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Volumn 24, Issue 10, 1999, Pages 1099-1106

Ras farnesyltransferase inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

2 [[2 [[2 [(2 AMINO 3 MERCAPTOPROPYL)AMINO] 3 METHYLPENTYL]OXY] 1 OXO 3 PHENYLPROPYL]AMINO] 4 (METHYLSULFONYL)BUTANOIC ACID ISOPROPYL ESTER; 4 (8 CHLORO 5,6 DIHYDRO 11H BENZO[5,6]CYCLOHEPTA[1,2 B]PYRIDIN 11 YLIDENE) 1 (4 PYRIDYLACETYL)PIPERIDINE; 4 [2 [4 [3,10 DIBROMO 8 CHLORO 6,11 DIHYDRO 5H BENZO(5,6) CYCLOHEPTA[1,2 B]PYRIDIN 11 YL] 1 PIPERIDINYL] 2 OXOETHYL] 1 PIPERIDINECARBOXAMIDE; B 581; BENZODIAZEPINE; BENZYLOXYCARBONYLHISTIDYL(O BENZYLTYROSYL)(O BENZYLSERYL)TRYPTOPHYL DEXTRO ALANINAMIDE; BZA 2B; DIMETHYLALLYLTRANSFERASE; L 731734; L 731735; L 745631; N (8 AMINO 2 BENZYL 5 ISOPROPYL 9 MERCAPTO 3,6 NONADIENOYL)METHIONINE; N (8 AMINO 2 BENZYL 5 ISOPROPYL 9 MERCAPTO 3,6 NONADIENOYL)METHIONINE METHYL ESTER; N [2 [2 (2 AMINO 3 MERCAPTOPROPYLAMINO) 3 METHYLPENTYLOXY] 3 PHENYLPROPIONYL]METHIONINE SULFONE; N [2 [2 (2 AMINO 3 MERCAPTOPROPYLAMINO) 3 METHYLPENTYLOXY] 3 PHENYLPROPIONYL]METHIONINE SULFONE METHYL ESTER; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; PD 152440; PD 169451; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; TIPIFARNIB; UNCLASSIFIED DRUG;

EID: 0032696858     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1999.024.10.858630     Document Type: Review
Times cited : (12)

References (59)
  • 2
    • 0024406286 scopus 로고
    • All ras proteins are polyisoprenylated but only some are palmitoylated
    • Hancock, J.F., Magee, A.I., Chilad, J.E., Marshall, C.J. All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 1989, 57: 1167-77.
    • (1989) Cell , vol.57 , pp. 1167-1177
    • Hancock, J.F.1    Magee, A.I.2    Chilad, J.E.3    Marshall, C.J.4
  • 3
    • 0024316475 scopus 로고
    • Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans
    • Schafer, W.R., Kim, R., Sterne, R., Thorner, J., Kim, S-H., Rine, J. Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans. Science 1989, 245: 379-85.
    • (1989) Science , vol.245 , pp. 379-385
    • Schafer, W.R.1    Kim, R.2    Sterne, R.3    Thorner, J.4    Kim, S.-H.5    Rine, J.6
  • 5
    • 0025194466 scopus 로고
    • Inhibition of purified p21 ras farnesyl:Protein transferase by Cys-AAX tetrapeptides
    • Reiss, Y., Goldstein, J.L., Seabra, M.C., Casey, P.J., Brown, M.S. Inhibition of purified p21 ras farnesyl:protein transferase by Cys-AAX tetrapeptides. Cell 1990, 62: 81-8.
