메뉴 건너뛰기




Volumn 47, Issue 2, 1999, Pages 69-75

The Complexities of CD28 and CTLA-4 Signalling: PI3K and Beyond

Author keywords

CD28; CTLA 4; PI3K; Signalling; T cell

Indexed keywords

ABATACEPT; ANTIBODY CONJUGATE; CD28 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN; PHOSPHATIDYLINOSITOL 3 KINASE;

EID: 0032619557     PISSN: 0004069X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (7)

References (51)
  • 1
    • 0028146530 scopus 로고
    • CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukaemic T cell line
    • AUGUST A., GIBSON S., KAWAKAMI Y., KAWAKAMI T., MILLS G. B. and DUPONT B. (1994): CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukaemic T cell line. Proc. Natl. Acad. Sci. USA, 91, 9347-9351.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 9347-9351
    • August, A.1    Gibson, S.2    Kawakami, Y.3    Kawakami, T.4    Mills, G.B.5    Dupont, B.6
  • 4
    • 0014941813 scopus 로고
    • A theory of self-nonself discrimination
    • BRETSCHER J. F. and COHN M. (1970): A theory of self-nonself discrimination. Science, 169, 1042-1046.
    • (1970) Science , vol.169 , pp. 1042-1046
    • Bretscher, J.F.1    Cohn, M.2
  • 5
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in PI3K signal transduction
    • BURGERING B. M. T. and COFFER P. J. (1995): Protein kinase B (c-Akt) in PI3K signal transduction. Nature, 376, 599-602.
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.T.1    Coffer, P.J.2
  • 7
    • 2642607871 scopus 로고    scopus 로고
    • CD28 receptor endocytosis is targeted by mutations that disrupt PI3K binding and costimulation
    • CEFAI D., SCHNEIDER H., MATANGKASOMBUT O., KANG H., BRODY J. and RUDD C. E. (1998): CD28 receptor endocytosis is targeted by mutations that disrupt PI3K binding and costimulation. J. Immunol., 160, 2223-2230.
    • (1998) J. Immunol. , vol.160 , pp. 2223-2230
    • Cefai, D.1    Schneider, H.2    Matangkasombut, O.3    Kang, H.4    Brody, J.5    Rudd, C.E.6
  • 8
    • 0026700604 scopus 로고
    • Prolonged IL-2Rα/CD25 expression after T cell activation via the adhesion molecules CD2 and CD28
    • CERDAN C., MARTIN Y., COURCOUL M., BRAILLY H., MAWAS C., BIRG F. and OLIVE D. (1992): Prolonged IL-2Rα/CD25 expression after T cell activation via the adhesion molecules CD2 and CD28. J. Immunol., 149, 2255-2261.
    • (1992) J. Immunol. , vol.149 , pp. 2255-2261
    • Cerdan, C.1    Martin, Y.2    Courcoul, M.3    Brailly, H.4    Mawas, C.5    Birg, F.6    Olive, D.7
  • 10
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD coupled survival signals to the cell-intrinsic death machinary
    • DATTA S. R., DUDEK H., TAO X., MASTERS S., FU H., GOTOH Y. and GREENBERG M. E. (1997): Akt phosphorylation of BAD coupled survival signals to the cell-intrinsic death machinary. Cell, 91, 231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 11
    • 0030587924 scopus 로고    scopus 로고
    • Induction of AP-1 and NFκB by CD28 stimulation involves both PI3K and acidic sphingomyelinase signals
    • EDMEAD C., PATEL Y. I., WILSON A., BOULOUGOURIS G., HALL N. D., WARD S. G. and SANSOM D. M. (1996): Induction of AP-1 and NFκB by CD28 stimulation involves both PI3K and acidic sphingomyelinase signals. J. Immunol., 157, 3290-3297.
