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1
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0025828377
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Most peripheral B cells in mice are ligand selected
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Gu H, Tarlinton D, Muller W, Rajewsky K, Forster I. Most peripheral B cells in mice are ligand selected. J Exp Med. 173:1991;1357-1371.
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J Exp Med
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Gu, H.1
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Forster, I.5
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2
-
-
0031203032
-
A truncated heavy chain protein relieves the requirement for surrogate light chains in early B cell development
-
-/- B cell development in the absence of surrogate light chain association. Thus, the pre-BCR does not appear to require surrogate light chain or a putative ligand for surrogate light chain for B cell development. Possibly, surface immunoglobulin expression and basal signaling is all that is required for B cell progression.
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-/- B cell development in the absence of surrogate light chain association. Thus, the pre-BCR does not appear to require surrogate light chain or a putative ligand for surrogate light chain for B cell development. Possibly, surface immunoglobulin expression and basal signaling is all that is required for B cell progression.
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(1997)
J Immunol
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Shaffer, A.L.1
Schlissel, M.S.2
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3
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0342711256
-
In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
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of outstanding interest. This reports that B cell antigen receptor (BCR) ablation at the mature B cell stage by a conditional knockout shortens B cell survival. These experiments suggest that B cells require continual BCR signal transduction for peripheral maintenance.
-
of outstanding interest Lam K-P, Kühn R, Rajewsky K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell. 90:1997;1073-1083 This reports that B cell antigen receptor (BCR) ablation at the mature B cell stage by a conditional knockout shortens B cell survival. These experiments suggest that B cells require continual BCR signal transduction for peripheral maintenance.
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(1997)
Cell
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, pp. 1073-1083
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Lam K-P1
Kühn, R.2
Rajewsky, K.3
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4
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0027447188
-
Elimination of self-rective B lymphocytes proceeds in two stages: Arrested development and cell death
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Hartley SB, Cooke MP, Fulcher DA, Harris AW, Cory S, Basten A, Goodnow CC. Elimination of self-rective B lymphocytes proceeds in two stages: arrested development and cell death. Cell. 72:1993;325-335.
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Cell
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Hartley, S.B.1
Cooke, M.P.2
Fulcher, D.A.3
Harris, A.W.4
Cory, S.5
Basten, A.6
Goodnow, C.C.7
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5
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0030483540
-
Receptor editing, immune diversification, and self-tolerance
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Radic MZ, Zouali M. Receptor editing, immune diversification, and self-tolerance. Immunity. 5:1996;505-511.
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Immunity
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Radic, M.Z.1
Zouali, M.2
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6
-
-
0030997499
-
Editing disease-associated autoantibodies
-
of special interest. B cell tolerance was studied in mice expressing site-directed heavy- and light-chain knock-ins that encode disease-related B cell antigen receptors (BCRs) recognizing double-stranded DNA. Unlike conventional transgenic models, the developmental expression and regulation of these knock-in receptors are controlled by the endogenous locus and represent a more physiologically relevant model of B cell tolerance. The BCRs recognizing double-stranded DNA were shown to undergo extensive receptor editing at the light-chain locus, above the levels reported with conventional transgenic models, or to be functionally anergized.
-
of special interest Chen C, Prak EL, Weigert M. Editing disease-associated autoantibodies. Immunity. 6:1997;97-105 B cell tolerance was studied in mice expressing site-directed heavy- and light-chain knock-ins that encode disease-related B cell antigen receptors (BCRs) recognizing double-stranded DNA. Unlike conventional transgenic models, the developmental expression and regulation of these knock-in receptors are controlled by the endogenous locus and represent a more physiologically relevant model of B cell tolerance. The BCRs recognizing double-stranded DNA were shown to undergo extensive receptor editing at the light-chain locus, above the levels reported with conventional transgenic models, or to be functionally anergized.
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(1997)
Immunity
, vol.6
, pp. 97-105
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-
Chen, C.1
Prak, E.L.2
Weigert, M.3
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7
-
-
0031424315
-
Receptor editing in a transgenic mouse model: Site, efficiency and role in B cell tolerance and antibody diversity
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Pelanda R, Schwers S, Sonoda E, Torres RM, Nemazee D, Rajewsky K. Receptor editing in a transgenic mouse model: site, efficiency and role in B cell tolerance and antibody diversity. Immunity. 7:1997;765-775.
