Activation of Nuclear Factor-κB via T Cell Receptor Requires a Raf Kinase and Ca2+ Influx: Functional Synergy between Raf and Calcineurin

Journal of Immunology

Volumn 157, Issue 12, 1996, Pages 5277-5283

  Kanno, Tomohiko ^b   Siebenlist, Ulrich ^a,c  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b KYOTO UNIVERSITY   (Japan)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCIUM; CALMODULIN BINDING PROTEIN; DNA BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; ONCOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; RAF PROTEIN;

ARTICLE; CELL CULTURE; HUMAN; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCINEURIN; CALCIUM; CALMODULIN-BINDING PROTEINS; DNA-BINDING PROTEINS; HUMANS; NF-KAPPA B; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RAF; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 0030589362     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Weiss, A. and D. R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell 76:263.
2. Crabtree, G. R., and N. A. Clipstone. 1994. Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem. 63:1045.
3. Samelson, L. E., Donovan, J. A., Isakov, N., Ota, Y. and R. L. Wange. 1995. Signal transduction mediated by the T-cell antigen receptor. Ann. NY Acad. Sci. 776:157.
4. Truneh, A., F. Albert, P. Golstein, and A. M. Schmitt-Verhulst. 1985. Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester. Nature 313:318.
5. Genot, E. M., P. J. Parker and D. A. Cantrell. 1995. Analysis of the role of protein kinase C-α, -ε, -ζ in T cell activation. J. Biol. Chem. 270:9833.
6. Serfling, E., R. Barthelmas, I. Pfeuffer, B. Schenk, S. Zarius, R. Swoboda, F. Mercurio, and M. Karin. 1989. Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes. EMBO J. 8:465.
7. Emmel, E. A., C. L. Verweij, D. B. Durand, K. M. Higgins, E. Lacy, and G. R. Crabtree. 1989. Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science 246:1617.
8. Bohnlein, E., J. W. Lowenthal, M. Siekevits, D. W. Ballard, B. R. Franza, and W. C. Greene. 1988. The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV. Cell 53:827.
9. Siebenlist, U., G. Franzoso, and K. Brown. 1994. Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10:405.
10. Siebenlist, U., K. Brown, and G. Franzoso. 1994. NF-κB: a mediator of pathogen and stress responses. In: Inducible Gene Expression, Vol. 1. P. Baeuerle, ed. Birkhaeuser, Boston, p. 93.
11. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141.
12. Manila, P. S., K. S. Ullman, S. Fiering, E. A. Emmel, M. McCutcheon, G. R. Crabtree, and L. A. Herzenberg. 1990. The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes. EMBO J 9:4425.
13. Schmidt, A., L. Hennighausen, and U. Siebenlist. 1990. Inducible nuclear factor binding to the κB elements of the human immunodeficiency virus enhancer in T cells can be blocked by cyclosporin A in a signal-dependent manner. J. Virol. 64:4037.
14. Liu, J., J. D. Farmer, W. S. Lane, J. Friedman, I. Weissman, S. L. Schreiber. 1991. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66:807.
15. Cardenas, M. E., and J. Heitman. 1995. Role of calcium in T-lymphocyte activation. In Advances in Second Messenger and Phosphorylation Research, Vol. 30. A. R. Means, ed. Raven Press, Ltd., New York, p. 281.
16. Frantz, B., E. C. Nordby, G. Bren, N. Steffan, C V. Paya, R. L. Kincaid, M. J. Tocci, S. J. O'Keefe, and E. A. O'Neill. 1994. Calcineurin acts in synergy with PMA to inactivate IκB/MAD3, and inhibitor of NF-κB. EMBO J. 13:861.
17. ras regulatory pathways coexist in T cells. Mol. Cell. Biol. 12:3305.
18. Williams, D. H., M. Woodrow, D. A. Cantrell, and E. J. Murray. 1995. Protein kinase C is not a downstream effector of p21ras in activated T cells. Eur. J. Immunol. 25:42.
19. 2+-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science 252:1427.
20. Wegner, M., Z. Cao, and M. G. Rosenfeld. 1992. Calcium-regulated phosphorylation within the leucine zipper of C/EBPβ. Science 256:370.
21. Matthews, R. P., C. R. Guthrie, L. M. Wailes, X. Zhao, A. R. Means, and G. S. McKnight. 1994. Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. Mol. Cell. Biol. 14: 6107.
22. 2+/calmodulin-dependent protein kinases involves phosphorylation of a negative regulatory site. Genes Dev. 8:2527.
