메뉴 건너뛰기




Volumn 97, Issue 12, 1996, Pages 2772-2783

Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD65 and IA2 marks the early phases of autoimmune response in type 1 diabetes

Author keywords

Autoantibodies; Autoantigen; Insulin dependent diabetes mellitus; Islet; Membrane glycoprotein

Indexed keywords

ASPARAGINE LINKED OLIGOSACCHARIDE; AUTOANTIBODY; GLIMA 38 ANTIGEN; GLUTAMATE DECARBOXYLASE; MEMBRANE ANTIGEN; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

EID: 0029977765     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118732     Document Type: Article
Times cited : (86)

References (44)
  • 1
    • 0002247147 scopus 로고
    • Human Diabetes. Genetic, Environmental and Autoimmune Etiology
    • Bækkeskov, S., and B. Hansen, editors. 1990. Human Diabetes. Genetic, Environmental and Autoimmune Etiology. Curr. Top. Microbiol. Immunol. Vol. 164. 198 pp.
    • (1990) Curr. Top. Microbiol. Immunol. , vol.164
    • Bækkeskov, S.1    Hansen, B.2
  • 4
    • 0025169983 scopus 로고
    • An overview on possible mechanisms of destruction of the insulin-producing beta cell
    • Cooke. A. 1990. An overview on possible mechanisms of destruction of the insulin-producing beta cell. Curr. Top. Microbiol. Immunol. 164:125-142.
    • (1990) Curr. Top. Microbiol. Immunol. , vol.164 , pp. 125-142
    • Cooke, A.1
  • 6
    • 0019959221 scopus 로고
    • Autoantibodies in newly diagnosed diabetic children immunoprecipitate specific human pancreatic islet cell proteins
    • Bækkeskov, S., J.H. Nielsen, B. Marner, T. Bilde, J. Ludvigsson, and Å. Lernmark. 1982. Autoantibodies in newly diagnosed diabetic children immunoprecipitate specific human pancreatic islet cell proteins. Nature (Lond.). 298: 167-169.
    • (1982) Nature (Lond.) , vol.298 , pp. 167-169
    • Bækkeskov, S.1    Nielsen, J.H.2    Marner, B.3    Bilde, T.4    Ludvigsson, J.5    Lernmark, Å.6
  • 7
    • 0025050449 scopus 로고
    • Distinct antibody specificities to a 64-kD islet cell antigen in type 1 diabetes as revealed by trypsin treatment
    • Christie, M.R., G. Vohra, P. Champagne, D. Daneman, and T.L. Delovitch. 1990. Distinct antibody specificities to a 64-kD islet cell antigen in type 1 diabetes as revealed by trypsin treatment. J. Exp. Med. 172:789-794.
    • (1990) J. Exp. Med. , vol.172 , pp. 789-794
    • Christie, M.R.1    Vohra, G.2    Champagne, P.3    Daneman, D.4    Delovitch, T.L.5
  • 8
    • 0029120042 scopus 로고
    • r tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512)
    • r tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). J. Clin. Invest. 96:1506-1511.
    • (1995) J. Clin. Invest. , vol.96 , pp. 1506-1511
    • Paylon, M.A.1    Hawkes, C.J.2    Christie, M.R.3
  • 9
    • 0029051788 scopus 로고
    • The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2
    • Passini, N., J.D. Larigan, S. Genovese, E. Appella, F. Sinigaglia, and L. Rogge. 1995. The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2. Proc. Natl. Acad. Sci. USA. 92:9412-9416.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9412-9416
    • Passini, N.1    Larigan, J.D.2    Genovese, S.3    Appella, E.4    Sinigaglia, F.5    Rogge, L.6
  • 10
    • 0029078283 scopus 로고
    • Immunoglobulin variable gene analysis of human autoantibodies reveals antigen-driven immune response to glutamate decarboxylase in type 1 diabetes mellitus
    • Richter, W., K.M. Jury, D. Loeffler, B.J. Manfras, T.E. Eiermann, and B.O. Boehm. 1995. Immunoglobulin variable gene analysis of human autoantibodies reveals antigen-driven immune response to glutamate decarboxylase in type 1 diabetes mellitus. Eur. J. Immunol. 25:1703-1712.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1703-1712
