In vivo biological effects of various forms of thrombopoietin in a murine model of transient pancytopenia

Stem Cells

Volumn 14, Issue SUPPL. 1, 1996, Pages 246-255

  Thomas, G Roger ^a   Thibodeaux, Harold ^a   Errett, Carol J ^a   Mathias, Joanne ^a   Marian, Melinda ^a   Meng, Gloria ^a   Vandlen, Richard L ^a   Eaton, Dan L ^a  

^a GENENTECH INC   (United States)

Author keywords

Anemia; Carboplatin; Erythropoiesis; Gamma irradiation; Thrombocytopenia; Thrombopoiesis; Thrombopoietin

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; MACROGOL DERIVATIVE; RECOMBINANT PROTEIN; THROMBOPOIETIN;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; C57BL MOUSE; CELL LINEAGE; CHEMISTRY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; ERYTHROCYTE; FEMALE; GAMMA RADIATION; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; KINETICS; LEUKOCYTE; MALE; MEGAKARYOCYTE; METABOLISM; MOUSE; PANCYTOPENIA; SUBCUTANEOUS DRUG ADMINISTRATION; TEMPERATURE; THROMBOCYTE; TIME;

ANIMALS; ANTINEOPLASTIC AGENTS; AREA UNDER CURVE; BLOOD PLATELETS; CARBOPLATIN; CELL LINEAGE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; FEMALE; GAMMA RAYS; HUMANS; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; KINETICS; LEUKOCYTES; MALE; MEGAKARYOCYTES; MICE; MICE, INBRED C57BL; PANCYTOPENIA; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; TEMPERATURE; THROMBOPOIETIN; TIME FACTORS;

EID: 0030307632     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.5530140732     Document Type: Article

References (17)

1. Debili N, Wendling F, Katz A et al. The Mpl-ligand or thrombopoietin has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Blood 1995;86:2516-2525.
2. Banu N, Wang J, Deng B et al. Modulation of megakaryocytopoiesis by thrombopoietin: the c-Mpl ligand. Blood 1995;86:1331-1338.
3. Nichol JL, Hokom MM, Hornkohl A et al. Megakaryocyte growth and development factor. J Clin Invest 1995;95:2973-2978.
4. Zeigler FC, de Sauvage F, Widmer HR et al. In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 1994;84:4045-4052.
5. Choi E, Nichol JL, Hokom MM et al. Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional. Blood 1995;85:402-413.
6. Kaushansky K, Lok S, Holly RD et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 1994;369:568-571.
7. Farese AM, Hunt P, Boone T et al. Recombinant megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates. Blood 1995;86:54-59.
8. Gurney AL, Carver-Moore K, de Sauvage F et al. Thrombocytopenia in c-Mpl-deficient mice. Science 1994;265:1445-1447.
9. de Sauvage F, Carver-Moore K, Luoh S et al. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J Exp Med 1996 (in press).
10. Sprugel KH, Humes JM, Grossman A et al. Recombinant thrombopoietin stimulates rapid platelet recovery in thrombocytopenic mice. Blood 1994;84:242a.
11. Thibodeaux H, Mathias J, Eaton DL et al. Evaluation of thrombopoietin (TPO) in murine models of thrombocytopenia induced by whole body irradiation and cancer chemotherapeutic agents. Blood 1995;86:1977a.
12. Fibbe WE, Heemskerk L, Laterveer L et al. Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow derived from thrombopoietin pretreated donor mice. Blood 1995;86:3308-3313.
13. Kaushansky K, Broudy VC, Grossman A et al. Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J Clin Invest 1995; 96:1683-1687.
14. Leonard JP, Quinto CM, Kozitka TY et al. Recombinant IL-11 stimulates multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin. Blood 1994;83:1499-1506.
15. Kobayashi M, Laver JH, Kato T et al. Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors. Blood 1995;86:2494-2499.
16. de Sauvage FJ, Hass PE, Spencer SD et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 1994;369:533-538.
17. Eaton DL, Gurney A, Malloy B et al. Biological activity of human thrombopoietin (TPO), the c-Mpl ligand, and TPO variants and the chromosomal localization of TPO. Blood 1994;84:241a.