Infections in the immunopathogenesis of chronic inflammatory bowel disease

Seminars in Immunology

Volumn 10, Issue 1, 1998, Pages 69-78

  Merger, Michael ^a   Croitoru, Ken ^b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

Author keywords

Autoimmunity; IBD; Immunology; Infection

Indexed keywords

AUTOIMMUNE DISEASE; BACTERIAL FLORA; DISEASE COURSE; ENTERITIS; ENVIRONMENTAL FACTOR; HUMAN; IMMUNOPATHOGENESIS; INFECTION; INFLAMMATION; INTESTINE FLORA; INTESTINE MUCOSA; REVIEW;

EID: 0032006738     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1006/smim.1997.0106     Document Type: Article

References (66)

1. 1. Elson CO, McCabe RP (1995) The immunology of inflammatory bowel disease, in Inflammatory Bowel Disease (Kirsner JB, Shorter RG, eds), pp 203-251. Williams and Wilkins, Baltimore, Philadelphia, Hong Kong, London, Munch, Sydney, Tokyo
2. 2. Yang H, Rotter JI (1993) Genetics of inflammatory bowel disease, in Inflammatory Bowel Disease. From Bench to Bedside (Targan SR, Shanahan F, eds), pp 32-64
3. 3. Theofilopoulos AN (1995) The basis of autoimmunity: Part II. Genetic predisposition. Immunol Today 16:150-159
4. 4. Theofilopoulos AN 1995. The basis of autoimmunity: Part I. Mechanisms of aberrant self-recognition. Immunol Today 16:90-98
5. 5. Hafler DA, Flavell R (1996) Autoimmunity. How to know thy self [editorial]. Curr Opin Immunol 8:805-807
6. 6. Shanahan F, Targan SR (1993) Genetics of inflammatory bowel disease, in Inflammatory Bowel Disease. From Bench to Bedside. (Targan SR, Shanahan F, eds), pp 78-88
7. 7. Calkins BM, Mendeloff AI (1995) The epidemiology of idiopathic inflammatory bowel disease, in Inflammatory Bowel Disease (Kirsner JB, Shorter RG, eds), pp 31-68. Williams and Wilkins, Baltimore, Philadelphia, Hong Kong, London, Munch, Sydney, Tokyo
8. 8. Retsky JE, Kraft SC (1995) The extraintestinal manifestations of inflammatory bowel disease, in Inflammatory Bowel Disease (Kirsner JB, Shorter RG, eds), pp 474-491. Williams and Wilkins, Baltimore, Philadelphia, Hong Kong, London, Munch, Sydney, Tokyo
9. 9. Veys EM, Mielants H, de Vos M, Cuvelier C (1996) Spondylarthropathies: from gut to target organs. Baillere's Clinical Rheumatology 10(1):123-146
10. 10. Hollander D (1993) Permeability in Crohn's disease: altered barrier functions in healthy relatives? [editorial; comment]. Gastroenterology 104:1848-1851
11. 11. Mayer L, Eisenhardt D (1990) Lack of induction of suppressor T cells by intestinal epithelial cells from patients with inflammatory bowel disease. J Clin Invest 86:1255-1260
12. 12. Smith PD, Janoff EN, Mosteller-Barnum M, Merger M, Orenstein JM, Kearney JF, Graham MF (1997) Isolation and purification of CD14-negative mucosal macrophages from normal human small intestine. J Immunol Methods 202:1-11
13. 13. Mowat AM, Vmey JL (1997) The anatomical basis of intestinal immunity. Immunol Rev 156:145-166
14. 14. Morise K, Yamaguchi T, Kuroiwa A, Kanayama K, Matsuura T, Shinoda M, Yamamoto H, Horiuchi Y, Furusawa A, Iwase H et al (1994) Expression of adhesion molecules and HLA-DR by macrophages and dendritic cells in aphthoid lesions of Crohn's disease: an immunocytochemical study. J Gastroenterol 29:257-264
15. 15. Rugtveit J, Haraldsen G, Hogasen AK, Bakka A, Brandtzaeg P, Scott H (1995) Respiratory burst of intestinal macrophages in inflammatory bowel disease is mainly caused by CD14 + L1 + monocyte derived cells. Gut 37:367-373
16. 16. Rugtveit J, Nilsen EM, Bakka A, Carlsen H, Brandtzaeg P, Scott H (1997) Cytokine profiles differ in newly recruited and resident subsets of mucosal macrophages from inflammatory bowel disease. Gastroenterology 112:1493-1505
17. 17. Fedorak RN (1995) Naturally occurring and experimental models of inflammatory bowel disease, in Inflammatory Bowel Disease (Kirsner JB, Shorter RG, eds), pp 71-95. Williams and Wilkins, Baltimore, Philadelphia, Hong Kong, London, Munch, Sydney, Tokyo
18. 18. Ehrhardt RO, Ludviksson BR, Gray B, Neurath M, Strober W (1997) Induction and prevention of colonie inflammation in IL-2 deficient mice. J Immunol 158:566-573
19. 19. Mizoguchi E, Mizoguchi A, Bhan AK (1997) Role of the cytokines in the early stages of inflammatory bowel disease in TCR α-mutant mice [Abstract]. Gastroenterology 112:A1044
