메뉴 건너뛰기




Volumn 11, Issue 4, 1997, Pages 201-223

Anthracyclines in haematology: Preclinical studies, toxicity and delivery systems

Author keywords

[No Author keywords available]

Indexed keywords

4' IODOESORUBICIN; ACLACINOMYCIN; ANNAMYCIN; ANTHRACYCLINE; ANTHRAQUINONE; ANTHRAQUINONE DERIVATIVE; BISANTRENE; CERAMIDE; DAUNORUBICIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; EPIRUBICIN; FAS ANTIGEN; GLYCOPROTEIN P; IDARUBICIN; LIPOSOME; MARCELLOMYCIN; MENOGARIL; MITOXANTRONE; PIRARUBICIN; ZORUBICIN;

EID: 0031468368     PISSN: 0268960X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0268-960X(97)90020-5     Document Type: Article
Times cited : (83)

References (273)
  • 1
    • 0001530185 scopus 로고
    • 'Daunomycin', a new antibiotic of the rhodomycin group
    • Di Marco A, Gaetani M, Orezzi B et al. 'Daunomycin', a new antibiotic of the rhodomycin group. Nature 1964; 201: 706-707.
    • (1964) Nature , vol.201 , pp. 706-707
    • Di Marco, A.1    Gaetani, M.2    Orezzi, B.3
  • 2
    • 0002252931 scopus 로고
    • Rubidomycin: A new antibiotic with cytostatic properties
    • Dubost M, Ganter P, Maral R et al. Rubidomycin: a new antibiotic with cytostatic properties. Cancer Chemother Rep 1964; 41: 35-45.
    • (1964) Cancer Chemother Rep , vol.41 , pp. 35-45
    • Dubost, M.1    Ganter, P.2    Maral, R.3
  • 3
    • 0001929802 scopus 로고
    • Daunomycin (Daunorubicin) and adriamycin and structural analogues: Biological activity and mechanism of action
    • Gottlieb D, Shaw P D, eds. Berlin, Springer Verlag
    • Di Marco A, Arcamone F, Zunino F. Daunomycin (Daunorubicin) and adriamycin and structural analogues: biological activity and mechanism of action. In: Gottlieb D, Shaw P D, eds). Antibiotics. Berlin, Springer Verlag, 1975; III: 101-128.
    • (1975) Antibiotics , vol.3 , pp. 101-128
    • Di Marco, A.1    Arcamone, F.2    Zunino, F.3
  • 5
    • 0014066067 scopus 로고
    • Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease
    • Tan C, Tasaka H, Yu K-P, Murphy ML, Karnofsky DA. Daunomycin, an antitumor antibiotic, in the treatment of neoplastic disease. Cancer 1967; 20: 333-353.
    • (1967) Cancer , vol.20 , pp. 333-353
    • Tan, C.1    Tasaka, H.2    Yu, K.-P.3    Murphy, M.L.4    Karnofsky, D.A.5
  • 7
    • 0026709749 scopus 로고
    • Infusional anthracyclines: Is slower better? if so, why?
    • Workman P. Infusional anthracyclines: Is slower better? If so, why? Ann Oncol 1992; 3: 591-594.
    • (1992) Ann Oncol , vol.3 , pp. 591-594
    • Workman, P.1
  • 8
    • 0027817393 scopus 로고
    • Anthracycline and anthraquinone anticancer agents: Current status and recent development
    • Lown JW. Anthracycline and anthraquinone anticancer agents: current status and recent development. Pharmac Ther 1993; 60: 185-214.
    • (1993) Pharmac Ther , vol.60 , pp. 185-214
    • Lown, J.W.1
  • 9
    • 0026714331 scopus 로고
    • The anthracyclines: Will we ever find a better doxorubicin?
    • Weiss RB. The anthracyclines: will we ever find a better doxorubicin? Semin Oncol 1992; 119 (6): 670-686.
    • (1992) Semin Oncol , vol.119 , Issue.6 , pp. 670-686
    • Weiss, R.B.1
  • 10
    • 0014945759 scopus 로고
    • Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: Evidence for molecular models involving intercalation
    • Waring M. Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: evidence for molecular models involving intercalation. J Mol Biol 1970; 54: 247-279.
    • (1970) J Mol Biol , vol.54 , pp. 247-279
    • Waring, M.1
  • 11
    • 0015494420 scopus 로고
    • Stereochemistry of intercalation: Interaction of daunomycin with DNA
    • Pigram WJ, Fuller W, Hamilton LD. Stereochemistry of intercalation: Interaction of daunomycin with DNA. Nature New Biol 1972; 235: 17-19.
    • (1972) Nature New Biol , vol.235 , pp. 17-19
    • Pigram, W.J.1    Fuller, W.2    Hamilton, L.D.3
  • 12
    • 0019364861 scopus 로고
    • DNA Modification and Cancer
    • Waring MJ. DNA Modification and Cancer. Ann Rev Biochem 1981; 50: 159-192.
    • (1981) Ann Rev Biochem , vol.50 , pp. 159-192
    • Waring, M.J.1
  • 13
    • 0025793927 scopus 로고
    • Sequence specificity in the binding of antitumour anthracyclines to DNA: A success of theory
    • Pullman B. Sequence specificity in the binding of antitumour anthracyclines to DNA: a success of theory. Anti-Cancer Drug Design 1991; 7: 95-105.
    • (1991) Anti-Cancer Drug Design , vol.7 , pp. 95-105
    • Pullman, B.1
  • 14
    • 0028130150 scopus 로고
    • Design and synthesis of anthracycline and distamycin derivatives as new, sequence specific, DNA-binding pharmacological agents
    • Arcamone F. Design and synthesis of anthracycline and distamycin derivatives as new, sequence specific, DNA-binding pharmacological agents. Gene 1994; 149: 57-61.
    • (1994) Gene , vol.149 , pp. 57-61
    • Arcamone, F.1
  • 15
    • 0016851896 scopus 로고
    • The inhibition in vitro of DNA polymerase and RNA polymerases by daunomycin and adriamycin
    • Zunino F, Gambetta R, DiMarco A. The inhibition in vitro of DNA polymerase and RNA polymerases by daunomycin and adriamycin. Biochem Pharmacol 1975; 24: 309-311.
    • (1975) Biochem Pharmacol , vol.24 , pp. 309-311
    • Zunino, F.1    Gambetta, R.2    DiMarco, A.3
  • 16
    • 0016798341 scopus 로고
    • Binding of daunomycin to DNA and the inhibition of RNA and DNA synthesis
    • Mizuno NS, Zakis B, Decker RW. Binding of daunomycin to DNA and the inhibition of RNA and DNA synthesis. Cancer Res 1975; 35: 1542-1546.
    • (1975) Cancer Res , vol.35 , pp. 1542-1546
    • Mizuno, N.S.1    Zakis, B.2    Decker, R.W.3
  • 17
    • 0017864686 scopus 로고
    • Protein-associated DNA breaks in cells treated with adriamycin or ellipticine
    • Ross WE, Glaubiger DL, Kohn KW. Protein-associated DNA breaks in cells treated with adriamycin or ellipticine. Biochim Biophys Acta 1978; 519: 23-30.
    • (1978) Biochim Biophys Acta , vol.519 , pp. 23-30
    • Ross, W.E.1    Glaubiger, D.L.2    Kohn, K.W.3
  • 18
    • 0021151237 scopus 로고
    • Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II
    • Tewey KM, Rowe TC, Yang L, Halligan BD, Liu LF. Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science 1984; 226: 466-468.
    • (1984) Science , vol.226 , pp. 466-468
    • Tewey, K.M.1    Rowe, T.C.2    Yang, L.3    Halligan, B.D.4    Liu, L.F.5
  • 19
    • 0021192054 scopus 로고
    • Intercalative antitumour drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II
    • Tewey KM, Chen GL, Nelson EM, Liu LF. Intercalative antitumour drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Biol Chem 1984; 259: 9182-9187.
    • (1984) J Biol Chem , vol.259 , pp. 9182-9187
    • Tewey, K.M.1    Chen, G.L.2    Nelson, E.M.3    Liu, L.F.4
  • 20
    • 0022402753 scopus 로고
    • DNA topoisomerases as targets for cancer therapy
    • Ross WE. DNA topoisomerases as targets for cancer therapy. Biochem Pharmacol 1985; 34: 4191-4195.
    • (1985) Biochem Pharmacol , vol.34 , pp. 4191-4195
    • Ross, W.E.1
  • 23
    • 0024583327 scopus 로고
    • Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukaemia cell lines
    • Deffie AM, Batra JK, Goldenberg GJ. Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukaemia cell lines. Cancer Res 1989; 49: 58-62.
    • (1989) Cancer Res , vol.49 , pp. 58-62
    • Deffie, A.M.1    Batra, J.K.2    Goldenberg, G.J.3
  • 24
    • 0019958596 scopus 로고
    • Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukaemia L1210 cells: Comparison with adriamycin and 4′-(9-acridinylamino) methanesulfon-m-anisidide
    • Zwelling LA, Kerrigan D, Michaels S. Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukaemia L1210 cells: comparison with adriamycin and 4′-(9-acridinylamino) methanesulfon-m-anisidide. Cancer Res 1982; 42: 2687-2691.
    • (1982) Cancer Res , vol.42 , pp. 2687-2691
    • Zwelling, L.A.1    Kerrigan, D.2    Michaels, S.3
  • 26
    • 0001780713 scopus 로고
    • Anthracycline metabolism and free radical formation
    • Powis G, Prough R A, eds. London, New York and Philadelphia: Taylor and Francis
    • Powis G. Anthracycline metabolism and free radical formation. In: Powis G, Prough R A, eds. Metabolism and Action of Anti-cancer Drugs. London, New York and Philadelphia: Taylor and Francis, 1987: 211-260.
    • (1987) Metabolism and Action of Anti-cancer Drugs , pp. 211-260
    • Powis, G.1
  • 27
    • 0015338377 scopus 로고
    • Daunorubicin metabolism in acute myelocytic leukaemia
    • Huffman DH, Bachur NR. Daunorubicin metabolism in acute myelocytic leukaemia. Blood 1972; 39: 637-643.
    • (1972) Blood , vol.39 , pp. 637-643
    • Huffman, D.H.1    Bachur, N.R.2
  • 28
    • 0024355564 scopus 로고
    • Comparative activity of anthracycline 13-dihydrometabolites against rat glioblastoma cells in culture
    • Schott B, Robert J. Comparative activity of anthracycline 13-dihydrometabolites against rat glioblastoma cells in culture. Biochem Pharmacol 1989; 38: 4069-4074.
    • (1989) Biochem Pharmacol , vol.38 , pp. 4069-4074
    • Schott, B.1    Robert, J.2
  • 29
    • 0026576715 scopus 로고
    • Anthracyclines and their C-13 alcohol metabolites: Growth inhibition and DNA damage following incubation with human tumor cells in culture
    • Kuffel MJ, Reid JM, Ames MM. Anthracyclines and their C-13 alcohol metabolites: growth inhibition and DNA damage following incubation with human tumor cells in culture. Cancer Chemother Pharmacol 1992; 30: 51-57.
    • (1992) Cancer Chemother Pharmacol , vol.30 , pp. 51-57
    • Kuffel, M.J.1    Reid, J.M.2    Ames, M.M.3
  • 30
    • 0017703085 scopus 로고
    • Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation
    • Bachur NR, Gordon SL, Gee MV. Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation. Mol Pharmacol 1977; 13: 901-910.
    • (1977) Mol Pharmacol , vol.13 , pp. 901-910
    • Bachur, N.R.1    Gordon, S.L.2    Gee, M.V.3
  • 31
    • 0018875204 scopus 로고
    • Relationship of the single-electron reduction potential of quinones to their reduction by flavoproteins
    • Powis G, Appel PL. Relationship of the single-electron reduction potential of quinones to their reduction by flavoproteins. Biochem Pharmacol 1980; 29: 2567-2572.
    • (1980) Biochem Pharmacol , vol.29 , pp. 2567-2572
    • Powis, G.1    Appel, P.L.2
  • 32
    • 0018741206 scopus 로고
    • NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals
    • Bachur NR, Gordon SL, Gee MV, Kon H. NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals. Proc Natl Acad Sci USA 1979; 76: 954-957.
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 954-957
    • Bachur, N.R.1    Gordon, S.L.2    Gee, M.V.3    Kon, H.4
  • 33
    • 0018865202 scopus 로고
    • Xanthine oxidase catalyzed reductive cleavage of anthracycline antibiotics and free radical formation
    • Pan S-S, Bachur NR. Xanthine oxidase catalyzed reductive cleavage of anthracycline antibiotics and free radical formation. Mol Pharmacol 1980; 17: 95-99.
    • (1980) Mol Pharmacol , vol.17 , pp. 95-99
    • Pan, S.-S.1    Bachur, N.R.2
  • 34
    • 0018194637 scopus 로고
    • A general mechanism for microsomal activation of quinone anticancer agents to free radicals
    • Bachur NR, Gordon SL, Gee MV. A general mechanism for microsomal activation of quinone anticancer agents to free radicals. Cancer Res 1978; 38: 1745-1750.
    • (1978) Cancer Res , vol.38 , pp. 1745-1750
    • Bachur, N.R.1    Gordon, S.L.2    Gee, M.V.3
  • 35
    • 0017646174 scopus 로고
    • Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents
    • Lown JW, Sim S-K, Majumdar KC, Chang R-Y. Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents. Biochem Biophys Res Commun 1977; 76: 705-710.
    • (1977) Biochem Biophys Res Commun , vol.76 , pp. 705-710
    • Lown, J.W.1    Sim, S.-K.2    Majumdar, K.C.3    Chang, R.-Y.4
  • 36
    • 0021341261 scopus 로고
    • Oxidative destruction of DNA by the adriamycin-iron complex
    • Eliot H, Gianni L, Myers C. Oxidative destruction of DNA by the adriamycin-iron complex. Biochemistry 1984; 23: 928-936.
