Beta-carotene and human health: A review of current research

Nutrition Research

Volumn 17, Issue 3, 1997, Pages 547-580

  Burri, Betty Jane ^a  

^a U S DEPARTMENT OF AGRICULTURE   (United States)

Author keywords

Antioxidant; Beta Carotene; Gap Junction; Health; Human; Immunology

Indexed keywords

BETA CAROTENE; RETINOL;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; CANCER PREVENTION; CELL JUNCTION; CYSTIC FIBROSIS; DIET SUPPLEMENTATION; DIETARY INTAKE; ERYTHROPOIETIC PROTOPORPHYRIA; HEART INFARCTION PREVENTION; IMMUNOLOGY; PRIORITY JOURNAL; REVIEW; VITAMIN DEFICIENCY;

EID: 0031019633     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0271-5317(97)00011-0     Document Type: Review

References (160)

1. Bauernfeind JC. Vitamin A deficiency and its control. Orlando: Academic Press, 1986.
2. Wasantwisut E, Attig GA. Empowering vitamin A foods: A food-based process for Asia and the Pacific Region. Institute of Nutrition, Mahidol University, Thailand, 1995.
3. Sommer A, West KP Jr. Vitamin A deficiency, health, survival, and vision. New York: Oxford Press, 1996.
4. Underwood BA. Hypovitaminosis and its control. Bull WHO 1978; 56:525-41.
5. Subcommittee on the Tenth Edition of the RDAs. Recommended Dietary Allowances, 10th ed. Washington DC: National Academy Press, 1989: 115-24.
6. Gerster H. Anticarcinogenic effect of common carotenoids. Internat J Vitam Nutr Res 1993; 63:93-121.
7. Peto R, Doll R, Buckley JD, Sporn MB. Can dietary beta-carotene materially reduce human cancer rates? Nature 1981; 290:201-8.
8. van Poppel G, Goldbohm RA. Epidemiological evidence for β-carotene and cancer prevention. Am J Clin Nutr 1995; 62:1393S-402S.
9. Kohlmeier L, Hastings S. Epidemiological evidence of a role of carotenoids in cardiovascular disease prevention. Am J Clin Nutr 1995; 62:1370S-6S.
10. Gey KF, Moser UK, Jordan P, Stahelin HB, Eichholzer M, Ludin E. Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: an epidemiological update with special attention to carotene and vitamin C. Am J Clin Nutr 1993; 57:8787-97.
11. Street DA, Comstock GW, Salkeld RM, Schuep W, Klag MJ. Serum antioxidants and myocardial infarction: are low levels of carotenoids and alpha-tocopherol risk factors for myocardial infarction? Circulation 1994; 90:1154-61.
12. Eye Disease Control Study Group. Antioxidant status and neovascular age-related macular degeneration. Arch Opthalmol 1993; 111:104-9.
13. Snodderley DM. Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins. Am J Clin Nutr 1995; 62:1448S-61S.
14. Ames BN, Shigenaga M, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci (USA) 1993; 90: 7915-22.
15. Diplock AT. Safety of antioxidant vitamins and beta-carotene. Am J Clin Nutr 1995; 62:1510S-16S.
16. Albanes D, Heinonen OP, Huttunen JK, Taylor PR, Virtamo J, Edwards BK, Haapakoski J, Rautalahti M, Hartman AM, Palmgren J, Greenwald P. Effects of alpha-tocopherol and beta-carotene supplements on cancer incidence in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study. Am J Clin Nutr 1995; 62:1427S-30S.
17. Alpha-tocopherol, Beta-carotene Cancer Prevention Study Group. The effect of vitamin E and beta-carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994; 330: 1029-35.
18. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhardt S, Hammar S. Effects of a combination of beta-carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996; 334:1150-5.
19. Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR, Belanger C, LaMotte F, Gaziano JM, Ridker PM, Willett W, Peto R. Lack of effect of long-term supplementation with beta-carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 1996; 334:1145-9.
20. Epler KS, Ziegler RG, Craft NE. Liquid Chromatographic method for the determination of carotenoids, retinoids and tocopherols in human serum and in food. J Chromatogr 1993; 619:37-48.