20. 20. Kuhn R, Lohler J, Rennick D, Rajewsky K, Muller W (1993) Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:263-274
21. 21. Powrie F, Leach MW, Mauze S, Menon S, Caddie LB, Coffman RL (1994) Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4 + T cells. Immunity 1:553-562
22. 22. Powrie F, Carlino J, Leach MW, Mauze S, Coffman RI (1996) A critical role for transforming growth factor-b but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RBlow CD4 + T cells. J Exp Med 183:2669-2674
23. 23. Plevy SE, Targan SR, Yang H, Fernandez D, Rotter JI, Toyoda H (1996) Tumor necrosis factor microsatellites define a Crohn's disease-associated haplotype on chromosome 6. Gastroenterology 110:1053-1060
24. 24. van Dullemen HM, Van Deventer SJ, Hommes DW, Bijl HA, Jansen J Tytgat GN, Woody J (1995) Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology 109:129-135
25. 25. Strober W, Kelsall B, Fuss I, Marth T, Ludviksson B, Ehrhardt R, Neurath M (1997) Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation. Immunol Today 18:61-64
26. 26. Neurath MF, Fuss I, Kelsall BL, Presky DH, Waegell W, Strober W (1996) Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance. J Exp Med 183:2605-2616
27. 27. Weiner HL (1997) Oral tolerance for the treatment of autoimmune diseases. Annu Rev Med 48:341-351
28. 28. Shirakawa T, Enomoto T, Shimazu S, Hopkin JM (1997) The inverse association between tuberculin responses and atopic disorder. Science 275:77-79
29. 29. Duchmann R, Kaiser I, Hermann E, Mayet W, Ewe K, Meyer zum Buschenfelde KH (1995) Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD) [see comments]. Clin Exp Immunol 102:448-455
30. 30. Sartor RB (1995) Microbial factors in the pathogenesis of Chron's disease, ulcerative colitis and experimental intestinal inflammation, in Inflammatory Bowel Disease (Kirsner JB, Shorter RG, eds), pp 96-124. Williams and Wilkins, Baltimore, Philadelphia, Hong Kong, London, Munch, Sydney, Tokyo
31. 31. Ekbom A, Wakefield AJ, Zack M, Adami HO (1994) Perinatal measles infection and subsequent Crohn's disease [see comments]. Lancet 344:508-510
32. 32. Ekbom A, Daszak P, Kraaz W, Wakefield AJ (1996) Crohn's disease after in-utero measles virus exposure. Lancet 348:515-517
33. 33. Folwaczny C, Noehl N, Tschoep K, Endres SP, Heldwein W, Loeschke K, Fricke H (1997) Goblet cell autoantibodies in patients with inflammatory bowel disease and their first degree relatives. Gastroenterology 113:101-106
34. 34. Biancone L, Mandal A, Yang H, Dasgupta T, Paoluzi AO, Marcheggiano A, Paoluzi P, Pallone F, Das KM (1995) Production of immunoglobulin G and G1 antibodies to cytoskeletal protein by lamina propria cells in ulcerative colitis. Gastroenterology 109:3-12
35. 35. Brandtzaeg P (1995) Autoimmunity and ulcerative colitis: can two enigmas make sense together? Gastroenterology 109:307-312
36. 36. Mountz JD, Edwards 3rd CK, Cheng J, Yang P, Wang Z, Liu C, Su X, Bluethmann H, Zhou T (1996) Autoimmunity due to defective Nur77, Fas, and TNF-RI apoptosis. Adv Exp Med Biol 406:241-262
37. 37. Zinkernagel RM, Ehl S, Aichele P, Oehen S, Kundig T, Hengartner H (1997) Antigen localisation regulates immune responses in a dose-and time-dependent fashion: a geographical view of immune reactivity. Immunol Rev 156:199-209
38. 38. Liblau RS, Singer SM, McDevitt HO (1995) Th1 and Th2 CD4 + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today 16:34-38
39. 39. Kroemer G, Hirsch F, Gonzalez-Garcia A, Martinez C (1996) Differential involvement of Th1 and Th2 cytokines in autoimmune diseases. Autoimmunity 24:25-33
40. 40. Rocken M, Shevach EM (1996) Immune deviation - the third dimension of nondeletional T cell tolerance. Immunol Rev 149:175-194
41. 41. Strater J, Wellisch I, Riedl S, Walczak H, Koretz K, Tandara A, Krammer PH, Moller P (1997) CD95 (APO-1/Fas)-mediated apoptosis in colon epithelial cells: a possible role in ulcerative colitis. Gastroenterology 113:160-167
42. 42. Sakai T, Kimura Y, Inagaki-Ohara K, Kusugami K, Lynch DH, Yoshikai Y (1997) Fas-mediated cytotoxicity by intestinal intraepithelial lymphocytes during acute graft -versus-host disease in mice. Gastroenterology 113:168-174