    • (1984) Biochemistry , vol.23 , pp. 928-936
    • Eliot, H.1    Gianni, L.2    Myers, C.3
  • 37
    • 0021920122 scopus 로고
    • Thiol-dependent DNA damage produced by anthracycline-iron complexes. The structure-activity relationships and molecular mechanisms
    • Muindi J, Sinha BK, Gianni L, Myers C. Thiol-dependent DNA damage produced by anthracycline-iron complexes. The structure-activity relationships and molecular mechanisms. Mol Pharmacol 1985; 27: 356-365.
    • (1985) Mol Pharmacol , vol.27 , pp. 356-365
    • Muindi, J.1    Sinha, B.K.2    Gianni, L.3    Myers, C.4
  • 38
    • 0020619895 scopus 로고
    • Relationship of adriamycin concentrations to the DNA lesions induced in hypoxic and euoxic L 1210 cells
    • Potmesil M, Kirschenbaum S, Israels M, Levin M, Khetarpal VK, Silber R. Relationship of adriamycin concentrations to the DNA lesions induced in hypoxic and euoxic L 1210 cells. Cancer Res 1983; 43: 3528-3533.
    • (1983) Cancer Res , vol.43 , pp. 3528-3533
    • Potmesil, M.1    Kirschenbaum, S.2    Israels, M.3    Levin, M.4    Khetarpal, V.K.5    Silber, R.6
  • 39
    • 0021185116 scopus 로고
    • Two mechanisms of adriamycin-DNA interaction in L1210
    • Potmesil M, Israels M, Silber R. Two mechanisms of adriamycin-DNA interaction in L1210. Biochem Pharmacol 1984; 33: 3137-3142.
    • (1984) Biochem Pharmacol , vol.33 , pp. 3137-3142
    • Potmesil, M.1    Israels, M.2    Silber, R.3
  • 40
    • 0023279787 scopus 로고
    • Temperature dependence studies of adriamycin uptake and cytotoxicity
    • Lane P, Vichi P, Bain DL, Tritton TR. Temperature dependence studies of adriamycin uptake and cytotoxicity. Cancer Res 1987; 47: 4038-4042.
    • (1987) Cancer Res , vol.47 , pp. 4038-4042
    • Lane, P.1    Vichi, P.2    Bain, D.L.3    Tritton, T.R.4
  • 41
    • 0024420036 scopus 로고
    • Temperature dependence of adriamycin-induced DNA damage in L1210 cells
    • Vichi P, Robison S, Tritton TR. Temperature dependence of adriamycin-induced DNA damage in L1210 cells. Cancer Res 1989; 49: 5575-5580.
    • (1989) Cancer Res , vol.49 , pp. 5575-5580
    • Vichi, P.1    Robison, S.2    Tritton, T.R.3
  • 42
    • 0019986638 scopus 로고
    • The anticancer agent adriamycin can be actively cytotoxic without entering cells
    • Tritton TR, Yee G. The anticancer agent adriamycin can be actively cytotoxic without entering cells. Science 1982; 217: 248-250.
    • (1982) Science , vol.217 , pp. 248-250
    • Tritton, T.R.1    Yee, G.2
  • 43
    • 0002961204 scopus 로고
    • Cell death in cancer chemotherapy: The case of adriamycin
    • Apoptosis: the Molecular Basis of Cell Death. Tomei LD, Cope FO, eds. New York: Cold Spring Harbor Laboratory Press
    • Tritton TR. Cell death in cancer chemotherapy: the case of adriamycin. In: Apoptosis: the Molecular Basis of Cell Death. Tomei LD, Cope FO, eds. Current Communications in Cell and Molecular Biology 3. New York: Cold Spring Harbor Laboratory Press, 1991.
    • (1991) Current Communications in Cell and Molecular Biology , vol.3
    • Tritton, T.R.1
  • 44
    • 0017284035 scopus 로고
    • Effect of adriamycin on the cell cycle traverse and kinetics of cultured human lymphoblasts
    • Krishan A, Frei III E. Effect of adriamycin on the cell cycle traverse and kinetics of cultured human lymphoblasts. Cancer Res 1976; 36: 143-150.
    • (1976) Cancer Res , vol.36 , pp. 143-150
    • Krishan, A.1    Frei III, E.2
  • 45
    • 0027968344 scopus 로고
    • DNA fragmentation as a consequence of cell cycle traverse in doxorubicin- and idarubicin-treated human lymphoma cells
    • Smith PJ, Rackstraw C, Cotter F. DNA fragmentation as a consequence of cell cycle traverse in doxorubicin- and idarubicin-treated human lymphoma cells. Ann Hematol 1994; 69: S7-S11.
    • (1994) Ann Hematol , vol.69
    • Smith, P.J.1    Rackstraw, C.2    Cotter, F.3
  • 46
    • 0027267578 scopus 로고
    • Cell cycle related uptake, retention and toxicity of idarubicin, daunorubicin and doxorubicin
    • Minderman H, Linssen P, Wessels J, Haanen C. Cell cycle related uptake, retention and toxicity of idarubicin, daunorubicin and doxorubicin. Anticancer Res 1993; 13: 1161-1166.
    • (1993) Anticancer Res , vol.13 , pp. 1161-1166
    • Minderman, H.1    Linssen, P.2    Wessels, J.3    Haanen, C.4
  • 47
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-257.
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.R.1    Wyllie, A.H.2    Currie, A.R.3
  • 48
    • 0021346318 scopus 로고
    • Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis
    • Wyllie AH, Morris RG, Smith AL, Dunlop D. Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J Pathol 1984; 142: 67-77.
    • (1984) J Pathol , vol.142 , pp. 67-77
    • Wyllie, A.H.1    Morris, R.G.2    Smith, A.L.3    Dunlop, D.4
  • 49
  • 50
    • 0018830636 scopus 로고
    • Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
    • Wyllie AH. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 1980; 284: 555-556.
    • (1980) Nature , vol.284 , pp. 555-556
    • Wyllie, A.H.1
  • 51
    • 0027217084 scopus 로고
    • Apoptotic death in epithelial cells: Cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation
    • Oberhammer F, Wilson JW, Dive C et al. Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J 1993; 12: 3679-3684.
    • (1993) EMBO J , vol.12 , pp. 3679-3684
    • Oberhammer, F.1    Wilson, J.W.2    Dive, C.3
  • 52
    • 0028338833 scopus 로고
    • Endonuclease activities associated with high molecular weight and internucleosomal DNA fragmentation in apoptosis
    • Walker PR, Weaver VM, Lach B, LeBlanc J, Sikorska M. Endonuclease activities associated with high molecular weight and internucleosomal DNA fragmentation in apoptosis. Exp Cell Res 1994; 213: 100-106.
    • (1994) Exp Cell Res , vol.213 , pp. 100-106
    • Walker, P.R.1    Weaver, V.M.2    Lach, B.3    Leblanc, J.4    Sikorska, M.5
  • 53
    • 0027278808 scopus 로고
    • Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug-resistant cells
    • Ling Y-H, Priebe W, Perez-Soler R. Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug-resistant cells. Cancer Res 1993; 53: 1845-1852.
    • (1993) Cancer Res , vol.53 , pp. 1845-1852
    • Ling, Y.-H.1    Priebe, W.2    Perez-Soler, R.3
  • 54
    • 0029942653 scopus 로고    scopus 로고
    • Daunorubicin-induced internucleosomal DNA fragmentation in acute myeloid cell lines
    • Quillet-Mary A, Mansat V, Duchayne E et al. Daunorubicin-induced internucleosomal DNA fragmentation in acute myeloid cell lines. Leukemia 1996; 10: 417-425.
    • (1996) Leukemia , vol.10 , pp. 417-425
    • Quillet-Mary, A.1    Mansat, V.2    Duchayne, E.3
  • 55
    • 0027994349 scopus 로고
    • The sphingomyelin cycle and the second messenger function of ceramide
    • Hannun YA. The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem 1994; 269: 3125-3128.
    • (1994) J Biol Chem , vol.269 , pp. 3125-3128
    • Hannun, Y.A.1
  • 56
    • 0028297068 scopus 로고
    • The sphingomyelin pathway in tumour necrosis factor and interleukin-1 signaling
    • Kolesnick R, Golde DW. The sphingomyelin pathway in tumour necrosis factor and interleukin-1 signaling. Cell 1994; 77: 325-328.
    • (1994) Cell , vol.77 , pp. 325-328
    • Kolesnick, R.1    Golde, D.W.2
  • 58
    • 0028095477 scopus 로고
    • Apoptotic signalling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase
    • Cifone MG, DeMaria R, Roncaioli P et al. Apoptotic signalling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. Exp Med 1994; 177: 1547-1552.
    • (1994) Exp Med , vol.177 , pp. 1547-1552
    • Cifone, M.G.1    DeMaria, R.2    Roncaioli, P.3
  • 59
    • 0029148660 scopus 로고
    • Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
    • Bose R, Verheij M, Haimovitz-Friedman A, Scotto K, Fuks Z, Kolesnick R. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 1995; 82: 405-414.
    • (1995) Cell , vol.82 , pp. 405-414
    • Bose, R.1    Verheij, M.2    Haimovitz-Friedman, A.3    Scotto, K.4    Fuks, Z.5    Kolesnick, R.6
  • 60
    • 0030006040 scopus 로고    scopus 로고
    • Daunorubicin-induced apoptosis: Triggering of ceramide generation through sphingomyelin hydrolysis
    • Jaffrézou J-P, Levade T, Bettaïeb A et al. Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis. EMBO J 1996; 15: 2417-2424.
    • (1996) EMBO J , vol.15 , pp. 2417-2424
    • Jaffrézou, J.-P.1    Levade, T.2    Bettaïeb, A.3
  • 61
    • 0024347970 scopus 로고
    • Monoclonal antibody-mediated tumor regression by induction of apoptosis
    • Trauth BC, Klas C, Peters AM et al. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 1989; 245: 301-305.
    • (1989) Science , vol.245 , pp. 301-305
    • Trauth, B.C.1    Klas, C.2    Peters, A.M.3
  • 63
    • 0027277064 scopus 로고
    • APO-1-induced apoptosis of leukemia cells from patients with adult T-cell leukemia
    • Debatin K-M, Goldmann CK, Waldmann TA, Krammer PH. APO-1-induced apoptosis of leukemia cells from patients with adult T-cell leukemia. Blood 1993; 81: 2972-2977.
    • (1993) Blood , vol.81 , pp. 2972-2977
    • Debatin, K.-M.1    Goldmann, C.K.2    Waldmann, T.A.3    Krammer, P.H.4
  • 64
    • 0029935682 scopus 로고    scopus 로고
    • Involvement of the CD95 (APO-I/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells
    • Friesen C, Herr I, Krammer PH, Debatin K-M. Involvement of the CD95 (APO-I/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nature Medicine 1996; 2: 574-577.
    • (1996) Nature Medicine , vol.2 , pp. 574-577
    • Friesen, C.1    Herr, I.2    Krammer, P.H.3    Debatin, K.-M.4
  • 65
    • 0030892234 scopus 로고    scopus 로고
    • Apoptosis by death factor
    • Nagata S. Apoptosis by death factor. Cell 1997; 88: 355-365.
    • (1997) Cell , vol.88 , pp. 355-365
    • Nagata, S.1
  • 66
    • 0022617601 scopus 로고
    • Pre-clinical selection of new anthracyclines
    • Casazza AM. Pre-clinical selection of new anthracyclines. Cancer Treat Rep 1986; 70: 43-49.
    • (1986) Cancer Treat Rep , vol.70 , pp. 43-49
    • Casazza, A.M.1
  • 67
    • 0022442584 scopus 로고
    • Phase I and II agents in cancer therapy: 1, anthracyclines and related compounds
    • Wadler S, Fuks JZ, Wiernik PH. Phase I and II agents in cancer therapy: 1, anthracyclines and related compounds. J Clin Pharmacol 1986; 26: 491-509.
    • (1986) J Clin Pharmacol , vol.26 , pp. 491-509
    • Wadler, S.1    Fuks, J.Z.2    Wiernik, P.H.3
  • 68
    • 0024949475 scopus 로고
    • Relationship of structure to anticancer activity and toxicity of anthracyclines
    • Arcamone F, Penco S. Relationship of structure to anticancer activity and toxicity of anthracyclines. Gann Monograph on Cancer Research 1989; 36: 81-94.
    • (1989) Gann Monograph on Cancer Research , vol.36 , pp. 81-94
    • Arcamone, F.1    Penco, S.2
  • 69
    • 0024344732 scopus 로고
    • Cellular and molecular pharmacology of 4′-epidoxorubicin in HeLa cells. Comparison with its parent drug doxorubicin
    • Cantoni O, Sestili P, Cattabeni F, Geroni C, Grandi M, Giuliani FC. Cellular and molecular pharmacology of 4′-epidoxorubicin in HeLa cells. Comparison with its parent drug doxorubicin. Cancer Res Clin Oncol 1989; 115: 373-378.
    • (1989) Cancer Res Clin Oncol , vol.115 , pp. 373-378
    • Cantoni, O.1    Sestili, P.2    Cattabeni, F.3    Geroni, C.4    Grandi, M.5    Giuliani, F.C.6
  • 70
    • 0025687394 scopus 로고
    • Comparative effects of doxorubicin and 4′-epidoxorubicin on nucleic acid metabolism and cytotoxicity in a human tumor cell line
    • Cantoni O, Sestili P, Cattabeni F, Geroni C, Giuliani FC. Comparative effects of doxorubicin and 4′-epidoxorubicin on nucleic acid metabolism and cytotoxicity in a human tumor cell line. Cancer Chemother Pharmacol 1990; 27: 47-51.
