC, Burri BJ, Wu MM. Effect of a low β-carotene diet on the immune functions of adult women. Am J Clin Nutr 1994;60:969-72.
19. Fletcher MA, Klimas N, Morgan R, Gjerset G. Lymphocyte proliferation. In: Rose NR, Conway DeMacario E, Fahey JL, Friedman H, Penn GM, eds. Manual of clinical laboratory immunology. 4th ed. Washington, DC: American Society for Microbiology, 1992:213-9.
20. Bloemena E, Roos MTL, Van Heijst JLAM, Vossen JMJJ, Schellekens PTA. Whole-blood lymphocyte cultures. J Immunol Methods 1989;122:161-7.
21. Frankenburg S. A simplified microtechnique for measuring human lymphocyte proliferation after stimulation with mitogen and specific antigen. J Immunol Methods 1988;112:177-82.
22. Friue D, Dystant P. Detection of impaired mitogen responses in autologous whole blood of cancer patients using an optimized method of lymphocyte stimulation. Immunol Lett 1984;8:243-7.
23. Chug-Ahuja JK, Holden JM, Forman MR, Mangels AR, Beecher GR, Lanza E. The development and application of a carotenoid database for fruits, vegetables, and selected multicomponent foods. J Am Diet Assoc 1993;93:318-23.
24. Khachik F, Beecher GR, Goli MB, Lusby WR. Separation and quantitation of carotenoids in foods. In; Packer L, ed. Methods in enzymology, carotenoids. Vol 213. Part A. Orlando, FL: Academic Press, 1992:347-59.
25. National Research Council. Recommended dietary allowances. 10th ed. Washington, DC: National Academy Press, 1989.
26. Sowell AL, Huff DL, Gunter EW, Driskell WJ. Identification of cis-carotenoids in human sera analyzed by reversed-phase high-performance liquid chromatography with diode array detection. J Chromatogr B Biomed Appl 1988;431:424-30.
27. Dixon ZR, Burri BJ, Clifford A, et al. Effects of carotene-deficient diet on measures of oxidative susceptibility and Superoxide dismutase activity in adult women. Free Radie Biol Med 1994;17:537-44.
28. Zhang YH, Kramer TR, Taylor PR, et al. Possible immunologic involvement of antioxidants in cancer prevention. Am J Clin Nutr 1995;62(suppl):1477S-82S.
29. Tukey JW. Comparing individual means in the analysis of variance. Biometrics 1949;5:99-114.
30. Box GEP, Cox DR. An analysis of transformations. J R Slat Soc Bull 1964;26:211-46.