The second extracellular loop of CXCR4 determines its function as a receptor for feline immunodeficiency virus

Journal of Virology

Volumn 72, Issue 8, 1998, Pages 6475-6481

  Willett, Brian J ^a   Adema, Karen ^a   Heveker, Nikolaus ^b   Brelot, Anne ^b   Picard, Laurent ^b   Alizon, Marc ^b   Turner, Julie D ^c   Hoxie, James A ^c   Peiper, Stephen ^d   Neil, James C ^a   Hosie, Margaret J ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b INSTITUT COCHIN   (France)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR;

ANIMAL CELL; ARTICLE; CAT; FELINE IMMUNODEFICIENCY VIRUS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; VIRUS CELL INTERACTION;

EID: 0031902658     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.8.6475-6481.1998     Document Type: Article

References (55)

1. Albritton, L. M., J. W. Kim, L. Tseng, and J. M. Cunningham. 1993. Envelope-binding domain in the cationic amino-acid transporter determines the host range of ecotropic murine retroviruses. J. Virol. 67:2091-2096.
2. Alkhatib, G., C. Combadiere, C. C. Broder, Y. Feng, P. E. Kennedy, P. M. Murphy, and E. A. Berger. 1996. CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272: 1955-1958.
3. Bagasra, O., E. Lavi, L. Bobroski, K. Khalili, J. P. Pestaner, and R. Pomerantz. 1996. Cellular reservoirs of HIV-1 in the central nervous system of HIV-infected individuals: identification by combination of in situ PCR and immunochemistry. AIDS 10:573-585.
4. Berger, E. A., R. W. Doms, E. M. Fenyo, B. T. M. Korber, D. R. Littman, J. P. Moore, Q. J. Sattentau, H. Schuitemaker, J. Sodroski, and R. A. Weiss. 1998. A new classification for HIV-1. Nature 391:240.
5. Bjorndal, A., H. K. Deng, M. Jansson, J. R. Fiore, C. Colognesis, A. Karlsson, J. Albert, G. Scarlatti, D. R. Littman, and E. M. Fenyo. 1997. Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype. J. Virol. 71:7478-7487.
6. Brelot, A., N. Heveker, O. Pleskoff, N. Sol, and M. Alizon. 1997. Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity. J. Virol. 71:4744-4751.
7. Cao, J., L. Bergeron, E. Helseth, M. Thali, H. Pepke, and J. Sodroski. 1993. Effects of amino acid changes in the extracellular domain of the human immunodeficiency virus type 1 gp41 envelope glycoprotein. J. Virol. 67:2747-2755.
8. Chaudry, G. J., and M. V. Eiden. 1997. Mutational analysis of the proposed gibbon ape leukemia virus binding site in Pit1 suggests that other regions are important for infection. J. Virol. 71:8078-8081.
9. Choe, H., M. Farzan, Y. Sun, N. Sullivan, B. Rollins, P. D. Ponath, L. Wu, C. R. Mackay, G. LaRosa, W. Newman, N. Gerard, C. Gerard, and J. Sodroski. 1996. The β-chemokine receptors CCR3 and CCR5 facilitate infection hy primary HIV-1 isolates. Cell 85:1135-1148.
10. Clapham, P. R., A. McKnight, and R. A. Weiss. 1992. Human immunodeficiency virus type 2 infection and fusion of CD4-negative human cell lines: induction and enhancement by soluble CD4. J. Virol. 66:3531-3537.
11. Connor, R. I., K. E. Sheridan, D. Ceradini, S. Choe, and N. R. Landau. 1997. Change in coreceptor use correlates with disease progression in HIV-1-infected individuals. J. Exp. Med. 185:621-628.
12. Davis, C. B., I. Dikic, D. Unutmaz, C. M. Hill, J. Arthos, M. A. Siani, D. A. Thompson, J. Schlessinger, and D. R. Littman. 1997. Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5. J. Exp. Med. 186:1793-1798.
13. Dean, G. A., G. H. Reubel, P. F. Moore, and N. C. Pedersen. 1996. Proviral burden and infection kinetics of feline immunodeficiency virus in lymphocyte subsets of blood and lymph node. J. Virol. 70:5165-5169.
14. de Jong, J. J., A. de Ronde, W. Keulen, M. Tersmette, and J. Goudsmit. 1992. Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncytium-inducing phenotype: analysis by single amino acid substitution. J. Virol. 66:6777-6780.
15. Deng, H., R. Liu, W. Ellmeir, S. Choe, D. Unutmaz, M. Burkhart, P. Di Marzio, S. Marmon, R. E. Sutton, C. M. Hill, C. B. Davis, S. C. Peiper, T. J. Schall, D. R. Littman, and N. R. Landau. 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661-666.
16. Deng, H. K., D. Unutmaz, V. N. KewalRamani, and D. R. Littman. 1997. Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 388:296-300.
