Kaposi's sarcoma herpesvirus as a new paradigm for virus-induced oncogenesis

Current Opinion in Oncology

Volumn 10, Issue 5, 1998, Pages 405-412

  Whitby, Denise ^a   Boshoff, Chris ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE;

HIGH RISK POPULATION; HUMAN; HUMAN HERPESVIRUS 8; KAPOSI SARCOMA; LYMPHOMA; PRIORITY JOURNAL; REVIEW; SEROPREVALENCE; SEXUALLY TRANSMITTED DISEASE; SKIN CARCINOGENESIS;

EID: 0031788737     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001622-199809000-00007     Document Type: Review

References (82)

1. Chang Y, Cesarman E, Pessin MS, et al.: Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994, 266:1865-1869.
2. Levy JA: A new human herpesvirus: KSHV or HHV8? [editorial]. Lancet 1995, 346:786.
3. Gao SJ, Kingsley L, Li M, et al.: KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nat Med 1996, 2:925-928.
4. Kedes DH, Operskalski E, Busch M, Kohn R, Flood J, Ganem D: The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med 1996, 2:918-924.
5. Simpson GR, Schulz TF, Whitby D, et al.: Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet 1996, 348:1133-1138.
6. Chatlynne LG, Lapps W, Handy M, et al.: Detection and titration of human herpesvirus-8-specific antibodies on sera from blood donors, acquired immunodeficiency syndrome patients, and Kaposi's sarcoma patient as using a whole virus enzyme-linked immunosorbent assay. Blood 1998, in press.
7. Davis DA, Humphrey RW, Newcomb FM, et al.: Detection of serum antibodies to a Kaposi's sarcoma-associated herpesvirus specific peptide. J Infect Dis 1997, 175:1071-1079.
8. Chandran B, Smith MS, Koelle DM, Corey L, Horvat R, Goldstein E: Reactivities of human sera with human herpesvirus-8 infected BCBL-1 cells and identification of HHV-8-specific proteins and glycoproteins and the encoding cDNAs. Virology 1998, 243:208-217.
9. Rainbow L, Platt GM, Simpson GR, et al.: The 222-234 kd nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf 73 and a component of the latency-associated nuclear antigen. J Virol 1997, 71:5915-5921.
10. Kellam P, Boshoff C, Whitby D, Matthews S, Weiss RA, Talbot SJ: Identification of a major latent nuclear antigen (LNA-1) in the human herpesvirus 8 (HHV-8) genome. J Hum Virol 1997, 1:19-29.
11. Kedes DH, Lagunoff M, Renne R, Ganem D: Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus. J Clin Invest 1997, 100:2606-2610.
12. Lennette ET, Blackbourn DJ, Levy JA: Antibodies to human herpesvirus type 8 in the general population and in Kaposi's sarcoma patients. Lancet 1996, 348:858-861.
13. Kedes DH, Ganem D, Ameli N, Bacchetti P, Greenblatt R: The prevalence of serum antibody to human herpesvirus 8 (Kaposi sarcoma-associated herpesvirus) among HIV-seropositive and high-risk HIV-seronegative women. JAMA 1997, 277:478-481.
14. Martin JN, Ganem DE, Osmond DH, Page-Shafer KA, Macrae D, Kedes DH: Sexual transmission and the natural history of human herpesvirus 8 infection. N Engl J Med 1998, 338:948-954. Shows clearly that KSHV is a sexually-transmitted disease in homosexual men.
15. Martin JN, Ganem DE, Osmond DH, Page-Shafer KA, Macrae D, Kedes DH: Sexual transmission and the natural history of human herpesvirus 8 infection. N Engl J Med 1998, 338:948-954.
16. Geddes M, Franceschi S, Balzi D, Arniani S, Gafa L, Zanetti R: Birthplace and classic Kaposi's sarcoma in Italy. J Natl Cancer Inst 1995, 87:1015-1017.
17. Franceschi S, Geddes M: Epidemiology of classic Kaposi's sarcoma, with special reference to Mediterranean population. Tumori 1995, 81:308-314.