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(1997)
Immunity
, vol.7
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Pelanda, R.1
Schwers, S.2
Sonoda, E.3
Torres, R.M.4
Nemazee, D.5
Rajewsky, K.6
-
8
-
-
0031019217
-
Changes in locus-specific V(D)J recombination activity induced by immunoglobulin gene products during B cell development
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+ B cells. Furthermore, these studies show that V(D)J recombinase specificity at the light chain locus promotes receptor editing by favoring upstream. Jκ subunits, and retaining downstream Jκ subunits for nested secondary immunoglobulin gene rearrangements.
-
+ B cells. Furthermore, these studies show that V(D)J recombinase specificity at the light chain locus promotes receptor editing by favoring upstream. Jκ subunits, and retaining downstream Jκ subunits for nested secondary immunoglobulin gene rearrangements.
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(1997)
J Exp Med
, vol.185
, pp. 609-620
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Constantinescu, A.1
Schlissel, M.S.2
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9
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0029006329
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Engagement of the antigen-receptor on immature murine B lymphocytes results in death by apoptosis
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Norvell A, Mandik L, Monroe JG. Engagement of the antigen-receptor on immature murine B lymphocytes results in death by apoptosis. J Immunol. 154:1995;4404-4413.
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J Immunol
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Norvell, A.1
Mandik, L.2
Monroe, J.G.3
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10
-
-
0030981639
-
- bone marrow B cells in vitro
-
- bone marrow B cells express elevated levels of recombination-activating gene (RAG) enzyme mRNA that lead to new V(D)J recombination events at the light chain locus and expression of new light chain molecules on the cell surface.
-
- bone marrow B cells express elevated levels of recombination-activating gene (RAG) enzyme mRNA that lead to new V(D)J recombination events at the light chain locus and expression of new light chain molecules on the cell surface.
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(1997)
Immunity
, vol.6
, pp. 429-436
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Hertz, M.1
Nemazee, D.2
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11
-
-
0030802147
-
Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest
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of special interest. This paper describes an experimental system that should permit a detailed biochemical analysis of receptor editing.
-
of special interest Melamed D, Nemazee D. Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest. Proc Natl Acad Sci USA. 94:1997;9267-9272 This paper describes an experimental system that should permit a detailed biochemical analysis of receptor editing.
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(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9267-9272
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Melamed, D.1
Nemazee, D.2
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12
-
-
0030694311
-
Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells
-
of special interest. The authors demonstrate that Bcl-2 expression promotes receptor editing in autoreactive immature B cells, suggesting that receptor editing may be limited by a window of time before the B cell undergoes apoptosis.
-
of special interest Lang J, Arnold B, Hammerling G, Harris AW, Korsmeyer S, Russell D, Strasser A, Nemazee D. Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells. J Exp Med. 186:1997;1513-1522 The authors demonstrate that Bcl-2 expression promotes receptor editing in autoreactive immature B cells, suggesting that receptor editing may be limited by a window of time before the B cell undergoes apoptosis.
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(1997)
J Exp Med
, vol.186
, pp. 1513-1522
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Lang, J.1
Arnold, B.2
Hammerling, G.3
Harris, A.W.4
Korsmeyer, S.5
Russell, D.6
Strasser, A.7
Nemazee, D.8
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13
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0029003671
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Transitional B cells are the target of negative selection in the B cell compartment
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Carsetti R, Köhler G, Lamers MC. Transitional B cells are the target of negative selection in the B cell compartment. J Exp Med. 181:1995;2129-2140.
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J Exp Med
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Carsetti, R.1
Köhler, G.2
Lamers, M.C.3
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14
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0029549283
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B lineage differentiation stages resolved by multiparameter flow cytometry
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Hardy RR, Hayakawa K. B lineage differentiation stages resolved by multiparameter flow cytometry. Ann NY Acad Sci. 764:1995;19-24.
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Hardy, R.R.1
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15
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0026644137
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Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics
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Allman DM, Ferguson SE, Cancro MP. Peripheral B cell maturation. I. Immature peripheral B cells in adults are heat-stable antigenhi and exhibit unique signaling characteristics. J Immunol. 149:1992;2533-2540.
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J Immunol
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Allman, D.M.1
Ferguson, S.E.2
Cancro, M.P.3
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16
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0027379716
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Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells
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Allman DM, Ferguson SE, Lentz VM, Cancro MP. Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J Immunol. 151:1993;4431-4444.
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Allman, D.M.1
Ferguson, S.E.2
Lentz, V.M.3
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18
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0029965138
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Balancing immunity and tolerance: Deleting and tuning lymphocyte repertoires
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Goodnow CC. Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. Proc Natl Acad Sci USA. 93:1996;2264-2271.