    • (1996) J. Immunol. , vol.157 , pp. 3290-3297
    • Edmead, C.1    Patel, Y.I.2    Wilson, A.3    Boulougouris, G.4    Hall, N.D.5    Ward, S.G.6    Sansom, D.M.7
  • 12
    • 0027942023 scopus 로고
    • Pivotal role of the B7: CD28 pathway in transplantation, tolerance and tumor immunity
    • GUINAN E. C., GRIBBEN J. G., BOUSSIOTIS V. A., FREEMAN G. J. and NADLER L. M. (1994): Pivotal role of the B7: CD28 pathway in transplantation, tolerance and tumor immunity. Blood, 84, 3261-3282.
    • (1994) Blood , vol.84 , pp. 3261-3282
    • Guinan, E.C.1    Gribben, J.G.2    Boussiotis, V.A.3    Freeman, G.J.4    Nadler, L.M.5
  • 13
    • 15144353776 scopus 로고    scopus 로고
    • Role of substrates and products of PI3K in regulating activation of Rac-related guanosine trisphosphatases by Vav
    • HAN J., LUBY-PHELPS K., DAS B., SHU X., XIA Y., MOSTELLER R. D., KRISHNA M., FALCK J. R., WHITE M. and BROEK D. (1998): Role of substrates and products of PI3K in regulating activation of Rac-related guanosine trisphosphatases by Vav. Science, 279, 558-561.
    • (1998) Science , vol.279 , pp. 558-561
    • Han, J.1    Luby-Phelps, K.2    Das, B.3    Shu, X.4    Xia, Y.5    Mosteller, R.D.6    Krishna, M.7    Falck, J.R.8    White, M.9    Broek, D.10
  • 14
    • 0028351218 scopus 로고
    • Disruption of PDGF receptor trafficking by mutation of its PI3K binding sites
    • JOLY M., KAZLAUSKAS A., FAY F. and CORVERA S. (1994): Disruption of PDGF receptor trafficking by mutation of its PI3K binding sites. Science, 263, 684-687.
    • (1994) Science , vol.263 , pp. 684-687
    • Joly, M.1    Kazlauskas, A.2    Fay, F.3    Corvera, S.4
  • 16
    • 0032080604 scopus 로고    scopus 로고
    • Activation of p21-Cdc42/Rac-activated kinases by CD28 signalling: P21-activated kinase (PAK) and MEK kinase 1 (MEKK1) may mediate the interplay between CD3 and CD28 signals
    • KAGA S., RAGG S., ROGERS K. A. and OCHI A. (1998): Activation of p21-Cdc42/Rac-activated kinases by CD28 signalling: p21-activated kinase (PAK) and MEK kinase 1 (MEKK1) may mediate the interplay between CD3 and CD28 signals. J. Immunol., 160, 4182-4189.
    • (1998) J. Immunol. , vol.160 , pp. 4182-4189
    • Kaga, S.1    Ragg, S.2    Rogers, K.A.3    Ochi, A.4
  • 17
    • 0031567886 scopus 로고    scopus 로고
    • Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases EMT and Lck
    • KING P. D., SADRA A., TENG J. M., LIU X. R., HAN A., SELVAKUMAR A., AUGUST A. and DUPONT B. (1997): Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases EMT and Lck. J. Immunol., 158, 580-590.
    • (1997) J. Immunol. , vol.158 , pp. 580-590
    • King, P.D.1    Sadra, A.2    Teng, J.M.3    Liu, X.R.4    Han, A.5    Selvakumar, A.6    August, A.7    Dupont, B.8
  • 18
    • 0031896945 scopus 로고    scopus 로고
    • Two distinct regions of the CD28 intracytoplasmic domain are involved in the tyrosine phosphorylation of Vav and GTPase activating protein-associated p62 protein
    • KLASEN S., PAGES F., PEYRON J. F., CANTRELL D. A. and OLIVE D. (1998): Two distinct regions of the CD28 intracytoplasmic domain are involved in the tyrosine phosphorylation of Vav and GTPase activating protein-associated p62 protein. Int. Immunol., 10, 481-489.