18. Whitby D, Luppi M, Barozzi P, Boshoff C, Weiss RA, Torelli G: HHV-8 seroprevalence in blood donors and lymphoma patients from different regions of Italy. J Natl Cancer Inst 1998, 90:395-397.
19. Calabro ML, Sheldon J, Favero A, et al.: Seroprevalence of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 in several regions in Italy. J Hum Virol 1998, 1:207-213.
20. Gao SJ, Kingsley L, Li M, et al.: KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma [see comments]. Nat Med 1996, 2:925-928.
21. Ariyoshi K, Schim van der Loeff M, Cook P, et al.: Kaposi's sarcoma in the Gambia, West Africa is less frequent in human immunodeficiency virus type 2 than in human immunodeficiency virus type 1 infection despite a high prevalence of human herpesvirus 8. J Hum Virol 1998, 1:192-199.
22. Sitas F, Carrara H, Beral V, Newton R, Reeves G, Bull D, et al.: The seroepidemiology of HHV-8/KSHV in a large population of black cancer patients in Johannesburg. 1998: N Eng J Med 1998, submitted.
23. Whitby D, Smith N, Ariyoshi K, et al.: Serologic evidence for different routes of transmission of HHV-8 in different populations [abstract]. Second Annual Meeting National AIDS Malignancy Conference 1998, Washington, DC: A12.
24. Ziegler JL, Katongole Mbidde E: Kaposi's sarcoma in childhood: an analysis of 100 cases from Uganda and relationship to HIV infection. Int J Cancer 1996, 65:200-203.
25. Bourboulia D, Whitby D, Boshoff C, et al.: Serological evidence for vertical transmission of KSHV/HHV-8 in healthy South African children. JAMA 1998, in press.
26. Gillison ML, Ambinder RF: Human herpesvirus 8. Curr Opin Oncol 1997, 9:440-449.
27. Di Alberti L, Piattelli A, Artese L, et al.: Human herpesvirus 8 variants in sarcoid tissues. Lancet 1997, 350:1655-1661.
28. Rettig MB, Ma HJ, Vescio RA, et al.: Kaposi's sarcoma associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma. Science 1997, 276:1851-1854.
29. Said JW, Rettig MR, Heppner K, et al.: Localisation of Kaposi's sarcoma-associated herpesvirus in bone marrow biopsy samples from patients with multiple myeloma. Blood 1998, 90:4278-4282.
30. Parravicini C, Lauri E, Baldini L, et al.: Kaposi's sarcoma-associated herpesvirus infection and multiple myeloma. Science 1997, 278:1969.
31. Masood R, Zheng T, Tulpule A, et al.: Kaposi's sarcoma-associated herpesvirus infection and multiple myeloma. Science 1997, 278:1969-1970.
32. Whitby D, Boshoff C, Luppi M, Torelli G: Kaposi's sarcoma-associated herpesvirus infection and multiple myeloma. Science 1997, 278:1971-1972.
33. Tarte K, Olsen SJ, Yang Lu Z, et al.: Clinical grade functional dendritic cells from patients with multiple myeloma are not infected with Kaposi's sarcoma-associated herpesvirus. Blood 1996, 91:1852-1857.
34. Parravicini C, Corbellino M, Paulli M, et al.: Expression of a virus-derived cytokine, KSHV vIL-6, in HIV seronegative Castleman's disease. Am J Pathol 1998, 6:1517-1522.
35. Boshoff C, Gao S-J, Healy LE, et al.: Establishment of a KSHV positive cell line (BCP-1) from peripheral blood and characterizing its growth in vivo. Blood 1998, 91:1671-1679. First description of a KSHV positive cell line established from peripheral blood.
36. Moore PS, Gao SJ, Dominguez G, et al.: Primary characterization of a herpesvirus agent associated with Kaposi's sarcoma. J Virol 1996, 70:549-558.
37. Mesri EA, Cesarman E, Arvanitakis L, et al.: Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells. J Exp Med 1996, 183:2385-2390.
38. Foreman KE, Friborg J Jr, Kong WP, et al.: Propagation of a human herpesvirus from AIDS-associated Kaposi's sarcoma. N Engl J Med 1997, 336:163-171.
