A transforming p53 mutant, which binds DNA, transactivates and induces apoptosis reveals a nuclear:cytoplasmic shuttling defect

Oncogene

Volumn 16, Issue 11, 1998, Pages 1429-1441

  Crook, Tim ^b   Parker, Gillian A ^a   Rozycka, Magda ^b   Crossland, Susan ^b   Allday, Martin J ^a  

^a ST MARY S HOSPITAL   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Cytoplasmic shuttling; Mutant p53; Nuclear; Transformation

Indexed keywords

DNA BINDING PROTEIN; PROTEIN P53;

AMINO ACID SUBSTITUTION; ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; BURKITT LYMPHOMA; CONTROLLED STUDY; FIBROBLAST; GENE MUTATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSACTIVATION; TUMOR SUPPRESSOR GENE;

ANIMALIA; RODENTIA;

EID: 0032546326     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1201699     Document Type: Article

References (76)

1. Allday MJ, Sinclair A, Parker G, Crawford DH and Farrell PJ. (1995a). EMBO J., 14, 1382-1391.
2. Allday MJ, Inman GJ, Crawford DH and Farrell PJ. (1995b). EMBO J., 14, 4994-5005.
3. Barak Y, Juven T, Haffner R and Oren M. (1993). EMBO J., 12, 461-468.
4. Bates S and Voudsden KH. (1996). Curr. Opin. Genet. Develop., 6, 12-19.
5. Buckbinder L, Talbott R, Velasco-Miguel S, Takenaka I, Faha B, Seizinger BR and Kley N. (1995). Nature, 377, 646-649.
6. Caelles C, Helmberg A and Karin M. (1994). Nature, 370, 220-223.
7. Canman C, Gilmer TM, Coutts SB and Kastan MB. (1995). Genes and Dev., 9, 600-601.
8. Chen X, Ko LJ, Jayaraman L and Prives C. (1996). Genes and Dev., 10, 2438-2451.
9. Cho Y, Goriana S, Jeffrey PD and Palevitch NP. (1994). Science, 265, 246-355.
10. Crook T, Fisher C and Vousden KH. (1991). J. Virol., 65, 505-511.
11. Crook T, Marston NJ, Sara EA and Vousden KH. (1994). Cell, 79, 817-827.
12. Dang CV and Lee WMF. (1989). J. Biol. Chem., 264, 18019-18023.
13. Diller L et al. (1990). Mol. Cell. Biol., 10, 5772-5781.
14. Dittmer D, Pati S, Zambetti G,. Chu S, Teresky AK, Moore M. Finlay C and Levine A. (1993). Nature Genet., 4, 42-45.
15. Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Wade-Harper J, Elledge SJ and Reed SI. (1994). Cell, 76, 1013-1023.
16. Duthu A, Debuire B, Romano J Ehrhart C, Fisella E, May E, Apella E and May P. (1992). Oncogene, 7, 2161-2167.
17. Edwards RH and Raab-Traub N. (1994). J. Virol., 68, 1309-1315.
18. El-Deiry WS et al. (1993). Cell, 75, 817-825.
19. Eliyahu D, Goldfinger N, Pinhasi-Kimhi, Shaulsky G, Skurnik Y, Arai N, Rotter V, Oren M. (1988). Oncogene, 3, 313-321.
20. Eliyahu D, Michalovitz D, Eliyahu S, Pinhasi-Kimhi O and Oren M. (1989). Proc. Natl. Acad. Sci. USA, 86, 8763-8767.
21. Farrell PJ, Allan GJ, Shanahan F, Vousden KH and Crook T. (1991). EMBO J., 10, 2879-2887.
22. Finlay CA, Hinds PW and Levine AJ. (1989). Cell, 57, 1083-1093.
23. Flamini G et al. (1996). Eur. J. Cancer, 32, 802-806.
24. Friedlander P, Haupt Y, Prives C and Oren M. (1996). Mol. Cell Biol., 16, 4961-4971.
25. Cannon JV and Lane DP. (1991). Nature, 349, 802-805.
26. Giadano G, Ballerini P, Gong JZ, Inghirami G, Neri A, Newcomb EW, McGrath I, Knowles DM and Dalla-Favera R. (1991). Proc. Natl. Acad. Sci. USA, 88, 5413-5417.
27. Goldman SC, Chen CY, Lansing TJ, Gilmer TM and Kastan MB. (1996). Am. J. Pathol., 148, 1381-1385.
28. Harlow E, Crawford LV, Pim DC and Williamson NM. (1981). J. Virol., 39, 861-869.
29. Haupt Y, Maya R, Kazaz A and Oren M. (1997). Nature. 387, 296-299.
30. Haupt Y, Rowan S, Shaulian E, Vousden KH and Oren M. (1995). Genes and Dev., 9, 2170-2183.
31. Hollstein M et al. (1994). Nucl. Acids Res., 22, 3551-3555.
32. Horack E, Smith K, Bromley L, LeJeune S, Greenall M, Lane D and Harris AL. (1991). Oncogene, 6, 2277-2284.
33. Knudson CM, Tung K, Brown G and Korsmeyer SJ. (1995). Science. 270, 96-99.