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Proc Natl Acad Sci USA
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Goodnow, C.C.1
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19
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0031003643
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Influences on the lifespan of B cell subpopulations defined by different phenotypes
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Fulcher DA, Basten A. Influences on the lifespan of B cell subpopulations defined by different phenotypes. Eur J Immunol. 27:1997;1189-1199.
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Eur J Immunol
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Fulcher, D.A.1
Basten, A.2
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20
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0030023652
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Regulation of B lymphocyte negative and positive selection by tyrosine phosphatase CD45
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of special interest. The receptor protein tyrosine phosphatase CD45 is a positive regulator of B cell signal transduction. This report shows that transgenic B cells lacking CD45 are produced normally in the bone marrow, but fail to accumulate in the periphery. Surprisingly, self-antigen that promotes the elimination of CD45-sufficient B cells positively selects CD45-deficient B cells. These results suggest not only that the quality of the B cell antigen receptor (BCR) signal is important in tolerance, but that B cells may require a BCR-generated signal to be selected into the mature recirculating B cell pool.
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of special interest Cyster JG, Healy JI, Kishihara K, Mak TM, Thomas ML, Goodnow CC. Regulation of B lymphocyte negative and positive selection by tyrosine phosphatase CD45. Science. 381:1996;325-328 The receptor protein tyrosine phosphatase CD45 is a positive regulator of B cell signal transduction. This report shows that transgenic B cells lacking CD45 are produced normally in the bone marrow, but fail to accumulate in the periphery. Surprisingly, self-antigen that promotes the elimination of CD45-sufficient B cells positively selects CD45-deficient B cells. These results suggest not only that the quality of the B cell antigen receptor (BCR) signal is important in tolerance, but that B cells may require a BCR-generated signal to be selected into the mature recirculating B cell pool.
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(1996)
Science
, vol.381
, pp. 325-328
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Cyster, J.G.1
Healy, J.I.2
Kishihara, K.3
Mak, T.M.4
Thomas, M.L.5
Goodnow, C.C.6
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21
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0030775139
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Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules
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Kirberg J, Berns A, Boehmer H. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules. J Exp Med. 186:1997;1269-1275.
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J Exp Med
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Kirberg, J.1
Berns, A.2
Boehmer, H.3
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22
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0030249953
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MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span
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Takeda S, Rodewald HR, Arakawa H, Bluethmann H, Shimizu T. MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span. Immunity. 5:1996;217-228.
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Immunity
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Takeda, S.1
Rodewald, H.R.2
Arakawa, H.3
Bluethmann, H.4
Shimizu, T.5
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23
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0030890949
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Initiation and processing of signals from the B cell antigen receptor
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Reth M, Wienands J. Initiation and processing of signals from the B cell antigen receptor. Annu Rev Immunol. 15:1997;453-479.
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(1997)
Annu Rev Immunol
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Reth, M.1
Wienands, J.2
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24
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0030901968
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The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity
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Tedder TF, Inaoki M, Sato S. The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity. Immunity. 6:1997;107-118.
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(1997)
Immunity
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, pp. 107-118
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Tedder, T.F.1
Inaoki, M.2
Sato, S.3
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25
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0029742201
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Requirement for invariant chain in B cell maturation and function
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Shachar I, Flavel Ra. Requirement for invariant chain in B cell maturation and function. Science. 274:1996;106-108.
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Science
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Shachar, I.1
Flavel Ra2
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0030795735
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Molecular mechanisms in B cell antigen receptor signaling
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Kurosaki T. Molecular mechanisms in B cell antigen receptor signaling. Curr Opin Immunol. 9:1997;309-318.
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Curr Opin Immunol
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Kurosaki, T.1
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27
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0030175744
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Regulation of antigen receptor signal transduction by protein tyrosine kinases
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Chan AC, Shaw AS. Regulation of antigen receptor signal transduction by protein tyrosine kinases. Curr Opin Immunol. 8:1996;394-401.
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Curr Opin Immunol
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Chan, A.C.1
Shaw, A.S.2
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28
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0030800121
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The motheaten mutation rescues B cell signaling and development in CD45-deficient mice
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Pani G, Siminovitch KA, Paige CJ. The motheaten mutation rescues B cell signaling and development in CD45-deficient mice. J Exp Med. 186:1997;581-588.
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J Exp Med
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Pani, G.1
Siminovitch, K.A.2
Paige, C.J.3
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0030250062
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The 'Clonal Selection Hypothesis' and current concepts of B cell tolerance
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Klinman NR. The 'Clonal Selection Hypothesis' and current concepts of B cell tolerance. Immunity. 5:1996;189-195.
