An insulin peptide that binds an alternative site in class II major histocompatibility complex

Journal of Experimental Medicine

Volumn 183, Issue 3, 1996, Pages 857-866

  Tompkins, S Mark ^a   Moore, Joseph C ^a   Jensen, Peter E ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIGEN BINDING; ARTICLE; BINDING SITE; CELL STIMULATION; CRYSTAL STRUCTURE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PURIFICATION; RECEPTOR AFFINITY; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CATTLE; CELLS, CULTURED; ENTEROTOXINS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-DR1 ANTIGEN; HUMANS; INSULIN; KINETICS; LYMPHOCYTE ACTIVATION; LYMPHOMA, B-CELL; MACROMOLECULAR SUBSTANCES; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

EID: 0029923412     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.3.857     Document Type: Article

References (58)

1. Schwartz, R.H. 1985. T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu. Rev. Immunol. 3:237-261.
2. Guillet, J.-G., M.-Z. Lai, T.J. Briner, J.A. Smith, and M.L. Gefter. 1986. Interaction of peptide antigens and class II major histocompatibility complex antigens. Nature (Lond.). 324: 260-262.
3. Guillet, J.-G., M.-Z. Lai, T.J. Briner, S. Buus, A. Sette, H.M. Grey, J.A. Smith, and M.L. Gefter. 1987. Immunological self, nonself discrimination. Science (Wash. DC). 235:865-844.
4. Babbitt, B.P., P.M. Allen, G. Matsueda, E. Haber, and E.R. Unanue. 1985. Binding of immunogenic peptides to Ia histocompatibility molecules. Nature (Lond.). 317:359-361.
5. Buus, S., A. Sette, S.M. Colon, D.M. Jenis, and H.M. Grey. 1986. Isolation and characterization of antigen-Ia complexes involved in T cell recognition. Cell. 47:1071-1077.
6. Buus, S., A. Sette, S.M. Colon, C Miles, and H.M. Grey. 1987. The relation between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind immunogenic peptides. Science (Wash. DC). 235:1353-1358.
7. Brown, J.H., T.S. Jardestzky, J.C. Gorga, L.J. Stern, R.G. Urban, J.L. Strominger, and D.C. Wiley. 1993. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature (Lond.). 364:33-39.
8. Stern, L.J., J.H. Brown, T.S. Jardetzky, J.C. Gorga, R.G. Urban, J.L. Strominger, and D.C. Wiley. 1994. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature (Lond.). 368:215-221.
9. Jardetzky, T.S., J.H. Brown, J.C. Gorga, L.J. Stern, R.G. Urban, Y.I. Chi, C. Stauffacher, J.L. Strominger, and D.C. Wiley. 1994. Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen. Nature (Lond.). 368:711-718.
10. Marrack, P., and J. Kappler. 1990. The staphylococcal enterotoxins and their relatives. Science (Wash. DC). 248:705-711.
11. Herman, A., J.W. Kappler, P. Marrack, and A.M. Pullen. 1991. Superantigens: mechanism of T-cell stimulation and role in immune responses. Annu. Rev. Immunol. 9:745-772.
12. Fraser, J D. 1989. High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR. Nature (Lond.). 339:221-223.
13. Mollick, J.A., R.G. Cook, and R.R. Rich. 1989. Class II MHC molecules are specific receptors for staphylococcus enterotoxin A. Science (Wash. DC). 244:817-820.
14. Fischer, H., M. Dohlsten, M. Lindvall, H.O. Sjogren, and R. Carlsson. 1989. Binding of staphylococcal enterotoxin A to HLA-DR on B cell lines. J. Immunol. 142:3151-3157.
15. Scholl, P., A. Diez, W. Mourad, J. Parsonnet, R.S. Geha, and T. Chatila. 1989. Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules. Proc. Natl. Acad. Sci. USA. 86:4210-4214.
16. Herrmann, T., R.S. Accolla, and H.R. MacDonald. 1989. Different staphylococcal enterotoxins bind preferentially to distinct major histocompatibility complex class II isotypes. Eur. J. Immunol. 19:2171-2174.
