메뉴 건너뛰기




Volumn 27, Issue 3, 1998, Pages 159-177

Autoimmune diabetes: The role of T cells, MHC molecules and autoantigens

Author keywords

Diabetes (IDDM); Human leukocyte antigen (HLA); Major histocompatibility complex (MHC); T cells; cell autoantigens

Indexed keywords

AUTOANTIGEN; EPITOPE; INSULIN; MAJOR HISTOCOMPATIBILITY ANTIGEN; PEPTIDE;

EID: 0031959942     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916939809003864     Document Type: Review
Times cited : (43)

References (146)
  • 1
    • 0028890866 scopus 로고
    • Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases
    • Liblau, R. S., Singer, S. M. and McDevitt, H. O. (1995). Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today, 16, 34-8.
    • (1995) Immunol. Today , vol.16 , pp. 34-38
    • Liblau, R.S.1    Singer, S.M.2    McDevitt, H.O.3
  • 2
    • 0027156812 scopus 로고
    • Selective differentiation of CD4+ T-helper cell subsets
    • Scott, P. (1993). Selective differentiation of CD4+ T-helper cell subsets. Curr Opin Immunol, 5, 391-7.
    • (1993) Curr Opin Immunol , vol.5 , pp. 391-397
    • Scott, P.1
  • 3
    • 0030050118 scopus 로고    scopus 로고
    • Immunology taught by viruses
    • Zinkernagel, R. M. (1996). Immunology taught by viruses. Science, 271, 173-8.
    • (1996) Science , vol.271 , pp. 173-178
    • Zinkernagel, R.M.1
  • 4
    • 0029817047 scopus 로고    scopus 로고
    • The role of interleukin-1 in the pathogenesis of IDDM
    • Mandrup-Poulsen, T. (1996). The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia, 39, 1005-29.
    • (1996) Diabetologia , vol.39 , pp. 1005-1029
    • Mandrup-Poulsen, T.1
  • 5
    • 0023917714 scopus 로고
    • T cell autoreactivity to insulin in diabetic and related non-diabetic individuals
    • Naquet, P., Ellis, J., Tibensky, D., Kenshole, A., Singh, B. and Hodges, R., et al. (1988). T cell autoreactivity to insulin in diabetic and related non-diabetic individuals. J. Immunol, 140, 2569-78.
    • (1988) J. Immunol , vol.140 , pp. 2569-2578
    • Naquet, P.1    Ellis, J.2    Tibensky, D.3    Kenshole, A.4    Singh, B.5    Hodges, R.6
  • 7
    • 0029837397 scopus 로고    scopus 로고
    • T-cell responses to autoantigens in IDDM. The search for the Holy Grail
    • Roep, B. O. (1996). T-cell responses to autoantigens in IDDM. The search for the Holy Grail. Diabetes, 45, 1147-56.
    • (1996) Diabetes , vol.45 , pp. 1147-1156
    • Roep, B.O.1
  • 8
    • 0028574073 scopus 로고
    • HLA-DQ-restricted, islet-specific T-cell clones of a type 1 diabetic patient. T-cell receptor sequence similarities to insulitis-inducing T-cells of nonobese diabetic mice
    • Durinovic Bello, I., Steinle, A., Ziegler, A. G. and Schendel, D. J. (1994). HLA-DQ-restricted, islet-specific T-cell clones of a type 1 diabetic patient. T-cell receptor sequence similarities to insulitis-inducing T-cells of nonobese diabetic mice. Diabetes, 43, 1318-25.
    • (1994) Diabetes , vol.43 , pp. 1318-1325
    • Durinovic Bello, I.1    Steinle, A.2    Ziegler, A.G.3    Schendel, D.J.4
  • 9
    • 0029991807 scopus 로고    scopus 로고
    • Cellular immune response to diverse islet cell antigens in IDDM
    • Durinovic Bello, I., Hummel, M. and Ziegler, A. G. (1996). Cellular immune response to diverse islet cell antigens in IDDM. Diabetes, 45, 795-800.
    • (1996) Diabetes , vol.45 , pp. 795-800
    • Durinovic Bello, I.1    Hummel, M.2    Ziegler, A.G.3
  • 11
    • 0027361654 scopus 로고
    • Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients
    • Itoh, N., Hanafusa, T., Miyazaki, A., Miyagawa. J., Yamagata, K., Yamamoto, K., et al. (1993). Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J. Clin. Invest., 92, 2313-22.
    • (1993) J. Clin. Invest. , vol.92 , pp. 2313-2322
    • Itoh, N.1    Hanafusa, T.2    Miyazaki, A.3    Miyagawa, J.4    Yamagata, K.5    Yamamoto, K.6
  • 12
    • 0021873134 scopus 로고
    • Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases
    • Sibley, R. K., Sutherland, D. E., Goetz, F. and Michael, A. F. (1985). Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. Lab. Invest., 53, 132-44.
    • (1985) Lab. Invest. , vol.53 , pp. 132-144
    • Sibley, R.K.1    Sutherland, D.E.2    Goetz, F.3    Michael, A.F.4
  • 13
    • 0022453771 scopus 로고
    • Prevention of diabetes in Bio-Breeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells
    • Like, A. A., Biron, C. A., Weringer, E. J., Byman, K., Sroczynski, E. and Guberski, D. L. (1986). Prevention of diabetes in Bio-Breeding/Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells. J. Exp. Med., 164, 1145-59.
    • (1986) J. Exp. Med. , vol.164 , pp. 1145-1159
    • Like, A.A.1    Biron, C.A.2    Weringer, E.J.3    Byman, K.4    Sroczynski, E.5    Guberski, D.L.6
  • 14
    • 0025735450 scopus 로고
    • Macrophage cytotoxicity towards isolated rat islet cells: Neither lysis nor its protection by nicotinamide are beta-cell specific
    • Kröncke, K. D., Funda, J., Berschick, B., Kolb, H. and Kolb Bachofen, V. (1991). Macrophage cytotoxicity towards isolated rat islet cells: neither lysis nor its protection by nicotinamide are beta-cell specific. Diabetologia, 34, 232-8.
    • (1991) Diabetologia , vol.34 , pp. 232-238
    • Kröncke, K.D.1    Funda, J.2    Berschick, B.3    Kolb, H.4    Kolb Bachofen, V.5
  • 15
    • 0030271678 scopus 로고    scopus 로고
    • Interleukin 12 mRNA expression in islets correlates with β-cell destruction in NOD mice
    • Rabinovitch, A., Suarez-Pinzon, W. L. and Sorensen, O. (1996). Interleukin 12 mRNA expression in islets correlates with β-cell destruction in NOD mice. J. Autoimmun, 9, 645-51.
    • (1996) J. Autoimmun , vol.9 , pp. 645-651
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Sorensen, O.3
  • 16
    • 0023544492 scopus 로고
    • Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells
    • Bendelac, A., Carnaud, C., Boitard, C. and Bach, J. F. (1987). Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells. J. Exp. Med., 166, 823-32.
    • (1987) J. Exp. Med. , vol.166 , pp. 823-832
    • Bendelac, A.1    Carnaud, C.2    Boitard, C.3    Bach, J.F.4
  • 17
    • 0029841157 scopus 로고    scopus 로고
    • The role of CDS+ T cells in the initiation of insulin-dependent diabetes mellitus
    • Wang, B., Gonzalez, A., Benoist, C. and Mathis, D. (1996). The role of CDS+ T cells in the initiation of insulin-dependent diabetes mellitus. Eur. J. Immunol., 26. 1762-9.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1762-1769
    • Wang, B.1    Gonzalez, A.2    Benoist, C.3    Mathis, D.4
  • 18
    • 0027367830 scopus 로고
    • Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice
    • Katz, J., Benoist, C. and Mathis, D. (1993). Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice. Eur. J. Immunol., 23, 3358-60.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 3358-3360
    • Katz, J.1    Benoist, C.2    Mathis, D.3
  • 19
    • 0023252262 scopus 로고
    • HLADQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
    • Todd, J. A., Bell, J. I. and McDevitt, H. O. (1987). HLADQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature, 329, 599-604.
    • (1987) Nature , vol.329 , pp. 599-604
    • Todd, J.A.1    Bell, J.I.2    McDevitt, H.O.3
  • 20
    • 0027181070 scopus 로고
    • Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles
    • Chicz, R. M., Urban, R. G., Gorga, J. C., Vignali, D. A., Lane, W. S. and Strominger, J. L. (1993). Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles, J. Exp. Med., 178, 27-47.
    • (1993) J. Exp. Med. , vol.178 , pp. 27-47
    • Chicz, R.M.1    Urban, R.G.2    Gorga, J.C.3    Vignali, D.A.4    Lane, W.S.5    Strominger, J.L.6
  • 21
    • 0030021722 scopus 로고    scopus 로고
    • Molecular mimicry in the MHC: Hidden clues to autoimmunity?