21. Epler KS, Sander L, Zeigler RG, Wise SA, Craft NE. Evaluation of reversed-phase liquid Chromatographic columns for recovery and selectivity of selected carotenoids. J Chromatogr 1992; 595:89-101.
22. Chug-Ahuja JK, Holden JM, Forman MR, Mangels AR, Beecher GR, Lanza E. The development and application of a carotenoid database for fruits, vegetables, and selected multicomponent foods. J Am Dietet Assoc 1993; 93:318-23.
23. Mangels AR, Holden JM, Beecher GR, Forman MR, Lanza E. Carotenoid content of fruits and vegetables: an evaluation of analytic data. J Am Dietet Assoc 1993; 93:284-96.
24. Block G. Nutrient sources of provitamin A carotenoids in the American diet. Am J Epidemiol 1994; 139:290-3.
25. Alaimo K, McDowell MA, Briefel RR, Bischof AM, Caughman CR, Loria CM, Johnson CL. Dietary intakes of vitamins, minerals, and fiber of persons ages 2 months and over in the United States: Third national health and nutrition examination survey, phase 1, 1988-91. Advanced Data from Vital and Health Statistics, no 258. Hyattsville MD: National Center for Health Statistics, 1994.
26. National Center for Health Statistics (US). Plan and operation of the Third National Health and Nutrition Examination Survey, 1988-94. Vital Health Stat 1(32). Hyattsville MD: US Dept Health Human Services, 1994.
27. Burton GW, Ingold KU. Beta-carotene: an unusual type of lipid antioxidant. Science 1984; 224:569-73.
28. Canfield LM, Forage JW, Valenzuela JG. Carotenoids as cellular antioxidants. Proc Soc Exper Biol Med 1992; 200:260-5.
29. Zhang L, Cooney RV, Bertram JS. Carotenoids up-regulate connexin43 gene expression independent of their pro-vitamin A or antioxidant properties. Cancer Res 1992; 52:5707-12.
30. Bertram JS, Bortkiewicz H. Dietary carotenoids inhibit neoplastic transformation and modulate gene expression in mouse and human cells. Amer J Clin Nutr 1995; 62:1327S-36S.
31. Bendich A. Beta-carotene and the immune response. Proc Nutr Soc 1991; 50: 263-74.
32. Prabhala RH, Garewal HS, Hicks MJ, Sampliner RE, Watson RR. The effects of 13-cis retinoic acid and beta-carotene on cellular immunity in humans. Cancer 1991; 67:1556-60.
33. Hoppe PP, Chew BP, Safer A, Stegemann I, Biesalski H. Dietary beta-carotene elevates plasma steady-state and tissue concentrations of beta-carotene and enhances vitamin A balance in preruminant calves. J Nutr 1996; 126:202-8.
34. Dueker SR, Jones AD, Smith GM, Clifford AJ. Stable isotope methods for the study of beta-carotene-d8 metabolism in humans using tandem mass spectrometry and high performance liquid chromatography. Anal Chem 1994; 66:4177-85.
35. Law C, Raad D. Beta-carotene fall from grace draws mixed reaction. J Natl Cancer Inst 1996; 88:235-6.
36. Rowe PM. Beta-carotene takes a collective beating. Lancet 1996; 347:249.
37. Mares-Perlman JA, Brady WE, Klein BEK, Klein R, Palta M, Bowen P, Stacewicz-Sapuntzakis M. Serum carotenoids and tocopherols and severity of nuclear and cortical opacities. Invest Ophtalmol Vis Sci 1995; 36:276-88.
38. Zeigler RG, Colavito EA, Hartge P, McAdams MJ, Schoenberg JB, Mason TJ, Fraumeni JF. Importance of alpha-carotene, beta-carotene and other phytochemicals in the etiology of lung cancer. J Natl Cancer Inst 1996; 88:612-5.
39. De Pee S, West CE, Muhilal, Karyadi D, Hautvast JGAJ. Lack of improvement in vitamin A status with increased consumption of dark-green leafy vegetables. Lancet 1995; 346:75-81.
40. Phillips M, Sanghvi T, Suarez R, McKigney J, Fiedler J. The costs and effectiveness of three vitamin A interventions in Guatemala. Soc Sci Med 1996: 42:1661-8.
