Chapter 6. Thrombin and Factor Xa Inhibition

Annual Reports in Medicinal Chemistry

Volumn 31, Issue C, 1996, Pages 51-60

  Edmunds, Jeremy J ^a   Rapundalo, Stephen T ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77957154728     PISSN: 00657743     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-7743(08)60445-5     Document Type: Article

References (112)

1. Luchtman-Jones L., and Broze Jr. G.J. Ann. Med. 27 (1995) 47
2. Fareed J., Callas D.D., Hoppensteadt D., Jeske W., and Walenga J.M. Exp. Opin. Invest. Drugs. 4 5 (1995) 389
3. Fitzgerald D. Ann. N.Y. Acad. Sci. 714 (1994) 41
4. Lefkovits J., and Topol E.J. Circulation 90 (1994) 1522
5. Kimball S.D. Curr. Pharm. Des. 1 (1995) 441
6. Das J., and Kimball S.D. Bioorg. Med. Chem. 3 8 (1995) 999
7. Kimball S.D. Blood Coagul. Fibrin. 6 6 (1995) 511
8. Verstraete M., and Zoldhelyi P. Drugs 49 6 (1995) 856
9. Iino M., Takeya H., Takemitsu T., Nakagaki T., Gabazza E.C., and Suzuki K. Eur. J. Biochem. 232 1 (1995) 90
10. Nakao Y., Matsunaga S., and Fusetani N. Bioorg. Med. Chem. 3 8 (1995) 1115
11. Bonjouklian R., Smitka T.A., Hunt A.H., Occolowitz J.L., Perun Jr. T.J., Doolin L., Stevenson S., Knauss L., Wijayaratne R., Szewczyk S., and Patterson G.M.L. Tetrahedron 52 (1996) 395
12. Bush L.R. Cardiovasc. Drug Rev. 9 3 (1991) 247
13. Brandstetter H., Turk D., Hoeffken W.H., Grosse D., Stuerzebecher J., Martin P.D., Edwards B.F.P., and Bode W. J. Mol. Biol. 226 4 (1992) 1085
14. Bergner A., Bauer M., Brandstetter H., Stuerzebecher J., and Bode W. Enzyme Inhib. 9 1 (1995) 101
15. G. Lassalle, T. Purcell, D. Galtier, P.H. Williams and F. Galli, US 5453430 (1995).
16. Dickneite G., Seiffge D., Diehl K.H., Reers M., Czech J., Weinmann E., Hoffmann D., and Stuber W. Thromb. Res. 77 4 (1995) 357
17. Mack H., Pfeiffer T., Hornberger W., Boehm H.-J., and Hoeffken H.W. Enzyme Inhib 9 1 (1995) 73
18. J.C. Danilewicz, D. Ellis and R.J. Kobylecki, WO 9513274 (1995).
19. Hilpert K., Ackermann J., Banner D.W., Gast A., Gubernator K., Schmid G., Tschopp T.B., and van de Waterbeemb H. Eur. J. Med. Chem. 30 (1995) 131
20. Hilpert K., Ackermann J., Banner D.W., Gast A., Gubernator K., Hadvary P., Labler L., Muller K., Schmid G., Tschopp T.B., and van de Waterbeemb H. J. Med. Chem. 37 (1994) 3889
21. J. Ackermann, D. Banner, K. Gubernator, K. Hilpert and G. Schmid, EP 641779 (1995).
22. Tabernero L., Chang C.Y., Ohringer S.L., Lau W.F., Iwanowicz E.J., Han W.-C., Wang T.C., Seiler S.M., Roberts D.G.M., and Sack J.S. J. Mol. Biol. 246 1 (1995) 14
23. Iwanowicz E.J., Lau W.F., Lin J., Roberts D.G.M., and Seiler S.M. J. Med. Chem. 37 (1994) 2122
24. Malley M.F., Tabernero L., Chang C.Y., Ohringer S.L., Roberts D.G.M., Das J., and Sack J.S. Protein Sci. 5 (1996) 221