17. Dellabona, P., J. Peccoud, J. Kappler, P. Marrack, C. Benoist, and D. Mathis. 1990. Superantigens interact with MHC class II molecules outside of the antigen groove. Cell. 62:1115-1121.
18. Herman, A., N. Labrecque, J. Thibodeau, P. Marrack, J.W. Kappler, and R.-P. Sekaly. 1991. Identification of the staphylococcal enterotoxin A superantigen binding site in the β1 domain of the human histocompatibility antigen HLA-DR. Proc. Natl. Acad. Sci. USA. 88:9954-9958.
19. Panina-Bordignon, P., X. Fu, A. Lanzavecchia, and R.W. Karr. 1992. Identification of HLA-DRα chain residues critical for binding of the toxic shock syndrome toxin superantigen. J. Exp. Med. 176:1779-1784.
20. Karp, D.R., and E.O. Long. 1992. Identification of HLA-DR1 beta chain residues critical for binding staphylococcal enterotoxins A and E. J. Exp. Med. 175:415-424.
21. Karp, D.R., C.L. Teletski, P. Scholl, R. Geha, and E.O. Long. 1990, The alpha 1 domain of the HLA-DR molecule is essential for high-affinity binding of the toxic shock syndrome toxin-1. Nature (Lond.). 346:474-476.
22. Kim, J., R.G. Urban, J.L. Strominger, and D.C. Wiley. 1994. Toxic shock syndrome toxin-1 complexed with a class II major histocompatibility molecule HLA-DR1. Science (Wash. DC). 266:1870-1874.
23. Kim, K.J., C. Kanellopoulos-Langevin, R.M. Merwin, D.H. Sachs, and R. Asofsky. 1979. Establishment and characterization of BALB/c lymphoma lines with B cell properties. J. Immunol. 122:549-554.
24. Jensen, P.E. 1991. Enhanced binding of peptide antigen to purified class II major histocompatibility glycoproteins at acidic pH. J. Exp. Med. 174:1111-1120.
25. + normal B cells. Immunol. Rev. 93:35-51.
26. Stern, L.J., and D.C. Wiley. 1992. The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide. Cell. 68:465-477.
27. Tompkins, S.M., P.A. Rota, J.C. Moore, and P.E. Jensen. 1993. A europium fluoroimmunoassay for measuring binding of antigen to class II MHC glycoproteins. J. Immunol. Methods. 163:209-216.
28. Sherman, M.A., H.A. Runnels, J.C. Moore, L.J. Stern, and P.E. Jensen. 1994. Membrane interactions influence the peptide binding behavior of DR1. J. Exp. Med. 179:229-234.
29. Xu, Y.Y., I. Hemmila, V.M. Mukkala, S. Holttinen, and T. Lovgren. 1991. Co-fluorescence of europium and samarium in time-resolved fluorimetric immunoassays. Analyst. 116: 1155-1158.
30. Callahan, J.E., A. Herman, J.W. Kappler, and P. Marrack. 1990. Stimulation of B10.BR T cells with superantigenic staphylococcal toxins. J. Immunol. 144:2473-2479.
31. Sinigaglia, F., and J. Hammer. 1995. Motifs and supermotifs for MHC class II binding peptides. J. Exp. Med. 181:449-451.
32. Rothbard, J.B., R.I. Lechler, K. Howland, V. Bal, D.D. Eckels, R. Sekaly, E.O. Long, W.R. Taylor, and J.R. Lamb. 1988. Structural model of HLA-DR1 restricted T cell antigen recognition. Cell. 52:515-523.
33. Roche, P.A., and P. Cresswell. 1990. High-affinity binding of an influenza hemagglutinin-derived peptide to purified HLA-DR. J. Immunol. 144:1849-1856.
34. Sadegh-Nasseri, S., and H.M. McConnell. 1989. A kinetic intermediate in the reaction of an antigenic peptide and I-Ek. Nature (Lond.). 337:274-276.
35. Sadegh-Nasseri, S., and R.N. Germain. 1991. A role for peptide in determining MHC class II structure. Nature (Lond.). 353:167-170.
36. Seth, A., L.J. Stern, T.H. Ottenhoff, I. Engel, M.J. Owen, J.R. Lamb, R.D. Klausner, and D.C. Wiley. 1994. Binary and ternary complexes between T-cell receptor, class II MHC and superantigen in vitro. Nature (Lond.). 369:324-327.
37. Mollick, J.A., M. Chintagumpala, R.G. Cook, and R.R. Rich. 1991. Staphylococcal exotoxin activation of T cells. Role of exotoxin-MHC class II binding affinity and class II isotype. J. Immunol. 146:463-468.
38. Scholl, P.R., A. Diez, and R.S. Geha. 1989. Staphylococcal enterotoxin B and toxic shock syndrome toxin-1 bind to distinct sites on HLA-DR and HLA-DQ molecules. J. Immunol. 143:2583-2588.