    • Baum, H., Davies, H. and Peakman, M. (1996). Molecular mimicry in the MHC: hidden clues to autoimmunity? Immunol. Today, 17, 68-70.
    • (1996) Immunol. Today , vol.17 , pp. 68-70
    • Baum, H.1    Davies, H.2    Peakman, M.3
  • 22
    • 0029954214 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellitus
    • Tisch, R. and McDevitt, H. (1996). Insulin-dependent diabetes mellitus. Cell, 85, 291-7.
    • (1996) Cell , vol.85 , pp. 291-297
    • Tisch, R.1    McDevitt, H.2
  • 23
    • 0018091003 scopus 로고
    • Type I diabetes mellitus
    • Cudworth, A. G. (1978). Type I diabetes mellitus. Diahetologia, 14, 281-91.
    • (1978) Diahetologia , vol.14 , pp. 281-291
    • Cudworth, A.G.1
  • 25
    • 0024295286 scopus 로고
    • HLA antigens and insulin-dependent diabetes
    • Todd, J. A., Bell, J. I. and McDevitt, H. O. (1988). HLA antigens and insulin-dependent diabetes. Nature, 333, 710.
    • (1988) Nature , vol.333 , pp. 710
    • Todd, J.A.1    Bell, J.I.2    McDevitt, H.O.3
  • 26
    • 0024399692 scopus 로고
    • New susceptibility haplotype for type 1 diabetes
    • DIME Study Group
    • Tuomilehto Wolf, E., Tuomilehto, J., Cepaitis, Z. and Lounamaa, R. (1989). New susceptibility haplotype for type 1 diabetes. DIME Study Group. Lancet, 2, 299-302.
    • (1989) Lancet , vol.2 , pp. 299-302
    • Tuomilehto Wolf, E.1    Tuomilehto, J.2    Cepaitis, Z.3    Lounamaa, R.4
  • 27
    • 0022365292 scopus 로고
    • Susceptibility to IDDM is marked by MHC supratypes rather than individual alleles
    • Kelly, H., McCann, V. J., Kay, P. H. and Dawkins, R. L. (1985). Susceptibility to IDDM is marked by MHC supratypes rather than individual alleles. Immunogenetics, 22, 643-51.
    • (1985) Immunogenetics , vol.22 , pp. 643-651
    • Kelly, H.1    McCann, V.J.2    Kay, P.H.3    Dawkins, R.L.4
  • 28
    • 0027460340 scopus 로고
    • A novel diabetes-susceptibility HLA haplotype is present in the Croatian population
    • Durinovic Bello, I., Schendel, D. J., Kastelan, A. and Segurado, O. G. (1993). A novel diabetes-susceptibility HLA haplotype is present in the Croatian population. Tissue Antigens., 41, 107-9.
    • (1993) Tissue Antigens , vol.41 , pp. 107-109
    • Durinovic Bello, I.1    Schendel, D.J.2    Kastelan, A.3    Segurado, O.G.4
  • 29
    • 0027217789 scopus 로고
    • Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1
    • see comments
    • Brown, J. H., Jardetzky, T. S., Gorga, J. C., Stern, L. J., Urban, R. G., Strominger, J. L. et al. (1993). Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1 [see comments]. Nature, 364, 33-9.
    • (1993) Nature , vol.364 , pp. 33-39
    • Brown, J.H.1    Jardetzky, T.S.2    Gorga, J.C.3    Stern, L.J.4    Urban, R.G.5    Strominger, J.L.6
  • 30
    • 0028348369 scopus 로고
    • Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
    • Stern, L. J., Brown, J. H., Jardetzky, T. S., Gorga, J. C., Urban, R. G., Strominger, J. L. et al. (1994). Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature, 368, 215-21.
    • (1994) Nature , vol.368 , pp. 215-221
    • Stern, L.J.1    Brown, J.H.2    Jardetzky, T.S.3    Gorga, J.C.4    Urban, R.G.5    Strominger, J.L.6
  • 31
    • 0025369192 scopus 로고
    • Peptide binding to HLA-DR1 : A peptide with most residues substituted to alanine retains MHC binding
    • Jardetzky, T. S., Gorga, J. C, Busch, R., Rothbard, J., Strominger, J. L. and Wiley, D. C. (1990). Peptide binding to HLA-DR1 : a peptide with most residues substituted to alanine retains MHC binding. EMBO J., 9, 1797-803.
    • (1990) EMBO J. , vol.9 , pp. 1797-1803
    • Jardetzky, T.S.1    Gorga, J.C.2    Busch, R.3    Rothbard, J.4    Strominger, J.L.5    Wiley, D.C.6
  • 32
    • 0028985984 scopus 로고
    • MHC ligands and peptide motifs: First listing
    • Rammensee, H. G., Friede, T. and Stevanovic, S. (1995). MHC ligands and peptide motifs: first listing. Immunogenetics, 41, 178-228.
    • (1995) Immunogenetics , vol.41 , pp. 178-228
    • Rammensee, H.G.1    Friede, T.2    Stevanovic, S.3
  • 33
    • 0001330676 scopus 로고
    • HLA class II associations in insulin-dependent diabetes mellitus among Blacks, Caucasoids and Japanese
    • Tsuji, K., Aitawa, M., Sasazuki. T. (eds.). Oxford, U.K., Oxford Science Publications
    • Ronningen, K. S., et al. (1993). HLA class II associations in insulin-dependent diabetes mellitus among Blacks, Caucasoids and Japanese. In: HLA 1991. Vol. 1. Tsuji, K., Aitawa, M., Sasazuki. T. (eds.). Oxford, U.K., Oxford Science Publications, 713-22.
    • (1993) HLA 1991 , vol.1 , pp. 713-722
    • Ronningen, K.S.1
  • 34
    • 7144252901 scopus 로고
    • A restricted number of HLA-DQα/β heterodimers confer varying degrees of susceptibility to insulin-dependent diabetes mellitus
    • Tsuji, K., Aitawa, M., Sasazuki, T. (eds.). Oxford, U.K., Oxford Science Publications
    • Khalil, I., et al. (1993). A restricted number of HLA-DQα/β heterodimers confer varying degrees of susceptibility to insulin-dependent diabetes mellitus. In: HLA 1991. Vol. 1. Tsuji, K., Aitawa, M., Sasazuki, T. (eds.). Oxford, U.K., Oxford Science Publications, 483-492.
    • (1993) HLA 1991 , vol.1 , pp. 483-492
    • Khalil, I.1
  • 35
    • 0028952168 scopus 로고
    • Peptide binding specificity of HLA-DR4 molecules: Correlation with rheumatoid arthritis association
    • Hammer, J., Gallazzi, F., Bono, E., Karr, R. W., Guenot, J., Valsasnini, P., et al. (1995). Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association. J. Exp. Med., 181, 1847-55.
    • (1995) J. Exp. Med. , vol.181 , pp. 1847-1855
    • Hammer, J.1    Gallazzi, F.2    Bono, E.3    Karr, R.W.4    Guenot, J.5    Valsasnini, P.6
  • 36
    • 0029589932 scopus 로고
    • Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: Charged residues of a single MHC binding pocket confer selective presentation of selfpeptides in pemphigus vulgaris
    • Wucherpfennig, K. W., Yu, B., Bhol, K., Monos, D. S., Argyris, E., Karr. R. W., et al. (1995). Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of selfpeptides in pemphigus vulgaris. Proc. Natl. Acad. Sci. U.S.A., 92, 11935-9.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 11935-11939
    • Wucherpfennig, K.W.1    Yu, B.2    Bhol, K.3    Monos, D.S.4    Argyris, E.5    Karr, R.W.6
  • 38
    • 0025301142 scopus 로고
    • MHC-linked protection from diabetes dissociated from clonal deletion of T cells
    • Böhme, J., Schuhbaur, B., Kanagawa, O., Benoist, C. and Mathis, D. (1990). MHC-linked protection from diabetes dissociated from clonal deletion of T cells. Science, 249, 293-5.
    • (1990) Science , vol.249 , pp. 293-295
    • Böhme, J.1    Schuhbaur, B.2    Kanagawa, O.3    Benoist, C.4    Mathis, D.5
  • 39
    • 0027238178 scopus 로고
    • Particular HLA-DQ molecules play a dominant role in determining susceptibility or resistance to type 1 (insulin-dependent) diabetes mellitus
    • Thorsby, E. and Ronningen, K. S. (1993). Particular HLA-DQ molecules play a dominant role in determining susceptibility or resistance to type 1 (insulin-dependent) diabetes mellitus. Diabetologia, 36, 371-7.
    • (1993) Diabetologia , vol.36 , pp. 371-377
    • Thorsby, E.1    Ronningen, K.S.2
  • 40
    • 0029979525 scopus 로고    scopus 로고
    • Allele-specific motifs characterize HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase
    • Kwok, W. W., Domeier, M. E., Raymond, F. C., Byers, P. and Nepom, G. T. (1996). Allele-specific motifs characterize HLA-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase. J. Immunol., 156, 2171-7.