    • (1990) Cancer Chemother Pharmacol , vol.27 , pp. 47-51
    • Cantoni, O.1    Sestili, P.2    Cattabeni, F.3    Geroni, C.4    Giuliani, F.C.5
  • 72
    • 0021748487 scopus 로고
    • Cellular uptake and efflux and cytostatic activity of 4′-0-tetrahydropyranyladriamycin in adriamycin-sensitive and resistant tumour cell lines
    • Kunimoto S, Miura K, Umezawa K et al. Cellular uptake and efflux and cytostatic activity of 4′-0-tetrahydropyranyladriamycin in adriamycin-sensitive and resistant tumour cell lines. J Antibiot 1984; 37: 1697-1702.
    • (1984) J Antibiot , vol.37 , pp. 1697-1702
    • Kunimoto, S.1    Miura, K.2    Umezawa, K.3
  • 73
    • 0021950736 scopus 로고
    • Relationship between the intracellular level and growth inhibition of a new anthracyclin THP in Friend leukaemia cell variants
    • Munck JN, Fourcade A, Bennoun M, Tapiero H. Relationship between the intracellular level and growth inhibition of a new anthracyclin THP in Friend leukaemia cell variants. Leuk Res 1985; 9: 289-296.
    • (1985) Leuk Res , vol.9 , pp. 289-296
    • Munck, J.N.1    Fourcade, A.2    Bennoun, M.3    Tapiero, H.4
  • 74
    • 0021828072 scopus 로고
    • In vitro sensitivity of leukemic clonogenic cells to four anthracyclines (adriamycin, daunorubicin, rubidazone and aclacinomycin) in human myeloid leukemia
    • Marie JP, Thevenin D, Zittoun R. In vitro sensitivity of leukemic clonogenic cells to four anthracyclines (adriamycin, daunorubicin, rubidazone and aclacinomycin) in human myeloid leukemia. Nouv Rev Fr Hematol 1985; 27: 163-167.
    • (1985) Nouv Rev Fr Hematol , vol.27 , pp. 163-167
    • Marie, J.P.1    Thevenin, D.2    Zittoun, R.3
  • 76
    • 0017667933 scopus 로고
    • Relationship between effects on nucleic acid synthesis in cell cultures and cytotoxicity of 4-demethoxy derivatives of daunorubicin and adriamycin
    • Supino R, Necco A, Dasdia T, Casazza AM, Di Marco A. Relationship between effects on nucleic acid synthesis in cell cultures and cytotoxicity of 4-demethoxy derivatives of daunorubicin and adriamycin. Cancer Res 1977; 37: 4523-4528.
    • (1977) Cancer Res , vol.37 , pp. 4523-4528
    • Supino, R.1    Necco, A.2    Dasdia, T.3    Casazza, A.M.4    Di Marco, A.5
  • 77
    • 0027200184 scopus 로고
    • Action mechanism of idarubicin (4-demethoxydaunorubicin) as compared with daunorubicin in leukemic cells
    • Fukushima T, Ueda T, Uchida M, Nakamura T. Action mechanism of idarubicin (4-demethoxydaunorubicin) as compared with daunorubicin in leukemic cells. Int J Hematol 1993; 57: 121-130.
    • (1993) Int J Hematol , vol.57 , pp. 121-130
    • Fukushima, T.1    Ueda, T.2    Uchida, M.3    Nakamura, T.4
  • 78
    • 0028905362 scopus 로고
    • Sensitivities of AML blast stem cells to idarubicin and daunorubicin: A comparision with normal hematopoietic progenitors
    • Curtis JE, Minden MD, Minkin S, McCulloch EA. Sensitivities of AML blast stem cells to idarubicin and daunorubicin: a comparision with normal hematopoietic progenitors. Leukemia 1995; 9: 396-404.
    • (1995) Leukemia , vol.9 , pp. 396-404
    • Curtis, J.E.1    Minden, M.D.2    Minkin, S.3    McCulloch, E.A.4
  • 79
    • 0021842654 scopus 로고
    • A study on the comparative efficacy of aclacinomycin-A and adriamycin on two solid tumours, in vitro and in vivo
    • abs 881
    • Ballou RJ, Tseng MT. A study on the comparative efficacy of aclacinomycin-A and adriamycin on two solid tumours, in vitro and in vivo. Proc Am Assoc Cancer Res 1985; 26: 224 (abs 881).
    • (1985) Proc Am Assoc Cancer Res , vol.26 , pp. 224
    • Ballou, R.J.1    Tseng, M.T.2
  • 80
    • 0021276294 scopus 로고
    • Inhibition of glycoprotein biosynthesis by the inducers of HL-60 cell differentiation, aclacinomycin A and marcellomycin
    • Morin MJ, Sartorelli AC. Inhibition of glycoprotein biosynthesis by the inducers of HL-60 cell differentiation, aclacinomycin A and marcellomycin. Cancer Res 1984; 44: 2807-2812.
    • (1984) Cancer Res , vol.44 , pp. 2807-2812
    • Morin, M.J.1    Sartorelli, A.C.2
  • 81
    • 0023222671 scopus 로고
    • Comparative in vitro activity of 4′-deoxy-4′-iododoxorubicin and other anthracyclines in the human tumor clonogenic assay
    • Schwartz JE, Salmon SE. Comparative in vitro activity of 4′-deoxy-4′-iododoxorubicin and other anthracyclines in the human tumor clonogenic assay. Invest New Drugs 1987; 5: 231-234.
    • (1987) Invest New Drugs , vol.5 , pp. 231-234
    • Schwartz, J.E.1    Salmon, S.E.2
  • 82
    • 0022360180 scopus 로고
    • Properties of antitumor anthracyclines and new developments in their application: Cain Memorial Award Lecture
    • Arcamone F. Properties of antitumor anthracyclines and new developments in their application: Cain Memorial Award Lecture. Cancer Res 1985; 45: 5995-5999.
    • (1985) Cancer Res , vol.45 , pp. 5995-5999
    • Arcamone, F.1
  • 84
    • 0022830084 scopus 로고
    • Effects of 7-R-O-Methylnogarol (Menogaril) on L1210 cell progression in vitro and in vivo
    • Adams EG, Bhuyan BK. Effects of 7-R-O-Methylnogarol (Menogaril) on L1210 cell progression in vitro and in vivo. Cancer Res 1986; 46: 6125-6130.
    • (1986) Cancer Res , vol.46 , pp. 6125-6130
    • Adams, E.G.1    Bhuyan, B.K.2
  • 85
    • 0025046376 scopus 로고
    • Menogaril, an anthracycline compound with a novel mechanism of action: Cellular pharmacology
    • Wierzba K, Sugimato Y, Matsuo K et al. Menogaril, an anthracycline compound with a novel mechanism of action: cellular pharmacology. Jpn J Cancer Res 1990; 81: 842-849.
    • (1990) Jpn J Cancer Res , vol.81 , pp. 842-849
    • Wierzba, K.1    Sugimato, Y.2    Matsuo, K.3
  • 86
    • 0026746056 scopus 로고
    • Menogaril, an anthracycline derivative, inhibits DNA topoisomerase II by stabilizing cleavable complexes
    • Ono K, Ikegami Y, Nishizawa M, Andoh T. Menogaril, an anthracycline derivative, inhibits DNA topoisomerase II by stabilizing cleavable complexes. Jpn J Cancer Res 1992; 83: 1018-1023.
    • (1992) Jpn J Cancer Res , vol.83 , pp. 1018-1023
    • Ono, K.1    Ikegami, Y.2    Nishizawa, M.3    Andoh, T.4
  • 87
    • 0025768299 scopus 로고
    • Pharmacological and physicochemical properties of a new anthracycline with potent antileukemic activity
    • Nafziger J, Auclair C, Florent J-C, Guillosson J-J, Monneret C. Pharmacological and physicochemical properties of a new anthracycline with potent antileukemic activity. Leuk Res 1991; 15: 709-713.
    • (1991) Leuk Res , vol.15 , pp. 709-713
    • Nafziger, J.1    Auclair, C.2    Florent, J.-C.3    Guillosson, J.-J.4    Monneret, C.5
  • 88
    • 0029873324 scopus 로고    scopus 로고
    • Enhanced topoisomerase II-induced DNA breaks and free radical production by a new anthracycline with potent antileukemic activity
    • Andrivon W, Saucier J-M, Auclair C et al. Enhanced topoisomerase II-induced DNA breaks and free radical production by a new anthracycline with potent antileukemic activity. Leuk Res 1996; 20: 119-126.
    • (1996) Leuk Res , vol.20 , pp. 119-126
    • Andrivon, W.1    Saucier, J.-M.2    Auclair, C.3
  • 89
    • 0028886260 scopus 로고
    • A new anthracycline with potent antileukemic activity exhibits reduced mutagenicity
    • Andrivon W, Callais F, Nafziger J, Monneret C, Guillosson J-J. A new anthracycline with potent antileukemic activity exhibits reduced mutagenicity. Mutation Res 1995; 344: 135-140.
    • (1995) Mutation Res , vol.344 , pp. 135-140
    • Andrivon, W.1    Callais, F.2    Nafziger, J.3    Monneret, C.4    Guillosson, J.-J.5
  • 90
    • 0027419378 scopus 로고
    • In vitro cytotoxicity, cellular pharmacology, and DNA lesions induced by annamycin, an anthracycline derivative with high affinity for lipid membranes
    • Ling Y-H, Priebe W, Yang L-Y, Burke TG, Pommier Y, Perez-Soler R. In vitro cytotoxicity, cellular pharmacology, and DNA lesions induced by annamycin, an anthracycline derivative with high affinity for lipid membranes. Cancer Res 1993; 53: 1583-1589.
    • (1993) Cancer Res , vol.53 , pp. 1583-1589
    • Ling, Y.-H.1    Priebe, W.2    Yang, L.-Y.3    Burke, T.G.4    Pommier, Y.5    Perez-Soler, R.6
  • 91
    • 0030013639 scopus 로고    scopus 로고
    • The novel anthracycline annamycin is not affected by p-glycoproteinelated multidrug resistance: Comparison with idarubicin and doxorubicin in HL-60 leukaemia cell lines
    • Consoli U, Priebe W, Ling Y-H et al. The novel anthracycline annamycin is not affected by p-glycoproteinelated multidrug resistance: comparison with idarubicin and doxorubicin in HL-60 leukaemia cell lines. Blood 1996; 88: 633-644.
    • (1996) Blood , vol.88 , pp. 633-644
    • Consoli, U.1    Priebe, W.2    Ling, Y.-H.3
  • 92
    • 0020568034 scopus 로고
    • Cellular pharmacology of 3′-(4-morpholinyl) and 3′-(4-methoxy-1- piperidinyl) derivatives of 3′-deaminodaunorubicin in human colon carcinoma cells in vitro
    • Johnston JB, Glazer RI. Cellular pharmacology of 3′-(4-morpholinyl) and 3′-(4-methoxy-1- piperidinyl) derivatives of 3′-deaminodaunorubicin in human colon carcinoma cells in vitro. Cancer Res 1983; 43: 1606-1610.
    • (1983) Cancer Res , vol.43 , pp. 1606-1610
    • Johnston, J.B.1    Glazer, R.I.2
  • 93
    • 0021070084 scopus 로고
    • 3′-(3-cyano-4-morpholinyl)-3′-deaminoadriamycin: A new anthracycline with intense potency
    • Johston JB, Habernicht B, Acton EM, Glazer RI. 3′-(3-cyano-4-morpholinyl)-3′-deaminoadriamycin: a new anthracycline with intense potency. Biochem Pharmacol 1983; 32: 3255-3258.
    • (1983) Biochem Pharmacol , vol.32 , pp. 3255-3258
    • Johston, J.B.1    Habernicht, B.2    Acton, E.M.3    Glazer, R.I.4
  • 94
    • 0021921004 scopus 로고
    • Dissociation of antitumour potency from anthracycline cardiotoxicity in a doxorubicin analog
    • Sikic BI, Ehsan MN, Harker WG et al. Dissociation of antitumour potency from anthracycline cardiotoxicity in a doxorubicin analog. Science 1985; 228: 1544-1546.
    • (1985) Science , vol.228 , pp. 1544-1546
    • Sikic, B.I.1    Ehsan, M.N.2    Harker, W.G.3
  • 95
    • 0021913929 scopus 로고
    • Formation of DNA-adducts and induction of DNA-crosslinks and chromosomal aberrations by the new potent anthracycline antitumour antibiotics: Morpholinodaunomycin, cyanomorpholinodaunomycin and cyanomorpholinoadriamycin
    • Westendorf J, Groth G, Steinheider G, Marquardt H. Formation of DNA-adducts and induction of DNA-crosslinks and chromosomal aberrations by the new potent anthracycline antitumour antibiotics: morpholinodaunomycin, cyanomorpholinodaunomycin and cyanomorpholinoadriamycin. Cell Biol Toxicol 1985; 1: 87-101.
    • (1985) Cell Biol Toxicol , vol.1 , pp. 87-101
    • Westendorf, J.1    Groth, G.2    Steinheider, G.3    Marquardt, H.4
  • 96
    • 0022448231 scopus 로고
    • Effects of 3′-deamino-3′-(3-cyano-4-morpholinyl) doxorubicin and doxorubicin on the survival, DNA integrity, and nucleolar morphology of human leukaemia cells in vitro
    • Wasserman K, Zwelling LA, Mullins TD et al. Effects of 3′-deamino-3′-(3-cyano-4-morpholinyl) doxorubicin and doxorubicin on the survival, DNA integrity, and nucleolar morphology of human leukaemia cells in vitro. Cancer Res 1986; 46: 4041-4046.
    • (1986) Cancer Res , vol.46 , pp. 4041-4046
    • Wasserman, K.1    Zwelling, L.A.2    Mullins, T.D.3
  • 97
    • 0023573208 scopus 로고
    • Effects of 3′-(3-cyano-4-morpholinyl)-3′-deaminoadriamycin and structural analogues on DNA on HT-29 human colon carcinoma cells
    • Jesson MI, Johnston JB, Anhalt CD, Begleiter A. Effects of 3′-(3-cyano-4-morpholinyl)-3′-deaminoadriamycin and structural analogues on DNA on HT-29 human colon carcinoma cells. Cancer Res 1987; 47: 5935-5938.