    • (1990) Cell , vol.62 , pp. 81-88
    • Reiss, Y.1    Goldstein, J.L.2    Seabra, M.C.3    Casey, P.J.4    Brown, M.S.5
  • 6
    • 0026521412 scopus 로고
    • Endoproteolytic processing of a farnesylated peptide in vitro
    • Ashby, M.N., King, D.S., Rine, J. Endoproteolytic processing of a farnesylated peptide in vitro. Proc Natl Acad Sci USA 1992, 89: 4613-7.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4613-4617
    • Ashby, M.N.1    King, D.S.2    Rine, J.3
  • 7
    • 0026680433 scopus 로고
    • A microsomal endoprotease that specifically cleaves isoprenylated peptides
    • Ma, Y-T., Rando, R.R. A microsomal endoprotease that specifically cleaves isoprenylated peptides. Proc Natl Acad Sci USA 1992, 89: 6275-9.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6275-6279
    • Ma, Y.-T.1    Rando, R.R.2
  • 8
    • 0031664339 scopus 로고    scopus 로고
    • Roles of prenyl protein proteases in maturation of Saccharomyces cerevisiae α-factor
    • Boyartchuk, V.L., Rine, J. Roles of prenyl protein proteases in maturation of Saccharomyces cerevisiae α-factor. Genetics 1998, 150: 95-101.
    • (1998) Genetics , vol.150 , pp. 95-101
    • Boyartchuk, V.L.1    Rine, J.2
  • 9
    • 0033605743 scopus 로고    scopus 로고
    • Cloning and characterization of a mammalian prenyl protein specific protease
    • Otto, J.C., Kim, E., Young, S.G., Casey, P.J. Cloning and characterization of a mammalian prenyl protein specific protease. J Biol Chem 1999, 274: 8379-82.
    • (1999) J Biol Chem , vol.274 , pp. 8379-8382
    • Otto, J.C.1    Kim, E.2    Young, S.G.3    Casey, P.J.4
  • 10
    • 0000081175 scopus 로고
    • Posttranslational modification of the Ha-ras oncogene protein: Evidence for a third class of protein carboxyl methyltransferases
    • Clarke, S., Vogel, J.P., Deschenes, R.J., Stock, J. Posttranslational modification of the Ha-ras oncogene protein: Evidence for a third class of protein carboxyl methyltransferases. Proc Natl Acad Sci USA 1988, 85: 4643-6.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 4643-4646
    • Clarke, S.1    Vogel, J.P.2    Deschenes, R.J.3    Stock, J.4
  • 11
    • 0026346215 scopus 로고
    • Methylation and demethylation reactions of guanine nucleotidebinding proteins of retinal rod outer segments
    • Perez-Sala, D., Tan, E.W., Canada, F.J., Rando, R.R. Methylation and demethylation reactions of guanine nucleotidebinding proteins of retinal rod outer segments. Proc Natl Acad Sci USA 1991, 88, 3043-6.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 3043-3046
    • Perez-Sala, D.1    Tan, E.W.2    Canada, F.J.3    Rando, R.R.4
  • 12
    • 0029789954 scopus 로고    scopus 로고
    • Purification of a protein palmitoyl transferase that acts on H-Ras protein and on C-terrninal N-ras peptide
    • Liu, L., Dudler, T., Gelb, M.H. Purification of a protein palmitoyl transferase that acts on H-Ras protein and on C-terrninal N-ras peptide. J Biol Chem 1996, 271: 23269-76.
    • (1996) J Biol Chem , vol.271 , pp. 23269-23276
    • Liu, L.1    Dudler, T.2    Gelb, M.H.3
  • 13
    • 0029127725 scopus 로고
    • Binding of prenylated and polybasic peptides to membranes: Affinities and intervesicle exchange
    • Ghomashchi, F., Zhang, X., Liu, L., Gelb, M. Binding of prenylated and polybasic peptides to membranes: Affinities and intervesicle exchange. Biochemistry 1995, 34: 11910-8.
    • (1995) Biochemistry , vol.34 , pp. 11910-11918
    • Ghomashchi, F.1    Zhang, X.2    Liu, L.3    Gelb, M.4
  • 14
    • 0030909826 scopus 로고    scopus 로고
    • Crystal structure of protein farnesyl transferase at 2.25 Å resolution
    • Park, H., Boduliri, S., Moomaw, J., Casey, P., Beese, L. Crystal structure of protein farnesyl transferase at 2.25 Å resolution. Science 1997, 275: 1800-4.
    • (1997) Science , vol.275 , pp. 1800-1804
    • Park, H.1    Boduliri, S.2    Moomaw, J.3    Casey, P.4    Beese, L.5
  • 15
    • 0032564385 scopus 로고    scopus 로고
    • Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue
    • Strickland, C.L., Windsor, W.T., Syto, R. et al. Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue. Biochemistry 1998, 37: 16601-11.