    • (1996) J. Immunol. , vol.156 , pp. 2171-2177
    • Kwok, W.W.1    Domeier, M.E.2    Raymond, F.C.3    Byers, P.4    Nepom, G.T.5
  • 41
    • 0026584174 scopus 로고
    • DIME Study Group. HLA haplotypes in type 1 (insulin-dependent) diabetes mellitus: Molecular analysis of the HLA-DQ locus
    • Tienari, P. J., Tuomilehto-Wolf, E. and Peltonen, L. (1992). DIME Study Group. HLA haplotypes in type 1 (insulin-dependent) diabetes mellitus: molecular analysis of the HLA-DQ locus. Diabetologia, 35, 254-60.
    • (1992) Diabetologia , vol.35 , pp. 254-260
    • Tienari, P.J.1    Tuomilehto-Wolf, E.2    Peltonen, L.3
  • 42
    • 0027957088 scopus 로고
    • A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population
    • Childhood Diabetes in Finland (DiMe) Study Group.
    • Fennessy, M., Metcalfe, K., Hitman, G. A., Niven, M., Biro, P. A., Tuomilehto, J., et al. (1994). A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population. Childhood Diabetes in Finland (DiMe) Study Group. Diabetologia, 37, 937-44.
    • (1994) Diabetologia , vol.37 , pp. 937-944
    • Fennessy, M.1    Metcalfe, K.2    Hitman, G.A.3    Niven, M.4    Biro, P.A.5    Tuomilehto, J.6
  • 43
    • 0028907414 scopus 로고
    • A new marker in the HLA class I region is associated with the age at onset of IDDM
    • Demaine, A. G., Hibberd, M. L., Mangles, D. and Millward, B. A. (1995). A new marker in the HLA class I region is associated with the age at onset of IDDM. Diabetologia, 38, 623-8.
    • (1995) Diabetologia , vol.38 , pp. 623-628
    • Demaine, A.G.1    Hibberd, M.L.2    Mangles, D.3    Millward, B.A.4
  • 44
    • 0027182192 scopus 로고
    • MHC-linked diabetogenic gene of the NOD mouse: Molecular mapping of the 3' boundary of the diabetogenic region
    • Ikegami, H., Kawaguchi, Y., Ueda, H., Fukuda, M., Takakawa, K., Fujioka, Y., et al. (1993). MHC-linked diabetogenic gene of the NOD mouse: molecular mapping of the 3' boundary of the diabetogenic region. Biochem. Biophys. Res. Commun., 192, 677-82.
    • (1993) Biochem. Biophys. Res. Commun. , vol.192 , pp. 677-682
    • Ikegami, H.1    Kawaguchi, Y.2    Ueda, H.3    Fukuda, M.4    Takakawa, K.5    Fujioka, Y.6
  • 45
  • 46
    • 0026664422 scopus 로고
    • Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen
    • Lehmann, P. V., Forsthuber, T., Miller, A. and Sercarz, E. E. (1992). Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature, 358, 155-7.
    • (1992) Nature , vol.358 , pp. 155-157
    • Lehmann, P.V.1    Forsthuber, T.2    Miller, A.3    Sercarz, E.E.4
  • 47
    • 0026012271 scopus 로고
    • Proinsulin autoantibodies are more closely associated with type 1 (insulin-dependent) diabetes mellitus than insulin autoantibodies
    • Böhmer, K., Keilacker, H., Kuglin, B., Hubinger, A., Bertrams, J., Gries, F. A., et al. (1991). Proinsulin autoantibodies are more closely associated with type 1 (insulin-dependent) diabetes mellitus than insulin autoantibodies. Diabetologia, 34, 830-4.
    • (1991) Diabetologia , vol.34 , pp. 830-834
    • Böhmer, K.1    Keilacker, H.2    Kuglin, B.3    Hubinger, A.4    Bertrams, J.5    Gries, F.A.6
  • 48
    • 0023128259 scopus 로고
    • Multiple immunological abnormalities in patients with type 1 (insulin-dependent) diabetes mellitus
    • Drell, D. W. and Notkins, A. L. (1987). Multiple immunological abnormalities in patients with type 1 (insulin-dependent) diabetes mellitus. Diabetologia, 30, 132-43.
    • (1987) Diabetologia , vol.30 , pp. 132-143
    • Drell, D.W.1    Notkins, A.L.2
  • 49
    • 0025841845 scopus 로고
    • Identification and cloning of a granule autoantigen (carboxypeptidase-H) associated with type I diabetes
    • Castano, L., Russo, E., Zhou, L., Lipes, M. A. and Eisenbarth, G. S. (1991). Identification and cloning of a granule autoantigen (carboxypeptidase-H) associated with type I diabetes. J. Clin. Endocrinol. Metab., 73, 1197-201.
    • (1991) J. Clin. Endocrinol. Metab. , vol.73 , pp. 1197-1201
    • Castano, L.1    Russo, E.2    Zhou, L.3    Lipes, M.A.4    Eisenbarth, G.S.5
  • 50
    • 0025039679 scopus 로고
    • Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
    • Baekkeskov, S., Aanstoot, H. J., Christgau, S., Reetz, A., Solimena, M., Cascalho, M., et al. (1990). Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature, 347, 151-6.
    • (1990) Nature , vol.347 , pp. 151-156
    • Baekkeskov, S.1    Aanstoot, H.J.2    Christgau, S.3    Reetz, A.4    Solimena, M.5    Cascalho, M.6
  • 51
    • 0027201783 scopus 로고
    • Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen
    • Pietropaolo, M., Castano, L., Babu, S., Buelow, R., Kuo, Y. L., Martin, S., et al. (1993). Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen. J. Clin. Invest., 92, 359-71.
    • (1993) J. Clin. Invest. , vol.92 , pp. 359-371
    • Pietropaolo, M.1    Castano, L.2    Babu, S.3    Buelow, R.4    Kuo, Y.L.5    Martin, S.6
  • 52
    • 0027930455 scopus 로고
    • Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma
    • Lan, M. S., Lu, J., Goto, Y. and Notkins, A. L. (1994). Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol., 13, 505-14.
    • (1994) DNA Cell Biol. , vol.13 , pp. 505-514
    • Lan, M.S.1    Lu, J.2    Goto, Y.3    Notkins, A.L.4
  • 53
    • 0030272780 scopus 로고    scopus 로고
    • IA-2 and IA-2β are major autoantigens in IDDM and the precursors of the 40 kDa and 37 kDa tryptic fragments
    • Notkins, A. L., Lu, J., Qing, L., VanderVegt, F. P., Wasserfall, C., Maclaren, N. K. and Lan, M. S. (1996). IA-2 and IA-2β are major autoantigens in IDDM and the precursors of the 40 kDa and 37 kDa tryptic fragments. J. Autoimm., 9, 677-82.
    • (1996) J. Autoimm. , vol.9 , pp. 677-682
    • Notkins, A.L.1    Lu, J.2    Qing, L.3    Vandervegt, F.P.4    Wasserfall, C.5    Maclaren, N.K.6    Lan, M.S.7
  • 54
    • 0029818739 scopus 로고    scopus 로고
    • Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2
    • Hawkes, C. J., Wasmeier, C., Christie, M. R. and Hutton, J. C. (1996). Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2. Diabetes, 45, 1187-92.
    • (1996) Diabetes , vol.45 , pp. 1187-1192
    • Hawkes, C.J.1    Wasmeier, C.2    Christie, M.R.3    Hutton, J.C.4
  • 55
    • 0029977765 scopus 로고    scopus 로고
    • Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes
    • Aanstoot, H. J., Kang, S. M., Kim. J., Lindsay, L. A., Roll, U., Knip, M., et at. (1996). Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes. J. Clin. Invest., 97, 2772-83.
    • (1996) J. Clin. Invest. , vol.97 , pp. 2772-2783
    • Aanstoot, H.J.1    Kang, S.M.2    Kim, J.3    Lindsay, L.A.4    Roll, U.5    Knip, M.6
  • 56
    • 0027169319 scopus 로고
    • Detection of pancreatic islet 64,000 M(r) autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase
    • Christie, M. R., Hollands, J. A., Brown, T. J., Michelsen, B. K. and Delovitch, T. L. (1993). Detection of pancreatic islet 64,000 M(r) autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase. J. Clin. Invest., 92, 240-8.
    • (1993) J. Clin. Invest. , vol.92 , pp. 240-248
    • Christie, M.R.1    Hollands, J.A.2    Brown, T.J.3    Michelsen, B.K.4    Delovitch, T.L.5
  • 57
    • 0026502693 scopus 로고
    • Peripherin: An islet antigen that is cross-reactive with nonobese diabetic mouse class II gene products
    • Boitard, C., Villa, M. C., Becourt, C., Gia, H. P., Hue, C, Sempe, P., et al. (1992). Peripherin: an islet antigen that is cross-reactive with nonobese diabetic mouse class II gene products. Proc. Natl. Acad. Sci. U.S.A., 89, 172-6.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 172-176
    • Boitard, C.1    Villa, M.C.2    Becourt, C.3    Gia, H.P.4    Hue, C.5    Sempe, P.6
  • 58
    • 0030026955 scopus 로고    scopus 로고
    • Imogen 38: A novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient
    • Arden, S. D., Roep, B. O., Neophytou, P. I., Usac, E. F., Duinkerken, G., de Vries, R. R., et al. (1996) Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient. J. Clin. Invest., 97, 551-61.