25. Obst U., Gramlich V., Diederich F., Weber L., and Banner D.W. Angew. Chem., Int. Ed. Engl. 34 16 (1995) 1739
26. A-C. Teger-Nilsson and R. E Bylund, WO 9311152 (1993).
27. Teger-Nilsson A.C., Gyzander E., Andersson S., Englund M., Mattsson C., Ulvinge J.C., and Gustafsson D. Thromb. Haemostasis 73 (1995) 1325
28. Gustafsson D., Elg M., Lenfors S., Borjesson I., and Teger-Nilsson A.C. Thromb. Haemostasis 73 (1995) 1319
29. Eriksson U.G., Renberg L., Vedin C., and Strimfors M. Thromb. Haemostasis 73 (1995) 1318
30. K.T. Antonsson, R.E. Bylund, N.D. Gustafsson and N.O. I. Nilsson, WO 9429336 (1994).
31. Jones D.M., Atrash B., Ryder H., Teger-Nilsson A.-C., Gyzander E., and Szelke M. Enzyme Inhib. 9 1 (1995) 43
32. Jones D.M., Atrash B., Teger-Nilsson A.-C., Gyzander E., Deinum J., and Szelke M. Lett. Pept. Sci. 2 3/4 (1995) 147
33. G.P. Vlasuk, T.R. Webb and D.A. Pearson, WO 9315756 (1993).
34. G.P. Vlasuk, T.R. Webb, D.A. Pearson and M.M. Abelman, WO 9417817 (1994).
35. O.E. Levy, S.Y. Tamura, R.F. Nutt and W.C. Ripka, WO 9535312 (1995).
36. J.E. Semple, O.E. Levy, R.F. Nutt and W.C. Ripka, WO 9535313 (1995).
37. Lewis S.D., Ng A.S., Lyle E.A., Mellott M.J., Appleby S.D., Brady S.F., Stauffer K.J., Sisko J.T., Mao S.-S., Veber D.F., Nutt R.F., Lynch J.J., Cook J.J., Gardell S.J., and Shafer J.A. Thromb. Haemostasis 74 4 (1995) 1107
38. D.F. Veber, S.D. Lewis, J.A. Shafer, D-M. Feng, R.F. Nutt, S.F. Brady, WO 9425051 (1994).
39. Fevig J.M., Abelman M.M., Brittelli D.R., Kettner C.A., Knabb R.M., and Weber P.C. Biorg. Med. Chem. Lett. 6 (1996) 295
40. Cacciola J., Fevig J.M., Alexander R.S., Brittelli D.R., Kettner C.A., Knabb R.M., and Weber P.C. Biorg. Med. Chem. Letts. (1996) 301
41. Jetten M., Peters C.A.M., Visser A., Grootenhuis P.D.J., van Nispen J.W., and Ottenheijm H.C.J. Bioorg. Med. Chem. 3 8 (1995) 1099
42. Kaiser B., and Hauptmann J. Cardiovasc. Drug Rev. 12 (1994) 225
43. Yamazaki M. Drugs of the Future 20 9 (1995) 911
44. Broze Jr. G.J. Blood Coagul. Fibrin. 6 1 (1995) S7
45. Broze Jr. G.J. Annu. Rev. Med. 46 (1995) 103
46. Joubert A.M., Crause J.C., Gaspar A.R.M.D., Clarke F.C., Spickett A.M., and Neitz A.W.H. Exp. Appl. Acarol. 19 (1995) 79
47. Gaspar A.R.M.D., Crause J.C., and Neitz A.W.H. Exp. Appl. Acarol. 19 (1995) 117
48. Apitz-Castro R., Beguin S., Tablante A., Bartoli F., Holt J.C., and Hemker H.C. Thromb. Haemostasis 73 1 (1995) 94
49. Lim-Wilby M.S.L., Hallenga K., De Maeyer M., Lasters I., Vlasuk G.P., and Brunck T.K. Protein Sci. 4 2 (1995) 178
50. Sanyal G., Marquis-Omer D., Waxman L., Mach H., Ryan J.A., O'Brien Gress J., and Middaugh C.R. Biochim. Biophys. Acta. 1249 10 (1995) 100
51. Mao S.-S., Huang J., Welebob C., Neeper M.P., Garsky V.M., and Shafer J.A. Biochem. 34 15 (1995) 5098
52. Cappello M., Vlasuk G.P., Bergum P.W., Huang S., and Hotez P.J. Proc. Natl. Acad. Sci. USA 92 13 (1995) 6152
53. Mahdi F., van Nostrand W.E., and Schmaier A.H. Biol. 270 (1995) 23468
54. McGrath M.E., Gillmor S.A., and Fletterick R.J. Protein Sci. 4 2 (1995) 141
55. Seymour J.L., Lindquist R.N., Dennis M.S., Moffat B., Yansura D., Reilly D., Wessinger M.E., and Lazarus R.A. Biochem. 33 13 (1994) 3949
