Wortmannin inhibits the production of reactive oxygen and nitrogen intermediates and the killing of the Saccharomyces cerevisiae by isolated chicken macrophages

Immunopharmacology and Immunotoxicology

Volumn 18, Issue 4, 1996, Pages 597-608

  Yang, M ^a   Wu, W ^a   Mirocha, C J ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; NITRIC OXIDE; PHORBOL 13 ACETATE 12 MYRISTATE; SUPEROXIDE; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CHICKEN; IMMUNOMODULATION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ANIMALIA; AVES; GALLUS GALLUS; SACCHAROMYCES CEREVISIAE;

EID: 0029826561     PISSN: 08923973     EISSN: None     Source Type: Journal    
DOI: 10.3109/08923979609052756     Document Type: Article

References (15)

1. Brian P. W., Curtis P. J., Hemming H. G. and Norris G. L. F., Wortmannin, an antibiotic produced by Penicillium wortmannni, Trans. Br. Mycol. Soc., 40:365, 1957.
2. Haefliger W. and Hauser D., Isolierung und strukturaunfklarung von 11-Desacetoxy-Wortmannin, Helv. Chim. Acta, 56:2901, 1973.
3. Petcher T. J., Weber H. P. and Kis Z., Crystal structure and absolute configuration of wortmannin and of wortmannin p-Bromobenzoate, J. Chem. Soc. Comm., 1332:1062, 1972.
4. Abbas H. K. and Mirocha C. J., Isolation and purification of a hemorrhagic factor (wortmannin) from Fusarium oxysporum (N17B), Appl. Environ. Microbiol., 54: 1268, 1988.
5. Wiesinger D., Gubler H. U., Haefliger W. and Hauser D., Antiinflammatory activity of the new mould metabolite 11-desacetoxywortmannin and some of its derivatives, Experientia, 30:135, 1974.
6. Gunther R., Abbas H. K. and Mirocha C. J., Acute pathological effects of orally administered wortmannin-containing preparation and purified wortmannin from Fusarium oxyspourum, Fd. Chem. Toxic., 27:173, 1989.
7. Gunther R., Kishore P. N., Abbas H. K. and Mirocha C. J., Immunosuppressive effects of dietary wortmannin on rats and mice, Immunopharmacol. Immunotoxicol., 11(4):559, 1989.
8. Wu W. and Mirocha C. J., Decreased immunological responses by wortmannin-containing rice culture of fusarium oxysporum and by purified wortmannin in avian species, Immunopharmacol. Immunotoxicol., 14(4):913, 1992.
9. Kuby J., Immunology; 2nd edition, W. H. Freeman and Company, New York, 1994.
10. Baggiolini M., Dewald B., Schnyder J., Rush W., Cooper P. H. and Payne T. G., Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and analogues, Exp. Cell Res., 169:408, 1987.
11. Carrasco-Marin E., Alvarez-Dominguez C. and Leyva-Cobian F., Wortmannin, an inhibitor of phospholipase D activation, selectively blocks major histocompatibility complex class II-restricted antigen presentation, Eur. J. Immunol., 24:2031, 1994.
12. Sabet T., Hsia W. C., Stanisz M., El-Domeiri A. and Alten P. V., A simple method for obtaining peritoneal macrophages from chickens, J. Immunol. Methods, 14:103, 1977.
13. Hansen M., Nielsen S. and Berg K., Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill, J. Immunol. Methods, 119:203, 1989.
14. Moncada S., Palmer R. M. J. and Higgs E. A., Nitric oxide: Physiology, Pathophysiology and Pharmacology, Pharmacol. Rev., 43:109, 1991.
15. Pick E. and Keisari Y., Superoxide anion and hydrogen peroxide production by chemically elicited peritoneal macrophages-induction by multiple nonphagocytic stimuli, Cell. Immunol., 59:301, 1981.