17. Doranz, B. J., J. Rucker, Y. Yi, R. J. Smyth, M. Samson, S. C. Peiper, M. Parmentier, R. G. Collman, and R. W. Doms. 1996. A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion co-factors. Cell 85:1149-1158.
18. Dragic, T., T. Litwin, G. P. Allaway, S. R. Martin, Y. Huang, K. A. Nagashima, C. Cayanan, P. J. Maddon, R. A. Koup, J. P. Moore, and W. A. Paxton. 1996. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR5. Nature 381:667-673.
19. Dubay, J. W., S. J. Roberts, B. Brody, and E. Hunter. 1992. Mutations in the leucine zipper of the human immunodeficiency virus type 1 transmembrane glycoprotein affect fusion and infectivity. J. Virol. 66:4748-4756.
20. Endres, M. J., P. R. Clapham, M. Marsh, M. Ahuja, J. D. Turner, A. McKnight, J. F. Thomas, B. Stoebenau-Haggarty, S. Choe, P. J. Vance, T. N. C. Wells, C. A. Power, S. S. Sutterwala, R. W. Doms, N. R. Landau, and J. A. Hoxie. 1996. CD4-independent infection by HIV-2 is mediated by fusin. Cell 87:745-756.
21. Feng, Y., C. C. Broder, P. E. Kennedy, and E. A. Berger. 1996. HIV-1 entry co-factor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272:872-877.
22. Heiber, M., A. Marchese, N. Y. Nguyen, H. Heng, S. George, and B. O'Dowd. 1996. A novel human gene encoding a G-protein-coupled receptor (gpr15) is located on chromosome 3. Genomics 32:462-465.
23. Hesselgesser, J., M. HalksMiller, V. DelVecchio, S. C. Peiper, J. Hoxie, D. L. Kolson, D. Taub, and R. Horuk. 1997. CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons. Curr. Biol. 7:112-121.
24. Ho, D. D., M. G. Sarngadharan, M. S. Hirsch, R. T. Schooley, T. R. Rota, R. C. Kennedy, T. C. Chanh, and V. L. Sato. 1987. Human immunodeficiency virus neutralizing antibodies recognize several conserved domains on the envelope glycoprotein. J. Virol. 61:2024-2028.
25. Hosie, M. J., N. Broere, J. Hesselgesser, J. D. Turner, J. A. Hoxie, J. C. Neil, and B. J. Willett. 1998. Modulation of feline immunodeficiency virus infection by stromal cell-derived factor. J. Virol. 72:2097-2104.
26. Ikeuchi, K., S. Kim, R. A. Byrn, S. R. Goldring, and J. E. Groopman. 1990. Infection of nonlymphoid cell by human immunodeficiency virus type 1 or type 2. J. Virol. 64:4226-4231.
27. Karlsson, A., K. Parsmyr, E. Sandstrom, E. M. Fenyo, and J. Albert. 1994. MT-2 cell tropism as a prognostic marker for disease progression in human immunodeficiency virus type 1 infection. J. Clin. Microbiol. 32:364-370.
28. Koot, M., I. P. M. Keet, A. H. V. Vos, R. E. Y. De Goede, M. T. L. Roos, R. A. Coutinho, F. Miedema, P. T. A. Schellekens, and M. Tersmette. 1993. Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS. Ann. Intern. Med. 118:681-688.
29. Lerner, D. L., and J. H. Elder. 1997. Unpublished data.
30. Liao, F., G. Alkhatib, K. W. C. Peden, G. Sharma, E. A. Berger, and J. M. Farber. 1997. STRL33, a novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J. Exp. Med. 185:2015-2023.
31. Livingstone, W. J., M. Moore, D. Innes, J. E. Bell, P. Simmonds, J. Whitelaw, R. Wyld, J. R. Robertson, and R. P. Brettle. 1996. Frequent infection of peripheral-blood CD8-positive T-lymphocytes with HIV-1. Lancet 348:649-654.
32. Lu, Z. H., J. F. Berson, Y. H. Chen, J. D. Turner, T. Y. Zhang, M. Sharron, M. H. Jenks, Z. X. Wang, J. Kim, J. Rucker, J. A. Hoxie, S. C. Peiper, and R. W. Doms. 1997. Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains. Proc. Natl. Acad. Sci. USA 94:6426-6431.
33. Mankowski, J. L., J. P. Spelman, H. G. Ressetar, J. D. Strandberg, J. Laterra, D. L. Carter, J. E. Clements, and M. C. Zink. 1994. Neurovirulent simian immunodeficiency virus replicates productively in endothelial cells of the central nervous system in vivo and in vitro. J. Virol. 68:8202-8208.
34. Marchese, A., J. Docherty, N. Y. Nguyen, M. Heiber, R. Cheng, H. Heng, L. Tsui, X. Shi, S. George, and B. O'Dowd. 1994. Cloning of human genes encoding novel G protein-coupled receptors. Genomics 23:609-618.
35. Martin, K. A., R. Wyatt, M. Farzan, H. Choe, L. Marcon, E. Desjardins, J. Robinson, J. Sodroski, C. Gerard, and N. P. Gerard. 1997. CD4-independent binding of SIV gp120 to rhesus CCR5. Science 278:1470-1473.
36. McKnight, A., P. R. Clapham, and R. A. Weiss. 1994. HIV-2 and SIV infection of non-primate cell lines expressing human CD4: restrictions to replication at distinct stages. Virology 201:8-18.