    • (1998) Biochemistry , vol.37 , pp. 16601-16611
    • Strickland, C.L.1    Windsor, W.T.2    Syto, R.3
  • 16
    • 0023068346 scopus 로고
    • The ras oncogen
    • Barbacid, M. The ras oncogen. Annu Rev Biochem 1987, 56: 779-828.
    • (1987) Annu Rev Biochem , vol.56 , pp. 779-828
    • Barbacid, M.1
  • 17
    • 0028835253 scopus 로고
    • A peptidomimetic inhibitor of farnesyl:Protein transferase blocks the anchorage-dependent and independent growth of human tumor cell lines
    • Sepp-Lorenzino, L., Ma, Z., Rands, E. et al. A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and independent growth of human tumor cell lines. Cancer Res 1995, 55: 5302-9.
    • (1995) Cancer Res , vol.55 , pp. 5302-5309
    • Sepp-Lorenzino, L.1    Ma, Z.2    Rands, E.3
  • 18
    • 0033016719 scopus 로고    scopus 로고
    • Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB
    • Du, W., Lebowitz, P.F., Prendergast, G.C. Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB. Mol Cell Biol 1999, 19: 1831-40.
    • (1999) Mol Cell Biol , vol.19 , pp. 1831-1840
    • Du, W.1    Lebowitz, P.F.2    Prendergast, G.C.3
  • 19
    • 0030865773 scopus 로고    scopus 로고
    • Ras farnesyltransferase: A new therapeutic target
    • Leonard, D.M. Ras farnesyltransferase: A new therapeutic target. J Med Chem 1997, 30: 2971-90.
    • (1997) J Med Chem , vol.30 , pp. 2971-2990
    • Leonard, D.M.1
  • 20
    • 0031943826 scopus 로고    scopus 로고
    • Inhibitors of protein farnesylation 1998
    • Williams, T.M. Inhibitors of protein farnesylation 1998. Exp Opin Ther Patents 1998, 8: 553-69.
    • (1998) Exp Opin Ther Patents , vol.8 , pp. 553-569
    • Williams, T.M.1
  • 21
  • 22
    • 0027248872 scopus 로고
    • Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor
    • Kohl, N. E., Mosser, S.D., de Solms, S.J. et al. Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science 1993, 260: 1934-7.
    • (1993) Science , vol.260 , pp. 1934-1937
    • Kohl, N.E.1    Mosser, S.D.2    De Solms, S.J.3
  • 23
    • 0028211246 scopus 로고
    • Pseudopeptide inhibitors of ras farnesyl-protein transferase
    • Graham, S.L., de Solms, S.J., Giuliani, E.A. et al. Pseudopeptide inhibitors of ras farnesyl-protein transferase. J Med Chem 1994, 37: 725-32.
    • (1994) J Med Chem , vol.37 , pp. 725-732
    • Graham, S.L.1    De Solms, S.J.2    Giuliani, E.A.3
  • 24
    • 0028603395 scopus 로고
    • Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice
    • Kohl, N.E., Wilson, F.R., Mosser, S.D. et al. Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice. Proc Natl Acad Sci USA 1994, 91: 9141-5.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9141-9145
    • Kohl, N.E.1    Wilson, F.R.2    Mosser, S.D.3
  • 25
    • 0028318136 scopus 로고
    • Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton
    • Prendergast, G.C., Davide, J.P., de Solms, S.J. et al. Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton. Mol Cell Biol 1994, 14: 4193-202.
    • (1994) Mol Cell Biol , vol.14 , pp. 4193-4202
    • Prendergast, G.C.1    Davide, J.P.2    De Solms, S.J.3
  • 26
    • 0029150669 scopus 로고
    • Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice
    • Kohl, N.E., Omer, C.A., Conner, M.W. et al. Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nat Med 1995, 1: 792-7.