    • (1987) Cancer Res , vol.47 , pp. 5935-5938
    • Jesson, M.I.1    Johnston, J.B.2    Anhalt, C.D.3    Begleiter, A.4
  • 98
    • 0023840029 scopus 로고
    • Facile exchange of the cyano group in highly potent anticancer cyanomorpholinyl anthracyclines
    • Peters JH, Gordon GR, Nolen HW, Tracey M, Thomas DW. Facile exchange of the cyano group in highly potent anticancer cyanomorpholinyl anthracyclines. Biochem Pharmacol 1988; 37; 357-361.
    • (1988) Biochem Pharmacol , vol.37 , pp. 357-361
    • Peters, J.H.1    Gordon, G.R.2    Nolen, H.W.3    Tracey, M.4    Thomas, D.W.5
  • 99
    • 0025949705 scopus 로고
    • The DNA sequence specificity of cyanomorpholinoadriamycin
    • Cullinane C, Phillips DR. The DNA sequence specificity of cyanomorpholinoadriamycin. FEBS Lett 1991; 293: 195-198.
    • (1991) FEBS Lett , vol.293 , pp. 195-198
    • Cullinane, C.1    Phillips, D.R.2
  • 100
    • 0023677312 scopus 로고
    • Selective inhibition of human ribosomal gene transcription by the morpholinyl anthracyclines cyanomorpholinyl- and morpholinyldoxorubicin
    • Wasserman K, Newman RA, Davis FM, Mullins TD, Rose KM. Selective inhibition of human ribosomal gene transcription by the morpholinyl anthracyclines cyanomorpholinyl- and morpholinyldoxorubicin. Cancer Res 1988; 48: 4101-4106.
    • (1988) Cancer Res , vol.48 , pp. 4101-4106
    • Wasserman, K.1    Newman, R.A.2    Davis, F.M.3    Mullins, T.D.4    Rose, K.M.5
  • 101
    • 0025303197 scopus 로고
    • Effects of morpholinyl doxorubicin, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II
    • Wasserman K, Markovits J, Jaxel C, Capranico G, Kohn KW, Pommier Y. Effects of morpholinyl doxorubicin, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II. Mol Pharmacol 1990; 38: 38-45.
    • (1990) Mol Pharmacol , vol.38 , pp. 38-45
    • Wasserman, K.1    Markovits, J.2    Jaxel, C.3    Capranico, G.4    Kohn, K.W.5    Pommier, Y.6
  • 102
    • 0022560064 scopus 로고
    • Uptake and retention of morpholinyl anthracyclines by adriamycin-sensitive and -resistant P388 cells
    • Streeter DG, Johl JS, Gordon GR, Peters JH. Uptake and retention of morpholinyl anthracyclines by adriamycin-sensitive and -resistant P388 cells. Cancer Chemother Pharmacol 1986; 16: 247-252.
    • (1986) Cancer Chemother Pharmacol , vol.16 , pp. 247-252
    • Streeter, D.G.1    Johl, J.S.2    Gordon, G.R.3    Peters, J.H.4
  • 103
    • 0028100220 scopus 로고
    • Growth-inhibitory properties of novel anthracyclines in human leukemia cell lines expressing either Pgp-MDR or at-MDR
    • Mariani M, Capolongo L, Suarato A et al. Growth-inhibitory properties of novel anthracyclines in human leukemia cell lines expressing either Pgp-MDR or at-MDR. Invest New Drugs 1994; 12: 93-97.
    • (1994) Invest New Drugs , vol.12 , pp. 93-97
    • Mariani, M.1    Capolongo, L.2    Suarato, A.3
  • 104
    • 0024271425 scopus 로고
    • MX2, a morpholino anthracycline, as a new antitumor agent against drug-sensitive and multidrug-resistant human and murine tumor cells
    • Watanabe M, Komeshima N, Nakajima S, Tsuruo T. MX2, a morpholino anthracycline, as a new antitumor agent against drug-sensitive and multidrug-resistant human and murine tumor cells. Cancer Res 1988; 48: 6653-6657.
    • (1988) Cancer Res , vol.48 , pp. 6653-6657
    • Watanabe, M.1    Komeshima, N.2    Nakajima, S.3    Tsuruo, T.4
  • 105
    • 0025079614 scopus 로고
    • 9-alkyl, morpholinyl anthracyclines in the circumvention of multidrug resistance
    • Coley HM, Twentyman PR, Workman P. 9-alkyl, morpholinyl anthracyclines in the circumvention of multidrug resistance. Eur J Cancer 1990; 26: 665-667.
    • (1990) Eur J Cancer , vol.26 , pp. 665-667
    • Coley, H.M.1    Twentyman, P.R.2    Workman, P.3
  • 106
    • 0026338729 scopus 로고
    • Biochemical pharmacology of anthracenediones and anthrapyrazoles
    • Fry DW. Biochemical pharmacology of anthracenediones and anthrapyrazoles. Pharmac Ther 1991; 52: 109-125.
    • (1991) Pharmac Ther , vol.52 , pp. 109-125
    • Fry, D.W.1
  • 108
    • 0021047161 scopus 로고
    • Molecular and biochemical pharmacology of mitoxantrone
    • Durr RE, Wallace RE, Citarella RV. Molecular and biochemical pharmacology of mitoxantrone. Cancer Treat Rev 1983; 10 (suppl B): 3-11.
    • (1983) Cancer Treat Rev , vol.10 , Issue.SUPPL. B , pp. 3-11
    • Durr, R.E.1    Wallace, R.E.2    Citarella, R.V.3
  • 109
    • 0020518678 scopus 로고
    • Mitoxantrone (novatrone): A review of experimental and early clinical studies
    • Smith IE. Mitoxantrone (novatrone): a review of experimental and early clinical studies. Cancer Treat Rev 1983; 10: 103-115.
    • (1983) Cancer Treat Rev , vol.10 , pp. 103-115
    • Smith, I.E.1
  • 110
    • 0021690087 scopus 로고
    • Biologic and biochemical effects of mitoxantrone
    • Durr FE. Biologic and biochemical effects of mitoxantrone. Semin Oncol 1984; 11 (suppl 1): 3-10.
    • (1984) Semin Oncol , vol.11 , Issue.1 SUPPL. , pp. 3-10
    • Durr, F.E.1
  • 111
    • 0018875893 scopus 로고
    • Action of dihydroxyanthraquinone on cell cycle progression and survival of a variety of cultured mammalian cells
    • Traganos F, Evenson DP, Staiano-Coico L, Darzynkiewicz Z, Melamed MR. Action of dihydroxyanthraquinone on cell cycle progression and survival of a variety of cultured mammalian cells. Cancer Res 1980; 40: 671-681.
    • (1980) Cancer Res , vol.40 , pp. 671-681
    • Traganos, F.1    Evenson, D.P.2    Staiano-Coico, L.3    Darzynkiewicz, Z.4    Melamed, M.R.5
  • 112
    • 0022340391 scopus 로고
    • Characteristics of the binding of the anticancer agents mitoxantrone and ametantrone and related structures to deoxyribonucleic acid
    • Lown JW, Morgan AR, Yen SF, Wang YH, Wilson WD. Characteristics of the binding of the anticancer agents mitoxantrone and ametantrone and related structures to deoxyribonucleic acid. Biochemistry 1985; 24: 4028-4035.
    • (1985) Biochemistry , vol.24 , pp. 4028-4035
    • Lown, J.W.1    Morgan, A.R.2    Yen, S.F.3    Wang, Y.H.4    Wilson, W.D.5
  • 113
    • 0022384174 scopus 로고
    • Comparative molecular pharmacology in leukemic L1210 cells of the anthracene anticancer drugs mitoxantrone and bisantrene
    • Bowden GT, Roberts R, Alberts DS, Peng Y-M, Garcia D. Comparative molecular pharmacology in leukemic L1210 cells of the anthracene anticancer drugs mitoxantrone and bisantrene. Cancer Res 1985; 45: 4915-4920.
    • (1985) Cancer Res , vol.45 , pp. 4915-4920
    • Bowden, G.T.1    Roberts, R.2    Alberts, D.S.3    Peng, Y.-M.4    Garcia, D.5
  • 114
    • 0025139099 scopus 로고
    • DNA damage and cytotoxicity of mitoxantrone and doxorubicin in doxorubicin-sensitive and -resistant human colon carcinoma cells
    • Capolongo L, Belvedere G, D'Incalci M. DNA damage and cytotoxicity of mitoxantrone and doxorubicin in doxorubicin-sensitive and -resistant human colon carcinoma cells. Cancer Chemother Pharmacol 1990; 25: 430-434.
    • (1990) Cancer Chemother Pharmacol , vol.25 , pp. 430-434
    • Capolongo, L.1    Belvedere, G.2    D'Incalci, M.3
  • 115
    • 0021823689 scopus 로고
    • Mitoxantrone: Propensity for free radical formation and lipid peroxidation - Implications for cardiotoxicity
    • Novak RF, Kharasch ED. Mitoxantrone: propensity for free radical formation and lipid peroxidation - implications for cardiotoxicity. Invest New Drugs 1985; 3: 95-99.
    • (1985) Invest New Drugs , vol.3 , pp. 95-99
    • Novak, R.F.1    Kharasch, E.D.2
  • 116
    • 0023229330 scopus 로고
    • Are reduced quinones necessarily involved in the antitumour activity of quinone drugs?
    • Butler J, Hoey BM. Are reduced quinones necessarily involved in the antitumour activity of quinone drugs? Br J Cancer 1987; 55 suppl VIII: 53-59.
    • (1987) Br J Cancer , vol.55 , Issue.8 SUPPL. , pp. 53-59
    • Butler, J.1    Hoey, B.M.2
  • 117
    • 0020549236 scopus 로고
    • Comparative cytotoxicity of bisantrene mitoxantrone, ametantrone, dihydroxyanthracenedione, dihydroxyanthracenedione diacetate and doxorubicin on human cells in vitro
    • Drewinko B, Yang L-Y, Barlogie B, Trujillo JM. Comparative cytotoxicity of bisantrene mitoxantrone, ametantrone, dihydroxyanthracenedione, dihydroxyanthracenedione diacetate and doxorubicin on human cells in vitro. Cancer Res 1983; 43: 2648-2653.
    • (1983) Cancer Res , vol.43 , pp. 2648-2653
    • Drewinko, B.1    Yang, L.-Y.2    Barlogie, B.3    Trujillo, J.M.4
  • 118
    • 0022349519 scopus 로고
    • Anthrapyrazoles, a new class of intercalating agents with high-level, broad spectrum activity against murine tumors
    • Leopold WR, Nelson JM, Plowman J, Jackson RC. Anthrapyrazoles, a new class of intercalating agents with high-level, broad spectrum activity against murine tumors. Cancer Res 1985; 45: 5532-5539.
    • (1985) Cancer Res , vol.45 , pp. 5532-5539
    • Leopold, W.R.1    Nelson, J.M.2    Plowman, J.3    Jackson, R.C.4
  • 119
    • 0023475540 scopus 로고
    • The effect of the anthrapyrazole antitumour agent CI941 on rat liver microsome and cytochrome P-450 reductase mediated free radical processes
    • Graham MA, Newell DR, Butler J, Hoey B, Patterson LH. The effect of the anthrapyrazole antitumour agent CI941 on rat liver microsome and cytochrome P-450 reductase mediated free radical processes. Biochem Pharmacol 1987; 36: 3345-3351.
    • (1987) Biochem Pharmacol , vol.36 , pp. 3345-3351
    • Graham, M.A.1    Newell, D.R.2    Butler, J.3    Hoey, B.4    Patterson, L.H.5
  • 120
    • 0026167668 scopus 로고
    • Anthrapyrazoles: True successors to the anthracyclines?
    • Judson IR. Anthrapyrazoles: true successors to the anthracyclines? Anti-cancer Drugs 1991; 2: 223-231.
    • (1991) Anti-cancer Drugs , vol.2 , pp. 223-231
    • Judson, I.R.1
  • 121
    • 0026676488 scopus 로고
    • The anthrapyrazoles: A new class of compounds with clinical activity in breast cancer
    • Judson IR. The anthrapyrazoles: a new class of compounds with clinical activity in breast cancer. Semin Oncol 1992; 19: 687-694.
    • (1992) Semin Oncol , vol.19 , pp. 687-694
    • Judson, I.R.1
  • 122
    • 0018776373 scopus 로고
    • Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukaemia
    • Inaba M, Kobayashi H, Sakurai Y, Johnson RK. Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukaemia. Cancer Res 1979; 39: 2200-2203.
    • (1979) Cancer Res , vol.39 , pp. 2200-2203
    • Inaba, M.1    Kobayashi, H.2    Sakurai, Y.3    Johnson, R.K.4
  • 123
    • 0018566696 scopus 로고
    • Purification of p-glycoprotein from plasma membrane vesicles of chinese hamster ovary cell mutants with reduced colchicine permeability
    • Riordan JR, Ling V. Purification of p-glycoprotein from plasma membrane vesicles of chinese hamster ovary cell mutants with reduced colchicine permeability. J Biol Chem 1979; 254: 12701-12705.
    • (1979) J Biol Chem , vol.254 , pp. 12701-12705
    • Riordan, J.R.1    Ling, V.2
  • 124
    • 0020578356 scopus 로고
    • Cell surface p-glycoprotein associated with multidrug resistance in mammalian cell lines
    • Kartner N, Riordan JR, Ling V. Cell surface p-glycoprotein associated with multidrug resistance in mammalian cell lines. Science 1983; 221: 1285-1288.
    • (1983) Science , vol.221 , pp. 1285-1288
    • Kartner, N.1    Riordan, J.R.2    Ling, V.3
  • 125
    • 0027977771 scopus 로고
    • Anthracycline antibiotics in cancer therapy. Focus on drug resistance
    • Booser DJ, Hortobagyi GN. Anthracycline antibiotics in cancer therapy. Focus on drug resistance. Drugs 1994; 47: 223-258.