41. Sharpless KE, Thomas JB, Sander LC, Wise SA. Liquid-chromatographic determination of carotenoids in human serum using an engineered C-30 and a C-18 stationary phase. J Chromatogr B 1996; 678:187-95.
42. Brady WE, Mares-Perlman JA, Bowen P, Stacewicz-Sapuntzakis M. Human serum carotenoid concentrations are related to physiologic and lifestyle patterns. J Nutr 1996; 126:129-37.
43. Ito Y, Ochiai J, Saski R, Suzuki S, Yasuhiro K, Kusuhara Y, Morimitsu Y, Otani M, Aoki K. Serum concentrations of carotenoids, retinol, and alpha-tocopherol in healthy persons determined by high-performance liquid chromatography. Clin Chim Acta 1990; 194:131-44.
44. Van Popple G, Kok FJ, Hermus RJJ. Beta-carotene supplementation in smokers reduces the frequency of micronuclei in sputum. Br J Cancer 1992; 66:1164-8.
45. Rougereau A, Person O, Rougereau G: Retinol, beta-carotene and alpha-tocopherol status in a French population of healthy subjects Int J Vit Nutr Res 1987; 57:31-35.
46. Kaplan LA, Stein EA, Willett WC, Stampfer MJ, Stryker WS. Reference ranges of retinol, tocopherols, lycopene and alpha-and beta-carotene in plasma by simultaneous high-performance liquid Chromatographic analysis. Clin Physiol Biochem 1987; 5:297-304.
47. Roggi C, Silva S, Tenconi MT, Simonetti F, Porrini M, Testolin G, Maccarini L, Mazzei B, Meroni G. Distribution of serum retinol, alpha-tocopherol and beta-carotene in a sample of population. L'igiene Moderna 1991; 95:628-42.
48. Stacewicz-Sapuntzakis M, Bowen PE, Kikendall JW, Burgess M. Simultaneous determination of serum retinol and various carotenoids:their distribution in middle-aged men and women. J Micronutr Anal 1987; 3:27-45.
49. Block G. Antioxidant intake in the U.S. Toxicol Indust Health 1993; 9:295-301.
50. Pandey DK, Shekelle R, Selwyn BJ, Tangney C, Stamler J. Dietary vitamin C and beta-carotene and risk of death in middle-aged men, the Western Electric study. Am J Epidemiol 1995; 142:1269-78.
51. LeMarchand L, Hankin JH, Bach F, Kolonel LN, Wilkens LR, Stacewicz-Sapuntzakis M, Bowen PE, Beecher GR, Laudon F, Baque P, Daniel R, Seruvatu L, Henderson BE. Intake of specific carotenoids and lung cancer risk. Cancer Epid Biomark Prevent 1993; 2:183-7.
52. Wang X-D, Krinsky NI, Marini RP, Tang G, Yu J, Hurley R, Fox JG, Russell RM. Intestinal uptake and lymphatic absorption of β-carotene in ferrets: a model for human β-carotene metabolism. Am J Physiol 1992; 263:480-6.
53. Poor CL, Bierer TL, Merchen NR, Fahey GC Jr, Murphy MR, Erdman JW Jr. Evaluation of the preruminant calf as a model for the study of human carotenoid metabolism. J Nutr 1992; 122:262-8.
54. Handelman GL, Haskell MJ, Jones AD, Clifford AJ, Improved GC/MS determination of d4-retinol/retinol ratios in human plasma. Anal Chem 1993; 65:2024-8.
55. Parker RS. Carotenoids in human blood and tissues. J Nutr 1989; 119:101-4.
56. 13C-beta-carotene and high precision isotope ratio mass spectrometry. Ann N Y Acad Sci 1993; 691:86-95.
57. Parker RS. Absorption, metabolism, and transport of carotenoids. FASEB J 1996; 10:542-51.
58. Novotny JA, Dueker SR, Zech LA, Clifford AJ. Compartmental analysis of the dynamics of β-carotene metabolism in an adult volunteer. J Lipid Res 1995; 36:1825-38.