56. Gillmor S.A., McGrath M.E., and Fletterick R.J. Perspect. Drug Discovery Des. 2 3 (1995) 475
57. R.A. Lazarus, M.S. Dennis and J.S. Ulmer, WO 9507986 (1995).
58. Nagahara T., Yokoyama Y., Inamura K., Katakura S.-I., Komoriya S., Yamaguchi H., Hara T., and Iwamoto M. J. Med. Chem. 37 (1994) 1200
59. Nagahara T., Katakura S.-I., Yokoyama Y., Kanaya N., Inamura K., Komoriya S., Yamada K., Yamaguchi H., Tanabe K., Morishima Y., Ishihara H., Hara T., Yamazaki K.-I., Kunitada S., and Iwamoto M. Eur. J. Med. Chem. 30 (1995) 139s
60. Walsmann P., Horn H., Markwardt F., Richter P., Sturzebecher J., Vieweg H., and Wagner G. Acta. Biol. Med. Ger. 35 (1976) K1
61. Sturzebecher J., Sturzebecher U., Vieweg H., Wagner G., Hauptmann J., and Markwardt F. Thromb Res 54 (1989) 245
62. Stubbs M.T., and Bode W. Curr. Opin. Struct. Biol. 4 (1994) 823
63. Stubbs M.T., Huber R., and Bode W. FEBS Lett 375 (1995) 103
64. Stubbs M.T., and Bode W. Trends Cardiovasc. Med. 5 4 (1995) 157
65. Tidwell R.R., Webster W.P., Shaver S.R., and Geratz J.D. Thromb. Res. 19 (1980) 339
66. Hara T., Yokoyama A., Morishima Y., and Kunitada S. Thromb. Res. 80 1 (1995) 99
67. T.K. Brunck, T.R. Webb and W.C. Ripka, WO 9413693 (1994).
68. Ripka W., Brunck T., Stanssens P., LaRoche Y., Lauwereys M., Lambeir A.-M., Lasters I., DeMaeyer M., Vlasuk G., Levy O., Miller T., Webb T., Tamura S., and Pearson D. Eur. J. Med. Chem. 30 (1995) 87s
69. F. Al-Obeidi, M. Lebl, J. Ostrem, P. Safar, A. Stierandova, P. Strop and A. Walser, WO 9529189 (1995).
70. Ofosu F.A., Lormeau J.C., Craven S., Dewar L., and Anvari N. Thromb. Haemostasis 72 6 (1994) 862
71. Berry C.N., Girardot C., Lecoffre C., and Lunven C. Throm. Haemostasis 72 3 (1994) 381
72. Callas D.D., Hoppensteadt D., and Fareed J. Semin. Thromb. Hemostasis 21 2 (1995) 177
73. Gast A., and Tschopp T.B. Blood Coag. Fibrinolysis 6 6 (1995) 553
74. Legnani C., Palareti G., Biagi R., Ludovici S., Maggiore L., Milani M.R., and Coccheri S. Eur. J. Clin. Pharmacol. 47 3 (1994) 247
75. Eichinger S., Wolzt M., Nieszpaur-Los M., Schneider B., Lechner K., Eichler H.-G., and Kyrle P.A. Thromb. Haemostasis 72 6 (1994) 831
76. Eichinger S., Wolzt M., Schneider B., Nieszpaur-Los M., Heinrichs H., Lechner K., Eichler H.-G., and Kyrle P.A. Arterioscler. Thromb. Vasc. Biol. 15 7 (1995) 886
77. Eriksson B.I., Soederberg K., Wildlund L., Wandeli B., Tengborn L., and Risberg B. Thromb. Haemostasis 73 3 (1995) 398
78. Weinmann E.E., and Salzman E.W. N. Engl. J. Med. 331 (1994) 1630
79. Lindmarker P., Holmstrom M., Granqvist S., Johnsson H., and Lockner D. Thromb. Haemostasis 72 2 (1994) 186
80. Alhenc-Gelas M., Jestin-Le Guernic C., Vitoux J.F., Kher A., Aiach M., and Fiessinger J.N. Thromb. Haemostasis 71 6 (1994) 698
81. Diquelou A., Dupouy D., Cariou R., Sakariassen K.S., Boneu B., and Cadroy Y. Thromb. Haemostasis 74 (1995) 1286
82. Berry C.N., Girard D., Lochot S., and Lecoffre C. Br. J. Pharmacol. 113 4 (1994) 1209
83. Valji K., Arun K., and Bookstein J.J. J. Vasc. Interv. Radiol. 6 1 (1995) 91