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(1996)
Immunity
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Klinman, N.R.1
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30
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0030966218
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Different nuclear signals are activated by the B cell receptor during positive versus negative signaling
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Healy JI, Dolmetsch RE, Timmerman LA, Cyster JG, Thomas ML, Crabtree GR, Lewis RS, Goodnow CG. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity. 6:1997;419-428.
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(1997)
Immunity
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Healy, J.I.1
Dolmetsch, R.E.2
Timmerman, L.A.3
Cyster, J.G.4
Thomas, M.L.5
Crabtree, G.R.6
Lewis, R.S.7
Goodnow, C.G.8
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31
-
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0030848576
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Outer periarteriolar lymphoid sheath arrest and subsequent differentiation of both naive and tolerant immunoglobulin transgenic B cells is determined by B cell receptor occupancy
-
of special interest. This reports that anergic B cells are retained in the outer periarteriolar lymphoid sheath and excluded from primary follicles during an immune response. BCR occupancy appears to be the main factor determining B cell follicular distribution. Above a critical threshold of antigen concentration, self-reactive B cells are excluded from follicules irrespective of the B cell repertoire of neighboring B cells.
-
of special interest Cook MC, Basten A, Fazekas de St. Growth B. Outer periarteriolar lymphoid sheath arrest and subsequent differentiation of both naive and tolerant immunoglobulin transgenic B cells is determined by B cell receptor occupancy. J Exp Med. 186:1997;631-643 This reports that anergic B cells are retained in the outer periarteriolar lymphoid sheath and excluded from primary follicles during an immune response. BCR occupancy appears to be the main factor determining B cell follicular distribution. Above a critical threshold of antigen concentration, self-reactive B cells are excluded from follicules irrespective of the B cell repertoire of neighboring B cells.
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(1997)
J Exp Med
, vol.186
, pp. 631-643
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Cook, M.C.1
Basten, A.2
Fazekas De, St.3
Growth, B.4
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0029550111
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Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate
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Cyster JG, Goodnow CC. Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate. Immunity. 3:1995;691-701.
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Immunity
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Cyster, J.G.1
Goodnow, C.C.2
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33
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0030827382
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Regulation of anti-double-stranded DNA B cells in nonautoimmune mice: Localization to the T-B interface of the splenic follicle
-
of special interest. This demonstrates that B cells expressing disease-related transgenic anti-dsDNA B cell antigen receptors are located at the T/B cell interface in splenic follicles. The anti-dsDNA B cells are functionally inactive and failure to enter the follicle is due to a lack of T-cell help rather than competition from nonautoreactive B cells.
-
of special interest Mandik-Nayak L, Bui A, Noorchashm H, Eaton A, Erikson J. Regulation of anti-double-stranded DNA B cells in nonautoimmune mice: localization to the T-B interface of the splenic follicle. J Exp Med. 186:1997;1257-1267 This demonstrates that B cells expressing disease-related transgenic anti-dsDNA B cell antigen receptors are located at the T/B cell interface in splenic follicles. The anti-dsDNA B cells are functionally inactive and failure to enter the follicle is due to a lack of T-cell help rather than competition from nonautoreactive B cells.
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(1997)
J Exp Med
, vol.186
, pp. 1257-1267
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Mandik-Nayak, L.1
Bui, A.2
Noorchashm, H.3
Eaton, A.4
Erikson, J.5
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34
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0030592564
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Expansion or elimination of B cell in vivo: Dual roles for CD40- And Fas (CD95)-ligands modulated by the B cell antigen receptor
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of special interest. This shows that prior antigenic exposure dictates the fate of B cells. CD40 ligand and Fas ligand on T cells are both required for the expansion of nontolerant B cells, and for the elimination of tolerant B cells.
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of special interest Rathmell JC, Townsend SE, Xu JC, Flavell RA, Goodnow CC. Expansion or elimination of B cell in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor. Cell. 87:1996;319-329 This shows that prior antigenic exposure dictates the fate of B cells. CD40 ligand and Fas ligand on T cells are both required for the expansion of nontolerant B cells, and for the elimination of tolerant B cells.
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(1996)
Cell
, vol.87
, pp. 319-329
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Rathmell, J.C.1
Townsend, S.E.2
Xu, J.C.3
Flavell, R.A.4
Goodnow, C.C.5
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35
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0030266548
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IL-4 induces Fas resistance in B cells
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+ Th1 effector cells can upregulate Fas and Fas sensitivity on B cells through a CD40 ligand: CD40 interaction, priming B cells for Fas-mediated killing. Importantly, B cell antigen receptor ligation or IL-4, through distinct mechanisms, can both induce Fas resistance in B cells otherwise destined to die.