37. Moses, A. V., F. E. Bloom, C. D. Pauza, and J. A. Nelson. 1993. Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism. Proc. Natl. Acad. Sci. USA 90:10474-10478.
38. Muster, T., F. Steindl, M. Purtscher, A. Trkola, A. Klima, G. Himmler, F. Ruker, and H. Katinger. 1993. A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1. J. Virol. 67:6642-6647.
39. Parolin, C., A. Borsetti, H. Choe, M. Farzan, P. Kolchinsky, M. Heesen, Q. Ma, C. Gerard, G. Palu, M. E. Dorf, T. Springer, and J. Sodroski. 1998. Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency virus. J. Virol. 72:1652-1656.
40. Picard, L., D. A. Wilkinson, A. McKnight, P. W. Gray, J. A. Hoxie, P. R. Clapham, and R. A. Weiss. 1997. Role of the amino-terminal extracellular domain of CXCR-4 in human immunodeficiency virus type 1 entry. Virology 231:105-111.
41. Pleskoff, O., C. Treboute, A. Brelot, N. Heveker, M. Seman, and M. Alizon. 1997. Identification of a chemokine receptor encoded by human cytomegalovirus as a cofactor for HIV-1 entry. Science 276:1874-1878.
42. Raport, C. J., V. L. Schweickart, R. L. Eddy, T. B. Shows, and P. W. Gray. 1995. The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues. Gene 163:295-299.
43. Reeves, J. D., A. McKnight, S. Potempa, G. Simmons, P. W. Gray, C. A. Power, T. Wells, R. A. Weiss, and S. J. Talbot. 1997. CD4-independent infection by HIV-2 (ROD/B): use of the 7-transmembrane receptors CXCR-4, CCR-3, and V28 for entry. Virology 231:130-134.
44. Reeves, J. D., and T. F. Schultz. 1997. The CD4-independent tropism of human immunodeficiency virus type 2 involves several regions of the envelope protein and correlates with a reduced activation threshold for envelope-mediated fusion. J. Virol. 71:1453-1465.
45. Schuitemaker, H., M. Koot, N. A. Koostra, M. W. Dercksen, R. E. Y. De Goede, R. P. Van Steenwijk, J. M. Lange, J. K. Eeftink Schattenkerk, F. Miedema, and M. Tersmette. 1992. Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus populations. J. Virol. 66:1354-1360.
46. Siebelink, K. H. J., J. A. Karlas, G. F. Rimmelzwaan, A. D. M. E. Osterhaus, and M. L. Bosch. 1995. A determinant of feline immunodeficiency virus involved in CrFK tropism. Vet. Immunol. Immunopathol. 46:61-69.
47. Simmons, G., D. Wilkinson, J. D. Reeves, M. T. Dittmar, S. Beddows, J. Weber, G. Carnegie, U. Desselberger, P. W. Gray, R. A. Weiss, and P. R. Clapham. 1996. Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry. J. Virol. 70:8355-8360.
48. Speck, R. F., K. Wehrly, E. J. Platt, R. E. Atchison, I. F. Charo, D. Kabat, B. Chesebro, and M. A. Goldsmith. 1997. Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the V3 loop. J. Virol. 71:7136-7139.
49. Tailor, C. S., and D. Kabat. 1997. Variable regions A and B in the envelope glycoproteins of feline leukemia virus subgroup B and amphotropic murine leukemia virus interact with discrete receptor domains. J. Virol. 71:9383-9391.
50. Tateno, M., F. Gonzalez-Scarano, and J. A. Levy. 1989. The human immunodeficiency virus can infect CD4-human fibroblastoid cells. Proc. Natl. Acad. Sci. USA 86:4287-4290.
51. Vahlenkamp, T. W., E. J. Verschoor, N. N. M. P. Schuurman, A. L. W. van Vliet, M. C. Horzinek, H. F. Egberink, and A. de Ronde. 1997. A single amino acid substitution in the transmembrane envelope glycoprotein of feline immunodeficiency virus alters cellular tropism. J. Virol. 71:7132-7135.
52. Verschoor, E. J., L. A. Boven, H. Blaak, A. R. W. van Vliet, M. C. Horzinek, and A. de Ronde. 1995. A single mutation within the V3 envelope neutralization domain of feline immunodeficiency virus determines its tropism for CRFK cells. J. Virol. 69:4752-4757.
53. Wild, C., T. Greenwell, and T. Matthew. 1993. A synthetic peptide from HIV-1 is a potent inhibitor of virus-mediated cell-cell fusion. AIDS Res. Hum. Retroviruses 9:1051-1053.
54. Willett, B. J., M. J. Hosie, J. C. Neil, J. D. Turner, and J. A. Hoxie. 1997. Common mechanism of infection by lentiviruses. Nature 385:587.
55. Willett, B. J., L. Picard, M. J. Hosie, J. D. Turner, K. Adema, and P. R. Clapham. 1997. Shared usage of the chemokine receptor CXCR4 by the feline and human immunodeficiency viruses. J. Virol. 71:6407-6415.