84. Tapparelli C., Metternich R., Gfeller P., Gafner B., and Powling M. Thromb. Hemostasis 73 (1995) 641
85. Biemond B.J., Friederich P.W., Levi M., Vlasuk G.P., Buller H.R., and ten Cate J.W. Circulation 93 (1996) 153
86. Yokoyama T., Kelly A.B., Marzec U.M., Hanson S.R., Kunitada S., and Harker L.A. Circulation 92 3 (1995) 485
87. Kotze H.F., Lamprecht S., and Badenhorst P.N. Blood 85 11 (1995) 3158
88. Carteaux J.P., Gast A., Tschopp T.B., and Roux S. Circulation 91 5 (1995) 1568
89. Takiguchi Y., Asai F., Wada K., Hayashi H., and Nakashima M. Br. J. Pharmacol. 116 (1995) 3056
90. Schumacher W.A., Balasubramanian N., St. Laurent D.R., and Seiler S.M. Eur. J. Pharmacol. 259 2 (1994) 165
91. Lynch J.J., Sitko G.R., Lehman E.D., and Vlasuk G.P. Thromb. Haemostasis 74 (1995) 640
92. Orvim U., Barstad R.M., Vlasuk G.P., and Sakariassen K.S. Arterioscler. Thromb. Vasc. Biol. 15 (1995) 2188
93. Eisenberg P.R. J. Thromb. Thrombolysis 1 3 (1995) 237
94. Lidon R.M., Theroux P., and Bonan R. Circulation 89 (1994) 1567
95. Lee L.V. Am. J. Cardiol. 75 (1995) 7
96. Theroux P., Perez Villa F., Waters D., Lesperance J., Shabani F., and Bonan R. Circulation 91 8 (1995) 2132
97. Cannon C.P., and Braunwald E. J. Am. Coll. Cardiol. 25 7 Suppl (1995) 30s
98. Jun L., Arnout J., Vanhove P., Dol F., Lormeau J.C., Herbert J.M., Collen D., and Van de Werf F. Coron. Artery. Dis. 6 3 (1995) 257
99. Chen L.Y., Nichols W.W., Mattsson C., Tegernilson A.C., Wallin R., Saldeen T.G.P., and Mehta J.L. Cardiovasc. Res. 30 (1995) 866
100. Lyle E.M., Fujita T., Conner M.W., Connolly T.M., Vlasuk G.P., and Lynch Jr. J.L. J. Pharmacol. Toxicol. Methods 33 1 (1995) 53
101. Meyer B.J., Fernandez-Ortiz A., Mailhac A., Falk E., Badimon L., Michael A.D., Chesebro J.H., Fuster V., and Badimon J.J. Circulation 90 5 (1994) 2474
102. Serruys P.W., Herrman J.P., Simon R., Rutsch W., Bode C., Laarman G.J., van Dijk R., van den Bos A.A., Umans V.A., Fox K.A., Close P., and Deckers J.W. N. Engl. J. Med. 333 12 (1995) 757
103. Suzuki S., Sakamoto S., Adachi K., Mizutani K., Koide M., Ohga N., Miki T., and Matsuo T. Thromb. Res. 77 4 (1995) 369
104. Fuchs J., and Cannon C.P. Circulation 92 4 (1995) 727
105. Bittl J.A. Am. Heart. J. 130 (1995) 658
106. Bittl J.A., Strony J., Brinker J.A., Ahmed W.H., Meckel C.R., Chaitman B.R., Maraganore J., Deutsch E., and Adelman B. N. Engl. J. Med. 333 12 (1995) 764
107. Jang Y., Guzman L.A., Lincoff M., Gottsauner-Wolf M., Forudi F., Hart C.E., Courtman D.W., Ezban M., Ellis S.G., and Topol E.J. Circulation 92 (1995) 3041-3050
108. Hara T., Iwamoto M., Ishihara M., and Tomikawa M. Haemostasis 24 (1994) 351
109. Umemura K., Kawai H., Ishihara H., and Nakashima M. Jpn. J. Pharmacol. 67 3 (1995) 253
110. Yamazaki M., Asakura H., Aoshima K., Saito M., Jokaji H., Uotani C., Kumabashiri I., Morishita E., Ikeda T., and Matsuda T. Thromb. Haemostasis 72 3 (1994) 393
111. Hara T., Yokoyama A., Tanabe K., Ishihara H., and Iwamoto M. Thromb. Haemostasis 74 2 (1995) 635
112. Herbert J.M., Bernat A., Dol F., Herault J.P., Crepon B., and Lormeau J.C. J. Pharmacol. Exp. Ther. 276 (1996) 1030