59. McCollum EV, Davis M. The nature of the dietary deficiencies of rice. J Biol Chem 1915; 23:181-4.
60. Sommer A. Vitamin A, infectious disease and childhood mortality; a 2 cent solution? J Infect Dis 1993; 167:1003-7.
61. Fawsi WW, Chalmers TC, Herrera G, Mosteller F. Vitamin A supplementation and child mortality: a meta-analysis. JAMA 1993; 269:898-903.
62. Carlier C, Coste J, Etchepare M, Periquet B, Amedee-Manesme O. A randomized trial to test equivalence between retinyl palmitate and beta-carotene for vitamin A deficiency. Brit Med J 1993; 307:1106-10.
63. Moore T. Vitamin A and carotene. VI. The conversion of beta carotene to vitamin A in vivo. Biochem J 1930; 24:692-702.
64. Glover J. The conversion of beta-carotene into vitamin A. Vitam Horm 1960; 18:371-86.
65. Goodman DS, Huang HS. Biosynthesis of vitamin A with rat intestinal enzymes. Science 1965; 149:879-80.
66. Olson JA, Hayaishi O. The enzymatic cleavage of beta-carotene into vitamin A by soluble enzymes of rat liver and intestine. Proc Natl Acad Sci (USA) 1965; 54:1364-9.
67. Blomstrand R, Werner B. Studies on the intestinal absorption of radioactive β-carotene and vitamin A in man: conversion of β-carotene into vitamin A. Scand J Clin Lab Invest 1967; 19:339-345.
68. Goodman DS, Blomstrand R, Werner B, Huang HS, Shiratori T. The intestinal absorption and metabolism of vitamin A and β-carotene in man. J Clin Invest 1966; 45:1615-23.
69. Ganguly J, Sastry PS. Mechanism of conversion of beta-carotene into vitamin A - central cleavage versus random cleavage. World Rev Nutr Dietet 1985; 45:198-220.
70. Olson JA. Provitamin A function of carotenoids: the conversion of β-carotene into vitamin A. J Nutr 1989; 119:105-8.
71. Van Vliet T. Intestinal absorption and cleavage of β-carotene in rat, hamster and human models. Delft: Eburon P&L. 1995.
72. Canfield LM, Forage JW, Valenzuela JG. Carotenoids as cellular antioxidants. Proc Soc Exp Biol Med 1992; 200:260-5.
73. Moreno FS, Rossiello MR, Manjeshwar S, Nath R, Rao PM, Rajalakshmi S, Sarma DSR. Effect of beta-carotene on the expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat liver. Cancer Lett 1995; 96:201-8.
74. Frommel TO, Lietz H, Mobarhan S. Expression of mRNA for the gap-junctional protein connexin 43 in human colonic tissue is variable in response to beta-carotene supplementation. Nutr Cancer 1994; 22:257-65.
75. Zhang L-X, Cooney RV, Bertram JS. Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action. Carcinogenesis 1991; 12:2109-14.
76. Allard JP, Royall D, Kurian R, Muggli R, Jeejeebhoy KN. Effects of β-carotene supplementation on lipid peroxidation in humans. Am J Clin Nutr 1994; 59:884-90.
77. Jialal I, Norkus EP, Cristol L, Grundy SM. β-Carotene inhibits the oxidative modification of low-density lipoprotein. Biochim Biophys Acta 1991; 1086:134-8.
78. Sies H, Stahl W. Vitamins E and C, beta-carotene, and other carotenoids as antioxidants. Am J Clin Nutr 1995; 62:13158-21S.
79. Dixon ZR, Burri BJ, Clifford AJ, Frankel EN, Schneeman BO, Parks E, Keim NL, Barbieri T, Wu M-M, Fong AKH, Kretsch MJ, Sowell AL, Erdman JW Jr. Effects of a carotene-deficient diet on measures of oxidative susceptibility and superoxide dismutase activity in adult women. Free Rad Med Biol 1994; 6:537-44.
80. Colacchio TA, Memoli VA, Hildebrandt L. Antioxidants vs carotenoids. Inhibitors or promoters of experimental colorectal cancers. Arch Surg 1989; 124:217-21.
