Dissociation of ras oncogene-induced gene expression and anchorage- independent growth in a series of somatic cell mutants

Molecular Carcinogenesis

Volumn 16, Issue 3, 1996, Pages 139-148

  Feinleib, Jessica L ^a   Krauss, Robert S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

anchorage independent growth; gene expression; ras oncogene; somatic cell mutant

Indexed keywords

CATHEPSIN L; COLLAGENASE; ORNITHINE DECARBOXYLASE; OSTEOPONTIN; SOMATOMEDIN C; STROMELYSIN;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; ARTICLE; CELL GROWTH; CELL HYBRIDIZATION; CELL MUTANT; FIBROBLAST CULTURE; GENE EXPRESSION; NONHUMAN; ONCOGENE C FOS; ONCOGENE C JUN; ONCOGENE C MYC; ONCOGENE RAS; PRIORITY JOURNAL; RAT; SOMATIC CELL;

ANIMALS; CELL ADHESION; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, IMMEDIATE-EARLY; GENES, RAS; HYBRID CELLS; PROTEIN KINASE C; RATS;

ANIMALIA; UNIDENTIFIED RETROVIRUS;

EID: 0029737433     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199607)16:3<139::AID-MC4>3.0.CO;2-C     Document Type: Article

References (43)

1. Barbacid M. ras genes. Annu Rev Biochem 56:779-827, 1987.
2. Boguski MS, McCormick F. Proteins regulating Ras and its relatives. Nature 366:643-654, 1993.
3. Lowy DR, Willumsen BM. Function and regulation of Ras. Annu Rev Biochem 62:851-891, 1993.
4. Freedman VH, Shin S-I. Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium. Cell 3:355-359, 1974.
5. Colburn NH, Vorder Bruegge WF, Bates JR, et al. Correlation of anchorage-independent growth with tumorigenicity of chemically transformed mouse epidermal cells. Cancer Res 38:624-634, 1978.
6. Bortner DM, Langer SJ, Ostrowski MC. Non-nuclear oncogenes and the regulation of gene expression in transformed cells. Crit Rev Oncog 4:137-160, 1993.
7. Herschman HR. Primary response genes induced by growth factors and tumor promoters. Annu Rev Biochem 60:281-319, 1991.
8. Chang E, Barr M, Wang Y, Jung V, Xu H-P, Wigler MH. Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell 79:131-141, 1994.
9. White AM, Nicolette C, Mindeb A, et al. Multiple Ras functions can contribute to mammalian cell transformation. Cell 80:533-541, 1995.
10. Qiu R-G, Chen J, Kirn D, McCormick F, Symons M. An essential role for Rac in Ras transformation. Nature 374:457-459, 1995.
11. Vojtek AB, Hollenberg SM, Cooper JA. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74:205-214, 1993.
12. Zhang X-F, Settleman J, Kyriakis JM, et al. Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf 1. Nature 364:308-313, 1993.
13. Warne PH, Rodriguez-Viciana P, Downward J. Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro. Nature 364:352-355, 1993.
14. Moodie SA, Willumsen BM, Weber MJ, Wolfman A. Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase. Science 260:1658-1661, 1993.
15. Rodriguez-Viciana P, Warne PH, Dhand R, et al. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370:527-532, 1994.
16. Adari H, Lowy DR, Willumsen BM, Der CJ, McCormick F. Guanosine triphosphate activating protein (GAP) interacts with the p21 ras effector binding domain. Science 240:518-521, 1988.
17. Hofer F, Fields S, Schneider C, Martin GS. Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator. Proc Natl Acad Sci USA 91:11089-11093, 1994.
18. Kikuchi A, Demo SD, Ye Z-H, Chen Y-W, Williams LT. ralGDS family interacts with the effector loop of ras p21. Mol Cell Biol 14:7483-7491, 1994.
19. Han L, Colicelli J. A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf 1. Mol Cell Biol 15:1318-1323, 1995.
20. Spaargaren M, Bischoff JR. Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector of R-ras, H-ras, K-ras, and Rap. Proc Natl Acad Sci USA 91:12609-12613, 1994.