    • (1995) Nat Med , vol.1 , pp. 792-797
    • Kohl, N.E.1    Omer, C.A.2    Conner, M.W.3
  • 27
    • 0031983131 scopus 로고    scopus 로고
    • A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis
    • Barrington, R.E., Subler, M.A., Rands, E. et al. A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Mol Cell Biol 1998, 18: 85-92.
    • (1998) Mol Cell Biol , vol.18 , pp. 85-92
    • Barrington, R.E.1    Subler, M.A.2    Rands, E.3
  • 28
    • 0027320616 scopus 로고
    • Peptidomimetic inhibitors of ras farnesylation and function in whole cells
    • Garcia, A.M., Rowell, C., Ackermann, K., Kowalczyk, J.J., Lewis, M.D. Peptidomimetic inhibitors of ras farnesylation and function in whole cells. J Biol Chem 1993, 268: 18415-8.
    • (1993) J Biol Chem , vol.268 , pp. 18415-18418
    • Garcia, A.M.1    Rowell, C.2    Ackermann, K.3    Kowalczyk, J.J.4    Lewis, M.D.5
  • 29
    • 0027998986 scopus 로고
    • The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation
    • Cox, A.D., Garcia, A.M., Westwick, J.K. et al. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. J Biol Chem 1994, 269: 19203-6.
    • (1994) J Biol Chem , vol.269 , pp. 19203-19206
    • Cox, A.D.1    Garcia, A.M.2    Westwick, J.K.3
  • 30
    • 0028869067 scopus 로고
    • Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956
    • Nagasu, T., Yoshimatsu, K., Rowell, C., Lewis, M.D., Garcia, A.M. Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956. Cancer Res 1995, 55: 5310-4.
    • (1995) Cancer Res , vol.55 , pp. 5310-5314
    • Nagasu, T.1    Yoshimatsu, K.2    Rowell, C.3    Lewis, M.D.4    Garcia, A.M.5
  • 31
    • 0027323459 scopus 로고
    • Benzodiazepine peptidomimetics: Potent inhibitors of ras farnesylation in animal cells
    • James, G.L., Goldstein, J.L., Brown, M.S. et al. Benzodiazepine peptidomimetics: Potent inhibitors of ras farnesylation in animal cells. Science 1993, 260: 1937-42.
    • (1993) Science , vol.260 , pp. 1937-1942
    • James, G.L.1    Goldstein, J.L.2    Brown, M.S.3
  • 32
    • 0028063058 scopus 로고
    • Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-ras-transformed rat-1 cells, but not in untransformed cells
    • James, G.L., Brown, M.S., Cobb, M.H., Goldstein, J.L. Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-ras-transformed rat-1 cells, but not in untransformed cells. J Biol Chem 1994, 269: 27705-14.
    • (1994) J Biol Chem , vol.269 , pp. 27705-27714
    • James, G.L.1    Brown, M.S.2    Cobb, M.H.3    Goldstein, J.L.4
  • 33
    • 0029091930 scopus 로고
    • The farnesyl protein transferase inhibitor BZA-5B blocks farnesylation of nuclear lamins and p21 ras but does not affect their function or localization
    • Dalton, M.B., Fantle, K.S., Bechtold, H.A. et al. The farnesyl protein transferase inhibitor BZA-5B blocks farnesylation of nuclear lamins and p21 ras but does not affect their function or localization. Cancer Res 1995, 55: 3295-304.
    • (1995) Cancer Res , vol.55 , pp. 3295-3304
    • Dalton, M.B.1    Fantle, K.S.2    Bechtold, H.A.3
  • 35
    • 0028352281 scopus 로고
    • Design and structural requirements of potent peptidomimetic inhibitors of p21 ras farnesyltransferase
    • Qian, Y., Blaskovich, M.A., Saleem, M. et al. Design and structural requirements of potent peptidomimetic inhibitors of p21 ras farnesyltransferase. J Biol Chem 1994, 269: 12410-3.
