Proliferative lymphocyte responses to virus antigene homologous to GAD65 in IDDM

Diabetologia

Volumn 39, Issue 11, 1996, Pages 1318-1324

  Jones, D B ^a,b   Crosby, I ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b Wirral Hospital   (United Kingdom)

Author keywords

Adenovirus; Coxsackie; Glutamic acid decarboxylase (GAD65); Insulin dependent diabetes mellitus; Lymphocyte; Major histocompatibility complex (MHC); Viruses

Indexed keywords

HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; VIRUS ANTIGEN;

ADENOVIRUS; ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; COXSACKIE VIRUS B; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL;

ADENOVIRIDAE; ADOLESCENT; ADULT; AMINO ACID SEQUENCE; ANTIGENS, VIRAL; DIABETES MELLITUS, TYPE 1; ENTEROVIRUS B, HUMAN; GLUTAMATE DECARBOXYLASE; HLA-DR ANTIGENS; HUMANS; LYMPHOCYTE ACTIVATION; MULTIVARIATE ANALYSIS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; T-LYMPHOCYTES;

EID: 0029959628     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050576     Document Type: Article

References (31)

1. Atkinson MA, MacLaren NK (1994) The pathogenesis of insulin-dependent diabetes mellitus. New Engl J Med 331: 1428-1436
2. Davies JL, Kawaguchi Y, Bennett ST et al. (1994) A genome-wide search for human type-I diabetes susceptibility genes. Nature 371: 130-136
3. Kaprio J, Tuomilehto J, Koskenvuo M et al. (1992) Concordance for type 1 (insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland. Diabetologia 35: 1060-1067
4. Harris HF (1899) A case of diabetes mellitus quickly following mumps. Boston Med Surg J 140: 465-469
5. Szopa TM, Titchener PA, Portwood ND, Taylor KW (1993) Diabetes mellitus due to viruses - some recent developments. Diabetologia 36: 687-695
6. Menser MA, Forrest JM, Bransby RD (1978) Rubella infection and diabetes mellitus. Lancet I: 57-60
7. Yoon J-W, Austin M, Onodera T, Notkins AL (1979) Virus-induced diabetes mellitus. Isolation of a virus from a child with diabetic ketoacidosis. New Engl J Med 300: 1173-1178
8. Buesagomez J, Delatorre JC, Dyrberg T et al. (1994) Failure to detect genomic viral sequences in pancreatic tissues from two children with acute-onset diabetes mellitus. J Med Virol 42: 193-197
9. Karjalainen J, Martin JM, Knip M et al. (1992) A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N Engl J Med 327: 302-307
10. Miyazaki I, Cheung RK, Gaedigk R et al. (1995) T cell activation and anergy to islet cell antigen in type I diabetes. J Immunol 154: 1461-1469
11. Atkinson MA, Bowman MA, Kao KJ et al. (1993) Lack of immune responsiveness to bovine serum albumin in insulin-dependent diabetes. N Engl J Med 329: 1853-1858
12. Karounos DG, Wolinsky IS, Thomas JW (1993) Monoclonal antibody to rubella virus capsid protein recognizes a beta-cell antigen. J Immunol 150: 3080-3085
13. Kaufman DL, Erlander MG, Clare SM et al. (1992) Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J Clin Invest 89: 283-292
14. Atkinson MA, Kaufman DL, Campbell L et al. (1992) Response of peripheral blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet 339: 458-459
15. Tisch R, Yang XD, Singer SM, Liblau RS, Fugger L, McDevitt HO (1993) Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366: 72-75
16. Barrett-Connor E (1985) Is insulin-dependent diabetes mellitus caused by coxsackievirus B infection? A review of the epidemiologic evidence. Rev Infect Dis 7: 207-215
17. King ML, Bidwell D, Shaikh A, Voller A, Banatvala JE (1983) Coxsackie-B-virus-specific IgM responses in children with insulin-dependent (juvenile-onset/type 1)diabetes-mellitus. Lancet 1: 1397-1399
18. Frisk G, Friman G, Tuvemo T, Fohlman J, Diderholm H (1992) Coxsackie B virus IgM in children at onset of type 1 (insulin-dependent) diabetes mellitus: evidence for IgM induction by a recent or current infection. Diabetologia 35: 249-253
19. Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kaufman DL, Maclaren NK (1994) Cellular-immunity to a determinant common to glutamate-decarboxylase and coxsackie-virus in insulin-dependent diabetes. J Clin Invest 94: 2125-2129
20. Leslie RDG, Elliot RB (1994) Early environmental events as a cause of IDDM - evidence and implications. Diabetes 43: 843-849
21. Lohmann T, Leslie R, Hawa M, Geysen M, Rodda S, Londei M (1994) Immunodominant epitopes of glutamic-acid decarboxylase-65 and decarboxylase-67 in insulin dependent diabetes mellitus. Lancet 343: 1607-1608
22. Olerup O, Zetterquist H (1993) HLA-DR typing by polymerase chain reaction amplification with sequence specific primers (PCR-SSP). In: Hui KH, Bidwell L (eds) Handbook of HLA typing techniques. CRC Press, London, pp 149-173
23. Jones DB, Armstrong NW (1995) Coxsackie virus and diabetes revisited. Nature Medicine 1: 284
24. Armstrong NW, Jones DB (1994) Epitopes of GAD65 in insulin dependent diabetes mellitus. Lancet 344: 406-407
25. Dalessio DJ (1992) A case-control study of group-B coxsackievirus immunoglobulin-M antibody prevalence and HLA-DR antigens in newly diagnosed cases of insulin dependent diabetes mellitus. Am J Epidem 135: 1331-1338
26. Bruserud O, Thorsby E (1985) T lymphocyte responses to coxsackie B4 and mumps virus. Influence of HLA-DR restriction elements. Tissue Antigens 26: 41-50
27. Richter W, Mertens T, Schoel B et al. (1994) Sequence homology of the diabetes associated autoantigen glutamate decarboxylase with coxsackie B4-2C protein and heat shock protein 60 mediates no molecular mimicry of autoantibodies. J Exp Med 180: 721-726
28. Hou J, Said C, Franchi D, Dockstader P, Chatterjee NK (1994) Antibodies to glutamic acid decarboxylase and P2-C peptides in sera from coxsackie virus B4-infected mice and IDDM patients. Diabetes 43: 1260-1266
29. Kaufman DL, Clare SM, Tian J et al. (1993) Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366: 69-72
30. Tian J, Lehmann PV, Kaufman DL (1994) T-cell cross-reactivity between coxsackie virus and glutamate-decarboxylase is associated with a murine diabetes susceptibility allele. J Exp Med 180: 1979-1984
31. Wucherpfennig KW, Strominer JL (1995) Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80: 69.5-70.5