Tumor-specific expression of alternatively spliced estrogen receptor messenger ribonucleic acid variants in human pituitary adenomas

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 4, 1997, Pages 1058-1065

  Chaidarun, Sushela S ^a   Klibanski, Anne ^a   Alexander, Joseph M ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; ESTROGEN RECEPTOR; GROWTH HORMONE; MESSENGER RNA;

ADULT; AGED; ALTERNATIVE RNA SPLICING; ARTICLE; BRAIN TUMOR; CELL PROLIFERATION; CLINICAL ARTICLE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYPOPHYSIS ADENOMA; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE SPECIFICITY; TRANSSPHENOIDAL HYPOPHYSECTOMY;

ADENOMA; ADULT; AGED; ALTERNATIVE SPLICING; BASE SEQUENCE; BLOTTING, SOUTHERN; EXONS; HUMANS; MIDDLE AGED; PITUITARY GLAND; PITUITARY NEOPLASMS; POLYMERASE CHAIN REACTION; RECEPTORS, ESTROGEN; REFERENCE VALUES; RNA, MESSENGER; TRANSCRIPTION, GENETIC; VARIATION (GENETICS);

EID: 0030896576     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.4.1058     Document Type: Article

References (26)

1. Lieberman ME, Maurer RA, Claude P, Wiklund J, Wertz N, Gorski J. 1980 Regulation of pituitary growth and prolactin gene expression by estrogen, hormones and cancer. In Leavitt WW, ed. Hormones and cancer. New York: Plenum Press; 151-163.
2. Shupnik MA, Gharib SD, Chin WW. 1989 Divergent effects of estradiol on gonadotropin gene transcription in pituitary fragments. Mol Endocrinol. 3:474-480.
3. Chaidarun SS, Eggo MC, Stewart PM, Barber PC, Sheppard MC. 1994 Role of growth factors and estrogen as modulators and growth, differentiation and expression of gonadotropin subunit genes in primary cultured sheep pituitary cells. Endocrinology. 134:935-944.
4. Holmgren U, Bergstrand G, Hagenfeldt K, Werner S. 1986 Women with prolactinoma-effect of pregnancy and lactation on serum prolactin and on tumor growth. Acta Endocrinol (Copenh). 111:452-459.
5. Furth J. 1955 Experimental pituitary rumors. Recent Prog Horm Res. 11:221-249.
6. Lloyd RV. 1983 Estrogen-induced hyperplasia and neoplasia in the rat anterior pituitary gland. Am J Pathol. 113:198-206.
7. Kumar V, Green S, Stack G, Berry M, Jin JR, Chambon P. 1987 Functional domains of the human estrogen receptor. Cell. 51:941-951.
8. Ponglikitmongkol M, Green S, Chambon P. 1988 Genomic organization of the human estrogen receptor gene. EMBO J. 7:3385-3388.
9. Green S, Walter P, Kumar V, et al. 1986 Human estrogen receptor cDNA: sequence, expression and homology to v-erbA. Nature. 320:134-139.
10. Ignar-Trowbridge DM, Pimentel M, Parker MG, McLachlan JA, Korach KS. 1996 Peptide growth factor cross-talk with estrogen receptor requires the A/B domain and occurs independently of protein kinase C or estradiol. Endocrinology. 137:1735-1744.
11. Newton CJ, Buric R, Trapp T, Brockmeier S, Pagotto U, Stalla GK. 1994 The unliganded estrogen receptor (ER) transduces growth factor signals. J Steroid Biochem Mol Biol. 48:481-486.
12. Fuqua SAW, Allred DC, Auchus RJ. 1993 Expression of estrogen receptor variants. J Cell Biochem. 17G:194-197.
13. Fuqua SAW. 1994 Estrogen receptor mutagenesis and hormone resistance. Cancer. 74:1026-1029.
14. Gotteland M, Desauty G, Delarue JC, Liu L, May E. 1995 Human estrogen receptor messenger RNA variants in both normal and tumor breast tissues. Mol Cell Endocrinol. 112:1-13.
15. Fuqua SAW, Fitzgerald SD, Chamness GC, et al. 1991 Variant human breast tumor estrogen receptor with constitutive transcriptional activity. Cancer Res. 51:105-109.
16. Weisz A, Rosales R. 1990 Identification of an estrogen response element upstream of the human c-fos gene that binds the estrogen receptor and the AP-1 transcription factor. Nucleic Acids Res. 185097-5105.
17. Wang Y, Miksicek RJ. 1991 Identification of a dominant negative form of the human estrogen receptor. Mol Endocrinol. 5:1707-1715.
18. Friend KE, Chiou YK, Lopes MBS, Laws ER, Hughes KM, Shupnik MA. 1994 Estrogen receptor expression in human pituitary: correlation with immunohistochemistry in normal tissue, and immunohistochemistry and morphology in macroadenomas. J Clin Endocrinol Metab. 78:1497-1504.
19. Zafar M, Ezzat S, Ramyar L, Pan N, Smyth HS, Asa SL. 1995 Cell-specific expression of estrogen receptor in the human pituitary and its adenomas. J Clin Endocrinol Metab. 80:3621-3627.
20. Chomczynski P, Sacchi N. 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol chloroform extraction. Anal Biochem. 162:156-159.
21. Alexander JM, Klibanski A. 1994 Gonadotropin-releasing hormone receptor mRNA expression by human pituitary tumors in vitro. J Clin Invest. 93:2332-2339.
22. Ambrosino C, Cicatiello L, Cobellis G, et al. 1993 Functional antagonism between the estrogen receptor and Fos on the regulation of c-fos protooncogene transcription. Mol Endocrinol. 7:1472-1483.
23. McDonnell DP, Lieberman BA, Norris J. 1995 Development of tissue-selective estrogen receptor modulators. In Organ-selective actions of steroid hormones. Baird DT, Schutz G, Krattenmacher R, ed. New York: Springer-Verlag; 1-28.
24. Pfeffer U, Fecarotta E, Vidali G. 1995 Coexpression of multiple estrogen receptor variant messenger RNAs in normal and neoplastic breast tissues and in MCF-7 cells. Cancer Res. 55:2158-2165.
25. Koehorst SGA, Cox JJ, Donker GH, et al. 1994 Functional analysis of an alternatively spliced estrogen receptor lacking exon 4 isolated from MCF-7 breast cancer cells and meningioma tissue. Mol Cell Endocrinol. 101:237-245.
26. Fuqua SA, Fitzgerald SD, Allred DC, et al. 1992 Inhibition of estrogen receptor action by a naturally occurring variant in human breast tumors. Cancer Res. 52:483-486.