    • (1994) J Biol Chem , vol.269 , pp. 12410-12413
    • Qian, Y.1    Blaskovich, M.A.2    Saleem, M.3
  • 36
    • 0028132044 scopus 로고
    • Peptidomimetic inhibitors of p21 ras farnesyl transferase: Hydrophobic functionalization leads to disruption of p21 ras membrane association in whole cells
    • Qian, Y., Blaskovich, M.A., Seong, C-M., Vogt, A., Hamilton, A.D., Sebti, S.M. Peptidomimetic inhibitors of p21 ras farnesyl transferase: Hydrophobic functionalization leads to disruption of p21 ras membrane association in whole cells. Bioorg Med Chem Lett 1994, 4: 2579-84.
    • (1994) Bioorg Med Chem Lett , vol.4 , pp. 2579-2584
    • Qian, Y.1    Blaskovich, M.A.2    Seong, C.-M.3    Vogt, A.4    Hamilton, A.D.5    Sebti, S.M.6
  • 37
    • 0028973293 scopus 로고
    • Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic ras signaling by inducing cytoplasmic accumulation of inactive ras-raf complexes
    • Lerner, E.C., Qian, Y., Blaskovich, M.A. et al. Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic ras signaling by inducing cytoplasmic accumulation of inactive ras-raf complexes. J Biol Chem 1995, 270: 26802-6.
    • (1995) J Biol Chem , vol.270 , pp. 26802-26806
    • Lerner, E.C.1    Qian, Y.2    Blaskovich, M.A.3
  • 38
    • 0029023145 scopus 로고
    • Ras CAAX peptidomimetic FTI-276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-ras mutation and p53 deletion
    • Sun, J., Qian, Y., Hamilton, A.D., Sebti, S.M. Ras CAAX peptidomimetic FTI-276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-ras mutation and p53 deletion. Cancer Res 1995, 55: 4243-7.
    • (1995) Cancer Res , vol.55 , pp. 4243-4247
    • Sun, J.1    Qian, Y.2    Hamilton, A.D.3    Sebti, S.M.4
  • 39
    • 0028912593 scopus 로고
    • A non-peptide mimetic of ras-CAAX: Selective inhibition of farnesyltransferase and ras processing
    • Vogt, A., Qian, Y., Blaskovich, M.A., Fossum, R.D., Hamilton, A.D., Sebti, S.M. A non-peptide mimetic of ras-CAAX: Selective inhibition of farnesyltransferase and ras processing. J Biol Chem 1995, 270: 660-4.
    • (1995) J Biol Chem , vol.270 , pp. 660-664
    • Vogt, A.1    Qian, Y.2    Blaskovich, M.A.3    Fossum, R.D.4    Hamilton, A.D.5    Sebti, S.M.6
  • 40
    • 15144355763 scopus 로고    scopus 로고
    • Potent and selective non-cysteine-containing inhibitors of protein farnesyltransferase
    • Augeri, D.J., O'Connor, S.J., Janowick, D. et al. Potent and selective non-cysteine-containing inhibitors of protein farnesyltransferase. J Med Chem 1998, 41: 4288-300.
    • (1998) J Med Chem , vol.41 , pp. 4288-4300
    • Augeri, D.J.1    Janowick, D.2
  • 41
    • 0344840856 scopus 로고
    • Design and biological activity of a series of small, low molecular weight farnesyl protein transferase inhibitors
    • Abst 2612
    • Williams, T.M., Ciccarone, T.M., MacTough, S.C. et al. Design and biological activity of a series of small, low molecular weight farnesyl protein transferase inhibitors. Proc Am Assoc Cancer Res 1995, 36: Abst 2612.
    • (1995) Proc Am Assoc Cancer Res , vol.36
    • Williams, T.M.1    Ciccarone, T.M.2    TacTough, S.C.3
  • 42
    • 0029986149 scopus 로고    scopus 로고
    • 2-Substituted piperazines as constrained amino acids. Application to the synthesis of potent, noncarboxylic acid inhibitors of farnesyl transferase
    • Williams, T.M., Ciccarone, T.M., MacTough, S.C. et al. 2-Substituted piperazines as constrained amino acids. Application to the synthesis of potent, noncarboxylic acid inhibitors of farnesyl transferase. J Med Chem 1996, 39: 1345-8.