    • (1996) J. Clin. Invest. , vol.97 , pp. 551-561
    • Arden, S.D.1    Roep, B.O.2    Neophytou, P.I.3    Usac, E.F.4    Duinkerken, G.5    De Vries, R.R.6
  • 59
    • 0027502526 scopus 로고
    • Transcription factor jun-B is target of autoreactive T-cells in IDDM
    • Honeyman, M. C., Cram, D. S. and Harrison, L. C. (1993). Transcription factor jun-B is target of autoreactive T-cells in IDDM. Diabetes, 42, 626-30.
    • (1993) Diabetes , vol.42 , pp. 626-630
    • Honeyman, M.C.1    Cram, D.S.2    Harrison, L.C.3
  • 60
    • 0007102288 scopus 로고    scopus 로고
    • Identification of T cell epitopes of glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients
    • Endl, J., Otto, H., Jung, G., Dreisbusch, B., Donie, F., Stahl, P., Elbracht, R., Schmitz, G., Meinl, E., Zieglar, A.-G., Wank, R. and Schendel, D. J. (1997). Identification of T cell epitopes of glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients. J Exp Med, 99, 2405-15.
    • (1997) J Exp Med , vol.99 , pp. 2405-2415
    • Endl, J.1    Otto, H.2    Jung, G.3    Dreisbusch, B.4    Donie, F.5    Stahl, P.6    Elbracht, R.7    Schmitz, G.8    Meinl, E.9    Zieglar, A.-G.10    Wank, R.11    Schendel, D.J.12
  • 61
    • 0030175881 scopus 로고    scopus 로고
    • T cell clones to epitopes of glutamic acid decarboxylase 65 raised from normal subjects and patients with insulin-dependent diabetes
    • Lohmann, T., Leslie, R. D. and Londei, M. (1996). T cell clones to epitopes of glutamic acid decarboxylase 65 raised from normal subjects and patients with insulin-dependent diabetes. J. Autoimmun., 9, 385-9.
    • (1996) J. Autoimmun. , vol.9 , pp. 385-389
    • Lohmann, T.1    Leslie, R.D.2    Londei, M.3
  • 63
    • 0030051666 scopus 로고    scopus 로고
    • HLA-associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent-onset insulin-dependent diabetes mellitus
    • Roep, B. O., Duinkerken, G., Schreuder, G. M., Kolb, H., de Vries, R. R. and Martin, S. (1996). HLA-associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent-onset insulin-dependent diabetes mellitus. Ear. J. Immunol., 26, 1285-9.
    • (1996) Ear. J. Immunol. , vol.26 , pp. 1285-1289
    • Roep, B.O.1    Duinkerken, G.2    Schreuder, G.M.3    Kolb, H.4    De Vries, R.R.5    Martin, S.6
  • 64
    • 0018940983 scopus 로고
    • Associations of antibodies to native DNA with HLA-DRw3. A possible major histocompatibility complex-linked human immune response gene
    • Griffing, W. L., Moore, S. B., Luthra, H. S., McKenna, C. H. and Fathman, C. G. (1980). Associations of antibodies to native DNA with HLA-DRw3. A possible major histocompatibility complex-linked human immune response gene. J. Exp. Med., 152, 319-25.
    • (1980) J. Exp. Med. , vol.152 , pp. 319-325
    • Griffing, W.L.1    Moore, S.B.2    Luthra, H.S.3    McKenna, C.H.4    Fathman, C.G.5
  • 66
    • 0028932630 scopus 로고
    • Pancreatic islet beta cells drive T cell-immune responses in the nonobese diabetic mouse model
    • Larger, E., Becourt, C., Bach, J. F. and Boitard, C. (1995). Pancreatic islet beta cells drive T cell-immune responses in the nonobese diabetic mouse model. J. Exp. Med., 181, 1635-42.
    • (1995) J. Exp. Med. , vol.181 , pp. 1635-1642
    • Larger, E.1    Becourt, C.2    Bach, J.F.3    Boitard, C.4
  • 67
    • 0025001666 scopus 로고
    • Cellular immunity to human insulin in individuals at high risk for the development of type I diabetes mellitus
    • Keller, R. J. (1990). Cellular immunity to human insulin in individuals at high risk for the development of type I diabetes mellitus. J. Autoimmun., 3, 321-7.
    • (1990) J. Autoimmun. , vol.3 , pp. 321-327
    • Keller, R.J.1
  • 68
    • 0030935082 scopus 로고    scopus 로고
    • Altered immune response to insulin in newly diagnosed compared to insulin-treated diabetic patients and healthy control subjects
    • Schloot, N. C., Roep, B. O., Wegmann, D., Yu, L., Chase, H. P., Wang, T. and Eisenbarth, G. S. (1997). Altered immune response to insulin in newly diagnosed compared to insulin-treated diabetic patients and healthy control subjects. Diabetologia, 40, 564-672.
    • (1997) Diabetologia , vol.40 , pp. 564-672
    • Schloot, N.C.1    Roep, B.O.2    Wegmann, D.3    Yu, L.4    Chase, H.P.5    Wang, T.6    Eisenbarth, G.S.7
  • 69
    • 0029351614 scopus 로고
    • Sequence similarity between beta-cell autoanti-gens
    • Rudy, G., Brusic, V., Harrison, L. C. and Lew, A. M. (1995). Sequence similarity between beta-cell autoanti-gens. Immunol. Today, 16, 406-7.
    • (1995) Immunol. Today , vol.16 , pp. 406-407
    • Rudy, G.1    Brusic, V.2    Harrison, L.C.3    Lew, A.M.4
  • 70
    • 0029360443 scopus 로고
    • Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes
    • Rudy, G., Stone, N., Harrison, L. C., Colman, P. G., McNair, P., Brusic, V., et al. (1995). Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes. Mol. Med., 1, 625-33.
    • (1995) Mol. Med. , vol.1 , pp. 625-633
    • Rudy, G.1    Stone, N.2    Harrison, L.C.3    Colman, P.G.4    McNair, P.5    Brusic, V.6
  • 71
    • 0029946743 scopus 로고    scopus 로고
    • Perinatal autoimmunity in offspring of diabetic parents. The German Multicenter BABY-DIAB study: Detection of humoral immune responses to islet antigens in early childhood
    • Roll, U., Christie, M. R., Fuchtenbusch, M., Payton, M. A., Hawkes, C. J. and Ziegler, A. G. (1996). Perinatal autoimmunity in offspring of diabetic parents. The German Multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes, 45, 967-73.
    • (1996) Diabetes , vol.45 , pp. 967-973
    • Roll, U.1    Christie, M.R.2    Fuchtenbusch, M.3    Payton, M.A.4    Hawkes, C.J.5    Ziegler, A.G.6
  • 72
    • 0027368141 scopus 로고
    • Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes
    • Kaufman, D. L., Clare Salzler, M., Tian, J., Forsthuber, T., Ting, G. S., Robinson, P., et al. (1993). Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature, 366, 69-72.
    • (1993) Nature , vol.366 , pp. 69-72
    • Kaufman, D.L.1    Clare Salzler, M.2    Tian, J.3    Forsthuber, T.4    Ting, G.S.5    Robinson, P.6
  • 73
    • 0028145676 scopus 로고
    • Insulin-Specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice
    • Wegman, D. R., Norbury-Glaser, M. and Daniel, D. (1994). Insulin-Specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice. Eur. J. Immunol., 24, 1853-57.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 1853-1857
    • Wegman, D.R.1    Norbury-Glaser, M.2    Daniel, D.3
  • 74
    • 0030069688 scopus 로고    scopus 로고
    • Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)
    • Daniel, D. and Wegman, D. R. (1996). Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc. Natl. Acad. Sci., 93, 956-69.
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 956-969
    • Daniel, D.1    Wegman, D.R.2
  • 75
    • 0029923412 scopus 로고    scopus 로고
    • An insulin peptide that binds an alternative site in class II major histocompatibility complex
    • Tompkins, S. M., Moore, J. C. and Jensen, P. E. (1996). An insulin peptide that binds an alternative site in class II major histocompatibility complex. J. Exp. Med., 183, 857-66.
    • (1996) J. Exp. Med. , vol.183 , pp. 857-866
    • Tompkins, S.M.1    Moore, J.C.2    Jensen, P.E.3
  • 76
    • 0025689791 scopus 로고
    • T cells from nonre-sponder mice. MHC restricted and unrestricted recognition of insulin
    • Jensen, P. E. and Kraft, A. O. (1990). T cells from nonre-sponder mice. MHC restricted and unrestricted recognition of insulin. J Immunol., 145, 3985-91.
