Carotenoid and tocopherol concentrations in plasma, peripheral blood mononuclear cells, and red blood cells after long-term β-carotene supplementation in men

American Journal of Clinical Nutrition

Volumn 63, Issue 4, 1996, Pages 553-558

  Fotouhi, Nader ^b   Meydani, Mohsen ^a   Santos, Michelle S ^b   Meydani, Simin N ^b   Hennekens, Charles H ^b   Gaziano, J Michael ^b  

^a TUFTS UNIVERSITY   (United States)

^b NONE

Author keywords

Carotenoids; humans; peripheral blood mononuclear cells; plasma; red blood cells; tocopherol

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA TOCOPHEROL; BETA CAROTENE; CRYPTOXANTHIN;

ADULT; AGED; ARTICLE; CELL LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; ERYTHROCYTE; HUMAN; HUMAN EXPERIMENT; MALE; MONONUCLEAR CELL; NUTRITIONAL STATUS; TREATMENT OUTCOME; VITAMIN BLOOD LEVEL; VITAMIN INTAKE;

EID: 0029877149     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/63.4.553     Document Type: Article

References (31)

1. Ziegler RG. A review of epidemiologic evidence that carotenoids reduce the risk of cancer. J Nutr 1989;119:116-22.
2. Byers T, Perry G. Dietary carotenes, vitamin C, and vitamin E as protective antioxidants in human cancers. Annu Rev Nutr 1992;12: 139-59.
3. Aschiero A, Stampfer MJ, Colditz GA, Rimm EB, Litin L, Willett WC. Correlations of vitamin A and E intakes with the plasma concentrations of carotenoids and tocopherols among American men and women. J Nutr 1992;122:1792-801.
4. Willett WC, Stampfer MJ, Underwood BA, Taylor JO, Hennekens CH. Vitamins A, E, and carotene: effects of supplementation on their plasma levels. Am J Clin Nutr 1983;38:559-66.
5. Constantino JP, Huller LH, Begg L, Redmond CK, Bates MW. Serum level changes after administration of a pharmacologic dose of β-carotene. Am J Clin Nutr 1988;48:1277-83.
6. Ringer TV, DeLoof MJ, Winterrowd GE, et al. Beta-carotene's effects on serum lipoproteins and immunologic indices in humans. Am J Clin Nutr 1991;53:688-94.
7. Kaplan LA, Lau JM, Stein EA. Carotenoid composition, concentrations, and relationships in various human organs. Clin Physiol Biochem 1990;8:1-10.
8. Schmitz HH, Poor CL, Wellman RB, Erdman JWJ. Concentrations of selected carotenoids and vitamin A in human liver, kidney and lung tissue. J Nutr 1991;121:1613-21.
9. Leo MA, Rosman AS, Lieber CS. Differential depletion of carotenoids and tocopherol in liver disease. Hepatology 1993;17:977-86.
10. Tanumihardhjo SA, Furr HC, Amadee-Manesme O, Olson JA. Retinyl ester (vitamin A ester) and carotenoid composition in human liver. Int J Vitam Nutr Res 1990;60:307-13.
11. Parker RS. Carotenoid and tocopherol composition of human adipose tissue. Am J Clin Nutr 1988;47:33-6.
12. Murata T, Tamai H, Morinobu T, et al. Determination of β-carotene in plasma, blood cells and buccal mucosa by electrochemical detection. Lipids 1992;27:840-3.
13. Gilbert A-M, Stich HF, Rosin MP, Davidson AJ. Variation in the uptake of beta-carotene in the oral mucosa of individuals after 3 days of supplementation. Int J Cancer 1990;45:855-9.
14. Stich HF, Hornby AP, Dunn BP. Beta-carotene levels in exfoliated human mucosa cells following its oral administration. Cancer Lett 1986;30:133-41.
15. Norkus EP, Bhagavan HN, Nair PP. Relationship between individual carotenoids in plasma, platelets and red blood cells (RBC) of adult subjects. FASEB J 1990;4:A1174(abstr).
16. Leitner ZA, Moore T, Sharman IM. Vitamin A and vitamin E in human blood: levels of vitamin E in the blood of British men and women 1952-7. Br J Nutr 1960;14:281-7.
17. Xu MJ, Plezia PM, Alberts DS, et al. Reduction in plasma or skin alpha-tocopherol concentration with long-term oral administration of beta-carotene in humans and mice. J Natl Cancer Inst 1992;84:1559-65.
18. Mobarhan S, Shiau A, Grande A, et al. β-Carotene supplementation results in an increased serum and colonic mucosal concentration of β-carotene and a decrease in α-tocopherol concentration in patients with colonic neoplasia. Cancer Epidemiol Biomarkers Prev 1994;3: 501-5.
19. Nierenberg DW, Stukel TA, Mott LA, Greenberg ER. Steady-state serum concentration of alpha tocopherol not altered by supplementation with oral beta carotene. J Natl Cancer Inst 1994;86:117-20.
20. Mobarhan S, Bowen P, Andersen B, et al. Effect of β-carotene repletion of β-carotene absorption, lipid peroxidation, and neutrophil superoxide formation in young men. Nutr Cancer 1990;14:195-206.
21. Bendich A, Shapiro SS. Effect of β-carotene and canthaxanthin on the immune response of rats. J Nutr 1986;116:2254-62.
22. Andersen HJ, Chen H, Pellett JJ, Tappel AL. Ferrous-iron-induced oxidation in chicken liver slices as measured by hemichrome formation and thiobarbituric acid-reactive substances: effects of dietary vitamin E and β-carotene. Free Radic Biol Med 1993;15:37-48.
23. Satterfield S, Greco PJ, Goldhaber SZ, et al. Biochemical markers of compliance in the physicians' health study. Am J Prev Med 1990;6: 290-4.
24. Boyum AI. Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Invest 1968;97(suppl 21):77-89.
25. Tang G, Dolnikowski GG, Blanco MC, Fox JG, Russell RM. Serum carotenoids and retinoids in ferrets fed canthaxanthin. J Nutr Biochem 1993;4:58-63.
26. Murata T, Tamai H, Morinobu T, et al. Effect of long-term administration of β-carotene on lymphocyte subsets in humans. Am J Clin Nutr 1994;60:597-602.
27. Meydani M, Martin M, Ribaya-Mercado JD, Gong J, Blumberg JB, Russell RM. β-Carotene supplementation increases antioxidant capacity of plasma in older women. J Nutr 1994;124:2397-403.
28. Gugger ET, Bierer TL, Henze TM, White WS, Erdman JW. β-Carotene uptake and tissue distribution in ferrets (Mustela putorius furo). J Nutr 1992;122:115-9.
29. Micozzi MS, Brown ED, Edwards BK, et al. Plasma carotenoid response to chronic intake of selected foods and β-carotene supplements in men. Am J Clin Nutr 1992;55:1120-5.
30. Bowen PE, Stacewicz-Sapuntakis M, Dawicki M, Erdman JW, White WS. Interactive effect of oral beta-carotene and canthaxanthin in humans. FASEB J 1992;6:A1646(abstr).
31. White WS, Peck KM, Bierer TL, Gugger ET, Erdman JW. Interactions of oral β-carotene and canthaxanthin in ferrets. J Nutr 1993;123:1405-13.