39. Renne R, Blackbourn D, Whitby D, Levy J, Ganem D: Limited transmission of Kaposi's sarcoma-associated herpesvirus in cultured cells. J Virol 1998, 72:5182-5188.
40. Panyutich EA, Said JW, Miles SA: Infection of primary dermal microvascular endothelial cells by Kaposi's sarcoma-associated herpesvirus. AIDS 1998, 12:467-472.
41. Moore PS, Boshoff C, Weiss RA, Chang Y: Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 1996, 274:1739-1744.
42. Boshoff C: Coupling herpesvirus to angiogenesis. Nature 1998, 391:24-25.
43. Godden-Kent D, Talbot SJ, Boshoff C, et al.: The cyclin encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) stimulates cdk6 to phosphorylate the retinoblastoma protein and Histone H1. J Virol 1997, 71:4193-4198.
44. Li M, Lee H, Yoon DW, et al.: Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin. J Virol 1997, 71:1984-1991.
45. Swanton C, Mann DJ, Fleckenstein B, Neipel F, Peters G, Jones N: Herpesviral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins. Nature 1997, 390:184-187. Describes the unique functions of the viral encoded cyclin homologues.
46. Sheaff RJ, Groudine M, Gordon M, Roberts JM, Clurman BE: Cyclin E-CDK2 is a regulator of p27Kip1. Genes Dev 1997, 11:1464-1478.
47. Davis MA, Sturzl MA, Blasig C, et al.: Expression of human herpesvirus 8-encoded cyclin D in Kaposi's sarcoma spindle cells. J Natl Cancer Inst 1997, 89:1829-1831.
48. Reed JA, Nador RG, Spaulding D, Tani Y, Cesarman E, Knowles DM: Demonstration of Kaposi's sarcoma-associated herpesvirus cyclin D homolog in cutaneous Kaposi's sarcoma by colorimetric in situ hybridisation using a catalysed signal amplification system. Blood 1998, 91:3825-3832.
49. Skapek SX, Rhee J, Spicer DB, Lassar AB: Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase. Science 1995, 267:1022-1024.
50. Jones DL, Alani RM, Munger K: The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation pathways in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2. Genes Dev 1997, 11:2101-2111.
51. Arvanitakis L, Geras-Raaka E, Varma A, Gershengorn MC, Cesarman E: Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Nature 1997, 385:347-349.
52. Bais C, Santomasso B, Coso O, et al.: Kaposi's sarcoma associated herpesvirus (KSHV/HHV-8) G protein-coupled receptor is a viral oncogene and angiogenesis activator. Nature 1998, 391:86-89.
53. Alblas J, Van Etten I, Moolenaar WH: Truncated, desensitization-defective neurokinin receptors mediate sustained MAP kinase activation, cell growth and transformation by a Ras-independent mechanism. EMBO J 1996, 15:3351-3360.
54. Coughlin SR: Expanding horizons for receptors coupled to G proteins: diversity and disease. Curr Opin Cell Biol 1994, 6:191-197.
55. Julius D, Livelli TJ, Jessell TM, Axel R: Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation. Science 1989, 244(4908):1057-1062.
56. Milano CA, Allen LF, Rockman HA, et al.: Enhanced myocardial function in transgenic mice overexpressing the beta2-adrenergic receptor. Science 1994, 264:582-586.
57. Cesarman E, Nador RG, Bai F, et al.: Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma. J Virol 1996, 70:8218-8223.
58. Guo HG, Browning P, Nicholas J, et al.: Characterization of a chemokine receptor-related gene in human herpesvirus 8 and its expression in Kaposi's sarcoma. Virology 1997, 228:371-378.
59. Karin M, Liu Z, Zandi E: Curr Opin Cell Biol 1997, 9:240-246.
60. Kolch W, Martiny-Baron G, Kieser A, Marme D. Breast Cancer Res Treat 1995, 36:139-155.
61. Geras-Raaka E, Arvanitakis L, Bais C, Cesarman E, Mesri EA, Gershengorn MC: Inhibition of constitutive signaling of Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor by protein kinases in mammalian cells in culture. J Exp Med 1998, 187:801-806.