    • (1990) J Immunol. , vol.145 , pp. 3985-3991
    • Jensen, P.E.1    Kraft, A.O.2
  • 77
    • 0015400143 scopus 로고
    • Emergence of insulin receptors on human lymphocytes during in vitro transformation
    • Krug, U., Krug, F. and Cuatrecasas, P., et al. (1972). Emergence of insulin receptors on human lymphocytes during in vitro transformation. Proc. Natl. Acad. Sci. U.S.A., 69, 2604-8.
    • (1972) Proc. Natl. Acad. Sci. U.S.A. , vol.69 , pp. 2604-2608
    • Krug, U.1    Krug, F.2    Cuatrecasas, P.3
  • 78
    • 0020000944 scopus 로고
    • Mitogen-induced changes in glycolytic enzymes of mouse lymphocytes: Influence of insulin on cell activation in vitro
    • Diaz Espada, F. and Lopez Alarcon, L. (1982). Mitogen-induced changes in glycolytic enzymes of mouse lymphocytes: influence of insulin on cell activation in vitro. Immunology, 46, 705-12.
    • (1982) Immunology , vol.46 , pp. 705-712
    • Diaz Espada, F.1    Lopez Alarcon, L.2
  • 79
    • 0018582056 scopus 로고
    • Role of protein and RNA synthesis in the development of insulin binding sites on activated thymus-derived lymphocytes
    • Helderman, J. H. and Strom, T. B. (1979). Role of protein and RNA synthesis in the development of insulin binding sites on activated thymus-derived lymphocytes. J. Biol. Chem., 254, 7203-7.
    • (1979) J. Biol. Chem. , vol.254 , pp. 7203-7207
    • Helderman, J.H.1    Strom, T.B.2
  • 80
    • 0016634622 scopus 로고
    • Insulin-induced augmentation of lymphocyte-mediated cytotoxicity
    • Strom, T. B., Bear, R. A. and Carpenter, C. B. (1975). Insulin-induced augmentation of lymphocyte-mediated cytotoxicity. Science, 187, 1206-8.
    • (1975) Science , vol.187 , pp. 1206-1208
    • Strom, T.B.1    Bear, R.A.2    Carpenter, C.B.3
  • 81
    • 0020584347 scopus 로고
    • T cell subpopulation dynamics following insulin-induced hypoglycemia in normal subjects
    • Bhakri, H. L., Jones, H., Jones, D. A., Pettingale, K. W. and Tee D. E. H. (1983). T cell subpopulation dynamics following insulin-induced hypoglycemia in normal subjects. Clin. Exp. Immunol., 53, 83-7.
    • (1983) Clin. Exp. Immunol. , vol.53 , pp. 83-87
    • Bhakri, H.L.1    Jones, H.2    Jones, D.A.3    Pettingale, K.W.4    Tee, D.E.H.5
  • 82
    • 0028239150 scopus 로고
    • Two subsets of HLA-DQA1 alleles mark phenotypic variation in levels of insulin autoantibodies in first degree relatives at risk for insulin-dependent diabetes
    • Pugliese, A., Bugawan, T., Moromisato, R., Awdeh, Z. L., Alper, C. A., Jackson, R. A., et al. (1994). Two subsets of HLA-DQA1 alleles mark phenotypic variation in levels of insulin autoantibodies in first degree relatives at risk for insulin-dependent diabetes. J. Clin. Invest., 93, 2447-52.
    • (1994) J. Clin. Invest. , vol.93 , pp. 2447-2452
    • Pugliese, A.1    Bugawan, T.2    Moromisato, R.3    Awdeh, Z.L.4    Alper, C.A.5    Jackson, R.A.6
  • 83
    • 0025896881 scopus 로고
    • Specific association of HLA-DR4 with increased prevalence and level of insulin autoantibodies in first-degree relatives of patients with type I diabetes
    • Ziegler, R., Alper, C. A., Awdeh, Z. L., Castano, L., Brink, S. J., Soeldner J. S., et al. (1991). Specific association of HLA-DR4 with increased prevalence and level of insulin autoantibodies in first-degree relatives of patients with type I diabetes. Diabetes, 40, 709-14.
    • (1991) Diabetes , vol.40 , pp. 709-714
    • Ziegler, R.1    Alper, C.A.2    Awdeh, Z.L.3    Castano, L.4    Brink, S.J.5    Soeldner, J.S.6
  • 84
    • 0025899032 scopus 로고
    • HLA-associated insulin autoantibody formation in newly diagnosed type I diabetic patients
    • Ziegler, A. G., Standl, E., Albert, E. and Mehnert, H. (1991). HLA-associated insulin autoantibody formation in newly diagnosed type I diabetic patients. Diabetes, 40, 1146-9.
    • (1991) Diabetes , vol.40 , pp. 1146-1149
    • Ziegler, A.G.1    Standl, E.2    Albert, E.3    Mehnert, H.4
  • 85
    • 0027908753 scopus 로고
    • Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
    • Tisch, R., Yang, X. D., Singer, S. M., Liblau, R. S., Fugger, L. and McDevitt, H. O. (1993). Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature, 366, 72-5.
    • (1993) Nature , vol.366 , pp. 72-75
    • Tisch, R.1    Yang, X.D.2    Singer, S.M.3    Liblau, R.S.4    Fugger, L.5    McDevitt, H.O.6
  • 86
    • 0030069688 scopus 로고    scopus 로고
    • Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)
    • Dylan, D. and Wegmann, D. R. (1996). Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc. Natl. Acad. Sci. U.S.A., 93, 956-60.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 956-960
    • Dylan, D.1    Wegmann, D.R.2
  • 87
    • 0025837184 scopus 로고
    • Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin
    • Zhang, Z. J., Davidson, L., Eisenbarth, G. and Weiner, H. L. (1991). Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc. Natl. Acad. Sci. U.S.A., 88, 10252-6
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 10252-10256
    • Zhang, Z.J.1    Davidson, L.2    Eisenbarth, G.3    Weiner, H.L.4
  • 88
    • 0028143519 scopus 로고
    • T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele
    • Tian, J., Lehmann, P. V. and Kaufman, D. L. (1994). T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele. J. Exp. Med., 180, 1979-84.
    • (1994) J. Exp. Med. , vol.180 , pp. 1979-1984
    • Tian, J.1    Lehmann, P.V.2    Kaufman, D.L.3
  • 89
    • 0028586035 scopus 로고
    • Immunization with the larger isoform of mouse glutamic acid decarboxylase (GAD67) prevents autoimmune diabetes in NOD mice
    • Elliott, J. F., Qin, H.-Y., Bhatti, S., Smith, D. K., Singh, R. K., Dillon, T., et al. (1994). Immunization with the larger isoform of mouse glutamic acid decarboxylase (GAD67) prevents autoimmune diabetes in NOD mice. Diabetes, 43, 1494-9.
    • (1994) Diabetes , vol.43 , pp. 1494-1499
    • Elliott, J.F.1    Qin, H.-Y.2    Bhatti, S.3    Smith, D.K.4    Singh, R.K.5    Dillon, T.6
  • 90
    • 0028007192 scopus 로고
    • Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes
    • Atkinson, M. A., Bowman, M. A., Campbell, L., Darrow, B. L., Kaufman, D. L. and Maclaren, N. K. (1994). Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J. Clin. Invest., 94, 2125-9.
    • (1994) J. Clin. Invest. , vol.94 , pp. 2125-2129
    • Atkinson, M.A.1    Bowman, M.A.2    Campbell, L.3    Darrow, B.L.4    Kaufman, D.L.5    Maclaren, N.K.6
  • 91
    • 0028333066 scopus 로고
    • Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus
    • see comments
    • Lohmann, T., Leslie, R. D., Hawa, M., Geysen, M., Rodda, S. and Londei, M. (1994). Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus [see comments]. Lancet, 343, 1607-8.
    • (1994) Lancet , vol.343 , pp. 1607-1608
    • Lohmann, T.1    Leslie, R.D.2    Hawa, M.3    Geysen, M.4    Rodda, S.5    Londei, M.6
  • 92
    • 0029959628 scopus 로고    scopus 로고
    • Proliferate lymphocyte responses to virus antigens homologous to GAD65 in IDDM
    • Jones, D. B. and Crosby, I. (1996). Proliferate lymphocyte responses to virus antigens homologous to GAD65 in IDDM. Diabetologia, 39, 1318-24.
    • (1996) Diabetologia , vol.39 , pp. 1318-1324
    • Jones, D.B.1    Crosby, I.2
  • 93
    • 0021799839 scopus 로고
    • HLA-DR3 and -DR4 control T-lymphocyte responses to mumps and Coxsackie B4 virus: Studies on patients with type 1 (insulin-dependent) diabetes and healthy subjects
    • Bruserud, O., Jervell, J. and Thorsby, E. (1985). HLA-DR3 and -DR4 control T-lymphocyte responses to mumps and Coxsackie B4 virus: studies on patients with type 1 (insulin-dependent) diabetes and healthy subjects. Diabetologia, 28, 420-6.