    • (1996) J Med Chem , vol.39 , pp. 1345-1348
    • Williams, T.M.1    Ciccarone, T.M.2    MacTough, S.C.3
  • 43
    • 15444339430 scopus 로고    scopus 로고
    • Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyl transferase
    • Leonard, D.M., Shuler, K.R., Poulter, C.J. et al. Structure-activity relationships of cysteine-lacking pentapeptide derivatives that inhibit ras farnesyl transferase. J Med Chem 1997, 40: 192-200.
    • (1997) J Med Chem , vol.40 , pp. 192-200
    • Leonard, D.M.1    Shuler, K.R.2    Poulter, C.J.3
  • 47
    • 33646758912 scopus 로고    scopus 로고
    • C-Terminal modifications of histidyl-N-benzylglycinamides to give improved inhibition of ras FTase, cellular activity, and anticancer activity in mice
    • McNamara, D.J., Dobrusin, E., Leonard, D.M. et al. C-Terminal modifications of histidyl-N-benzylglycinamides to give improved inhibition of ras FTase, cellular activity, and anticancer activity in mice. J Med Chem 1997, 40: 3319-22.
    • (1997) J Med Chem , vol.40 , pp. 3319-3322
    • McNamara, D.J.1    Dobrusin, E.2    Leonard, D.M.3
  • 48
    • 0345272219 scopus 로고    scopus 로고
    • Cellular activity of histidinyl-(N-benzylglycinamides) against ras farnesyl transferase
    • Abst 2343
    • Sebolt-Leopold, J.S., Gowan, R.C., Latash, M.P. et al. Cellular activity of histidinyl-(N-benzylglycinamides) against ras farnesyl transferase. Proc Am Assoc Cancer Res 1997, 38: Abst 2343.
    • (1997) Proc Am Assoc Cancer Res , vol.38
    • Sebolt-Leopold, J.S.1    Gowan, R.C.2    Latash, M.P.3
  • 49
    • 0344409221 scopus 로고    scopus 로고
    • In vivo evaluation of histidine-(N-benzylglycinamides) as inhibitors of ras farnesyl transferase
    • Abst 2344
    • Przybranowski, S.A., Sebolt-Leopold, J.S., Leonard, D. et al. In vivo evaluation of histidine-(N-benzylglycinamides) as inhibitors of ras farnesyl transferase. Proc Am Assoc Cancer Res 1997, 38: Abst 2344.
    • (1997) Proc Am Assoc Cancer Res , vol.38
    • Przybranowski, S.A.1    Sebolt-Leopold, J.S.2    Leonard, D.3
  • 50
    • 0029586503 scopus 로고
    • Novel tricyclic inhibitor of farnesyl protein transferase: Biochemical characterization and inhibition of ras modification in transfected Cos cells
    • Bishop, W.R., Bond, R., Petrin, J. et al. Novel tricyclic inhibitor of farnesyl protein transferase: Biochemical characterization and inhibition of ras modification in transfected Cos cells. J Biol Chem 1995, 270: 30611-8.
    • (1995) J Biol Chem , vol.270 , pp. 30611-30618
    • Bishop, W.R.1    Bond, R.2    Petrin, J.3
  • 51
    • 0031030828 scopus 로고    scopus 로고
    • Antitumor 8-chlorobenzocyclohepatapyridines: A new class of selective, non-peptidic, non-sulfhydryl inhibitors of ras farnesylation
    • Mallams, A.K., Njoroge, F.G., Doll, R.J. et al. Antitumor 8-chlorobenzocyclohepatapyridines: A new class of selective, non-peptidic, non-sulfhydryl inhibitors of ras farnesylation. Bioorg Med Chem 1997, 5: 93-9.
    • (1997) Bioorg Med Chem , vol.5 , pp. 93-99
    • Mallams, A.K.1    Njoroge, F.G.2    Doll, R.J.3
  • 52
    • 18544398961 scopus 로고    scopus 로고
    • Discovery of novel nonpeptide tricyclic inhibitors of ras farnesyl protein transferase
    • Njoroge, F.G., Doll, R.J., Vibulbhan, V. Discovery of novel nonpeptide tricyclic inhibitors of ras farnesyl protein transferase. Bioorg Med Chem 1997, 5: 101-13.