81. Princen HMG, van Popple G, Vogelezang C, Buytenhek R, Kok FJ. Supplementation with vitamin E but not beta-carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro: Effect of cigarette smoking. Arterioscler Thromb 1992; 12:554-62.
82. Reaven PD, Khouw A, Beltz WF, Parthasarathy S, Witztum JL. Effect of dietary antioxidant combinations in humans: Protection of LDL by vitamin E but not by β-carotene. Arterioscler Thromb 1993; 13:590-600.
83. Van Antwerpen VL, Theron AJ, Richards GA, Van Der Merwe CA, Viljoen E, Van Der Walt R, Anderson R. Plasma levels of beta-carotene are inversely correlated with circulating neutrophil counts in young male cigarette smokers. Inflammation 1995; 19:405-414.
84. Clausen SW. Carotenemia and resistance to infection. Trans Am Pediatr Soc 1931; 43:27-30.
85. Green HN, Mellanby E. Carotene and vitamin A: the anti-infective action of carotene. Br J Exper Pathol 1930; 11:81-9.
86. Alexander M, Newmark H, Miller RG. Oral beta carotene can increase the number of OKT4+ cells in human blood. Immun Let 1985; 9:221-4.
87. Bendich A, Shapiro SS. Effect of beta-carotene and canthaxanthin on the immune responses of the rat. J Nutr 1986; 116:2254-62.
88. Daudu PA, Kelley DS, Taylor PC, Bum BJ, Wu MM. Effect of a low β-carotene diet on the immune functions of adult women. Am J Clin Nutr 1994; 60:969-72.
89. Bruggemann J, Niesark K-H. Über die Beziehung der vitamine A und E und des β-carotins zum weiblichen sexualzyklus des rindes und schweines unter besonderer berucksichtigung der zyklussterilitat. Vit Horm 1957; 7:10-25.
90. Burri BJ. Serum thyroid hormone concentrations may increase during carotenoid depletion of healthy adult women. J Nutr Biochem 1995; 6:613-7.
91. Kretsch MJ, Fong AKH, Burri BJ, Jacob RA. Menstrual cycle abnormalities associated with low carotenoid diets. FASEB J 1995; 9:A997.
92. Hemken RW, Bremel DH. Possible role of beta-carotene in improving fertility in dairy cattle. J Dairy Sci 1982; 65:1069-73.
93. Pres J, Fuchs B, Schleicher A. The effect of carotene and vitamins A and E supplementation on the reproduction of sows. Archiv Vetrin Polon 1993; 33:55-64.
94. Hughes GS Jr., Ringer TV, Francom SF, Means LK, DeLoof MJ. Lack of effects of beta-carotene on lipids and sex steroid hormones in hyperlipidemics. Am J Med Sci 1994; 308:16-22.
95. Hume EM, Krebs HA. Vitamin A requirements of human adults: an experimental study of vitamin A deprivation in man. 1949; His Majesty's Stationery Office, London, 1949.
96. Sauberlich HE, Hodges HE, Wallace DL, Kolder H, Canham JE, Hood J, Raica N, Lowry LK. Vitamin A metabolism and requirements in the human studied with the use of labeled retinol. Vitam Horm 1974; 32:237-49.
97. Rodriguez MS, Irwin MI. A conspectus of research on vitamin A requirements of man. J Nutr 1972; 102:909-68.
98. Bum BJ, Neidlinger T, Clifford AJ. Serum beta-carotene concentrations during carotenoid depletion may be influenced by the body pool of vitamin A. FASEB J 1996; 10:A1371.
99. Brubacher GB, Weiser H. The vitamin A activity of beta-carotene. Int J Vit Nutr Res 1985; 55:5-15.
100. Jayarajan P, Reddy V, Mohanram M. Effect of dietary fat on absorption of β-carotene from green leafy vegetables in children. Indian J Med Res 1980; 71:53-6.
101. Rao CN, Rao BSN. Absorption of dietary carotenes in human subjects. Am J Clin Nutr 1970; 23:105-9.
102. De Pee S, West CE. Dietary carotenoids and their role in combating vitamin A deficiency: a review of the literature. Eur J Clin Nutr 1996; 50:S38-S53.