    • (1985) Diabetologia , vol.28 , pp. 420-426
    • Bruserud, O.1    Jervell, J.2    Thorsby, E.3
  • 94
    • 0028838831 scopus 로고
    • HLA-associated heterogeneity of the humoral response to islet antigens in insulin-dependent diabetes
    • Delamaire, M., Timsit, J., Caillat Zucman, S., Maugendre. D., Roussely, H., Semana, G., et al. (1995). HLA-associated heterogeneity of the humoral response to islet antigens in insulin-dependent diabetes. J. Autoimmun., 8, 645-57.
    • (1995) J. Autoimmun. , vol.8 , pp. 645-657
    • Delamaire, M.1    Timsit, J.2    Caillat Zucman, S.3    Maugendre, D.4    Roussely, H.5    Semana, G.6
  • 95
    • 0029051788 scopus 로고
    • The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2
    • Passini, N., Larigan, J. D., Genovese, S., Appella, E., Sinigaglia, F. and Rogge, L. (1995). The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2. Proc. Natl. Acad. Sci. U.S.A., 92, 9412-6.
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 9412-9416
    • Passini, N.1    Larigan, J.D.2    Genovese, S.3    Appella, E.4    Sinigaglia, F.5    Rogge, L.6
  • 96
    • 0029120042 scopus 로고
    • Relationship of the 37,000- and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512)
    • Payton, M. A., Hawkes, C. J. and Christie, M. R. (1995). Relationship of the 37,000- and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). J. Clin. Invest., 96, 1506-11.
    • (1995) J. Clin. Invest. , vol.96 , pp. 1506-1511
    • Payton, M.A.1    Hawkes, C.J.2    Christie, M.R.3
  • 97
    • 0023079312 scopus 로고
    • Endotoxins and disease mechanisms
    • Morrison, D. C. and Ryan, Y. L. (1987). Endotoxins and disease mechanisms. Ann Rev Med, 38, 417-32.
    • (1987) Ann Rev Med , vol.38 , pp. 417-432
    • Morrison, D.C.1    Ryan, Y.L.2
  • 98
    • 0028899305 scopus 로고
    • Lipopolysaccharide (LPS) signal transduction and clearance. Dual roles for LPS binding protein and membrane CD14
    • Gegner, J. A., et al. (1995). Lipopolysaccharide (LPS) signal transduction and clearance. Dual roles for LPS binding protein and membrane CD14. J Biol Chem, 270, 5320-25.
    • (1995) J Biol Chem , vol.270 , pp. 5320-5325
    • Gegner, J.A.1
  • 99
    • 0028154865 scopus 로고
    • Antibodies to islet 37 k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity
    • Christie, M. R., Genovese, S., Cassidy, D., Bosi. E., Brown, T. J., Lai, M., et al. (1994). Antibodies to islet 37 k antigen, but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity. Diabetes, 43, 1254-9.
    • (1994) Diabetes , vol.43 , pp. 1254-1259
    • Christie, M.R.1    Genovese, S.2    Cassidy, D.3    Bosi, E.4    Brown, T.J.5    Lai, M.6
  • 100
    • 0028276510 scopus 로고
    • Perspectives in diabetes: Early environmental events as a cause of IDDM. Evidence and implications
    • Leslie, R. D. G. and Elliott, R. B. (1994). Perspectives in diabetes: Early environmental events as a cause of IDDM. Evidence and implications. Diabetes, 43, 843-50.
    • (1994) Diabetes , vol.43 , pp. 843-850
    • Leslie, R.D.G.1    Elliott, R.B.2
  • 101
    • 0020466235 scopus 로고
    • Lymphocyte insulitis in NOD (non-obese diabetic) mice: An immunohistochemical and electron microscope investigation
    • Fujita, T., Yui, R., Kusumoto, J., Serizawa, J., Makino, S. and Tochino, Y. (1982). Lymphocyte insulitis in NOD (non-obese diabetic) mice: an immunohistochemical and electron microscope investigation. Biochem Res, 3, 429-30.
    • (1982) Biochem Res , vol.3 , pp. 429-430
    • Fujita, T.1    Yui, R.2    Kusumoto, J.3    Serizawa, J.4    Makino, S.5    Tochino, Y.6
  • 102
    • 0025234628 scopus 로고
    • Type-I diabetes: A chronic autoimmune disease of human, mouse, and rat
    • Castano, L. and Eisenbarth, G. S. (1990). Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat. Anna. Rev. Immunol., 8, 647-79.
    • (1990) Anna. Rev. Immunol. , vol.8 , pp. 647-679
    • Castano, L.1    Eisenbarth, G.S.2
  • 103
    • 0029560637 scopus 로고
    • Cellular and humoral autoimmunity in insulin-dependent diabetes mellitus
    • Scherbaum, W. A. and Seissler, J. (1995). Cellular and humoral autoimmunity in insulin-dependent diabetes mellitus. Exp. Clin. Endocrinol., 103, 88-94.
    • (1995) Exp. Clin. Endocrinol. , vol.103 , pp. 88-94
    • Scherbaum, W.A.1    Seissler, J.2
  • 104
    • 0030175582 scopus 로고    scopus 로고
    • Relation between cellular and humoral immunity to islet cell antigens in type 1 diabetes
    • Hummel. M., Durinovic Bello, I. and Ziegler, A. G. (1996). Relation between cellular and humoral immunity to islet cell antigens in type 1 diabetes. J. Autoimmun., 9, 427-30.
    • (1996) J. Autoimmun. , vol.9 , pp. 427-430
    • Hummel, M.1    Durinovic Bello, I.2    Ziegler, A.G.3
  • 105
    • 0027176158 scopus 로고
    • Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes
    • Harrison, L. C., Honeyman, M. C., De Aizpurua, H. J., et al. (1993). Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes. Lancet, 341, 1365-1369.
    • (1993) Lancet , vol.341 , pp. 1365-1369
    • Harrison, L.C.1    Honeyman, M.C.2    De Aizpurua, H.J.3
  • 106
    • 0027267589 scopus 로고
    • Suppressive effect of antibody on processing of T cell epitopes
    • Watts, C. and Lanzavecchia, A. (1993). Suppressive effect of antibody on processing of T cell epitopes. J Exp Med, 178, 1459-1463.
    • (1993) J Exp Med , vol.178 , pp. 1459-1463
    • Watts, C.1    Lanzavecchia, A.2
  • 107
    • 0029035307 scopus 로고
    • Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants
    • Simitsek, P. D., Campbell, D. G., Lanzavecchia, A., Fairweather, N. and Watts, C. (1995). Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants. J Exp Med, 181, 1957-1963.
    • (1995) J Exp Med , vol.181 , pp. 1957-1963
    • Simitsek, P.D.1    Campbell, D.G.2    Lanzavecchia, A.3    Fairweather, N.4    Watts, C.5
  • 108
    • 0029006389 scopus 로고
    • How can cryptic epitopes trigger autoimmunity?
    • Lanzavecchia, A. (1995). How can cryptic epitopes trigger autoimmunity? J Exp Med, 181, 1945-1948.
    • (1995) J Exp Med , vol.181 , pp. 1945-1948
    • Lanzavecchia, A.1
  • 109
    • 0029328373 scopus 로고
    • Analysis of families at risk for insulin-dependent diabetes mellitus reveals that HLA antigens influence progression to clinical disease
    • Honeyman, M. C., Harrison, L. C., Drummond, B., Colman, P. G. and Tait, B. (1995). Analysis of families at risk for insulin-dependent diabetes mellitus reveals that HLA antigens influence progression to clinical disease. Molecular Medicine, 5, 576-582.
    • (1995) Molecular Medicine , vol.5 , pp. 576-582
    • Honeyman, M.C.1    Harrison, L.C.2    Drummond, B.3    Colman, P.G.4    Tait, B.5
  • 110
    • 0028919877 scopus 로고
    • Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo
    • Pfeffer, C., Stein, J., Southwood, S., Ketelaar, H., Sette, A. and Bottomly, K. (1995). Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J Exp Med, 181, 1569-1574.
    • (1995) J Exp Med , vol.181 , pp. 1569-1574
    • Pfeffer, C.1    Stein, J.2    Southwood, S.3    Ketelaar, H.4    Sette, A.5    Bottomly, K.6
  • 111
    • 0025918161 scopus 로고
    • Selective activation of Th1 and Th2 like cells in vivo. Response to human collagen IV
    • Pfeffer, C., Murray, J. and Bottomly, K. (1991). Selective activation of Th1 and Th2 like cells in vivo. Response to human collagen IV. Immunol Rev, 123, 65-84.