34. Ko LJ and Prives C. (1996). Genes and Dev., 10, 1054-1072.
35. Kubbutat MHG, Jones SN and Vousden KH. (1997). Nature. 387, 299-302.
36. Landers JE, Haines DS, Strauss JF and George DL. (1994). Oncogene. 9, 2745-2750.
37. Lenoir GM and Bornkamm GW. (1987). Adv. Vir. Oncol., 7, 173-206.
38. Levine AJ. (1997). Cell. 88, 323-331.
39. Ludwig RL, Bates S and Vousden KH. (1996). Mol. Cell. Biol., 16, 4952-4960.
40. Martinez J, Georgoff I and Levine AJ. (1991). Genes and Dev., 5, 151-159.
41. Middeler G, Zerf K, Jenovai S, Thulig A, Tschodrich-Rotter M, Kubitscheck U and Peters R. (1997). Oncogene. 14, 1407-1417.
42. Miyashita T, Krajewski S, Krajewski M, Wang HG, Lin HK, Liebermann DA, Hoffman B and Reed JC. (1994). Oncogene, 9, 1799-1805.
43. Miyashita T and Reed JC. (1995). Cell. 80, 293-299.
44. Moll UM, Riou G and Levine AJ. (1992). Proc. Natl. Acad. Sci. USA. 89, 7262-7266.
45. Moll UM, Ostermyer AG, Haladay R, Winkfield B, Frazier M and Zambetti G. (1996). Mol. Cell Biol., 16, 1126-1137.
46. Nigro JM et al. (1989). Nature. 342, 705-708.
47. O'Connor PM, Jackman J, Jondle D, Bhatia K, McGrath I and Kohn KW. (1993). Cancer Res., 53, 4776-4780.
48. Okamato K and Beach D. (1994). EMBO J., 13, 4816-4822.
49. Oltavi ZN, Milliman CL and Korsmeyer SJ. (1993). Cell. 74, 609-619.
50. Ory K, Legros Y, Auguin C and Soussi T. (1994). EMBO J., 13, 3496-3504.
51. Parker GA, Crook T, Bain M, Sara EA, Farrell PJ and Allday MJ. (1996). Oncogene, 13, 2541-2549.
52. Picksley SM, Vojtesek B, Sparks A and Lane DP. (1994). Oncogene, 9, 2523-2529.
53. Pietenpol JA, Tokino T, Thiagaligam S, El Deiry W, Kinzler KW and Vogelstein B. (1994). Proc. Natl. Acad. Sci. USA, 91, 1998-2002.
54. Rovinski B and Benchimol S. (1988). Oncogene, 2, 445-452.
55. Rotter V, Abutbul H and Ben-Ze'ev. (1993). EMBO J., 2, 1041-1047.
56. Runnenbaum IB, Kieback DG, Mobus VJ, Tong XW and Kreienberg R. (1996). Gynecol. Oncol., 61, 266-271.
57. Rowan S, Ludwig RL, Haupt Y, Bates S, Lu X, Oren M and Vousden KH. (1996). EMBO J., 15, 827-838.
58. Sepehrnia B, Paz IB, Dasgupta G and Momand J. (1996). J. Biol. Chem., 271, 15081-15090.
59. Sambrook J, Fritsch EF and Maniatis T. (1989). Molecular Cloning - A Laboratory Manual, 2nd ed. Cold Spring Harbour Laboratory Press, USA.
60. Shaulsky G, Ben-Ze'ev A and Rotter V. (1990a). Oncogene, 5, 1707-1711.
61. Shaulsky G, Goldfinger N, Ben-Ze'ev A and Rotter V. (1990b). Mol. Cell Biol., 10, 6565-6577.
62. Sherr CJ. (1996). Science, 274, 1672-1677.
63. Slingerland JM, Jenkins JR and Benchimol S. (1983). EMBO J., 12, 1029-1037.
64. Sun Y, Nakamura K, Wendel E and Colburn N. (1993). Proc. Natl. Acad. Sci. USA, 90, 2827-2831.
65. Takahashi K and Suzuki K. (1994). Oncogene. 9, 183-188.
66. Takahashi T, Nau MM, Chiba I, Birrer MJ, Rosenberg RK, Vincour M, Levitt M, Pass H, Gazdar AF and Minna JD. (1989). Science. 246, 491-494.
67. Unger T, Meitz JA, Scheffner M, Yee CL and Howley PM. (1993). Mol. Cell. Biol., 13, 5186-5194.
68. Vojtesek B, Bartek J, Midgely CA and Lane DP. (1992). J. Immunol. Methods, 151, 237-244.
69. Waga S, Hannon GJ, Beach D and Stillman B. (1994). Nature, 369, 574-578.
70. Wagner AJ, Kokonitis JM and Hay N. (1994). Genes and Dev., 8, 2817-2830.
71. White E. (1996). Genes and Dev., 10, 1-15.
72. Wu X, Bayle JH, Olsen D and Levine AJ. (1993). Genes and Dev., 7, 1126-1132.
73. Yewdell JW, Gannon JV and Lane DP. (1986). J. Virol., 59, 444-452.
74. Zauberman A, Lup A and Oren M. (1995). Oncogene, 10, 2361-2366.
75. Zhan Q, Fan S, Bae I, Guillouf C, Liebermann DA, O'Connor PM and Fornace AJ. (1994). Oncogene, 9, 3743-3751.
76. Zhang W, Funk WD, Wright WE, Shay JW and Deisseroth AB. (1994). EMBO J., 13, 2535-2544.