    • (1994) Drugs , vol.47 , pp. 223-258
    • Booser, D.J.1    Hortobagyi, G.N.2
  • 126
    • 0023006005 scopus 로고
    • Isolation and expression of a complementary DNA that confers multidrug resistance
    • Gros P, Ben Neriah Y, Croop JM, Housman DE. Isolation and expression of a complementary DNA that confers multidrug resistance. Nature 1986; 323: 728-731.
    • (1986) Nature , vol.323 , pp. 728-731
    • Gros, P.1    Ben Neriah, Y.2    Croop, J.M.3    Housman, D.E.4
  • 127
    • 0021852930 scopus 로고
    • Detection of p-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies
    • Kartner N, Evernden-Porelie D, Bradley G, Ling V. Detection of p-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies. Nature 1985; 316: 820-823.
    • (1985) Nature , vol.316 , pp. 820-823
    • Kartner, N.1    Evernden-Porelie, D.2    Bradley, G.3    Ling, V.4
  • 128
    • 0022993652 scopus 로고
    • Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins
    • Gros P, Croop J, Housman D. Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 1986; 47: 371-380.
    • (1986) Cell , vol.47 , pp. 371-380
    • Gros, P.1    Croop, J.2    Housman, D.3
  • 129
    • 0027842835 scopus 로고
    • Classical and novel forms of multidrug resistance and the physiological functions of p-glycoproteins in mammals
    • Borst P, Schinkel AH, Smit JJM et al. Classical and novel forms of multidrug resistance and the physiological functions of p-glycoproteins in mammals. Pharmac Ther 1993; 60: 289-299.
    • (1993) Pharmac Ther , vol.60 , pp. 289-299
    • Borst, P.1    Schinkel, A.H.2    Smit, J.J.M.3
  • 130
    • 0024329881 scopus 로고
    • The biochemistry of p-glycoprotein-mediated multidrug resistance
    • Endicott JA, Ling V. The biochemistry of p-glycoprotein-mediated multidrug resistance. Ann Rev Biochem 1989; 58: 137-171.
    • (1989) Ann Rev Biochem , vol.58 , pp. 137-171
    • Endicott, J.A.1    Ling, V.2
  • 132
    • 0000712439 scopus 로고
    • Multidrug-resistance gene (p-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
    • Cordon-Cardo C, O'Brien JP, Casals D et al. Multidrug-resistance gene (p-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci USA 1989; 86: 695-698.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 695-698
    • Cordon-Cardo, C.1    O'Brien, J.P.2    Casals, D.3
  • 133
    • 0031047395 scopus 로고    scopus 로고
    • A low but functionally significant MDR1 expression protects primitive haemopoietic progenitor cells from anthracycline toxicity
    • Smeets M, Raymakers R, Vierwinden G et al. A low but functionally significant MDR1 expression protects primitive haemopoietic progenitor cells from anthracycline toxicity. Br J Haematol 1997; 96: 346-355.
    • (1997) Br J Haematol , vol.96 , pp. 346-355
    • Smeets, M.1    Raymakers, R.2    Vierwinden, G.3
  • 134
    • 0027892892 scopus 로고
    • Design and tumor targeting of anthracyclines able to overcome multidrug resistance: A double-advantage approach
    • Priebe W, Perez-Soler R. Design and tumor targeting of anthracyclines able to overcome multidrug resistance: a double-advantage approach. Pharmac Ther 1993; 60: 215-234.
    • (1993) Pharmac Ther , vol.60 , pp. 215-234
    • Priebe, W.1    Perez-Soler, R.2
  • 135
    • 0026666922 scopus 로고
    • Comparative cellular pharmacology of daunorubicin and idarubicin in human multidrug-resistant leukaemia cells
    • Berman E, McBride M. Comparative cellular pharmacology of daunorubicin and idarubicin in human multidrug-resistant leukaemia cells. Blood 1992; 79: 3267-3273.
    • (1992) Blood , vol.79 , pp. 3267-3273
    • Berman, E.1    McBride, M.2
  • 136
    • 0027322641 scopus 로고
    • A comparative analysis of the sensitivity of multidrug resistant (MDR) and non-MDR cells to different anthracycline derivatives
    • Michieli M, Michelutti A, Damiani D et al. A comparative analysis of the sensitivity of multidrug resistant (MDR) and non-MDR cells to different anthracycline derivatives. Leuk Lymphoma 1993; 9: 255-264.
    • (1993) Leuk Lymphoma , vol.9 , pp. 255-264
    • Michieli, M.1    Michelutti, A.2    Damiani, D.3
  • 137
    • 0027433322 scopus 로고
    • The efflux of anthracyclines in multidrug-resistant cell lines
    • Coley HM, Twentyman PR, Workman P. The efflux of anthracyclines in multidrug-resistant cell lines. Biochem Pharmacol 1993; 46: 1317-1326.
    • (1993) Biochem Pharmacol , vol.46 , pp. 1317-1326
    • Coley, H.M.1    Twentyman, P.R.2    Workman, P.3
  • 138
    • 0029071670 scopus 로고
    • Evaluation of resistance index of several anticancer agents on parental and resistant P-388 cell lines
    • Testi R, Mattii L, di Simone D et al. Evaluation of resistance index of several anticancer agents on parental and resistant P-388 cell lines. Leuk Res 1995; 19: 257-261.
    • (1995) Leuk Res , vol.19 , pp. 257-261
    • Testi, R.1    Mattii, L.2    Di Simone, D.3
  • 139
    • 0028130505 scopus 로고
    • P-glycoprotein mediates profound resistance to bisantrene
    • Zhang XP, Ritke MK, Yalowich JC et al. P-glycoprotein mediates profound resistance to bisantrene. Oncol Res 1994; 6: 291-301.
    • (1994) Oncol Res , vol.6 , pp. 291-301
    • Zhang, X.P.1    Ritke, M.K.2    Yalowich, J.C.3
  • 140
    • 0020426820 scopus 로고
    • Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors
    • Tsuruo T, Iida H, Tsukagashi S, Sakurai Y. Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors. Cancer Res 1982; 42; 4730-4733.
    • (1982) Cancer Res , vol.42 , pp. 4730-4733
    • Tsuruo, T.1    Iida, H.2    Tsukagashi, S.3    Sakurai, Y.4
  • 142
    • 0023691409 scopus 로고
    • Verapamil reversal of doxorubicin resistance in multidrug-resistant human myeloma cells and association with drug accumulation and DNA damage
    • Bellamy WT, Dalton WS, Kailey JM et al. Verapamil reversal of doxorubicin resistance in multidrug-resistant human myeloma cells and association with drug accumulation and DNA damage. Cancer Res 1988; 48: 6303-6308.
    • (1988) Cancer Res , vol.48 , pp. 6303-6308
    • Bellamy, W.T.1    Dalton, W.S.2    Kailey, J.M.3
  • 143
    • 0028428056 scopus 로고
    • Flow cytometric study of idarubicin and daunorubicin accumulation and the effect of verapamil in leukaemic cell lines and fresh cells from patients with acute non-lymphoblastic leukaemia
    • Boiron J-M, Belloc F, Montastruc M et al. Flow cytometric study of idarubicin and daunorubicin accumulation and the effect of verapamil in leukaemic cell lines and fresh cells from patients with acute non-lymphoblastic leukaemia. Leuk Res 1994; 18: 313-318.
    • (1994) Leuk Res , vol.18 , pp. 313-318
    • Boiron, J.-M.1    Belloc, F.2    Montastruc, M.3
  • 144
    • 0023640868 scopus 로고
    • Selective interactions of verapamil with anthraquinones in adriamycin-sensitive and -resistant murine and human tumour cell lines in vitro
    • Gibby EM, Boyse O, Hill BT. Selective interactions of verapamil with anthraquinones in adriamycin-sensitive and -resistant murine and human tumour cell lines in vitro. Cancer Chemother Pharmacol 1987; 20: 5-7.
    • (1987) Cancer Chemother Pharmacol , vol.20 , pp. 5-7
    • Gibby, E.M.1    Boyse, O.2    Hill, B.T.3
  • 145
    • 0023226943 scopus 로고
    • Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers
    • Safa AR, Glover CJ, Sewell JL, Meyers MB, Biedler JL, Felsted RL. Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers. J Biol Chem 1987; 262: 7884-7888.
    • (1987) J Biol Chem , vol.262 , pp. 7884-7888
    • Safa, A.R.1    Glover, C.J.2    Sewell, J.L.3    Meyers, M.B.4    Biedler, J.L.5    Felsted, R.L.6
  • 147
    • 0023513078 scopus 로고
    • Enhancement by cyclosporin A of daunorubicin efficacy in ehrlich ascites carcinoma and murine hepatoma 129
    • Meador J, Sweet P, Stupecky M et al. Enhancement by cyclosporin A of daunorubicin efficacy in ehrlich ascites carcinoma and murine hepatoma 129. Cancer Res 1987; 47: 6216-6219.
    • (1987) Cancer Res , vol.47 , pp. 6216-6219
    • Meador, J.1    Sweet, P.2    Stupecky, M.3
  • 148
    • 0024365556 scopus 로고
    • Identification of anthracyclines and related agents that retain preferential activity over adriamycin in multidrug-resistant cell lines, and further resistance modification by verapamil and cyclosporin A
    • Coley HM, Twentyman PR, Workman P. Identification of anthracyclines and related agents that retain preferential activity over adriamycin in multidrug-resistant cell lines, and further resistance modification by verapamil and cyclosporin A. Cancer Chemother Pharmacol 1989; 24: 284-290.
    • (1989) Cancer Chemother Pharmacol , vol.24 , pp. 284-290
    • Coley, H.M.1    Twentyman, P.R.2    Workman, P.3
  • 149
    • 0024819898 scopus 로고
    • Improved cellular accumulation is characteristic of anthracyclines which retain high activity in multidrug resistant cell lines, alone or in combination with verapamil or cyclosporin A
    • Coley HM, Twentyman PR, Workman P. Improved cellular accumulation is characteristic of anthracyclines which retain high activity in multidrug resistant cell lines, alone or in combination with verapamil or cyclosporin A. Biochem Pharmacol 1989; 38: 4467-4475.
    • (1989) Biochem Pharmacol , vol.38 , pp. 4467-4475
    • Coley, H.M.1    Twentyman, P.R.2    Workman, P.3
  • 150
    • 0029921377 scopus 로고    scopus 로고
    • Distribution and activity of doxorubicin combined with SDZ PSC 833 in mice with P388 and P388/DOX leukaemia
    • Colombo T, Gonzalez Paz O, D'Incalci M. Distribution and activity of doxorubicin combined with SDZ PSC 833 in mice with P388 and P388/DOX leukaemia. Br J Cancer 1996; 73: 866-871.
    • (1996) Br J Cancer , vol.73 , pp. 866-871
    • Colombo, T.1    Gonzalez Paz, O.2    D'Incalci, M.3
  • 151
    • 0028568614 scopus 로고
    • Restoring uptake and retention of daunorubicin and idarubicin in p170-related multidrug resistance cells by low concentration D-verapamil, cyclosporin A and SDZ PSC 833
    • Michieli M, Damiani D, Michelutti A et al. Restoring uptake and retention of daunorubicin and idarubicin in p170-related multidrug resistance cells by low concentration D-verapamil, cyclosporin A and SDZ PSC 833. Haematologica 1994; 79; 500-507.
    • (1994) Haematologica , vol.79 , pp. 500-507
    • Michieli, M.1    Damiani, D.2    Michelutti, A.3
  • 152
    • 0029074062 scopus 로고
    • Circumvention of P-glycoprotein-mediated drug resistance in human leukaemia cells by non-immunosuppressive cyclosporin D analogue, SDZ PSC 833
    • Jiang X-R, Kelsey SM, Wu Y-L, Newland AC. Circumvention of P-glycoprotein-mediated drug resistance in human leukaemia cells by non-immunosuppressive cyclosporin D analogue, SDZ PSC 833. Br J Haematol 1995; 90: 375-383.
    • (1995) Br J Haematol , vol.90 , pp. 375-383
    • Jiang, X.-R.1    Kelsey, S.M.2    Wu, Y.-L.3    Newland, A.C.4
  • 153
    • 0023712733 scopus 로고
    • Potentiation of adriamycin accumulation and effectiveness in adriamycin-resistant cells by aclacinomycin A
    • Tapiero H, Boulé D, Trincal G, Fourcade A, Lampidis TJ. Potentiation of adriamycin accumulation and effectiveness in adriamycin-resistant cells by aclacinomycin A. Leuk Res 1988; 12: 411-418.
    • (1988) Leuk Res , vol.12 , pp. 411-418
    • Tapiero, H.1    Boulé, D.2    Trincal, G.3    Fourcade, A.4    Lampidis, T.J.5
  • 154
    • 0024359172 scopus 로고
    • Role of the aclacinomycin A-doxorubicin association in reversal of doxorubicin resistance in K562 tumour cells
    • Millot J-M, Rasoanaivo TDW, Morjani H, Manfait M. Role of the aclacinomycin A-doxorubicin association in reversal of doxorubicin resistance in K562 tumour cells. Br J Cancer 1989; 60: 678-684.
    • (1989) Br J Cancer , vol.60 , pp. 678-684
    • Millot, J.-M.1    Rasoanaivo, T.D.W.2    Morjani, H.3    Manfait, M.4
  • 155
    • 0030030061 scopus 로고    scopus 로고
    • Reversal effect of itraconazole on adriamycin and etoposide resistance in human leukemia cells
    • Kurosawa M, Okabe M, Hara N et al. Reversal effect of itraconazole on adriamycin and etoposide resistance in human leukemia cells. Ann Hematol 1996; 72: 17-21.
    • (1996) Ann Hematol , vol.72 , pp. 17-21
    • Kurosawa, M.1    Okabe, M.2    Hara, N.3
  • 157
    • 0028277381 scopus 로고
    • Comparative activity of tamoxifen and N-desmethyltamoxifen in human multidrug resistant leukemia cell lines
    • Berman E, McBride M, Tong W. Comparative activity of tamoxifen and N-desmethyltamoxifen in human multidrug resistant leukemia cell lines. Leukemia 1994; 8: 1191-1196.