    • Richter, W.1    Jury, K.M.2    Loeffler, D.3    Manfras, B.J.4    Eiermann, T.E.5    Boehm, B.O.6
  • 11
    • 0025841845 scopus 로고
    • Identification and cloning of a granule autoantigen (carboxypeptidase-H) associated with type I diabetes
    • Castano, L., E. Russo, L. Zhou, M.A. Lipes, and G.A. Eisenbarth. 1991. Identification and cloning of a granule autoantigen (carboxypeptidase-H) associated with type I diabetes. J. Clin. Endocrinol. & Metab. 73:1197-1201.
    • (1991) J. Clin. Endocrinol. & Metab. , vol.73 , pp. 1197-1201
    • Castano, L.1    Russo, E.2    Zhou, L.3    Lipes, M.A.4    Eisenbarth, G.A.5
  • 12
    • 0025005634 scopus 로고
    • Recognition of common islet antigen by autoantibodies from NOD mice and humans with IDDM
    • Karounos, D.G., and J.W. Thomas. 1990. Recognition of common islet antigen by autoantibodies from NOD mice and humans with IDDM. Diabetes. 39:1085-1090.
    • (1990) Diabetes , vol.39 , pp. 1085-1090
    • Karounos, D.G.1    Thomas, J.W.2
  • 14
    • 0017148989 scopus 로고
    • High concentration of GABA and high glutamate decarboxylase activity in rat pancreatic islets and human insulinoma
    • Okada, Y., H. Taniguchi, and C. Shimada. 1976. High concentration of GABA and high glutamate decarboxylase activity in rat pancreatic islets and human insulinoma. Science (Wash. DC). 194:620-622.
    • (1976) Science (Wash. DC) , vol.194 , pp. 620-622
    • Okada, Y.1    Taniguchi, H.2    Shimada, C.3
  • 15
    • 0027510420 scopus 로고
    • Autoreactive epitopes in glutamic acid decarboxylase defined by diabetes-associated human monoclonal antibodies
    • Richter, W., Y. Shi, and S. Bækkeskov. 1993. Autoreactive epitopes in glutamic acid decarboxylase defined by diabetes-associated human monoclonal antibodies. Proc. Natl. Acad. Sci. USA. 90:2832-2836.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2832-2836
    • Richter, W.1    Shi, Y.2    Bækkeskov, S.3
  • 16
    • 0027340217 scopus 로고
    • Characterization of a linear epitope within the human pancreatic 64-kDa glutamic acid decarboxylase and its autoimmune recognition by sera from insulin-dependent diabetes mellitus patients
    • Mauch, L., C.C. Abney, H. Berg, W.A. Scherbaum, B. Liedvogel, and W. Northemann. 1993. Characterization of a linear epitope within the human pancreatic 64-kDa glutamic acid decarboxylase and its autoimmune recognition by sera from insulin-dependent diabetes mellitus patients. Eur. J. Biochem. 212: 597-603.
    • (1993) Eur. J. Biochem. , vol.212 , pp. 597-603
    • Mauch, L.1    Abney, C.C.2    Berg, H.3    Scherbaum, W.A.4    Liedvogel, B.5    Northemann, W.6
  • 17
    • 0026592996 scopus 로고
    • Cloning and expression of IDDM-specific human autoantigens
    • Rabin, D.U., S.M. Pleasic, R. Palmer-Crocker, and J.A. Shapiro. 1992. Cloning and expression of IDDM-specific human autoantigens. Diabetes. 41: 183-186.
    • (1992) Diabetes , vol.41 , pp. 183-186
    • Rabin, D.U.1    Pleasic, S.M.2    Palmer-Crocker, R.3    Shapiro, J.A.4
  • 18
    • 0025917425 scopus 로고
    • Studies on autoimmunity for initiation of beta-cell destruction. VII. Pancreatic beta cell dependent autoantibody to a 38kD protein precedes the clinical onset of diabetes in BB rats
    • Ko, I., S. Ihm, and J.W. Yoon. 1991. Studies on autoimmunity for initiation of beta-cell destruction. VII. Pancreatic beta cell dependent autoantibody to a 38kD protein precedes the clinical onset of diabetes in BB rats. Diabetologia. 34:548-554.
    • (1991) Diabetologia , vol.34 , pp. 548-554
    • Ko, I.1    Ihm, S.2    Yoon, J.W.3
  • 19
    • 0030026955 scopus 로고    scopus 로고