103. Brown ED, Micozzi MS, Craft NE, Bieri JG, Beecher G, Edwards BK, Rose A, Taylor PR, Smith JC Jr. Plasma carotenoids in normal men after a single ingestion of vegetables or purified beta-carotene. Am J Clin Nutr 1989; 49:1258-65.
104. Canfield LM, Bulux J, de Serrano JQ, Rivera C, Lima AF, Lopez CY, Perez R, Khan LK, Harrison GG, Solomons NW. Plasma response to oral beta-carotene in Guatemalan school children. Am J Clin Nutr 1991; 54:539-47.
105. Block G. The data support a role for antioxidants in reducing cancer risk. Nutr Rev 1992; 50:207-13.
106. Van Poppel G. Carotenoids and cancer; an update with emphasis on human intervention studies. Eur J Cancer 1993; 29A:1335-44.
107. Blumberg JB. Considerations of the scientific substantiation for antioxidant vitamins and β-carotene in disease prevention. Am J Clin Nutr 1995; 62:1521S-6S.
108. Flagg EW, Coates RJ, Greenberg RS. Epidemiological studies of antioxidants and cancer in humans. J Am Coll Nutr 1995; 14:419-27.
109. Torun M, Yardim S, Sargin H, Simsek B. Evaluation of serum beta-carotene levels in patients with cardiovascular diseases. J Clin Pharm Therapeut 1994; 19:61-3.
110. Gey KF, Stahelin HB, Ballmer PE. Essential antioxidants in cardiovascular disease: lessons from Europe. Ther Umsch 1994; 51:465-82.
111. Olson JA. Benefits and liabilities of vitamin A and carotenoids. J Nutr 1996; 126:1208S-12S.
112. Bohm F, Haley J, Truscott TG, Schalch W. Cellular bound beta-carotene quenches singlet oxygen in man. J Photochem Photobiol B: Biol 1993; 21:219-21.
113. Gey KF. Ten-year retrospective on the antioxidant hypothesis of arteriosclerosis: Threshold plasma levels of antioxidant micronutrients related to minimum cardiovascular risk. Nutr Biochem 1995; 6:206-36.
114. Kramer, T. R., and Burn, B. J. Modulation of T-lymphocyte proliferation by low-carotene diet and mixed-carotenoid supplementation of women. Am J Clin Nutr In Press.
115. Curran-Celentano J, Erdman JW Jr. A case study of carotenemia in anorexia nervous may support the interrelationship of vitamin A and thyroid hormone. Nutr Res 1993; 13:379-86.
116. Bartley W, Krebs HA, O'Brien JRP. Vitamin C requirements of human adults: a report by the vitamin C subcommittee of the accessory food factors committee. London: Her Majesty's Stationery Office, London, 1953.
117. Hodges RE, Canham JE. Vitamin C deficiency and experimental vitamin A deficiency in men. In: Proceeding of a workshop on problems of assessment and alleviation of malnutrition in the United States, ed Hansen RG, Munro HN. Washington DC: US Govt Printing Office, 1970, 115-28.
118. Hodges RE, Sauberlich HE, Canham JE, Wallace DL, Rucker RB, Mejia LA, Mohanram M. Heamatopoietic studies in vitamin A deficiency. Am J Clin Nutr 1978; 31:876-85.
119. Hodges RE, Canham JE. Vitamin deficiencies: studies of experimental vitamin C deficiency and experimental vitamin A deficiency in man. US Army Fitzimmons Reports 1970:115-28.
120. 14C acid in experimental human scurvy. Am J Clin Nutr 1969; 22:549-58.
121. Mobarhan S, Bowen P, Andersen B, Evans M, Stacewicz-Sapuntzakis M, Sugerman S, Simms P, Lucchesi D, Friedman H. Effects of beta-carotene repletion on beta-carotene absorption, lipid peroxidation, and neutrophil superoxide formation in young men. Nutr Cancer 1990; 14:195-206.
122. Omaye ST, Burri BJ, Swenseid ME, Henning SM, Stone LA, Bowen HT, Ota RB. Blood antioxidants changes in young women following β-carotene depletion and repletion. J Am Coll Nutr. In press.
123. Burri BJ, Dixon ZR, Fong AK, Kretsch MJ, Erdman, J. Possible association of skin lesions with a low carotene diet in premenopausal women. Ann N Y Acad Sci 1993; 691:290-1.
