Breast cancer and genetic instability: The molecules behind the scenes

Molecular Medicine Today

Volumn 4, Issue 6, 1998, Pages 263-267

  Feunteun Phd, Jean ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN;

BREAST CANCER; BREAST CARCINOGENESIS; CANCER RISK; GENE MUTATION; GENETIC STABILITY; HUMAN; ONCOGENE; REVIEW;

EID: 0031859111     PISSN: 13574310     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-4310(98)01262-3     Document Type: Review

References (31)

1. Malkin D. p53 and the Li-Fraumeni syndrome. Biochim. Biophys. Acta Rev. Cancer. 1198:1994;197-213.
2. Easton D.F. Cancer risks in A-T heterozygotes. Int. J. Radiat. Biol. 66:1994;S177-S182.
3. Meyn M.S. Ataxia-telangectasia and cellular responses to DNA damage. Cancer Res. 55:1995;5991-6001.
4. Feunteun J., Lenoir G.M. BRCA1, a gene involved in inherited predisposition to breast and ovarian cancer. Biochim. Biophys. Acta. Rev. Cancer. 1242:1996;177-180.
5. Scully R.et al. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell. 88:1997;265-275.
6. Sharan S.K.et al. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature. 386:1997;804-810.
7. Scully R.et al. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell. 90:1997;425-435.
8. Miki Y.et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 266:1994;66-71.
9. Scully R.et al. Location of BRCA1 in human breast and ovarian cancer cells. Science. 272:1996;123-125.
10. Mizuta R.et al. RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. Proc. Natl. Acad. Sci. U. S. A. 94:1997;6927-6932.
11. Monteiro A.N.A., August A., Hanafusa H. Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc. Natl. Acad. Sci. U. S. A. 93:1996;13595-13599.
12. Milner J.et al. Transcriptional activation functions in BRCA2. Nature. 386:1997;772-773.
13. Chapman M.S., Verma I.M. Transcriptional activation by BRCA1. Nature. 382:1996;678-679.
14. Scully R.et al. BRCA1 is a component of the RNA polymerase II holoenzyme. Proc. Natl. Acad. Sci. U. S. A. 94:1997;5605-5610.
15. WAF1/CiP1. Nature. 389:1997;187-190.
16. Thompson M.E.et al. Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nat. Genet. 9:1995;444-450.
17. Hakem R.et al. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell. 85:1996;1009-1023.
18. Ludwig T., Chapman D.L., Papaioannou V.E., Efstratiadis A. Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 11:1997;1226-1241.
19. Suzuki A.et al. Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev. 11:1997;1242-1252.
20. Connor F.et al. Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation. Nat. Genet. 17:1997;423-430.
21. 5-6 early embryonic lethality by p53 or p21 null mutation. Nat. Genet. 16:1997;298-302.
22. Boyd M.et al. A human BRCA1 gene knockout. Nature. 375:1995;541-542.
23. Jin Y.et al. Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains. Proc. Natl. Acad. Sci. U. S. A. 94:1997;12075-12080.
24. Wu L.J.C.et al. Identification of a RING protein that can interact in vivo with the BRCA1 gene product. Nat. Genet. 14:1996;430-440.
25. Keegan K.S.et al. The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes Dev. 10:1996;2423-2437.
26. Tsuzuki T.et al. Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. Proc. Natl. Acad. Sci. U. S. A. 93:1996;6236-6240.
27. Lim D.S., Hasty P. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol. Cell Biol. 16:1996;7133-7143.
28. Patel K.J.et al. Involment of Brca2 in DNA repair. Mol. Cell. 1:1998;347-357.
29. Kinzler K.W., Vogelstein B. Cancer-susceptibility genes - gatekeepers and caretakers. Nature. 386:1997;761-763.
30. Glebov O.K., McKenzie K.E., White C.A., Sukumar S. Frequent p53 gene mutations and novel alleles in familial breast cancer. Cancer Res. 54:1994;3703-3709.
31. Crook T.et al. p53 mutations in BRCA1-associated familial breast cancer. Lancet. 350:1997;638-639.