    • (1997) Bioorg Med Chem , vol.5 , pp. 101-113
    • Njoroge, F.G.1    Doll, R.J.2    Vibulbhan, V.3
  • 53
    • 15644380004 scopus 로고    scopus 로고
    • Inhibitors of farnesyl protein transferase. 4-Amido, 4-carbamoyl, and 4-carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl) piperazine
    • Mallam, A.K., Rossman, R.R., Doll, R.J. et al. Inhibitors of farnesyl protein transferase. 4-Amido, 4-carbamoyl, and 4-carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl) piperazine. J Med Chem 1998, 41: 877-93.
    • (1998) J Med Chem , vol.41 , pp. 877-893
    • Mallam, A.K.1    Rossman, R.R.2    Doll, R.J.3
  • 54
    • 7844233665 scopus 로고    scopus 로고
    • (+)-4-2-[4-(8-Chloro-3, 10-dibromo-6, 11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]-pyridin-11(R)-yl)-1 -piperidinyl-2-oxo-ethyl]-1 -piperidinecarboxamide (SCH-66336): A very potent farnesyl protein transferase inhibitor as a novel antitumor agent
    • Njoroge, F.G., Taveras, A.G., Kelly, J. et al. (+)-4-[2-[4-(8-Chloro-3, 10-dibromo-6, 11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]-pyridin-11(R)-yl)-1 -piperidinyl)-2-oxo-ethyl]-1 -piperidinecarboxamide (SCH-66336): A very potent farnesyl protein transferase inhibitor as a novel antitumor agent. J Med Chem 1998, 48:4890-902.
    • (1998) J Med Chem , vol.48 , pp. 4890-4902
    • Njoroge, F.G.1    Taveras, A.G.2    Kelly, J.3
  • 55
    • 15444345862 scopus 로고    scopus 로고
    • Potent, selective, and orally bioavailable tricyclic pyridyl acetamide N-oxide inhibitors of farnesyl protein transferase with enhanced in vivo antitumor activity
    • Njoroge, F.G., Vibulbhan, B., Pinto, P. et al. Potent, selective, and orally bioavailable tricyclic pyridyl acetamide N-oxide inhibitors of farnesyl protein transferase with enhanced in vivo antitumor activity. J Med Chem 1998, 41: 1561-7.
    • (1998) J Med Chem , vol.41 , pp. 1561-1567
    • Njoroge, F.G.1    Vibulbhan, B.2    Pinto, P.3
  • 56
    • 0344840854 scopus 로고    scopus 로고
    • Janssen Pharmaceuticals NV. WO9716443
    • Janssen Pharmaceuticals NV. WO9716443.
  • 57
    • 0344840855 scopus 로고    scopus 로고
    • Janssen Pharmaceuticals NV. WO9721701
    • Janssen Pharmaceuticals NV. WO9721701.
  • 58
    • 0000179878 scopus 로고    scopus 로고
    • R115777, a novel farnesyl protein transferase inhibitor (FTI): Biochemical and cellular effects in H-ras and K-ras dominant systems
    • Abst 1848
    • End, D., Skrzat, S., Devine, A. et al. R115777, a novel farnesyl protein transferase inhibitor (FTI): Biochemical and cellular effects in H-ras and K-ras dominant systems. Proc Am Assoc Cancer Res 1998, 39: Abst 1848.
    • (1998) Proc Am Assoc Cancer Res , vol.39
    • End, D.1    Skrzat, S.2    Devine, A.3
  • 59
    • 0000179877 scopus 로고    scopus 로고
    • R115777, a novel imidazole farnesyl protein transferase inhibitor (FTI) with potent oral antitumor activity
    • Abst 2169
    • Skrzat, S., Angibaud, P., Venet, M., Sanz, G., Bowden, C., End, D. R115777, a novel imidazole farnesyl protein transferase inhibitor (FTI) with potent oral antitumor activity. Proc Am Assoc Cancer Res 1998, 39: Abst 2169.
    • (1998) Proc Am Assoc Cancer Res , vol.39
    • Skrzat, S.1    Angibaud, P.2    Venet, M.3    Sanz, G.4    Bowden, C.5    End, D.6


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