메뉴 건너뛰기




Volumn 32, Issue 5, 1996, Pages 802-806

Prognostic significance of cytoplasmic p53 overexpression in colorectal cancer. An immunohistochemical analysis

Author keywords

Colorectal cancer; Cytoplasm; Immunohistochemistry; p53 protein; Prognosis

Indexed keywords

PROTEIN P53;

EID: 0030000199     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/0959-8049(95)00625-7     Document Type: Article
Times cited : (56)

References (31)
  • 1
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990, 61, 759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 2
    • 0025938038 scopus 로고
    • Identification and characterization of the familial adenomatous polyposis coli gene
    • Groden J, Thliveris A, Samowitz W, et al. Identification and characterization of the familial adenomatous polyposis coli gene. Cell 1991, 66, 589-600.
    • (1991) Cell , vol.66 , pp. 589-600
    • Groden, J.1    Thliveris, A.2    Samowitz, W.3
  • 3
    • 0026744752 scopus 로고    scopus 로고
    • Molecular genetics of colorectal carcinoma
    • Hamilton SR. Molecular genetics of colorectal carcinoma. Cancer 70, 1216-1221.
    • Cancer , vol.70 , pp. 1216-1221
    • Hamilton, S.R.1
  • 4
    • 0027410013 scopus 로고
    • Decreased expression of DCC mRNA in human colorectal cancer
    • Itoh F, Hinoda Y, Ohe M, et al. Decreased expression of DCC mRNA in human colorectal cancer. Int J Cancer 1992, 53, 260-263.
    • (1992) Int J Cancer , vol.53 , pp. 260-263
    • Itoh, F.1    Hinoda, Y.2    Ohe, M.3
  • 5
    • 0025909734 scopus 로고
    • Identification of a chromosome 5q21 gene that is mutated in colorectal cancers
    • Kinzler KW, Nilbert MC, Vogelstein B et al. Identification of a chromosome 5q21 gene that is mutated in colorectal cancers. Science 1991, 251, 1366-1370.
    • (1991) Science , vol.251 , pp. 1366-1370
    • Kinzler, K.W.1    Nilbert, M.C.2    Vogelstein, B.3
  • 6
    • 0025634118 scopus 로고
    • p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis
    • Baker SJ, Preisinger AC, Jessup M. p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res 1990, 50, 7717-7722.
    • (1990) Cancer Res , vol.50 , pp. 7717-7722
    • Baker, S.J.1    Preisinger, A.C.2    Jessup, M.3
  • 7
    • 0028071555 scopus 로고
    • Mutations in the p53 tumour suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in the p53 tumour suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 1994, 54, 4855-4878.
    • (1994) Cancer Res , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 8
    • 0027410585 scopus 로고
    • The transforming and suppressor functions of p53 alleles: Effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation
    • Slingerland JM, Jenkins JR, Benchimol S. The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation. EMBO J 1993, 12, 1029-1037.
    • (1993) EMBO J , vol.12 , pp. 1029-1037
    • Slingerland, J.M.1    Jenkins, J.R.2    Benchimol, S.3
  • 9
    • 0027109075 scopus 로고
    • p53, guardian of the genome
    • Lane DP. p53, guardian of the genome. Nature 1992, 358, 15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 10
    • 0027170841 scopus 로고
    • Frequently elevated content of immunochemically defined wild-type p53 protein in colorectal adenomas
    • Tominaga O, Hamelin R, Trouvat V, et al. Frequently elevated content of immunochemically defined wild-type p53 protein in colorectal adenomas. Oncogens 1993, 8, 2653-2658.
    • (1993) Oncogens , vol.8 , pp. 2653-2658
    • Tominaga, O.1    Hamelin, R.2    Trouvat, V.3
  • 11
    • 0028029124 scopus 로고
    • DNA synthesis-associated nuclear exclusion of p53 in normal human breast epithelial cells in culture
    • Takahashi K, Suzuki K. DNA synthesis-associated nuclear exclusion of p53 in normal human breast epithelial cells in culture. Oncogene 1994, 9, 183-188.
    • (1994) Oncogene , vol.9 , pp. 183-188
    • Takahashi, K.1    Suzuki, K.2
  • 12
    • 0027265285 scopus 로고
    • Mutations in p53 are frequent in the preneoplastic stage of mouse mammary tumor development
    • Jerry DJ, Ozbun MA, Kittrell FS, Lane DP, Medina D, Butel JS. Mutations in p53 are frequent in the preneoplastic stage of mouse mammary tumor development. Cancer Res 1993, 53, 3374-3381.
    • (1993) Cancer Res , vol.53 , pp. 3374-3381
    • Jerry, D.J.1    Ozbun, M.A.2    Kittrell, F.S.3    Lane, D.P.4    Medina, D.5    Butel, J.S.6
  • 13
    • 0026694826 scopus 로고
    • Two distinct mechanisms alter p53 in breast cancer: Mutation and nuclear exclusion
    • Moll UM, Riou G, Levine AJ. Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc Natl Acad Sci USA 1992, 89, 7262-7266.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7262-7266
    • Moll, U.M.1    Riou, G.2    Levine, A.J.3
  • 14
    • 0029049828 scopus 로고
    • Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors
    • Moll UM, La Quaglia M, Bénard J, Riou G. Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors. Proc Natl Acad Sci USA 1995, 92, 4407-4411.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4407-4411
    • Moll, U.M.1    La Quaglia, M.2    Bénard, J.3    Riou, G.4
  • 15
    • 0027204173 scopus 로고