    • (1998) Int. Immunol. , vol.10 , pp. 481-489
    • Klasen, S.1    Pages, F.2    Peyron, J.F.3    Cantrell, D.A.4    Olive, D.5
  • 19
    • 0030198344 scopus 로고    scopus 로고
    • Protein kinase cascades activated by stress and inflammatory cytokines
    • KYRIAKIS J. M. and AVRUCH J. (1996): Protein kinase cascades activated by stress and inflammatory cytokines. Bioessays, 18, 567-577.
    • (1996) Bioessays , vol.18 , pp. 567-577
    • Kyriakis, J.M.1    Avruch, J.2
  • 21
    • 0028852073 scopus 로고
    • CTLA-4, a high avidity receptor for CD80 and CD86 contains a intracellular localisation motif in its cytoplasmic tail
    • LEUNG H. T., BRADSHAW J., CLEVELAND J. S. and LINSLEY P. S. (1995): CTLA-4, a high avidity receptor for CD80 and CD86 contains a intracellular localisation motif in its cytoplasmic tail. J. Biol. Chem., 270, 25107-25114.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25107-25114
    • Leung, H.T.1    Bradshaw, J.2    Cleveland, J.S.3    Linsley, P.S.4
  • 23
    • 0030852623 scopus 로고    scopus 로고
    • Itk negatively regulates induction of T cell proliferation by CD28 costimulation
    • LIAO X., FOURNIER S., KILLEEN N., WEISS A., ALLISON J. P. and LITTMAN D. R. (1997): Itk negatively regulates induction of T cell proliferation by CD28 costimulation. J. Exp. Med., 186, 221-228.
    • (1997) J. Exp. Med. , vol.186 , pp. 221-228
    • Liao, X.1    Fournier, S.2    Killeen, N.3    Weiss, A.4    Allison, J.P.5    Littman, D.R.6
  • 24
    • 0027173512 scopus 로고
    • CD28 engagement by B7/BB-1 induces transient down-regulation of CD28 synthesis and prolonged unresponsiveness to CD28 signalling
    • LINSLEY P. S., BRADSHAW J., GROSMAIRE L. and LEDBEITER J. A. (1993): CD28 engagement by B7/BB-1 induces transient down-regulation of CD28 synthesis and prolonged unresponsiveness to CD28 signalling. J. Immunol., 150, 3161-3169.
    • (1993) J. Immunol. , vol.150 , pp. 3161-3169
    • Linsley, P.S.1    Bradshaw, J.2    Grosmaire, L.3    Ledbeiter, J.A.4
  • 27
    • 0031255110 scopus 로고    scopus 로고
    • The SH3 domain of ITK/EMT binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28
    • MARENGERE L. E. M., OKKENHAUG K., CLAVREUL A., COUEZ D., GIBSON S., MILLS G. B., MAK T. W. and ROTTAPEL R. (1997): The SH3 domain of ITK/EMT binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28. J. Immunol., 159, 3220-3229.
    • (1997) J. Immunol. , vol.159 , pp. 3220-3229
    • Marengere, L.E.M.1    Okkenhaug, K.2    Clavreul, A.3    Couez, D.4    Gibson, S.5    Mills, G.B.6    Mak, T.W.7    Rottapel, R.8
  • 28
    • 0030001318 scopus 로고    scopus 로고
    • Regulation of T cell receptor signalling by tyrosine phosphatase SYP association with CTLA-4
    • MARENGERE L. E. M., WATERHOUSE P., DUNCAN G. S., MITTRUCKER H. W., FENG G. S. and MAK T. W. (1996): Regulation of T cell receptor signalling by tyrosine phosphatase SYP association with CTLA-4. Science, 272, 1170-1173.
    • (1996) Science , vol.272 , pp. 1170-1173
    • Marengere, L.E.M.1    Waterhouse, P.2    Duncan, G.S.3    Mittrucker, H.W.4    Feng, G.S.5    Mak, T.W.6
  • 29
    • 0030884103 scopus 로고    scopus 로고
    • PKB/Akt: Connecting PI3K to cell survival and beyond
    • MARTE B. and DOWNWARD J. (1997): PKB/Akt: connecting PI3K to cell survival and beyond. Trends Biochem. Sci., 22, 355-358.