23. 2+/calmodulin kinase. Nature 371:347.
24. Hama, N., F. Paliogianni, B. J. Fessler, and D. T. Boumpas. 1995. Calcium/ calmodulin-dependent protein kinase II downregulates both calcineurin and protein kinase C-mediated pathways for cytokine gene transcription in human T cells. J. Exp. Med. 181:1217.
25. Lewis, R., and M. D. Cahalan. 1995. Potassium and calcium channels in lymphocytes. Annu. Rev. Immunol. 13:623.
26. Merritt, I. E., W. P. Armstrong, C. D. Benhan, T. J. Hallam, R. Jacob, A. Jaxa-Chamiec, B. K. Leigh, S. A. McCarthy, K. E. Moores, and T. J. Rink. 1990. SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. Biochem. J. 271:515.
27. Gao, I.-L., E. L. Becker, R. J. Freer, N. Muthukumaraswamy, and P. M. Murphy. 1994. A high potency nonformylated peptide agonist for the phagocyte N-formylpeptide chemotactic receptor. J. Exp. Med. 180:2191.
28. Kanno, T . K. Brown, G. Franzoso, and U. Siebenlist. 1994. Kinetic analysis of human T-cell leukemia virus type I Tax-mediated activation of NF-κB. Mol. Cell. Biol. 14:6443.
29. Fujita, T., G. P. Nolan, H.-C. Liou, M. L. Scott, and D. Baltimore. 1993. The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers. Genes Dev. 7:1354.
30. Bruder, J. T., G. Heidecker, and U. R. Rapp. 1992, Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. Genes Dev. 6:545.
31. O'Keefe, S. J., J. Tamura, R. L. Kincaid, M. J. Tocci, and E. A. O'Neill. 1992. FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin. Nature 357:692.
32. Sun, Z., P. Sassone-Corsi, and A. R. Means. 1995. Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene. Mol. Cell. Biol. 15:561.
33. Kanno, T., K. Brown, and U. Siebenlist. 1995. Evidence in support of a role for human T-cell leukemia virus type I Tax in activating NF-κB via stimulation of signaling pathway. J. Biol. Chem. 270:11745.
34. 2+ dependent protein kinase. Biochem. Biophys. Res. Commun. 135:397.
35. Nishizuka, Y. 1992. Intracellular signalling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607.
36. Dekker, L. V., and P. J. Parker. 1994. Protein kinase C-a question of specificity. Trends Biochem. Sci. 19:73.
37. Franzoso, G., V. Bours, S. Park, M. Tomita-Yamaguchi, K. Kelly, and U. Siebenlist. 1992. The candidate oncoprotein Bcl-3: an antagonist of p50/NF-κB-mediated inhibition. Nature 359:339.
38. Brown, K., S. Park, T. Kanno, O. Franzoso, and U. Siebenlist. 1993. Mutual regulation of the transcriptional activator NF-κB and its inhibitor, IκB-α. Proc. Natl. Acad. Sci. USA 90:2532.
39. Goldsmith, M. A., and A. Weiss. 1988. Early signal transduction by the antigen receptor without commitment to T cell activation. Science 240:1029.
40. 2+ current, IL-2 production and activation in T lymphocytes. Br. J. Pharmacol. 113:861.
41. Siegel, J. N., R. D. Klausner, U. R. Rapp, and L. E. Samelson. 1990. T cell antigen receptor engagement stimulates c-raf phosphorylation and induces c-raf-associated kinase activity via a protein kinase C-dependent pathway. J. Biol. Chem. 265:18472.
42. Bruder, J. T., G. Heidecker, T.-H. Tan, J. C. Weske, D. Derse, and U. R. Rapp. 1993. Oncogene activation of HIV-LTR-driven expression via the NF-αB binding sites. Nucleic Acids Res. 21:5229.
43. Finco, T. S., and A. S. Baldwin, Jr. 1993. B site-dependent induction of gene expression by diverse inducers of nuclear factor αB requires Raf-1. J. Biol. Chem. 268:17676.
44. Whitehurst, C. E., H. Owaki, J. T. Bruder, U. R. Rapp, and T. D. Geppert. 1995. The MEK kinase activity of the catalytic domain of RAF-1 is regulated independently of Ras binding in T cells. J. Biol. Chem. 270:5594.
45. ras and calcineurin synergize to regulate the nuclear factor of activated T cells. J. Exp. Med. 178: 1517.
46. Brown, K., S. Gerstberger, L. Carlson, G. Franzoso, and U. Siebenlist. 1995. Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation. Science 267:1485.
47. Baldi, L., K. Brown, O. Franzoso, and U. Siebenlist. 1996. A critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of IκB-α. J. Biol. Chem. 271:376.
48. Chen, Z., J. Hagler, V. J. Palombella, F. Melandri, D. Scherer, D. Ballard, and T. Maniatis. 1995. Signal-induced site-specific phosphorylation targets IκB-α to the ubiquitin-proteasome pathway. Genes Dev. 9:1586.