    • (1994) Leukemia , vol.8 , pp. 1191-1196
    • Berman, E.1    McBride, M.2    Tong, W.3
  • 159
    • 0025267059 scopus 로고
    • Mechanisms of multidrug resistance in HL-60 cells; detection of resistance-associated proteins with antibodies against synthetic peptides that correspond to the deduced sequence of P-glycoprotein
    • Marquardt D, McCrone S, Center MS. Mechanisms of multidrug resistance in HL-60 cells; detection of resistance-associated proteins with antibodies against synthetic peptides that correspond to the deduced sequence of P-glycoprotein. Cancer Res 1990; 50: 1426-1430.
    • (1990) Cancer Res , vol.50 , pp. 1426-1430
    • Marquardt, D.1    McCrone, S.2    Center, M.S.3
  • 160
    • 0027095653 scopus 로고
    • Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
    • Cole SPC, Bhardwaj G, Gerlach JH et al. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 1992; 258: 1650-1653.
    • (1992) Science , vol.258 , pp. 1650-1653
    • Cole, S.P.C.1    Bhardwaj, G.2    Gerlach, J.H.3
  • 161
    • 0027249710 scopus 로고
    • The MRP gene associated with a non-p-glycoprotein multidrug resistance encodes a 190 kDa membrane bound glycoprotein
    • Krishnamachary N, Center MS. The MRP gene associated with a non-p-glycoprotein multidrug resistance encodes a 190 kDa membrane bound glycoprotein. Cancer Res 1993; 53: 3658-3661.
    • (1993) Cancer Res , vol.53 , pp. 3658-3661
    • Krishnamachary, N.1    Center, M.S.2
  • 162
    • 0030070072 scopus 로고    scopus 로고
    • Transport mechanisms of anthracycline derivatives in human leukemia cell lines: Uptake and efflux of pirarubicin in HL60 and pirarubicin-resistant HL60 cells
    • Nagasawa K, Natazuka T, Chihara K et al. Transport mechanisms of anthracycline derivatives in human leukemia cell lines: uptake and efflux of pirarubicin in HL60 and pirarubicin-resistant HL60 cells. Cancer Chemother Pharmacol 1996; 37: 297-304.
    • (1996) Cancer Chemother Pharmacol , vol.37 , pp. 297-304
    • Nagasawa, K.1    Natazuka, T.2    Chihara, K.3
  • 163
    • 0030221523 scopus 로고    scopus 로고
    • Comparison of drug accumulation in p-glycoprotein-expressing and MRP-expressing human leukaemia cells
    • Davey MW, Hargrave RM, Davey RA. Comparison of drug accumulation in p-glycoprotein-expressing and MRP-expressing human leukaemia cells. Leuk Res 1996; 20: 657-664.
    • (1996) Leuk Res , vol.20 , pp. 657-664
    • Davey, M.W.1    Hargrave, R.M.2    Davey, R.A.3
  • 164
    • 0030052751 scopus 로고    scopus 로고
    • Expression of multidrug resistance-associated protein (MRP) mRNA in blast cells from acute leukemia (AML) patients
    • Ross DD, Doyle LA, Schiffer CA et al. Expression of multidrug resistance-associated protein (MRP) mRNA in blast cells from acute leukemia (AML) patients. Leukemia 1996; 10: 48-55.
    • (1996) Leukemia , vol.10 , pp. 48-55
    • Ross, D.D.1    Doyle, L.A.2    Schiffer, C.A.3
  • 165
    • 0022632982 scopus 로고
    • Cross-resistance to intercalating agents in an epipodophyllotoxin-resistant Chinese hamster ovary cell line: Evidence for a common intracelluar target
    • Glisson B, Gupta R, Hodges P, Ross W. Cross-resistance to intercalating agents in an epipodophyllotoxin-resistant Chinese hamster ovary cell line: evidence for a common intracelluar target. Cancer Res 1986; 46: 1939-1942.
    • (1986) Cancer Res , vol.46 , pp. 1939-1942
    • Glisson, B.1    Gupta, R.2    Hodges, P.3    Ross, W.4
  • 166
    • 0023221847 scopus 로고
    • Markedly reduced levels of anthracycline-induced DNA strand breaks in resistant P388 leukaemia cells and isolated nuclei
    • Capranico G, Riva A, Tinelli S, Dasdia T, Zunino F. Markedly reduced levels of anthracycline-induced DNA strand breaks in resistant P388 leukaemia cells and isolated nuclei. Cancer Res 1987; 47: 3752-3756.
    • (1987) Cancer Res , vol.47 , pp. 3752-3756
    • Capranico, G.1    Riva, A.2    Tinelli, S.3    Dasdia, T.4    Zunino, F.5
  • 167
    • 0023897804 scopus 로고
    • Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II
    • Potmesil M, Hsiang Y-H, Liu L F et al. Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II. Cancer Res 1988; 48: 3537-3543.
    • (1988) Cancer Res , vol.48 , pp. 3537-3543
    • Potmesil, M.1    Hsiang, Y.-H.2    Liu, L.F.3
  • 168
    • 0024583327 scopus 로고
    • Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukemia cell lines
    • Deffie AM, Batra JK, Goldenberg GJ. Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukemia cell lines. Cancer Res 1989; 49: 58-62.
    • (1989) Cancer Res , vol.49 , pp. 58-62
    • Deffie, A.M.1    Batra, J.K.2    Goldenberg, G.J.3
  • 169
    • 0025941508 scopus 로고
    • Mitoxantrone resistance in HL-60 leukemia cells: Reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase IIβ isoform
    • Harker WG, Slade DL, Drake FH, Parr RL. Mitoxantrone resistance in HL-60 leukemia cells: reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase IIβ isoform. Biochemistry 1991; 30: 9953-9961.
    • (1991) Biochemistry , vol.30 , pp. 9953-9961
    • Harker, W.G.1    Slade, D.L.2    Drake, F.H.3    Parr, R.L.4
  • 170
    • 0024382076 scopus 로고
    • Role of glutathione and dependent enzymes in anthracycline resistant HL60/AR cells
    • Lutzky J, Astor MB, Taub RN et al. Role of glutathione and dependent enzymes in anthracycline resistant HL60/AR cells. Cancer Res 1989; 49: 4120-4125.
    • (1989) Cancer Res , vol.49 , pp. 4120-4125
    • Lutzky, J.1    Astor, M.B.2    Taub, R.N.3
  • 171
    • 0015987706 scopus 로고
    • Adriamycin chemotherapy - Efficacy, safety and pharmacologic basis of an intermittent single high-dosage schedule
    • Benjamin RS, Wiernik PH, Bachur NR. Adriamycin chemotherapy - efficacy, safety and pharmacologic basis of an intermittent single high-dosage schedule. Cancer 1974; 35: 19-27.
    • (1974) Cancer , vol.35 , pp. 19-27
    • Benjamin, R.S.1    Wiernik, P.H.2    Bachur, N.R.3
  • 172
    • 0022511774 scopus 로고
    • Clinical pharmacology of 4-demethoxydaunorubicin (DMDR)
    • Lu K, Savaraj N, Kavanagh J et al. Clinical pharmacology of 4-demethoxydaunorubicin (DMDR). Cancer Chemother Pharmacol 1986; 17: 143-148.
    • (1986) Cancer Chemother Pharmacol , vol.17 , pp. 143-148
    • Lu, K.1    Savaraj, N.2    Kavanagh, J.3
  • 173
    • 0025907179 scopus 로고
    • Results of a randomized trial comparing idarubicin and cytosine arabinoside with daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia
    • Berman E, Heller G, Santorsa JA et al. Results of a randomized trial comparing idarubicin and cytosine arabinoside with daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia. Blood 1991; 77: 1666-1674.
    • (1991) Blood , vol.77 , pp. 1666-1674
    • Berman, E.1    Heller, G.2    Santorsa, J.A.3
  • 174
    • 0026586008 scopus 로고
    • Cytarabine plus idarubicin or daunorubicin as induction and consolidation therapy for previously untreated adult patients with acute myeloid leukaemia
    • Wiernik PH, Banks PLC, Case Jr DC et al. Cytarabine plus idarubicin or daunorubicin as induction and consolidation therapy for previously untreated adult patients with acute myeloid leukaemia. Blood 1992; 79: 313-319.
    • (1992) Blood , vol.79 , pp. 313-319
    • Wiernik, P.H.1    Banks, P.L.C.2    Case Jr., D.C.3
  • 175
    • 0026650021 scopus 로고
    • A phase III trial comparing idarubicin and daunorubicin in combination with cytarabine in acute myelogenous leukaemia: A Southeastern Cancer Study Group study
    • Vogler WR, Velez-Garcia E, Weiner RS et al. A phase III trial comparing idarubicin and daunorubicin in combination with cytarabine in acute myelogenous leukaemia: A Southeastern Cancer Study Group study. J Clin Oncol 1992; 10: 1103-1111.
    • (1992) J Clin Oncol , vol.10 , pp. 1103-1111
    • Vogler, W.R.1    Velez-Garcia, E.2    Weiner, R.S.3
  • 176
    • 0028280542 scopus 로고
    • Toxicity of idarubicin and doxorubicin towards normal and leukemic human bone marrow progenitors in relation to their proliferative state
    • Minderman H, Linssen P, van der Lely N et al. Toxicity of idarubicin and doxorubicin towards normal and leukemic human bone marrow progenitors in relation to their proliferative state. Leukemia 1994; 8: 382-387.
    • (1994) Leukemia , vol.8 , pp. 382-387
    • Minderman, H.1    Linssen, P.2    Van Der Lely, N.3
  • 177
    • 0021744523 scopus 로고
    • Clinical safety and tolerance of mitoxantrone
    • Crossley RJ. Clinical safety and tolerance of mitoxantrone. Semin Oncol 1984; 11 (Suppl 1): 54-58.
    • (1984) Semin Oncol , vol.11 , Issue.1 SUPPL. , pp. 54-58
    • Crossley, R.J.1
  • 179
    • 0019522401 scopus 로고
    • Effect of leukaemia therapy on neutrophil chemotaxis
    • Thompson EN, Sarab-Al-Nakeeb. Effect of leukaemia therapy on neutrophil chemotaxis. J Clin Pathol 1981; 34: 371-376.
    • (1981) J Clin Pathol , vol.34 , pp. 371-376
    • Thompson, E.N.1    Sarab-Al-Nakeeb2
  • 180
    • 0021226928 scopus 로고
    • Adriamycin impairs phagocytic function and induces morphologic alterations in human neutrophils
    • Vaudaux P, Kiefer B, Forni M, Joris I, Majno G, Waldvogel FA. Adriamycin impairs phagocytic function and induces morphologic alterations in human neutrophils. Cancer 1984; 54: 400-410.
    • (1984) Cancer , vol.54 , pp. 400-410
    • Vaudaux, P.1    Kiefer, B.2    Forni, M.3    Joris, I.4    Majno, G.5    Waldvogel, F.A.6
  • 181
    • 0017346479 scopus 로고
    • In vitro in vivo cytotoxicity of adriamycin and daunomycin for murine macrophages
    • Mantovani A. In vitro in vivo cytotoxicity of adriamycin and daunomycin for murine macrophages. Cancer Res 1977; 37: 815-820.
    • (1977) Cancer Res , vol.37 , pp. 815-820
    • Mantovani, A.1
  • 182
    • 0017195657 scopus 로고
    • Tumorigenicity in vivo and induction of malignant transformation and mutagenesis in cell cultures by adriamycin and daunomycin
    • Marquardt H, Philips FS, Sternberg SS. Tumorigenicity in vivo and induction of malignant transformation and mutagenesis in cell cultures by adriamycin and daunomycin. Cancer Res 1976; 36: 2065-2069.
    • (1976) Cancer Res , vol.36 , pp. 2065-2069
    • Marquardt, H.1    Philips, F.S.2    Sternberg, S.S.3
  • 183
    • 0002083102 scopus 로고
    • Carcinogenic effects of cancer treatment
    • Peckham M, Pinedo H, Veronesi U, eds. Oxford: Oxford University Press
    • Vallagussa PA, Bonadonna G. Carcinogenic effects of cancer treatment. In: Peckham M, Pinedo H, Veronesi U, eds. Oxford Textbook of Oncology. Oxford: Oxford University Press, 1995: 2348-2358.
    • (1995) Oxford Textbook of Oncology , pp. 2348-2358
    • Vallagussa, P.A.1    Bonadonna, G.2
  • 184
    • 0025949901 scopus 로고
    • Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic for myelodysplasia and leukaemia following therapy with cytostatic agents targeting at DNA-topoisomerase II
    • Pederson-Bjergaard J, Philip P. Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic for myelodysplasia and leukaemia following therapy with cytostatic agents targeting at DNA-topoisomerase II. Blood 1991; 78: 1147-1148.
    • (1991) Blood , vol.78 , pp. 1147-1148
    • Pederson-Bjergaard, J.1    Philip, P.2
  • 185
    • 0025023493 scopus 로고
    • Leukemia following chemotherapy for ovarian cancer
    • Kaldor JM, Day NE, Pettersson F et al. Leukemia following chemotherapy for ovarian cancer. N Engl J Med 1990; 322: 1-6.
    • (1990) N Engl J Med , vol.322 , pp. 1-6
    • Kaldor, J.M.1    Day, N.E.2    Pettersson, F.3
  • 186
    • 0027056223 scopus 로고
    • Acute monocytic or myelomonocytic leukemia with balanced chromosome translocations to band 11q23 after therapy with 4 epidoxorubicin and cisplatin or cyclophosphamide for breast cancer
    • Pedersen-Bjergaard J, Sigsgaard TC, Nielsen D et al. Acute monocytic or myelomonocytic leukemia with balanced chromosome translocations to band 11q23 after therapy with 4 epidoxorubicin and cisplatin or cyclophosphamide for breast cancer. J Clin Oncol 1992; 10: 1444-1451.