21. Blenis J. Signal transduction via the MAP kinases: Proceed at your own RSK. Proc Natl Acad Sci USA 90:5889-5892, 1993.
22. Davis RJ. The mitogen-activated protein kinase signal transduction pathway. J Biol Chem 268:14553-14556, 1993.
23. Marshall CJ. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr Opin Genet Dev 4:82-89, 1994.
24. Medema RH, De Latt WL, Martin GA, McCormick F, Bos JL. GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion. Mol Cell Biol 12:3425-3430, 1992.
25. Hu Q, Klippel A, Muslin AJ, Fantl WJ, Williams LT. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science 268:100-102, 1995.
26. Coso OA, Chiariello M, Yu J-C, et al. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137-1146, 1995.
27. Minden A, Lin A, Claret F-X, Abo A, Karin M. Selective activation of the JNK signaling cascade and c-Jun transcription activity by the small GTPases Rac and Cdc42Hs. Cell 81:1147-1157, 1995.
28. Krauss RS, Guadagno SN, Weinstein IB. Novel revertants of H-ras oncogene-transformed R6-PKC3 cells. Mol Cell Biol 12:3117-3129, 1992.
29. Hsiao W-LW, Lopez CA, Wu T, Weinstein IB. A factor present in fetal calf serum enhances oncogene-induced transformation of rodent fibroblasts. Mol Cell Biol 7:3380-3385, 1987.
30. Yang J-J, Kang J-S, Krauss RS. Transformation-restoring factor: A low molecular weight secreted factor required for anchorage-independent growth of oncogene-resistant mutant cell lines. Oncogene 10:1291-1299, 1995.
31. Housey GM, Johnson MD, Hsiao W-LW, et al. Overproduction of protein kinase causes disordered growth control in rat fibroblasts. Cell 52:343-354, 1988.
32. Krauss RS, Housey GM, Johnson MD, Weinstein IB. Disturbances in growth control and gene expression in a C3H/10T1/2 cell line that stably overproduces protein kinase C. Oncogene 4:991-998, 1989.
33. Rauscher III FJ, Voulalas PJ, Franza Jr. BR, Curran T. Fos and Jun bind cooperatively to the AP-1 site: Reconstruction in vitro. Genes Dev 2:1687-1699, 1988.
34. Wax SD, Rosenfeld CL, Taubman MB. Identification of a novel growth factor-responsive gene in vascular smooth muscle cells. J Biol Chem 269:13041-13047, 1994.
35. Matrisian LM, Glaichenhaus N, Gesnal M-C, Breatnach R. Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts. EMBO J 4:1435-1440, 1985.
36. Kahana C, Nathans D. Nucleotide sequence of murine ornithine decarboxylase mRNA. Proc Natl Acad Sci USA 82:1673-1677, 1985.
37. Angel P, Poting A, Mallick U, Rahmsdorf HJ, Schorpp M, Herrlich P. Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts. Mol Cell Biol 6:1760-1766, 1986.
38. Portnoy DA, Erickson AH, Kochan J, Ravetch JV, Unkeless JC. Cloning and characterization of a mouse cysteine protease. J Biol Chem 261:14697-14703, 1986.
39. Krauss RS, Weinstein IB. A novel, plasmid-based system for studying gene rearrangements in mammalian cells. Mol Cell Biol 11:3915-3924, 1991.
40. Morganstern JP, Land H. Advanced mammalian gene transfer: High titer retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res 18:3587-3596, 1990.
41. Hartman SC, Mulligan RC. Two dominant-acting selectable markers for gene transfer studies in mammalian cells. Proc Natl Acad Sci USA 85:8047-8051, 1988.
42. Han EK, Guadagno TM, Dalton SL, Assoain RK. A cell cycle and mutational analysis of anchorage-independent growth: Cell adhesion and TGF-β1 control G1/S transit specifically. J Cell Biol 122:461-471, 1993.
43. Liotta LA, Steeg PS, Stetler-Stevenson WG. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation. Cell 64:327-336, 1991.