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+ Th1 effector cells can upregulate Fas and Fas sensitivity on B cells through a CD40 ligand: CD40 interaction, priming B cells for Fas-mediated killing. Importantly, B cell antigen receptor ligation or IL-4, through distinct mechanisms, can both induce Fas resistance in B cells otherwise destined to die.
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(1996)
J Immunol
, vol.157
, pp. 2749-2753
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Foote, L.C.1
Howard, R.G.2
Marshak, R.A.3
Rothstein, T.L.4
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0028920079
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Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells
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Rothstein TL, Wang JK, Panka DJ, Foote LC, Wang Z, Stanger B, Cui H, Ju ST, Marshak RA. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature. 374:1995;163-165.
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Nature
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Rothstein, T.L.1
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Wang, Z.5
Stanger, B.6
Cui, H.7
Ju, S.T.8
Marshak, R.A.9
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0030987781
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Radiation and stress-induced apoptosis: A role for Fas/Fas ligand interactions
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Reap EA, Roof K, Maynor K, Borrero M, Booker J, Cohen PL. Radiation and stress-induced apoptosis: a role for Fas/Fas ligand interactions. Proc Natl Acad Sci USA. 94:1997;5750-5755.
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Reap, E.A.1
Roof, K.2
Maynor, K.3
Borrero, M.4
Booker, J.5
Cohen, P.L.6
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0029059370
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Soluble antigen can cause enhanced apoptosis of germinal-centre B cells
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Pulendran B, Kannourakis G, Nouri S, Smith KG, Nossal GJ. Soluble antigen can cause enhanced apoptosis of germinal-centre B cells. Nature. 375:1995;331-334.
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Nature
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Pulendran, B.1
Kannourakis, G.2
Nouri, S.3
Smith, K.G.4
Nossal, G.J.5
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0026052840
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Tolerance susceptibility of newly generating memory B cells
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Linton PJ, Rudie A, Klinman NR. Tolerance susceptibility of newly generating memory B cells. J Immunol. 146:1991;4099-4104.
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J Immunol
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Linton, P.J.1
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0029014435
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Antigen-induced B cell death and elimination during germinal-centre immune responses
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Shokat K, Goodnow CC. Antigen-induced B cell death and elimination during germinal-centre immune responses. Nature. 375:1995;334-338.
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Nature
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Shokat, K.1
Goodnow, C.C.2
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42
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0030460833
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Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells
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Han S, Zheng B, Schatz DG, Spanopoulou E, Kelsoe G. Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. Science. 274:1996;2094-2097.
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Han, S.1
Zheng, B.2
Schatz, D.G.3
Spanopoulou, E.4
Kelsoe, G.5
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43
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0030475466
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Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells
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of special interest. This reports that culture of primary splenic B cells with IL-4 plus lipopolysaccharide or with anti-CD40 induces the re-expression of recombination-activating gene (RAG)-1 and RAG-2 within 48 hours in vitro. RAG is also re-expressed in germinal center B cells.
-
of special interest Hikida M, Mori M, Takai T, Tomochika K, Hamatani K, Ohmori H. Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells. Science. 274:1996;2092-2094 This reports that culture of primary splenic B cells with IL-4 plus lipopolysaccharide or with anti-CD40 induces the re-expression of recombination-activating gene (RAG)-1 and RAG-2 within 48 hours in vitro. RAG is also re-expressed in germinal center B cells.
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(1996)
Science
, vol.274
, pp. 2092-2094
-
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Hikida, M.1
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of special interest Papavasiliou F, Casellas R, Suh H, Qin X-F, Besmer E, Pelanda R, Nemazee D, Rajewsky K, Nussenzweig MC. V(D)J recombination in mature B cells: a mechanism for altering antibody responses. Science. 278:1997;298-301 These studies show that in vitro culture conditions that upregulate expression of recombination-activating genes (RAGs)-1 and -2 in mature splenic B cells also lead to V(D)J recombinase activity and violate allelic exclusion.
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V(D)J recombinase activity in a subset of germinal center B lymphocytes
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of outstanding interest Melamed D, Nemazee D. Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor editing. Cell. 92:1998;173-182 This study shows that sensitivity to antigen-induced apoptosis arises relatively late in bone marrow B cell development and is preceded by a functionally distinct developmental stage capable of receptor editing.
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