    • (1991) Immunol Rev , vol.123 , pp. 65-84
    • Pfeffer, C.1    Murray, J.2    Bottomly, K.3
  • 112
    • 0028273244 scopus 로고
    • Initiation of autoimmunity to the p53 tumor suppressor protein by complexes of p53 and SV40 large T antigen
    • Dong, X., Hamilton, K. J., Satoh, M., Wang, J. and Reeves, W. H. (1994). Initiation of autoimmunity to the p53 tumor suppressor protein by complexes of p53 and SV40 large T antigen. J Exp Med, 179, 1243-1252.
    • (1994) J Exp Med , vol.179 , pp. 1243-1252
    • Dong, X.1    Hamilton, K.J.2    Satoh, M.3    Wang, J.4    Reeves, W.H.5
  • 114
    • 0028871202 scopus 로고
    • Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus
    • Bennett, S. T., Lucassen, A. M., Gough, S. C. L., Powell, E. E., Undlien, D. E., Pritchard, L. E., et al. (1995). Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nature Genetics, 9, 284-292.
    • (1995) Nature Genetics , vol.9 , pp. 284-292
    • Bennett, S.T.1    Lucassen, A.M.2    Gough, S.C.L.3    Powell, E.E.4    Undlien, D.E.5    Pritchard, L.E.6
  • 115
    • 0001982584 scopus 로고
    • Diabetogenic effects of lymphocyte transfusion on the NOD or NOD nude mouse
    • Rygaard, J., Brunner, N., Graem, N., Spang-Thomsen, N. (eds). Karger, Basel
    • Suzuki, T., Yamada, Y., Fujimura, T., et al. (1987). Diabetogenic effects of lymphocyte transfusion on the NOD or NOD nude mouse. In: Rygaard, J., Brunner, N., Graem, N., Spang-Thomsen, N. (eds). Immune-deficient animals in biomedical research. Karger, Basel, 112-6.
    • (1987) Immune-deficient Animals in Biomedical Research , pp. 112-116
    • Suzuki, T.1    Yamada, Y.2    Fujimura, T.3
  • 116
    • 0025295215 scopus 로고
    • Viruses as therapeutic agents. Treatment of nonobese insulin-dependent diabetes mice with virus prevents insulin-dependent diabetes mellitus while maintaining general immune competence
    • Oldstone, M. B. (1990). Viruses as therapeutic agents. Treatment of nonobese insulin-dependent diabetes mice with virus prevents insulin-dependent diabetes mellitus while maintaining general immune competence. J. Exp. Med., 171, 2077-89.
    • (1990) J. Exp. Med. , vol.171 , pp. 2077-2089
    • Oldstone, M.B.1
  • 117
    • 0027314785 scopus 로고
    • Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice
    • Qin, H. Y., Sadelain, M. W., Hitchon, C., Lauzon, J. and Singh, B. (1993). Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice. J. Immunol., 150, 2072-80.
    • (1993) J. Immunol. , vol.150 , pp. 2072-2080
    • Qin, H.Y.1    Sadelain, M.W.2    Hitchon, C.3    Lauzon, J.4    Singh, B.5
  • 118
    • 0028124541 scopus 로고
    • Predictive medicine in autoimmune diseases: From the identification of genetic predisposition and environmental influence to precocious immunotherapie
    • Bach, J. F. (1994). Predictive medicine in autoimmune diseases: from the identification of genetic predisposition and environmental influence to precocious immunotherapie. Clin Immunol Immunopathol, 72, 156-161.
    • (1994) Clin Immunol Immunopathol , vol.72 , pp. 156-161
    • Bach, J.F.1
  • 119
    • 0027213675 scopus 로고
    • Diabetes mellitus due to viruses-some recent developments
    • Szopa, T. M., Titchener, P. A., Portwood, N. D. and Taylor, K. W. (1993). Diabetes mellitus due to viruses-some recent developments. Diabetologia, 36, 687-695.
    • (1993) Diabetologia , vol.36 , pp. 687-695
    • Szopa, T.M.1    Titchener, P.A.2    Portwood, N.D.3    Taylor, K.W.4
  • 120
    • 0022812136 scopus 로고
    • Congenital rubella: Monoclonal antibody defined T-cell abnormalities in young children
    • Rabinowe, S. L., George, K. L., Laughlin, R., Soeldner, J. S. and Eisenbarth, G. S. (1986). Congenital rubella: monoclonal antibody defined T-cell abnormalities in young children. Am J Med, 81, 779-782.
    • (1986) Am J Med , vol.81 , pp. 779-782
    • Rabinowe, S.L.1    George, K.L.2    Laughlin, R.3    Soeldner, J.S.4    Eisenbarth, G.S.5
  • 121
    • 0017817291 scopus 로고
    • Rubella infection and diabetes mellitus
    • Menser, M. A., Forrest, J. M. and Bransby, R. D. (1978). Rubella infection and diabetes mellitus. Lancet, 1, 57-60.
    • (1978) Lancet , vol.1 , pp. 57-60
    • Menser, M.A.1    Forrest, J.M.2    Bransby, R.D.3
  • 122
    • 0018780417 scopus 로고
    • Congenital cytomegalovirus and diabetes
    • Ward, K. P., Galloway, W. H. and Aucherlonie, I. A. (1979). Congenital cytomegalovirus and diabetes. Lancet, I. 497-99.
    • (1979) Lancet , vol.1 , pp. 497-499
    • Ward, K.P.1    Galloway, W.H.2    Aucherlonie, I.A.3
  • 123
    • 84936204818 scopus 로고
    • Cytomegalovirus infection with autoimmune type I diabetes
    • Park, C-Y., McArthur, R. G., Eun. H.-M. and Yoon, J.-W. (1979). Cytomegalovirus infection with autoimmune type I diabetes. Lancet, I, 1-14.
    • (1979) Lancet , vol.1 , pp. 1-14
    • Park, C.-Y.1    McArthur, R.G.2    Eun, H.-M.3    Yoon, J.-W.4
  • 124
    • 0025734420 scopus 로고
    • Oncreased incidence of insulin dependent diabetes mellitus following an epidemic of Coxsackie B5
    • Wagenknecht, L. E., Roseman, J. M. and Herman, W. H. (1991). Oncreased incidence of insulin dependent diabetes mellitus following an epidemic of Coxsackie B5. Am J Epidemiol, 133, 1024-1031.
    • (1991) Am J Epidemiol , vol.133 , pp. 1024-1031
    • Wagenknecht, L.E.1    Roseman, J.M.2    Herman, W.H.3
  • 125
    • 0016659007 scopus 로고
    • Synthesis of proinsulin and large glucagon immunoreactivity in isolated islets of Largenhans from EMC virus infected mice
    • Petersen, K. G., Heilmeyer, P. and Kerp, L. (1975). Synthesis of proinsulin and large glucagon immunoreactivity in isolated islets of Largenhans from EMC virus infected mice. Diabetologia, 11, 21-25.
    • (1975) Diabetologia , vol.11 , pp. 21-25
    • Petersen, K.G.1    Heilmeyer, P.2    Kerp, L.3
  • 126
    • 0025649176 scopus 로고
    • Coxsackie B4 virus-induced changes in mouse pancreatic β-cell mRNAs
    • Portwood, N. D. and Taylor, K. W. (1990). Coxsackie B4 virus-induced changes in mouse pancreatic β-cell mRNAs. Biochem Soc Trans, 18, 1264-67.
    • (1990) Biochem Soc Trans , vol.18 , pp. 1264-1267
    • Portwood, N.D.1    Taylor, K.W.2
  • 127
    • 0026575035 scopus 로고
    • Mumps virus infects beta cells in human fetal islet cell cultures upregulating the expression of HLA class I molecules
    • Parkkonen, P., Hyoty, H., Koskinen, L. and Leinikki, P. (1992). Mumps virus infects beta cells in human fetal islet cell cultures upregulating the expression of HLA class I molecules. Diabetologia, 35, 63-69.
    • (1992) Diabetologia , vol.35 , pp. 63-69
    • Parkkonen, P.1    Hyoty, H.2    Koskinen, L.3    Leinikki, P.4
  • 128
    • 0026556291 scopus 로고
    • Viral infection induces cytokine release by islet beta cells
    • Cavallo, M. G., Baroni, M. G., Toto, A., et al. (1992). Viral infection induces cytokine release by islet beta cells. Immunology, 75, 664-668.
    • (1992) Immunology , vol.75 , pp. 664-668
    • Cavallo, M.G.1    Baroni, M.G.2    Toto, A.3
  • 129
    • 0025361556 scopus 로고
    • Prevention of diabetes in the BB rat by essential fatty acid deficiency: Relationship between physiological and biochemical changes
    • Lefkovith, J., Schreiner, G., Cormier, J., Handler, E. S., Driscol, H. F., Greiner, D., et al. (1990). Prevention of diabetes in the BB rat by essential fatty acid deficiency: Relationship between physiological and biochemical changes. J Exp Med, 171, 729-743.