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 355-358
    • Marte, B.1    Downward, J.2
  • 31
    • 0030060353 scopus 로고    scopus 로고
    • Signal transduction by CD28 costimulatory receptor on T cells: B7.1 and B7.2 regulation of tyrosine kinase adaptor molecules
    • NUNES J., TRUNEH A., OLIVE D. and CANTRELL D. A. (1996): Signal transduction by CD28 costimulatory receptor on T cells: B7.1 and B7.2 regulation of tyrosine kinase adaptor molecules. J. Biol. Chem., 271, 1591-1598.
    • (1996) J. Biol. Chem. , vol.271 , pp. 1591-1598
    • Nunes, J.1    Truneh, A.2    Olive, D.3    Cantrell, D.A.4
  • 33
    • 0030686560 scopus 로고    scopus 로고
    • Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B
    • PARRY R. V., REIF K., SMITH G., SANSOM D., HEMMINGS B. A. and WARD S. G. (1997): Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B. Eur. J. Immunol., 27, 2495-2501.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2495-2501
    • Parry, R.V.1    Reif, K.2    Smith, G.3    Sansom, D.4    Hemmings, B.A.5    Ward, S.G.6
  • 34
    • 0030053451 scopus 로고    scopus 로고
    • Involvement of PI3K in the activation of p70S6 kinase by the T cell costimulatory molecule CD28
    • PARRY R. V. and WARD S. G. (1996): Involvement of PI3K in the activation of p70S6 kinase by the T cell costimulatory molecule CD28. Biochem. Soc. Trans., 24, 88S.
    • (1996) Biochem. Soc. Trans. , vol.24
    • Parry, R.V.1    Ward, S.G.2
  • 35
    • 0028981212 scopus 로고
    • p56Lck and p59Fyn regulate CD28 binding to PI3K, Grb-2 and Itk: Implications for T cell costimulation
    • RAAB M., CAI Y. C., BUNNELL S. C., HEYECK S., BERG L. J. and RUDD C. E. (1995): p56Lck and p59Fyn regulate CD28 binding to PI3K, Grb-2 and Itk: implications for T cell costimulation. Proc. Natl. Acad. Sci. USA, 92, 8891.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 8891
    • Raab, M.1    Cai, Y.C.2    Bunnell, S.C.3    Heyeck, S.4    Berg, L.J.5    Rudd, C.E.6
  • 36
    • 0031148668 scopus 로고    scopus 로고
    • A negative role for PI3K in T cell antigen receptor signalling
    • REIF K., LUCAS S. and CANTRELL D. A. (1997): A negative role for PI3K in T cell antigen receptor signalling. Curr. Biol., 7, 285-293.
    • (1997) Curr. Biol. , vol.7 , pp. 285-293
    • Reif, K.1    Lucas, S.2    Cantrell, D.A.3
  • 37
    • 0030293886 scopus 로고    scopus 로고
    • PI3K signals activate a selective subset of Rac/Rho-dependent effector pathways
    • REIF K., NOBES C. D., THOMAS G., HALL A. and CANTRELL D. A. (1996): PI3K signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr. Biol., 6, 1445-1455.
    • (1996) Curr. Biol. , vol.6 , pp. 1445-1455
    • Reif, K.1    Nobes, C.D.2    Thomas, G.3    Hall, A.4    Cantrell, D.A.5
  • 39
    • 0030917081 scopus 로고    scopus 로고
    • Tyrosine phosphorylation controls internalisation of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2
    • SHIRATORI T., MIYATAKE S., OHNO H., NAKASEKO C., ISONO K., BONIFACINO J. and SPITO T. (1997): Tyrosine phosphorylation controls internalisation of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2. Immunity, 6, 583-589.
    • (1997) Immunity , vol.6 , pp. 583-589
    • Shiratori, T.1    Miyatake, S.2    Ohno, H.3    Nakaseko, C.4    Isono, K.5    Bonifacino, J.6    Spito, T.7
  • 40
    • 0031042493 scopus 로고    scopus 로고
    • Rho, Rac, and Cdc42 GTPases regulate the organisation of the actin cytoskeleton
    • TAPON N. and HALL A. (1997): Rho, Rac, and Cdc42 GTPases regulate the organisation of the actin cytoskeleton. Curr. Opin. Cell Biol., 9, 86-92.