    • (1992) J Clin Oncol , vol.10 , pp. 1444-1451
    • Pedersen-Bjergaard, J.1    Sigsgaard, T.C.2    Nielsen, D.3
  • 187
    • 0027154575 scopus 로고
    • Secondary acute myeloid leukaemia in children previously treated with alkylating agents, intercalating topoisomerase II inhibitors and irradiation
    • Sandoval C, Pin CH, Bowman LC et al. Secondary acute myeloid leukaemia in children previously treated with alkylating agents, intercalating topoisomerase II inhibitors and irradiation. J Clin Oncol 1993; 11: 1039-1045.
    • (1993) J Clin Oncol , vol.11 , pp. 1039-1045
    • Sandoval, C.1    Pin, C.H.2    Bowman, L.C.3
  • 188
    • 0021254118 scopus 로고
    • The use of scalp hypothermia in the prevention of doxorubicin-induced hair loss
    • Satterwhite B, Zimm S. The use of scalp hypothermia in the prevention of doxorubicin-induced hair loss. Cancer 1984; 54: 34-37.
    • (1984) Cancer , vol.54 , pp. 34-37
    • Satterwhite, B.1    Zimm, S.2
  • 189
    • 0028073328 scopus 로고
    • Scalp cooling has no place in the prevention of alopecia in adjuvant chemotherapy for breast cancer
    • Tollenaar RA, Liefers GJ, Repelaer van Driel OJ, van-de Velde CJ. Scalp cooling has no place in the prevention of alopecia in adjuvant chemotherapy for breast cancer. Eur J Cancer 1994; 30A: 1448-1453.
    • (1994) Eur J Cancer , vol.30 A , pp. 1448-1453
    • Tollenaar, R.A.1    Liefers, G.J.2    Repelaer Van Driel, O.J.3    Van-de Velde, C.J.4
  • 190
  • 191
    • 0022642510 scopus 로고
    • Doxorubicin-induced skin necrosis in the swine model: Protection with a novel radical dimer
    • Averbuch SD, Gaudiano G, Koch TH, Bachur NR. Doxorubicin-induced skin necrosis in the swine model: protection with a novel radical dimer. J Clin Oncol 1986; 4: 88-94.
    • (1986) J Clin Oncol , vol.4 , pp. 88-94
    • Averbuch, S.D.1    Gaudiano, G.2    Koch, T.H.3    Bachur, N.R.4
  • 192
    • 0016810932 scopus 로고
    • Radiation-adriamycin interactions: Preliminary clinical observations
    • Cassady JR, Richter MP, Piro AJ, Jaffe N. Radiation-adriamycin interactions: preliminary clinical observations. Cancer 1975; 36: 946-949.
    • (1975) Cancer , vol.36 , pp. 946-949
    • Cassady, J.R.1    Richter, M.P.2    Piro, A.J.3    Jaffe, N.4
  • 195
    • 0029996467 scopus 로고    scopus 로고
    • Oral administration of anti-doxorubicin monoclonal antibody prevents chemotherapy-induced gastrointestinal toxicity in mice
    • Morelli D, Ménard S, Colnaghi MI, Balsari A. Oral administration of anti-doxorubicin monoclonal antibody prevents chemotherapy-induced gastrointestinal toxicity in mice. Cancer Res 1996; 56: 2082-2085.
    • (1996) Cancer Res , vol.56 , pp. 2082-2085
    • Morelli, D.1    Ménard, S.2    Colnaghi, M.I.3    Balsari, A.4
  • 196
    • 0021994158 scopus 로고
    • Enhancement of reactive oxygen-dependent mitochondrial membrane lipid peroxidation by the anticancer drug adriamycin
    • Mimnaugh EG, Trush MA, Bhatnagar M, Gram TE. Enhancement of reactive oxygen-dependent mitochondrial membrane lipid peroxidation by the anticancer drug adriamycin. Biochem Pharmacol 1985; 34: 847-856.
    • (1985) Biochem Pharmacol , vol.34 , pp. 847-856
    • Mimnaugh, E.G.1    Trush, M.A.2    Bhatnagar, M.3    Gram, T.E.4
  • 197
    • 0027489682 scopus 로고
    • The role of iron and iron chelators in anthracycline cardiotoxicity
    • Hershko C, Link G, Tzahor M, Pinson A. The role of iron and iron chelators in anthracycline cardiotoxicity. Leuk Lymphoma 1993; 11: 207-214.
    • (1993) Leuk Lymphoma , vol.11 , pp. 207-214
    • Hershko, C.1    Link, G.2    Tzahor, M.3    Pinson, A.4
  • 198
    • 0027661677 scopus 로고
    • Anthracycline toxicity is potentiated by iron and inhibited by deferoxamine: Studies in rat heart cells in culture
    • Hershko C, Link G, Tzahor M et al. Anthracycline toxicity is potentiated by iron and inhibited by deferoxamine: studies in rat heart cells in culture. J Lab Clin Med 1993; 122: 245-251.
    • (1993) J Lab Clin Med , vol.122 , pp. 245-251
    • Hershko, C.1    Link, G.2    Tzahor, M.3
  • 199
    • 0028902346 scopus 로고
    • Secondary alcohol metabolites mediate iron delocalization in cytosolic fractions of myocardial biopsies exposed to anticancer anthracyclines
    • Minolti G, Cavaliere AF, Mordente A et al. Secondary alcohol metabolites mediate iron delocalization in cytosolic fractions of myocardial biopsies exposed to anticancer anthracyclines. J Clin Invest 1995; 95: 1595-1605.
    • (1995) J Clin Invest , vol.95 , pp. 1595-1605
    • Minolti, G.1    Cavaliere, A.F.2    Mordente, A.3
  • 200
    • 0018915753 scopus 로고
    • Enzymatic defenses of the mouse heart against reactive oxygen metabolites: Alterations produced by doxorubicin
    • Doroshow JH, Locker GY, Myers CE. Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin. J Clin Invest 1980; 65: 128-135.
    • (1980) J Clin Invest , vol.65 , pp. 128-135
    • Doroshow, J.H.1    Locker, G.Y.2    Myers, C.E.3
  • 201
    • 0020530823 scopus 로고
    • Mitochondrial membrane modifications induced by adriamycin-mediated electron transport
    • Goormaghtigh E, Pollakis G, Ruysschaert JM. Mitochondrial membrane modifications induced by adriamycin-mediated electron transport. Biochem Pharmacol 1983; 32: 889-893.
    • (1983) Biochem Pharmacol , vol.32 , pp. 889-893
    • Goormaghtigh, E.1    Pollakis, G.2    Ruysschaert, J.M.3
  • 203
    • 0023630851 scopus 로고
    • The major metabolite of doxorubicin is a potent inhibitor of membrane-associated ion pumps. A correlative study of cardiac muscle with isolated membrane fractions
    • Boucek Jr. RJ, Olson RD, Brenner DE, Oganuburnmi EM, Inui M, Fleischer S. The major metabolite of doxorubicin is a potent inhibitor of membrane-associated ion pumps. A correlative study of cardiac muscle with isolated membrane fractions. J Biol Chem 1987; 262: 15851-15856.
    • (1987) J Biol Chem , vol.262 , pp. 15851-15856
    • Boucek Jr., R.J.1    Olson, R.D.2    Brenner, D.E.3    Oganuburnmi, E.M.4    Inui, M.5    Fleischer, S.6
  • 204
    • 0013228058 scopus 로고
    • Doxorubicin cardiotoxicity may be caused by its metabolite doxorubicinol
    • Olson RD, Mushlin PS, Brenner DE et al. Doxorubicin cardiotoxicity may be caused by its metabolite doxorubicinol. Proc Natl Acad Sci USA 1988; 85: 3585-3589.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 3585-3589
    • Olson, R.D.1    Mushlin, P.S.2    Brenner, D.E.3
  • 205
    • 0025975910 scopus 로고
    • Increased toxicity of anthracycline antibiotics induced by calcium entry blockers in cultured cardiomyocytes
    • Santostasi G, Kutty RK, Krishna G. Increased toxicity of anthracycline antibiotics induced by calcium entry blockers in cultured cardiomyocytes. Toxicol App Pharmacol 1991; 108: 140-149.
    • (1991) Toxicol App Pharmacol , vol.108 , pp. 140-149
    • Santostasi, G.1    Kutty, R.K.2    Krishna, G.3
  • 206
    • 0026468266 scopus 로고
    • Anthracyclines selectively decrease α cardiac actin mRNA abundance in the rat heart
    • Papoian T, Lewis W. Anthracyclines selectively decrease α cardiac actin mRNA abundance in the rat heart. Am J Pathol 1992; 141: 1187-1195.
    • (1992) Am J Pathol , vol.141 , pp. 1187-1195
    • Papoian, T.1    Lewis, W.2
  • 207
    • 0014432176 scopus 로고
    • Rubidomycin in acute leukaemia in adults
    • Malpas JS, Bodley Scott R. Rubidomycin in acute leukaemia in adults. Br Med J 1968; 3: 227-229.
    • (1968) Br Med J , vol.3 , pp. 227-229
    • Malpas, J.S.1    Bodley Scott, R.2
  • 208
    • 0014481020 scopus 로고
    • Daunorubicin in acute myelocytic leukaemia
    • Malpas JS, Bodley Scott R. Daunorubicin in acute myelocytic leukaemia. Lancet 1969; i: 469-470.
    • (1969) Lancet , vol.1 , pp. 469-470
    • Malpas, J.S.1    Bodley Scott, R.2
  • 209
    • 0015849162 scopus 로고
    • A clinicopathological analysis of adriamycin cardiotoxicity
    • Lefrak EA, Pitha J, Rosenheim S, Gottlieb JA. A clinicopathological analysis of adriamycin cardiotoxicity. Cancer 1973; 32: 302-314.
    • (1973) Cancer , vol.32 , pp. 302-314
    • Lefrak, E.A.1    Pitha, J.2    Rosenheim, S.3    Gottlieb, J.A.4
  • 214
    • 0025850827 scopus 로고
    • Cardiac toxicity 4 to 20 years after completing anthracycline therapy
    • Steinherz LJ, Steinherz PG, Tan CTC, Heller G, Murphy ML. Cardiac toxicity 4 to 20 years after completing anthracycline therapy. JAMA 1991; 266: 1672-1677.
    • (1991) JAMA , vol.266 , pp. 1672-1677
    • Steinherz, L.J.1    Steinherz, P.G.2    Tan, C.T.C.3    Heller, G.4    Murphy, M.L.5
  • 215
    • 0030025542 scopus 로고    scopus 로고
    • Late echocardiographic findings following childhood chemotherapy with normal serial cardiac monitoring
    • Johnson GL, Moffett CB, Geil JD, Greenwood MF, Noonan JA. Late echocardiographic findings following childhood chemotherapy with normal serial cardiac monitoring. J Pediatr Hematol Oncol 1996; 18: 72-75.
    • (1996) J Pediatr Hematol Oncol , vol.18 , pp. 72-75
    • Johnson, G.L.1    Moffett, C.B.2    Geil, J.D.3    Greenwood, M.F.4    Noonan, J.A.5
  • 217
    • 0019748067 scopus 로고
    • Risk factors for development of daunorubicin cardiotoxicity
    • Von Hoff DD, Layard M. Risk factors for development of daunorubicin cardiotoxicity. Cancer Treat Rep 1981; 65 (Suppl 4): 19-23.
    • (1981) Cancer Treat Rep , vol.65 , Issue.4 SUPPL. , pp. 19-23
    • Von Hoff, D.D.1    Layard, M.2
  • 218
    • 0018716636 scopus 로고
    • Risk factors for doxorubicin-induced congestive heart failure
    • Von Hoff DD, Layard MW, Basa P et al. Risk factors for doxorubicin-induced congestive heart failure. Ann Intern Med 1979; 91: 710-717.
    • (1979) Ann Intern Med , vol.91 , pp. 710-717
    • Von Hoff, D.D.1    Layard, M.W.2    Basa, P.3
  • 219
    • 0026557788 scopus 로고
    • Guidelines for cardiac monitoring of children during and after anthracycline therapy: Report of the cardiology committee of the childrens cancer study group
    • Steinherz LJ, Graham T, Hurwitz R et al. Guidelines for cardiac monitoring of children during and after anthracycline therapy: report of the cardiology committee of the childrens cancer study group. Pediatrics 1992; 89: 942-949.
    • (1992) Pediatrics , vol.89 , pp. 942-949
    • Steinherz, L.J.1    Graham, T.2    Hurwitz, R.3
  • 221
    • 0023972572 scopus 로고
    • Peripartum heart failure in a patient previously treated with doxorubicin
    • Davis LE, Brown CEL. Peripartum heart failure in a patient previously treated with doxorubicin. Obstet Gynecol 1988; 71: 506-508.
    • (1988) Obstet Gynecol , vol.71 , pp. 506-508
    • Davis, L.E.1    Brown, C.E.L.2
  • 222
    • 0026642415 scopus 로고
    • Reducing the cardiotoxicity of the anthracyclines
    • Carlson RW. Reducing the cardiotoxicity of the anthracyclines. Oncology (Huntingt) 1992; 6: 95-104.
    • (1992) Oncology (Huntingt) , vol.6 , pp. 95-104
    • Carlson, R.W.1
  • 223
    • 0027343763 scopus 로고
    • Strategies for prevention of anthracycline cardiotoxicity
    • Basser RL, Green MD. Strategies for prevention of anthracycline cardiotoxicity. Cancer Treat Rev 1993; 19: 57-77.
    • (1993) Cancer Treat Rev , vol.19 , pp. 57-77
    • Basser, R.L.1    Green, M.D.2
  • 224
    • 0028000315 scopus 로고
    • Anthracyclines: Cardiotoxicity and its prevention
    • Hale JP, Lewis IJ. Anthracyclines: cardiotoxicity and its prevention. Arch Dis Child 1994; 71: 457-462.
