The age-associated decline in immune function of healthy individuals is not related to changes in plasma concentrations of β-carotene, retinol, α-tocopherol or zinc

Mechanisms of Ageing and Development

Volumn 94, Issue 1-3, 1997, Pages 55-69

  Gardner, Elizabeth M ^a   Bernstein, Erica D ^a   Dorfman, Marion ^a   Abrutyn, Elias ^a   Murasko, Donna M ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Aging; Immunity; Micronutrients; Vitamins

Indexed keywords

ALPHA TOCOPHEROL; BETA CAROTENE; CONCANAVALIN A; INFLUENZA VACCINE; MITOGENIC AGENT; PHYTOHEMAGGLUTININ; POKEWEED MITOGEN; RETINOL; ZINC;

ADULT; AGED; AGING; BLOOD LEVEL; CELL STIMULATION; CONFERENCE PAPER; CONTROLLED STUDY; DIET RESTRICTION; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNE RESPONSE; IMMUNITY; LYMPHOCYTE PROLIFERATION; MALE; MONONUCLEAR CELL; NORMAL HUMAN; NUTRITION; NUTRITIONAL STATUS; PRIORITY JOURNAL; ZINC BLOOD LEVEL;

ADULT; AGED; AGED, 80 AND OVER; BETA CAROTENE; CELL DIVISION; CONCANAVALIN A; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MITOGENS; PHYTOHEMAGGLUTININS; VITAMIN A; VITAMIN E; ZINC;

EID: 0031011168     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(96)01838-6     Document Type: Conference Paper

References (27)

1. D.M. Murasko and I.M. Goonewardene, T-cell function in aging: mechanisms of decline. Ann. Rev. Gerontol. Geriatrics, 10 (1990) 71-96.
2. T. Makinodan and M.B. Kay, Age influence on the immune system. Adv. Immunol., 29 (1980) 287-330.
3. S.J. Wayne, R.L. Rhyne, P.J. Garry and J.S. Goodwin, Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60. J. Gerontol., 45 (1990) 45-48.
4. D.M. Murasko, B.J. Nelson, R. Silver, D. Matour and D. Kaye, Immunologic response in an elderly population with a mean age of 85. Am. J. Med., 81 (1986) 612-618.
5. D.M. Murasko, P. Weiner and D. Kaye, Decline in mitogen induced proliferation of lymphocytes with increasing age. Clin. Exp. Immunol., 70 (1987) 440-448.
6. D.M. Murasko, M.S. Gold, M.T. Hessen and D. Kaye, Immune reactivity, morbidity, and mortality of elderly humans. Aging Immunol. Infect. Dis., 2 (1990) 171-179.
7. W.R. Beisel, Single nutrients and immunity. Am. J. Clin. Nutr., 35 (1982) 417-468.
8. A.C. Ross and U. Hammerling, Retinoids and the immune system. In M.B. Roberts, A.B. Roberts and D.S. Goodman (eds.), The Retinoids, Biology, Chemistry and Medicine, Raven Press, NY, 1994, pp. 521-544.
9. A. Bendich, Carotenoids and the immune response. J. Nutr., 119 (1989) 112-115.
10. S.N. Meydani, Micronutrients and immune function in the elderly. Ann. New York Acad. Sci., 587 (1990) 196-207.
11. P.J. Fraker, M.E. Gershwin, R.A. Good and A. Prasad, Interrelationships between zinc and immune function. Fed Proc., 45 (1986) 1474-1479.
12. S.N. Meydani, Dietary modulation of the immune response in the aged. Age, 14 (1991) 108-115.
13. N.D. Penn, L. Purkins, J. Kelleher, R.V. Heatley, B.H. Mascie-Taylor and P.W. Belfield, The effect of dietary supplementation with vitamins A, C and E on cell-mediated immune function in elderly long-stay patients: a randomized controlled trial. Age Ageing, 20 (1991) 169-174.
14. J.D. Bogden, A. Bendich, F.W. Kemp et al., Daily micronutrient supplements enhance delayed-hypersensitivity skin test response in older people. Am. J. Clin. Nutr., 60 (1994) 437-47.
15. J.D. Bogden, J.M. Oleske, M.A. Lavenhar et al., Effects of one year of supplementation with zinc and other micronutrients on cellular immunity in the elderly. J. Am. Coll. Nutr., 9 (1990) 214-225.
16. R.K. Chandra, Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet, 340 (1992) 1124-1127.
17. S.N. Meydani, M. Patrice Barklund, S. Liu et al., Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am. J. Clin. Nutr., 52 (1990) 557-563.
18. J. Duchateau, G. Delepesse, R. Vrijens and H. Collet, Beneficial effects of oral zinc supplementation on the immune response of old people. Am. J. Med., 70 (1981) 1001-1004.
19. J.S. Goodwin and P.J. Garry, Relationship between megadose vitamin supplementation and immunological function in a healthy elderly population. Clin. Exp. Immunol., 51 (1983) 647-653.
20. J.S. Goodwin and P.J. Garry, Lack of correlation between indices of nutritional status and immunologic function in elderly humans. J. Gerontol., 43 (1988) 46-49.
21. E.J. Remarque, L. Witkamp, N. Masurel and G.J. Lithart, Zinc supplementation does not enhance antibody formation to influenza virus vaccine in the elderly. Aging Immunol. Infect. Dis., 4 (1993) 17-23.
22. A.B. Barua, R.O. Batres, H.C. Furr and J.A. Olson, Analysis of carotenoids in human serum. J. Micronutr. Anal., 5 (1989) 291-302.
23. J.E. Romanchik, D.W. Morel and E.H. Harrison, Distribution of carotenoids and α-tocopherol among lipoproteins do not change when human plasma is incubated in vitro. J. Nutr., 125 (1995) 2610-2617.
24. M. Chavance, B. Herbeth, C. Fournier, C. Janot and G. Vernhes, Vitamin status, immunity and infections. Eur. J. Clin. Nutr., 43 (1989) 827-835.
25. R.A. Jacob, D.S. Kelley, F.S. Pianalto et al., Immunocompetence and oxidant defense during ascorbate depletion of healthy men. Am. J. Clin. Nutr., 54 (1991) 1302-1329.
26. M.C. Talbott, L.T. Miller and N.I. Kerkvliet, Pyroxidine supplementation: effect on lymphocyte responses in elderly persons. Am. J. Clin. Nutr., 46 (1987) 659-64.
27. S.N. Maydani, J.D. Ribaya-Mercada, R.M. Russell, N. Sahyoun, F.D. Morrow and S.N. Gershoff, Vitamin B6 deficiency impairs interleukin-2 production and lymphocyte proliferation in elderly adults. Am. J. Clin. Nutr., 53 (1991) 1275-1280.