43. 43. Croitoru K, Bienenstock J, Ernst PB (1994) Phenotypic and functional assessment of intraepithelial lymphocytes bearing a 'forbidden' alpha beta TCR. Int Immunol 6:1467-1473
44. 44. Aichele P, Bachmann MF, Hengartner H, Zinkernagel RM (1996) Immunopathology or organ-specific autoimmunity as a consequence of virus infection. Immunol Rev 152: 21-45
45. 45. Stevens TR, Winrow VR, Blake DR, Rampton DS (1992) Circulating antibodies to heat-shock protein 60 in Crohn's disease and ulcerative colitis. Clin Exp Immunol 90:271-274
46. 46. Elsaghier A, Prantera C, Bothamley G, Wilkins E, Jindal S, Ivanyi J (1992) Disease association of antibodies to human and mycobacterial hsp70 and hsp60 stress proteins. Clin Exp Immunol 89:305-309
47. 47. Szewczuk MR, Depew WT (1992) Evidence for T lymphocyte reactivity to the 65 kilodalton heat shock protein of mycobacterium in active Crohn's disease. Clin Invest Med 15:494-505
48. 48. Peetermans WE, GR D'Haens JL Ceuppens, P. Rutgeerts, and K. Geboes (1995) Mucosal expression by B7-positive cells of the 60-kilodalton heat-shock protein in inflammatory bowel disease. Gastroenterology 108:75-82
49. 49. Baca-Estrada ME, Gupta RS, Stead RH, Croitoru K (1994) Intestinal expression and cellular immune responses to human heat-shock protein 60 in Crohn's disease. Dig Dis Sci 39:498-506
50. 50. Nicholson LB, Kuchroo VK (1996) Manipulation of the Th1/Th2 balance in autoimmune disease. Curr Opin Immunol 8:837-842
51. 51. McDonald GB, Jewell DP (1987) Class II antigen (HLA-DR) expression by intestinal epithelial cells in inflammatory diseases of colon. J Clin Pathol 40:312-317
52. 52. Noguchi M, Hiwatashi N, Liu Z, Toyota T (1995) Enhanced interferon-gamma production and B7-2 expression in isolated intestinal mononuclear cells from patients with Crohn's disease. J Gastroenterol 30 Suppl 8:52-55
53. 53. MacDermott RP (1996) Alterations of the mucosal immune system in inflammatory bowel disease. J Gastroenterol 31:907-916
54. 54. Lenschow DJ, Walunas TL, Bluestone JA (1996) CD28/B7 system of T cellcostimulation. Annu Rev Immunol 14:233-258
55. 55. Baca-Estrada ME, Wong DK, Croitoru K (1995) Cytotoxic activity of V beta 8 + T cells in Crohn's disease: the role of bacterial superantigens. Clin Exp Immunol 99:398-403
56. 56. Shalon L, Gulwani-Akolkar B, Fisher SE, Akolkar PN, Panja A, Mayer L, Silver J (1994) Evidence for an altered T-cell receptor repertoire in Crohn's disease. Autoimmunity 17:301-307
57. 57. Sieper J, Kingsley GH, Marker-Hermann E (1996) Aetiological agents and immune mechanisms in enterogenic reactive arthritis. Baillieres Clin Rheumatol 10:105-121
58. 58. Baum H, Davies H, Peakman M (1996) Molecular mimicry in the MHC: hidden clues to autoimmunity? Immunol Today 17:64-70
59. 59. Rath HC, Herfarth HH, Ikeda JS, Grenther WB, Hamm Jr TE, Balish E, Taurog JD, Hammer RE, Wilson KH, Sartor RB (1996) Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J Clin Invest 98:945-953
60. 60. Elson CO, Sartor RB, Tennyson GS, Riddell RH (1995) Experimental models of inflammatory bowel disease. Gastroenterology 109:1344-1367
61. 61. Lobo AJ, Sagar PM, Roth well J, Quirke P, Godwin P, Johnston D, Axon AT (1993) Carriage of adhesive Escherichia coli after restorative proctocolectomy and pouch anal anastomosis: relation with functional outcome and inflammation. Gut 34:1379-1383
62. 62. von Wulffen H, Russmann H, Karch H, Meyer T, Bitzan M, Kohrt TC, Aleksic S (1989) Verocytotoxinp-roducing Escherichia coli O2:H5 isolated from patients with ulcerative colitis [letter]. Lancet 1:1449-1450
63. 63. Jung HC, Eckmann L, Yang SK, Panja A Fierer J, Morzycka-Wroblewska E, Kagnoff MF (1995) A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J Clin Invest 95:55-65
64. 64. Eckmann L, Kagnoff MF, Fierer J (1993) Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry. Infect Immunol 61:4569-4574
65. 65. Rasmussen SJ, Eckmann L, Quayle AJ, Shen L, Zhang YX, Anderson DJ, Fierer J, Stephens RS, Kagnoff MF (1997) Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis. J Clin Invest 99:77-87
66. 66. Meijssen MAC, Devaney K, Bhan AK, Podolsky DK (1996) Altered cytokine and CD14 expression by intestinal epithelial cells of interleukin-2 deficient mice. Gastroenterology 110:A966