    • J. Large E1B proteins of Adenovirus types 5 and 12 have different effects on p53 and distinct roles in cell transformation
    • van den Heuvel SJL, van Laar T, The I, van der EBA J. Large E1B proteins of Adenovirus types 5 and 12 have different effects on p53 and distinct roles in cell transformation. J Virol 1993, 67, 5226-5234.
    • (1993) J Virol , vol.67 , pp. 5226-5234
    • Van Den Heuvel, S.J.L.1    Van Laar, T.2    The, I.3    Van Der, E.B.A.4
  • 16
    • 0025975701 scopus 로고
    • Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport
    • Gannon JV, Lane DP. Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport. Nature 1991, 349, 802-806.
    • (1991) Nature , vol.349 , pp. 802-806
    • Gannon, J.V.1    Lane, D.P.2
  • 17
    • 0026741643 scopus 로고
    • Inhibition of DNA synthesis by TGF-b1 coincides with inhibition of phosphorylation and cytoplasmic translocation of p53 protein
    • Suzuki K, Ono T, Takahashi K. Inhibition of DNA synthesis by TGF-b1 coincides with inhibition of phosphorylation and cytoplasmic translocation of p53 protein. Biochem Biophys Res Commun 1992, 183, 1175-1183.
    • (1992) Biochem Biophys Res Commun , vol.183 , pp. 1175-1183
    • Suzuki, K.1    Ono, T.2    Takahashi, K.3
  • 18
  • 19
    • 0027225785 scopus 로고
    • Protein synthesis-dependent cytoplasmic translocation of p53 protein after serum stimulation of growth-arrested MCF-7 cells
    • Takahashi K, Sumimoto H, Suzuki K, Ono T. Protein synthesis-dependent cytoplasmic translocation of p53 protein after serum stimulation of growth-arrested MCF-7 cells. Mol Carcinog 1993, 8, 58-66.
    • (1993) Mol Carcinog , vol.8 , pp. 58-66
    • Takahashi, K.1    Sumimoto, H.2    Suzuki, K.3    Ono, T.4
  • 22
    • 0027410094 scopus 로고
    • Immunohistochemical detection of p53 and bcl-2 proteins in non-Hodgkin's lymphoma
    • Pezzella F, Morrison H, Jones M, et al. Immunohistochemical detection of p53 and bcl-2 proteins in non-Hodgkin's lymphoma. Histopathology 1993, 22, 39-44.
    • (1993) Histopathology , vol.22 , pp. 39-44
    • Pezzella, F.1    Morrison, H.2    Jones, M.3
  • 24
    • 0026453217 scopus 로고
    • Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma
    • Sun XF, Carstensen JM, Zhang H, et al. Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma. Lancet 1992, 340, 1369-1373.
    • (1992) Lancet , vol.340 , pp. 1369-1373
    • Sun, X.F.1    Carstensen, J.M.2    Zhang, H.3
  • 25
    • 0027134298 scopus 로고
    • Prognostic significance of p53 expression in relation to DNA ploidy in colorectal carcinoma
    • Sun XF, Carstensen JM, Stal O. Prognostic significance of p53 expression in relation to DNA ploidy in colorectal carcinoma. Virchows Archiv A Pathol Anat 1993, 423, 443-448.
    • (1993) Virchows Archiv a Pathol Anat , vol.423 , pp. 443-448
    • Sun, X.F.1    Carstensen, J.M.2    Stal, O.3
  • 26
    • 0028286988 scopus 로고
    • Cytoplasmic accumulation of p53 protein: An independent prognostic indicator in colorectal adenocarcinomas
    • Bosari S, Viale G, Bossi P, et al. Cytoplasmic accumulation of p53 protein: an independent prognostic indicator in colorectal adenocarcinomas. J Natl Cancer Inst 1994, 86, 681-687.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 681-687
    • Bosari, S.1    Viale, G.2    Bossi, P.3
  • 27
    • 0026569616 scopus 로고
    • Analysis of p53 expression in human tumors: An antibody raised against human p53 expressed in Escherichia coli
    • Midgley CA, Fisher CJ, Bartek J, Vojtesek B, Lane DP, Barnes DM. Analysis of p53 expression in human tumors: an antibody raised against human p53 expressed in Escherichia coli. J Cell Science 1992, 101, 185-189.
    • (1992) J Cell Science , vol.101 , pp. 185-189
    • Midgley, C.A.1    Fisher, C.J.2    Bartek, J.3    Vojtesek, B.4    Lane, D.P.5    Barnes, D.M.6
  • 28
    • 0026769713 scopus 로고
    • An immunochemical analysis of human p53: New monoclonal antibodies and epitope mapping using recombinant p53
    • Vojtesek B, Bartek J, Midgley CA, Lane DP. An immunochemical analysis of human p53: new monoclonal antibodies and epitope mapping using recombinant p53. J Immunol Meth 1992, 151, 237-244.
    • (1992) J Immunol Meth , vol.151 , pp. 237-244
    • Vojtesek, B.1    Bartek, J.2    Midgley, C.A.3    Lane, D.P.4
  • 29
    • 0026032511 scopus 로고
    • p53 in colorectal cancer: Clinicopathological correlation and prognostic significance
    • Scott N, Sagar P, Stewart J, Blair GE, Dixon MF, Quirke P. p53 in colorectal cancer: clinicopathological correlation and prognostic significance. Br J Cancer 1991, 63, 317-319.
    • (1991) Br J Cancer , vol.63 , pp. 317-319
    • Scott, N.1    Sagar, P.2    Stewart, J.3    Blair, G.E.4    Dixon, M.F.5    Quirke, P.6
  • 31
    • 0027509209 scopus 로고
    • Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer
    • Bell SM, Scott N, Cross D, et al. Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer. Gastroenterology 1993, 104, 57-64.
    • (1993) Gastroenterology , vol.104 , pp. 57-64
    • Bell, S.M.1    Scott, N.2    Cross, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.