    • Imogen 38: A novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient
    • Arden, S.D., B.O. Roep, P.I. Neophytou, E.F. Usac, G. Duinkerken, R.R.P. de Vries, and J.C. Mutton. 1996. Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient. J. Clin Invest. 97:551-561.
    • (1996) J. Clin Invest. , vol.97 , pp. 551-561
    • Arden, S.D.1    Roep, B.O.2    Neophytou, P.I.3    Usac, E.F.4    Duinkerken, G.5    De Vries, R.R.P.6    Mutton, J.C.7
  • 20
    • 0027502526 scopus 로고
    • Transcription factor jun-B is target of autoreactive T-cells in IDDM
    • Honeyman, M.C., D.S. Cram, and L.C. Harrison. 1993. Transcription factor jun-B is target of autoreactive T-cells in IDDM. Diabetes. 42:626-630.
    • (1993) Diabetes , vol.42 , pp. 626-630
    • Honeyman, M.C.1    Cram, D.S.2    Harrison, L.C.3
  • 21
    • 0024455978 scopus 로고
    • Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen
    • Bækkeskov, S., G. Warnock, M. Christie, R.V. Rajolte, P.M. Larson, and S. Fey. 1989. Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen. Diabetes. 38:1133-1141.
    • (1989) Diabetes , vol.38 , pp. 1133-1141
    • Bækkeskov, S.1    Warnock, G.2    Christie, M.3    Rajolte, R.V.4    Larson, P.M.5    Fey, S.6
  • 24
    • 0028092704 scopus 로고
    • High level of concordance between assays for glutamic acid decarboxylase antibodies. The First International Glutamic Acid Decarboxylase Antibody Workshop
    • Schmidli, R.S., P.G. Colman, E. Bonifacio, G.F. Botazzo, and L.C. Harrison. 1994. High level of concordance between assays for glutamic acid decarboxylase antibodies. The First International Glutamic Acid Decarboxylase Antibody Workshop. Diabetes. 43:1005-1009.
    • (1994) Diabetes , vol.43 , pp. 1005-1009
    • Schmidli, R.S.1    Colman, P.G.2    Bonifacio, E.3    Botazzo, G.F.4    Harrison, L.C.5
  • 26
    • 0027299925 scopus 로고
    • Pancreatic β cells cultured from individual preneoplastic foci in a multistage tumorigenesis pathway: A potentially general technique for isolating physiologically representative cell lines
    • Radvanyi, F., S. Christgau, S. Bækkeskov, C. Jolicoeur, and D. Hanahan. 1993. Pancreatic β cells cultured from individual preneoplastic foci in a multistage tumorigenesis pathway: a potentially general technique for isolating physiologically representative cell lines. Mol. Cell. Biol. 13:4223-4232.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4223-4232
    • Radvanyi, F.1    Christgau, S.2    Bækkeskov, S.3    Jolicoeur, C.4    Hanahan, D.5
  • 27
    • 0025349639 scopus 로고
    • Proglucagon processing similar to normal islets in pancreatic alpha-like cell line derived from transgenic mouse tumor
    • Powers, A.C., S. Efrat, S. Mojsov, D. Spector, J.F. Habener, and D. Hanahan. 1990. Proglucagon processing similar to normal islets in pancreatic alpha-like cell line derived from transgenic mouse tumor. Diabetes. 339:406-414.
    • (1990) Diabetes , vol.339 , pp. 406-414
    • Powers, A.C.1    Efrat, S.2    Mojsov, S.3    Spector, D.4    Habener, J.F.5    Hanahan, D.6
  • 28
    • 0026543426 scopus 로고
    • Generation and synchronization of gonadotropin-releasing hormone (GnRH) pulses: Intrinsic properties of the GT1-1 GnRH neuronal cell line
    • Martinez de la Escalera, G., A.L. Choi, and R.I. Weiner. 1990. Generation and synchronization of gonadotropin-releasing hormone (GnRH) pulses: intrinsic properties of the GT1-1 GnRH neuronal cell line. Proc. Natl. Acad. Sci. USA. 89:1852-1855.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 1852-1855
    • Martinez De La Escalera, G.1    Choi, A.L.2    Weiner, R.I.3
  • 29
    • 0023692497 scopus 로고