124. Dixon ZR, Shie F-S, Warden BA, Burri BJ. Effect of low carotene diet on malondialdehyde. FASEB J 1996; 10:A1380.
125. Lin Y, Burri BJ, Neidlinger TR, Clifford AJ. Effect of low dietary carotene intake on oxidative susceptibility in women. FASEB J 1996; 10:A2756.
126. Masaki K, Doi T, Yuge K, Yoshioka Y, Nagata Y. Plasma β-carotene response to intake of β-carotene drink in normal men. Ann N Y Acad Sci 1993; 691:290-2.
127. Ringer TV, DeLoof MJ, Winterrowd GE, Francom SF, Gaylor SK, Ryan JA, Sanders ME, Hughes GS. Beta-carotene's effects on serum lipoproteins and immunologic indices in humans. Am J Clin Nutr 1991; 53:688-94.
128. Constantino JP, Kuller LH, Begg L, Redmond CK, Bates MW. Serum level changes after administration of a pharmacologic dose of beta-carotene. Am J Clin Nutr 1988; 48:1277-83.
129. Blot WJ, Li JY, Taylor PR, Guo W, Dawsey S, Wang GQ, Yang CS, Zheng SF, Gail M, Li GY, Yu Y, Liu BQ, Tangrea J, Sun YH, Liu F, Fraumeni JF, Zhang YH, Li B. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst 1993; 85:1483-92.
130. Blot WJ, Li J, Taylor PR, Guo W, Dawsey SM, Li B. The Linxian trials: mortality rates by vitamin-mineral intervention group. Amer J Clin Nutr 1995; 62:1424S-26S.
131. Van Poppel G, Kok FJ, Duijzings P de Vogel N. No influence of beta-carotene on smoking-induced DNA damage as reflected by sister chromatid exchanges. Int J Cancer 1992; 51:355-8.
132. McLarty JW, Holiday DB, Girard WM, Yanagihara RH, Kummet TD, Greenberg SD. β-Carotene, vitamin A, and lung cancer chemoprevention: results of an intermediate endpoint study. Am J Clin Nutr 1995; 62:1431S-8S.
133. Micozzi MS, Brown ED, Taylor PR, Wolfe E. Carotenodermia in men with elevated carotenoid intake from foods and beta-carotene supplements. Am J Clin Nutr 1988; 48:1061-4.
134. Biesalski HK, Hemmes C, Hopfenmuller W, Schmid C, Gollnick HP. Effects of controlled exposure of sunlight on plasma and skin levels of β-carotene. Free Rad Res 1996; 24:215-24.
135. Greenberg ER, Baron JA, Karagas MR, Stukel TA, Nierenberg DW, Stevens MM, Mandel JS, Haile RW. Mortality associated with low plasma concentration of beta-carotene and the effect of oral supplementation. JAMA 1996; 275:699-703.
136. Ribaya-Mercado JD, Ordovas JM, Russell RM, Effect of beta-carotene supplementation on the concentration and distribution of carotenoids, vitamin E, vitamin A, and cholesterol in plasma lipoprotein and non-lipoprotein fractions in healthy older women. J Am Coll Nutr 1995; 14:614-20.
137. Mathews-Roth MM. Beta-carotene therapy for erythropoetic protoporphyria and other photosensitivity diseases. Biochimie 1986; 68:875-84.
138. Mathews-Roth M. Lack of genotoxicity with beta-carotene. Toxicol Lett 1988; 41:185-91.
139. Taylor PR, Wang G-Q, Dawsey SM, Guo W, Mark SD, Li J-Y, Blot WJ, Li B. Effect of nutrient intervention on intermediate endpoints in esophageal and gastric carcinogenesis Am J Clin Nutr 1995; 62:1420S-3S.
140. De Vet HCW, Knipschild PG, Willebrand D, Schouten HJA, Sturmans F. The effect of beta-carotene on the regression and progression of cervical dysplasia: a clinical experiment. J Clin Epidemiol 1991; 44:273-83.