    • (1990) J Exp Med , vol.171 , pp. 729-743
    • Lefkovith, J.1    Schreiner, G.2    Cormier, J.3    Handler, E.S.4    Driscol, H.F.5    Greiner, D.6
  • 130
    • 0023866258 scopus 로고
    • Dietary prevention of diabetes in the non-obese diabetic mouse
    • Elliot, R. B., Reddy, S. N., Bibby, N. J. and Kida, K. (1988). Dietary prevention of diabetes in the non-obese diabetic mouse. Diabetologia, 31, 62-64.
    • (1988) Diabetologia , vol.31 , pp. 62-64
    • Elliot, R.B.1    Reddy, S.N.2    Bibby, N.J.3    Kida, K.4
  • 131
    • 0030999981 scopus 로고    scopus 로고
    • Immunological aspects of nutritional diabetes pretension in NOD mice. A pilot study for the cow's milk-based IDDM prevention trial
    • Karges, W., Hammond-McKibben, D., Cheung, R., Visconti, M., Shibuya, N., Kemp, D., et al. (1997). Immunological aspects of nutritional diabetes pretension in NOD mice. A pilot study for the cow's milk-based IDDM prevention trial. Diabetes, 46, 557-564.
    • (1997) Diabetes , vol.46 , pp. 557-564
    • Karges, W.1    Hammond-McKibben, D.2    Cheung, R.3    Visconti, M.4    Shibuya, N.5    Kemp, D.6
  • 132
    • 0020954467 scopus 로고
    • Helper functions of antigen-induced specific and autoreactive T cell colonies
    • Zauderer, M., Campbell, H., Johnson, D. R. and Seman, M. (1984). Helper functions of antigen-induced specific and autoreactive T cell colonies. J. Mol. Cell Immunol., 1, 65-77.
    • (1984) J. Mol. Cell Immunol. , vol.1 , pp. 65-77
    • Zauderer, M.1    Campbell, H.2    Johnson, D.R.3    Seman, M.4
  • 133
    • 0023107185 scopus 로고
    • Autoreactive T cell clones of MHC class II specificities are produced during responses against foreign antigens in man
    • Tilkin, A. F., Michon, J., Juy, D., Kayibanda, M., Henin, Y., Sterkers, G., et al. (1987). Autoreactive T cell clones of MHC class II specificities are produced during responses against foreign antigens in man. J. Immunol., 138, 674-9.
    • (1987) J. Immunol. , vol.138 , pp. 674-679
    • Tilkin, A.F.1    Michon, J.2    Juy, D.3    Kayibanda, M.4    Henin, Y.5    Sterkers, G.6
  • 134
    • 0025195538 scopus 로고
    • Immunoregulatory function of human autoreactive T-cell lines and clones
    • Strober, W. and James, S. P. (1990). Immunoregulatory function of human autoreactive T-cell lines and clones. Immunol. Rev., 116, 117-38.
    • (1990) Immunol. Rev. , vol.116 , pp. 117-138
    • Strober, W.1    James, S.P.2
  • 135
    • 0022592965 scopus 로고
    • An autoreactive T cell clone that can be activated to provide both helper and suppressor function
    • Kotani, H., Mitsuya, H., Jarrett, R. F., Yenokida, G. G., James, S. P. and Strober, W. (1986). An autoreactive T cell clone that can be activated to provide both helper and suppressor function. J Immunol., 136, 1951-9.
    • (1986) J Immunol. , vol.136 , pp. 1951-1959
    • Kotani, H.1    Mitsuya, H.2    Jarrett, R.F.3    Yenokida, G.G.4    James, S.P.5    Strober, W.6
  • 136
    • 0021367850 scopus 로고
    • Delineation of an immunoregulatory amplifier population recognizing autologous la molecules. Analysis with human T cell clones
    • Bensussan, A., Meuer, S. C., Schlossman, S. F. and Reinherz, E. L. (1984). Delineation of an immunoregulatory amplifier population recognizing autologous la molecules. Analysis with human T cell clones. J. Exp. Med., 159, 559-76.
    • (1984) J. Exp. Med. , vol.159 , pp. 559-576
    • Bensussan, A.1    Meuer, S.C.2    Schlossman, S.F.3    Reinherz, E.L.4
  • 137
    • 0024990092 scopus 로고
    • Autoreactive T cell clones isolated from normal and autoimmune-susceptible mice exhibit lymphokine secrectory and functional properties of both Th1 and Th2 cells
    • Kakkanaiah, V. H., Seth, A., Nagarkatti, M. and Nagarkatti, P. S. (1990). Autoreactive T cell clones isolated from normal and autoimmune-susceptible mice exhibit lymphokine secrectory and functional properties of both Th1 and Th2 cells. Clin, Immunol. Immunopathol., 57, 148.
    • (1990) Clin, Immunol. Immunopathol. , vol.57 , pp. 148
    • Kakkanaiah, V.H.1    Seth, A.2    Nagarkatti, M.3    Nagarkatti, P.S.4
  • 138
    • 0027324721 scopus 로고
    • Autoreactive T cells from a type 1 diabetic recognize multiple class II products
    • Miller, G., Nepom, G. T., Reich, M. B. and Thomas, J. W. (1993). Autoreactive T cells from a type 1 diabetic recognize multiple class II products. Hum. Immunol., 36. 219-26.
    • (1993) Hum. Immunol. , vol.36 , pp. 219-226
    • Miller, G.1    Nepom, G.T.2    Reich, M.B.3    Thomas, J.W.4
  • 139
    • 0019983815 scopus 로고
    • Production of autoreactive I region-restricted T cell hybridomas
    • Glimcher, L. and Shevach, E. M. (1982). Production of autoreactive I region-restricted T cell hybridomas. J. Exp. Med., 156, 640.
    • (1982) J. Exp. Med. , vol.156 , pp. 640
    • Glimcher, L.1    Shevach, E.M.2
  • 141
    • 0019920676 scopus 로고
    • Functionally distinct helper T cells enriched under different culture conditions cooperate with different B cells
    • Imperiale, M. J., Faherty, D. A., Sproviero, J. F. and Zauderer, M. (1982). Functionally distinct helper T cells enriched under different culture conditions cooperate with different B cells. J Immunol., 129, 1843-8.
    • (1982) J Immunol. , vol.129 , pp. 1843-1848
    • Imperiale, M.J.1    Faherty, D.A.2    Sproviero, J.F.3    Zauderer, M.4
  • 142
    • 0025774177 scopus 로고
    • Characterization of autoreactive T cells: Relative importance of self-peptides versus MHC
    • Wang, Y. and Perkins, D. L. (1991). Characterization of autoreactive T cells: relative importance of self-peptides versus MHC. J. Immunol., 147, 804.
    • (1991) J. Immunol. , vol.147 , pp. 804
    • Wang, Y.1    Perkins, D.L.2
  • 143
    • 0031025574 scopus 로고    scopus 로고
    • Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice
    • French, M. B., Allison, J., Cram, D. S., Thomas, H. E., Dempsey-Collier, M., Silva, A., et al. (1997). Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice. Diabetes, 46, 34-39.
    • (1997) Diabetes , vol.46 , pp. 34-39
    • French, M.B.1    Allison, J.2    Cram, D.S.3    Thomas, H.E.4    Dempsey-Collier, M.5    Silva, A.6
  • 144
    • 0023851039 scopus 로고
    • Evidence of IgG autoantibodies against human proinsulin in patients with IDDM before insulin treatment
    • Kuglin, B., Gries, F. A. and Kolb, H. (1988). Evidence of IgG autoantibodies against human proinsulin in patients with IDDM before insulin treatment. Diabetes, 37, 130-2.
    • (1988) Diabetes , vol.37 , pp. 130-132
    • Kuglin, B.1    Gries, F.A.2    Kolb, H.3
  • 145
    • 0025077679 scopus 로고
    • Proinsulin autoantibodies: Association with type I diabetes but not with islet cell antibodies, insulin autoantibodies or HLA-DR type
    • Kuglin, B., Halder, B., Bertrams, J., Gruneklee, D., Gries, F. A. and Kolb, H. (1990). Proinsulin autoantibodies: association with type I diabetes but not with islet cell antibodies, insulin autoantibodies or HLA-DR type. J. Autoimmun., 3, 573-7.
    • (1990) J. Autoimmun. , vol.3 , pp. 573-577
    • Kuglin, B.1    Halder, B.2    Bertrams, J.3    Gruneklee, D.4    Gries, F.A.5    Kolb, H.6
  • 146
    • 0028881617 scopus 로고
    • The minisatelite in the diabetes susceptibility locus 1DDM2 regulates insulin transcription
    • Kennedy, G. C., German, M. S. and Rutter, W. J. (1995). The minisatelite in the diabetes susceptibility locus 1DDM2 regulates insulin transcription. Nature Genetics, 9, 293-298.
    • (1995) Nature Genetics , vol.9 , pp. 293-298
    • Kennedy, G.C.1    German, M.S.2    Rutter, W.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.