    • Neuronal cell differentiation of human neuroblastoma cells by relinoic acid plus herbimycin A
    • Preis, P.N., S. Hideyuki, L. Nádasdi, G. Hochhaus, V. Levin, and W. Sadée. 1988. Neuronal cell differentiation of human neuroblastoma cells by relinoic acid plus herbimycin A. Cancer Res. 48:6530-6534.
    • (1988) Cancer Res. , vol.48 , pp. 6530-6534
    • Preis, P.N.1    Hideyuki, S.2    Nádasdi, L.3    Hochhaus, G.4    Levin, V.5    Sadée, W.6
  • 30
    • 0019291033 scopus 로고
    • Temperature-dependent cytosolto-nucleus translocation of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in continuous cell culture lines
    • Okey, A.B., G.P. Bondy, M.E. Mason, D.W. Nebert, C.J. Forster-Gibson, J. Muncan, and M.J. Dufresne. 1980. Temperature-dependent cytosolto-nucleus translocation of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in continuous cell culture lines. J. Biol. Chem. 255:11415-11422.
    • (1980) J. Biol. Chem. , vol.255 , pp. 11415-11422
    • Okey, A.B.1    Bondy, G.P.2    Mason, M.E.3    Nebert, D.W.4    Forster-Gibson, C.J.5    Muncan, J.6    Dufresne, M.J.7
  • 32
    • 0025109113 scopus 로고
    • Islet cell antibodies and fasting C-peptide predict insulin requirement at diagnosis of diabetes mellitus
    • Landin-Olsson, M., K.O. Nilsson, Å. Lernmark, and G. Sundkvist. 1990. Islet cell antibodies and fasting C-peptide predict insulin requirement at diagnosis of diabetes mellitus. Diabetologia. 33:561-568.
    • (1990) Diabetologia , vol.33 , pp. 561-568
    • Landin-Olsson, M.1    Nilsson, K.O.2    Lernmark, Å.3    Sundkvist, G.4
  • 34
    • 0025082998 scopus 로고
    • Islet cell antibodies as predictive markers for IDDM in children with high background incidence of the disease
    • Karjalainen, J.K. 1990. Islet cell antibodies as predictive markers for IDDM in children with high background incidence of the disease. Diabetes. 39: 1144-1150.
    • (1990) Diabetes , vol.39 , pp. 1144-1150
    • Karjalainen, J.K.1
  • 37
    • 0025718751 scopus 로고
    • Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble
    • Christgau, S., H. Schierbeck, H.J. Aanstoot, L. Aagaard, K. Begley, H. Kofod, K. Hejnaes, and S. Bækkeskov. 1991. Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble. J. Biol. Chem. 266:21257-21264.
    • (1991) J. Biol. Chem. , vol.266 , pp. 21257-21264
    • Christgau, S.1    Schierbeck, H.2    Aanstoot, H.J.3    Aagaard, L.4    Begley, K.5    Kofod, H.6    Hejnaes, K.7    Bækkeskov, S.8
  • 41
    • 0024539633 scopus 로고
    • HLA and insulin-dependent diabetes: An overview
    • Svejgaard, A., and L.P. Ryder. 1989. HLA and insulin-dependent diabetes: an overview. Genet. Epidemiol. 6:1-14.
    • (1989) Genet. Epidemiol. , vol.6 , pp. 1-14
    • Svejgaard, A.1    Ryder, L.P.2
  • 42
    • 0021816281 scopus 로고
    • "Cytoplasmic" islet cell antibodies: Evidence that the target antigen is a sialoglycoconjugate
    • Nayak, R.C., M.A.K. Omar, A. Rabizadeh, S. Srikanta, and G.S. Eisenbarth. 1985. "Cytoplasmic" islet cell antibodies: evidence that the target antigen is a sialoglycoconjugate. Diabetes. 34:617-619.
    • (1985) Diabetes , vol.34 , pp. 617-619
    • Nayak, R.C.1    Omar, M.A.K.2    Rabizadeh, A.3    Srikanta, S.4    Eisenbarth, G.S.5
  • 43
    • 0024800229 scopus 로고
    • jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun
    • Schütte, J., D. Viallet, M. Nau, S. Segal, J. Fedorko, and J. Minna. 1989. jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun. Cell. 59:987-997.
    • (1989) Cell , vol.59 , pp. 987-997
    • Schütte, J.1    Viallet, D.2    Nau, M.3    Segal, S.4    Fedorko, J.5    Minna, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.