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 86-92
    • Tapon, N.1    Hall, A.2
  • 41
    • 0029885108 scopus 로고    scopus 로고
    • Structural requirements for CD28-mediated costimulation of IL-2 production in Jurkat T cells
    • TRUITT K. E., NAGEL T., SUEN L. F. and IMBODEN J. B. (1996): Structural requirements for CD28-mediated costimulation of IL-2 production in Jurkat T cells. J. Immunol., 156, 4539-4541.
    • (1996) J. Immunol. , vol.156 , pp. 4539-4541
    • Truitt, K.E.1    Nagel, T.2    Suen, L.F.3    Imboden, J.B.4
  • 43
    • 0029658306 scopus 로고    scopus 로고
    • p95Vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells
    • TUOSTO L., MICHEL F. and ACUTO O. (1996): p95Vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells. J. Exp. Med., 184, 1161-1166.
    • (1996) J. Exp. Med. , vol.184 , pp. 1161-1166
    • Tuosto, L.1    Michel, F.2    Acuto, O.3
  • 45
    • 0029814079 scopus 로고    scopus 로고
    • CD28: A signalling perspective
    • WARD S. G. (1996): CD28: a signalling perspective. Biochem. J., 318, 361-377.
    • (1996) Biochem. J. , vol.318 , pp. 361-377
    • Ward, S.G.1
  • 46
    • 0032127167 scopus 로고    scopus 로고
    • Chemokines and T lymphocytes: More than an attraction
    • WARD S. G., BACON K. B. and WESTWICK J. (1998): Chemokines and T lymphocytes: more than an attraction. Immunity. 9, 1-11.
    • (1998) Immunity. , vol.9 , pp. 1-11
    • Ward, S.G.1    Bacon, K.B.2    Westwick, J.3
  • 47
    • 0029965232 scopus 로고    scopus 로고
    • PI3K: A pivotal pathway in T cell activation
    • WARD S. G., JUNE C. H. and OLIVE D. (1996): PI3K: a pivotal pathway in T cell activation. Immunol. Today, 17, 187-197.
    • (1996) Immunol. Today , vol.17 , pp. 187-197
    • Ward, S.G.1    June, C.H.2    Olive, D.3
  • 48
    • 0029849012 scopus 로고    scopus 로고
    • Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 costimulatory pathway: Requirement for both B7.1 and B7.2
    • WEBB L., WALMSLEY M. J. and FELDMANN M. (1996): Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 costimulatory pathway: requirement for both B7.1 and B7.2. Eur. J. Immunol., 26, 2320-2328.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 2320-2328
    • Webb, L.1    Walmsley, M.J.2    Feldmann, M.3
  • 49
    • 0028809507 scopus 로고
    • Expression of costimulatory molecules B7.1 and B7.2 and IL-12 cytokine in multiple sclerosis lesions
    • WINDHAGEN A., NEWCOMBE J., DANGOND C., STRAND C., WOODROOFE N., CUZNER M. L. and HAFLER D. A. (1995): Expression of costimulatory molecules B7.1 and B7.2 and IL-12 cytokine in multiple sclerosis lesions. J. Exp. Med., 182, 1985-1996.
    • (1995) J. Exp. Med. , vol.182 , pp. 1985-1996
    • Windhagen, A.1    Newcombe, J.2    Dangond, C.3    Strand, C.4    Woodroofe, N.5    Cuzner, M.L.6    Hafler, D.A.7
  • 50
    • 0001584956 scopus 로고    scopus 로고
    • Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation
    • WU J., MOTTO D. G., KORETZKY G. A. and WEISS A. (1996): Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation. Immunity, 4, 593-602.
    • (1996) Immunity , vol.4 , pp. 593-602
    • Wu, J.1    Motto, D.G.2    Koretzky, G.A.3    Weiss, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.