62. Irmler M, Thome M, Hahne M, et al.: Inhibition of death receptor signals by cellular FLIP. Nature 1997, 388:190-195.
63. Zhong W, Wang H, Herndier B, Ganem D: Restricted expression of Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in Kaposi sarcoma. Proc Natl Acad Sci U S A 1996, 93:6641-6646.
64. Staskus KA, Zhong W, Gebhard K, et al.: Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol 1997, 71:715-719.
65. Muralidhar S, Pumfery AM, Hassani M, et al.: Identification of Kaposin (ORF K12) as a human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) transforming gene. J Virol 1998, 72:4980-4988.
66. Lagunoff D, Ganem D: The structure and coding organization of the genomic termini of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8). Virology 1997, 236:147-154.
67. Lee H, Veazey R, Williams K, et al.: Deregulation of cell growth by the K1 gene of Kaposi's sarcoma-associated herpesvirus. Nat Med 1998, 4:435-440. Focuses on the left end of the genome of KSHV, an area important in HVS transformation.
68. Nicholas J, Jian-Chao Z, Alcendor DJ, et al.: Novel organizational features, captured cellular genes, and strain variability within the genome of KSHV/HHV-8. J Natl Cancer Inst 1998, 23:79-88. Description of the variability of KSHV strains.
69. Neipel F, Albrecht JC, Ensser A, et al.: Human herpesvirus 8 encodes a homolog of interleukin-6. J Virol 1997, 71:839-842.
70. Molden J, Chang Y. You Y, Moore PS, Goldsmith MA: A Kaposi's sarcoma-associated herpesvirus-encoded cylokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit. J Biol Chem 1997, 272:19625-19631.
71. Kledal TN, Rosenkilde MM, Coulin F, et al.: A broad spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science 1997, 277:1656-1659.
72. Boshoff C, Endo Y, Collins PD, et al.: Angiogenic and HIV inhibitory functions of KSHV-encoded chemokines. Science 1997, 278:290-293. Describes the unique functions of the chemokines encoded by KSHV, including their promiscuity in chemokine receptor usage and angiogenic ability.
73. Whitby D, Howard MR, Tenant-Flowers M, et al.: Detection of Kaposi's sarcoma associated herpesvirus in peripheral blood of HIV-infected individuals and progression to Kaposi's sarcoma. Lancet 1995, 346:799-802.
74. Liestol K, Goplen AK, Dunlop O, Bruun JN, Moelen J: Kaposi's sarcoma and protection from HIV dementia. Science 1998, 280:361-362.
75. Baldeweg T, Catalan J, Gazzard BG, Weiss RA, Boshoff C: Kaposi's sarcoma and protection from HIV dementia. Science 1998, 280:361-362.
76. Boshoff C, Schulz TF, Kennedy MM, et al.: Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat Med 1995, 1:1274-1278.
77. Ganem D: KSHV and Kaposi's sarcoma: the end of the beginning. Cell 1997, 91:157-160.
78. Beral V, Jaffe HW, Weiss RA: Cancer Surveys 1990: Cancer, HIV and AIDS. New York: Cold Spring Harbor Laboratory Press; 1990.
79. Beral V: Epidemiology of Kaposi's sarcoma. In Cancer, HIV and AIDS. Beral V, Jaffe HW, Weiss RA, eds. New York: Cold Spring Harbor Laboratory Press, 1991:5-22.
80. Geddes M, Franceschi S, Barchielli A, Falcini F, Carli S, Cocconi G: Kaposi's sarcoma in Italy before and after the AIDS epidemic. Br J Cancer 1994, 69:333-336.
81. Biggar RJ, Melbye M, Kestems L, et al.: Kaposi's sarcoma in Zaire is not associated with HTLV-III infection [letter]. N Engl J Med 1984, 311:1051-1052.
82. Grulich AE, Beral V, Swerdlow AJ: Kaposi's sarcoma in England and Wales before the AIDS epidemic. Br J Cancer 1992, 66:1135-1137.