141. Garewal HS. Antioxidants in oral cancer prevention. Am J Clin Nutr 1995; 62:1410S-6S.
142. Stich HF, Mathew B, Sankaranarayana R, Nair MK. Remission of oral precancerous lesions or tobacco/areca nut chewers following administration of beta-carotene or vitamin A, and maintenance of the protective effect. Cancer Detect Prev 1991; 15:93-8.
143. Mayne ST. Beta-carotene, carotenoids, and disease prevention in humans. FASEB J. 1996; 10:690-701.
144. Nyyssonen K, Porkkala E, Salonen R, Korpela H, Salonen JT. Increase in oxidation resistance of atherogenic serum lipoproteins following antioxidant supplementation - a randomized double-blind placebo controlled clinical trial. Eur J Clin Nutr 1994; 48:633-42.
145. Meydani M, Martin A, Ribaya-Mercado JD, Gong J, Blumberg J B, Russell RM. Beta-carotene supplementation increases antioxidant capacity of plasma in older women. J Nutr 1994; 124:2397-403.
146. Gaziano JM, Hatta A, Flynn M, Johnson EJ, Krinsky NI, Ridker PM, Hennekens CH, Frie B. Supplementation with beta-carotene in vivo and in vitro does not inhibit low density lipoprotein oxidation. Atherosclerosis 1995; 112:187-95.
147. Olmedilla B, Granado F, Blanco I. Hyper-β-carotenemia unrelated to diet: a case of brain tumor. Internat J Vit Nutr Res 1995; 65:21-3.
148. Moore MR, McColl KEL, Rimington C, Goldberg A. Disorders of porphyrin metabolism. New York: Plenum 1988, 201-11.
149. Todd DJ. Erythropoetic protoporphyria. Brit J Dermatol 1994; 131:751-66.
150. Mathews-Roth MM. Carotenoids in erythropoetic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci 1993; 691:127-138.
151. Gollnick H, Hofenmuller W, Hemmes C, Chun SC, Schmid C, Sundermeier K, Biesalski HK. Systemic beta-carotene plus topical UV-sunscreen are an optimal protection against harmful effects of natural UV-sunlight: results of the Berlin-Eilath study. Eur J Dermatol 1996; 6:200-5.
152. Homnick DN, Cox JH, DeLoof MJ, Ringer TV. Carotenoid levels in normal children and in children with cystic fibrosis. J Pediatr 1993; 122:703-7.
153. Bui MH. Vitamin A, provitamin A and vitamin E serum concentrations in cystic fibrosis patients. Internat J Vit Nutr Res 1988; 58:354-5.
154. Portal BC, Richard M-J, Faure HS, Hadjian AJ, Favier AE. Altered antioxidant status and increased lipid peroxidation in children with cystic fibrosis. Am J Clin Nutr 1995; 61:843-7.
155. Winklhofer-Roob BM, Puhl H, Khoschsorur G, van't Hof MA, Esterbauer H, Shmerling DH. Enhanced resistance to oxidation of low density lipoproteins and decreased lipid peroxide formation during β-carotene supplementation in cystic fibrosis. Free Rad Biol Med 1995; 18:849-59.
156. Lepage G, Champagne J, Ronco N, Lamarre A, Osberg I, Sokol RJ, Roy CC. Supplementation with carotenoids corrects increased lipid peroxidation in children with cystic fibrosis. Am J Clin Nutr 1996; 64:87-93.
157. Phuaprad W, Caturac K, Taneepan S, Sirivara J, Khupulsu K, Lerdvuth N. Serum vitamin A and beta-carotene levels in pregnant women infected with human immunodeficiency virus. Obstet Gyn 1996; 87:564-7.
158. Coodley GO, Nelson HD, Loveless MO, Folk C Beta-carotene in HIV infection. J Acquir Immun Def Synd 1993;6:272-6.
159. Garewal HS, Ampel NM, Watson RR, Prabhala RH, Dois CL A preliminary trial of beta-carotene in subjects infected with the human immunodeficiency virus. J Nutr 1992; 122:728-32.
160. Fryburg DA, Mark RJ, Griffith BP, Askenase PW, Patterson TF. The effect of supplemental beta-carotene on immunologic indices in patients with AIDS: a pilot study. Yale J Biol Med 1995;68:19-23.