39. Lee, J.M., and T.H. Watts. 1990. Binding of staphylococcal enterotoxin A to purified murine MHC class II molecules in supported lipid bilayers. J. Immunol. 145:3360-3366.
40. Jensen, P.E. 1992. Long-lived complexes between peptide and class II MHC are formed at low pH with no requirement for pH neutralization. J. Exp. Med. 176:793-798.
41. Sette, A., S. Southwood, J. Miller, and E. Appella. 1995. Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II. J. Exp. Med. 181:677-683.
42. Malcherek, G., V. Gnau, G. Jung, H.-G. Rammensee, and A. Melms. 1995. Supermotifs enable natural invariant chain-derived peptides to interact with many major histocompatibility complex class II molecules. J. Exp. Med. 181:527-536.
43. Panina-Bordignon, P., A. Tan, A. Termijtelen, S. Demotz, G. Corradin, and A. Lanzavecchia. 1989. Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. Eur. J. Immunol. 19:2237-2242.
44. Sette, A., S. Buus, S. Colon, C. Miles, and H.M. Grey 1989. Structural analysis of peptides capable of binding to more than one Ia antigen. J. Immunol. 142:35-40.
45. Busch, R., G. Strang, K. Howland, and J.B. Rothbard. 1990. Degenerate binding of immunogenic peptides to HLA-DR proteins on B cell surfaces. Int. Immunol. 2:443-451.
46. Alexander, J., J. Sidney, S. Southwood, J. Ruppert, C. Oseroff, A. Maewal, K. Snoke, H.M. Serra, R.T. Kubo, A. Sette, and H.M. Grey. 1994. Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides. Immunity. 1:751-761.
47. Hammer, J., P. Valsasnini, K. Tolba, D. Bolin, J. Higelin, B. Takacs, and F. Sinigaglia. 1993. Promiscuous and allele-specific anchors in HLA-DR-binding peptides. Cell. 74:197-203.
48. O'Sullivan, D., J. Sidney, E. Appella, L. Walter, L. Phillips, S.M. Colon, C. Miles, R.W. Chestnut, and A. Sette. 1990. Characterization of the specificity of peptide binding to four DR haplotypes. J. Immunol. 145:1799-1808.
49. Thibodeau, J., I. Cloutier, P.M. Lavoie, N. Labrecque, W. Mourad, T. Jardetzky, and R.P. Sekaly. 1994. Subsets of HLA-DR1 molecules defined by SEB and TSST-1 binding. Science (Wash. DC). 266:1874-1878.
50. Pontzer, C.H., J.K. Russell, and H.M. Johnson. 1991. Structural basis for differential binding of staphylococcal enterotoxin A and toxic shock syndrome toxin 1 to class II major histocompatibility molecules. Proc. Natl. Acad. Sci. USA. 88: 125-128.
51. Tampe, R., B.R. Clark, and H.M. McConnell. 1991. Energy transfer between two peptides bound to one MHC class II molecule. Science (Wash. DC). 254:87-89.
52. Pedrazzini, T., A. Sette, M. Albertson, and H.M. Grey. 1991. Free ligand-induced dissociation of MHC-antigen complexes. J. Immunol. 146:3496-3501.
53. de Kroon, A.I., and H.M. McConnell. 1993. Enhancement of peptide antigen presentation by a second peptide Proc. Natl. Acad. Sci. USA. 90:8797-8801.
54. Beeson, C., and H.M. McConnell. 1994. Kinetic intermediates in the reactions between peptides and proteins of major histocompatibility complex class II. Proc. Natl. Acad. Sci. USA. 91:8842-8845.
55. Witt, S.N., and H.M. McConnell. 1994. Formation and dissociation of short-lived class II MHC-peptide complexes. Biochemistry. 33:1861-1868.
56. Sadegh-Nasseri, S., L.J. Stern, D.C. Wiley, and R.N. Germain. 1994. MHC class II function preserved by low-affinity peptide interactions preceding stable binding. Nature (Lond.). 370:647-650.
57. Mason, K., and H.M. McConnell. 1994. Short-lived complexes between myelin basic protein peptides and IAk. Proc. Natl. Acad. Sci. USA. 91:12463-12466.
58. Jensen, P.E., and A.O. Kraft. 1990. T cells from nonresponder mice. MHC restricted and unrestricted recognition of insulin. J. Immunol. 145:3985-3991.