    • (1994) Arch Dis Child , vol.71 , pp. 457-462
    • Hale, J.P.1    Lewis, I.J.2
  • 227
    • 0027772609 scopus 로고
    • Phase I clinical and pharmacokinetic study of menogaril (7-con-O-methylnogarol) in previously treated patients with acute leukaemia
    • Mazurek C, Dutcher JP, Schwartz EL, Garl S, Benson L, Wiernik PH. Phase I clinical and pharmacokinetic study of menogaril (7-con-O-methylnogarol) in previously treated patients with acute leukaemia. Invest New Drugs 1993; 11: 313-322.
    • (1993) Invest New Drugs , vol.11 , pp. 313-322
    • Mazurek, C.1    Dutcher, J.P.2    Schwartz, E.L.3    Garl, S.4    Benson, L.5    Wiernik, P.H.6
  • 228
    • 0027172853 scopus 로고
    • Bisantrene in relapsed and refractory acute myelogenous leukemia
    • Spadea A, Petti MC, Aloespiriti MA et al. Bisantrene in relapsed and refractory acute myelogenous leukemia. Leuk Lymphoma 1993; 9: 217-220.
    • (1993) Leuk Lymphoma , vol.9 , pp. 217-220
    • Spadea, A.1    Petti, M.C.2    Aloespiriti, M.A.3
  • 229
    • 0020061758 scopus 로고
    • Phase I clinical trial of 9, 10-anthracene dicarboxaldehyde (Bisantrene) administered in a 5-day schedule
    • Spiegel RJ, Blum RH, Levin M et al. Phase I clinical trial of 9, 10-anthracene dicarboxaldehyde (Bisantrene) administered in a 5-day schedule. Cancer Res 1982; 42: 354-358.
    • (1982) Cancer Res , vol.42 , pp. 354-358
    • Spiegel, R.J.1    Blum, R.H.2    Levin, M.3
  • 231
    • 0028869006 scopus 로고
    • A phase II study of menogaril (7R-O-methylnogarol) in patients with relapsed/refractory acute myeloid leukaemia: A study of the Eastern Cooperative Oncology Group
    • Dutcher JP, Leong T, Makary MZ et al. A phase II study of menogaril (7R-O-methylnogarol) in patients with relapsed/refractory acute myeloid leukaemia: a study of the Eastern Cooperative Oncology Group. Leukemia 1995; 9: 1638-1642.
    • (1995) Leukemia , vol.9 , pp. 1638-1642
    • Dutcher, J.P.1    Leong, T.2    Makary, M.Z.3
  • 232
    • 0028853576 scopus 로고
    • Idarubicin cardiotoxicity: A retrospective study in acute meyloid leukemia and myelodysplasia
    • Anderlini P, Benjamin RS, Wong FC et al. Idarubicin cardiotoxicity: a retrospective study in acute meyloid leukemia and myelodysplasia. J Clin Oncol 1995; 13: 2827-2834.
    • (1995) J Clin Oncol , vol.13 , pp. 2827-2834
    • Anderlini, P.1    Benjamin, R.S.2    Wong, F.C.3
  • 233
    • 0024506076 scopus 로고
    • Mitoxantrone induced congestive heart failure in patients previously treated with anthracyclines
    • Janmohammed R, Milligan DW. Mitoxantrone induced congestive heart failure in patients previously treated with anthracyclines. Br J Haematol 1989; 71: 292-293
    • (1989) Br J Haematol , vol.71 , pp. 292-293
    • Janmohammed, R.1    Milligan, D.W.2
  • 234
    • 0021063443 scopus 로고
    • Reduced cardiotoxicity of doxorubicin delivered on a weekly schedule
    • Torti FM, Bristow MR, Howes AE et al. Reduced cardiotoxicity of doxorubicin delivered on a weekly schedule. Ann Intern Med 1983; 99: 745-749.
    • (1983) Ann Intern Med , vol.99 , pp. 745-749
    • Torti, F.M.1    Bristow, M.R.2    Howes, A.E.3
  • 235
    • 0020038042 scopus 로고
    • Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion
    • Legha SS, Benjamin RS, Mackay B et al. Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion. Ann Intern Med 1982; 96: 133-139.
    • (1982) Ann Intern Med , vol.96 , pp. 133-139
    • Legha, S.S.1    Benjamin, R.S.2    Mackay, B.3
  • 236
    • 0025098002 scopus 로고
    • Reduced cardiotoxicity of doxorubicin by a 6-hour infusion regimen
    • Shapira J, Gotfried M, Lishner M, Ravid M. Reduced cardiotoxicity of doxorubicin by a 6-hour infusion regimen. Cancer 1990; 65: 870-873.
    • (1990) Cancer , vol.65 , pp. 870-873
    • Shapira, J.1    Gotfried, M.2    Lishner, M.3    Ravid, M.4
  • 237
    • 0027303695 scopus 로고
    • Cellular pharmacokinetics of doxorubicin in patients with chronic lymphocytic leukaemia: Comparison of bolus administration and continuous infusion
    • Muller C, Chatelut E, Gualano V et al. Cellular pharmacokinetics of doxorubicin in patients with chronic lymphocytic leukaemia: comparison of bolus administration and continuous infusion. Cancer Chemother Pharmacol 1993; 32: 379-384.
    • (1993) Cancer Chemother Pharmacol , vol.32 , pp. 379-384
    • Muller, C.1    Chatelut, E.2    Gualano, V.3
  • 238
    • 0025164668 scopus 로고
    • Evidence of the selective alteration of anthracycline activity due to modulation by ICRF-187 (ADR-529)
    • Green MD, Alderton P, Gross J, Muggia FM, Speyer JL. Evidence of the selective alteration of anthracycline activity due to modulation by ICRF-187 (ADR-529). Pharmac Ther 1990; 48: 61-69.
    • (1990) Pharmac Ther , vol.48 , pp. 61-69
    • Green, M.D.1    Alderton, P.2    Gross, J.3    Muggia, F.M.4    Speyer, J.L.5
  • 239
    • 0025942977 scopus 로고
    • Cardioxane - ICRF-187. Towards anticancer drug specificity through selective toxicity reduction
    • Koning J, Palmer P, Franks CR et al. Cardioxane - ICRF-187. Towards anticancer drug specificity through selective toxicity reduction. Cancer Treat Rev 1991; 18: 1-19.
    • (1991) Cancer Treat Rev , vol.18 , pp. 1-19
    • Koning, J.1    Palmer, P.2    Franks, C.R.3
  • 240
    • 0026575694 scopus 로고
    • Comparative study of doxorubicin, mitoxantrone, and epirubicin in combination with ICRF-187 (ADR-529) in a chronic cardiotoxicity animal model
    • Alderton PM, Gross J, Green MD. Comparative study of doxorubicin, mitoxantrone, and epirubicin in combination with ICRF-187 (ADR-529) in a chronic cardiotoxicity animal model. Cancer Res 1992; 52: 194-201.
    • (1992) Cancer Res , vol.52 , pp. 194-201
    • Alderton, P.M.1    Gross, J.2    Green, M.D.3
  • 241
    • 85030300670 scopus 로고    scopus 로고
    • Protective effect of cardioxane (ICRF-187, ADR-529) on doxorubicin-induced cardiotoxicity as studied with the isolated perfused rat heart
    • Amsterdam abs 408
    • Pouna P, Bonoron-Adèle S, Robert J. Protective effect of cardioxane (ICRF-187, ADR-529) on doxorubicin-induced cardiotoxicity as studied with the isolated perfused rat heart. Proc 9th NCI-EORTC Symposium on new drugs in cancer therapy. Amsterdam 1996; 116, abs 408.
    • (1996) Proc 9th NCI-EORTC Symposium on New Drugs in Cancer Therapy , pp. 116
    • Pouna, P.1    Bonoron-Adèle, S.2    Robert, J.3
  • 242
    • 0027169157 scopus 로고
    • Cardioprotection by ICRF-187 against high dose anthracycline toxicity in children with malignant disease
    • Bu'Lock FA, Gabriel HM, Oakhill A, Mott MG, Martin RP. Cardioprotection by ICRF-187 against high dose anthracycline toxicity in children with malignant disease. Br Heart J 1993; 70: 185-188.
    • (1993) Br Heart J , vol.70 , pp. 185-188
    • Bu'Lock, F.A.1    Gabriel, H.M.2    Oakhill, A.3    Mott, M.G.4    Martin, R.P.5
  • 243
    • 9044233260 scopus 로고    scopus 로고
    • Randomized trial of the cardioprotective agent ICRF-187 in pediatric sarcoma patients treated with doxorubicin
    • Wexler LH, Andrich MP, Verson D et al. Randomized trial of the cardioprotective agent ICRF-187 in pediatric sarcoma patients treated with doxorubicin. J Clin Oncol 1996; 14: 362-372.
    • (1996) J Clin Oncol , vol.14 , pp. 362-372
    • Wexler, L.H.1    Andrich, M.P.2    Verson, D.3
  • 244
    • 0026585672 scopus 로고
    • ICRF-187 permits longer treatment with doxorubicin in women with breast cancer
    • Speyer JL, Green MD, Zeleniuch-Jacquotte A et al. ICRF-187 permits longer treatment with doxorubicin in women with breast cancer. J Clin Oncol 1992; 10: 117-127.
    • (1992) J Clin Oncol , vol.10 , pp. 117-127
    • Speyer, J.L.1    Green, M.D.2    Zeleniuch-Jacquotte, A.3
  • 247
    • 0028883435 scopus 로고
    • Pharmacokinetics, targeting and delivery systems in anthracycline-resistant cancers
    • Cassidy J. Pharmacokinetics, targeting and delivery systems in anthracycline-resistant cancers. Eur J Cancer 1995; 31A (suppl 7): S18-S20.
    • (1995) Eur J Cancer , vol.31 A , Issue.7 SUPPL.
    • Cassidy, J.1
  • 248
    • 0021715566 scopus 로고
    • Daunorubicin-albumin copolymer targeting to leukemic cells in vitro and in vivo
    • Lagueux J, Pagé M, Delorme F. Daunorubicin-albumin copolymer targeting to leukemic cells in vitro and in vivo. Semin Oncol 1984; 11 (suppl 3): 59-63.
    • (1984) Semin Oncol , vol.11 , Issue.3 SUPPL. , pp. 59-63
    • Lagueux, J.1    Pagé, M.2    Delorme, F.3
  • 249
    • 0021713173 scopus 로고
    • Targeting of daunorubicin by association with DNA or proteins: A review
    • Trouét A, Jollès G. Targeting of daunorubicin by association with DNA or proteins: a review. Semin Oncol 1984; 11 (suppl 3): 64-72.
    • (1984) Semin Oncol , vol.11 , Issue.3 SUPPL. , pp. 64-72
    • Trouét, A.1    Jollès, G.2
  • 250
    • 0024508158 scopus 로고
    • Activity of N-(2-hydroxypropyl) methacrylamide copolymers containing daunomycin against a rat tumour model
    • Cassidy J, Duncan R, Morrison GJ et al. Activity of N-(2-hydroxypropyl) methacrylamide copolymers containing daunomycin against a rat tumour model. Biochem Pharmacol 1989; 38: 875-879.
    • (1989) Biochem Pharmacol , vol.38 , pp. 875-879
    • Cassidy, J.1    Duncan, R.2    Morrison, G.J.3
  • 252
    • 0021745628 scopus 로고
    • Potential of liposomes to ameliorate anthracycline-induced cardiotoxicity
    • Rahman A, Fumagalli A, Goodman A, Schein PS. Potential of liposomes to ameliorate anthracycline-induced cardiotoxicity. Semin Oncol 1984; 11(Suppl 3): 45-55.
    • (1984) Semin Oncol , vol.11 , Issue.3 SUPPL. , pp. 45-55
    • Rahman, A.1    Fumagalli, A.2    Goodman, A.3    Schein, P.S.4
  • 253
    • 0024325892 scopus 로고
    • Liposomes as carriers of antitumor agents: Toward a clinical reality
    • Perez-Soler R. Liposomes as carriers of antitumor agents: toward a clinical reality. Cancer Treat Rev 1989; 16: 78-82.
    • (1989) Cancer Treat Rev , vol.16 , pp. 78-82
    • Perez-Soler, R.1
  • 254
    • 0025948410 scopus 로고
    • Liposomes in Haematology
    • Gray A, Morgan J. Liposomes in Haematology. Blood Rev 1991; 5: 258-272.
    • (1991) Blood Rev , vol.5 , pp. 258-272
    • Gray, A.1    Morgan, J.2
  • 256
    • 0022587683 scopus 로고
    • Comparative pharmacokinetics of free doxorubicin and doxorubicin entrapped in cardiolipin liposomes
    • Rahman A, Carmichael D, Harris M, Roh JK. Comparative pharmacokinetics of free doxorubicin and doxorubicin entrapped in cardiolipin liposomes. Cancer Res 1986; 46: 2295-2299.
    • (1986) Cancer Res , vol.46 , pp. 2295-2299
    • Rahman, A.1    Carmichael, D.2    Harris, M.3    Roh, J.K.4
  • 257
    • 0024470863 scopus 로고
    • Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice
    • Mayer LD, Tai LCL, Ko DSC et al. Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice. Cancer Res 1989; 49: 5922-5930.
    • (1989) Cancer Res , vol.49 , pp. 5922-5930
    • Mayer, L.D.1    Tai, L.C.L.2    Ko, D.S.C.3
  • 258
    • 0026603586 scopus 로고
    • Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes
    • Gabizon AA. Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes. Cancer Res 1992; 52: 891-896.
    • (1992) Cancer Res , vol.52 , pp. 891-896
    • Gabizon, A.A.1
  • 259
    • 0026718957 scopus 로고
    • Selective in vivo localization of daunorubicin small unilamellar vesicles in solid tumors
    • Forssen EA, Coulter DM, Proffitt RT. Selective in vivo localization of daunorubicin small unilamellar vesicles in solid tumors. Cancer Res 1992; 52: 3255-3261.
    • (1992) Cancer Res , vol.52 , pp. 3255-3261
    • Forssen, E.A.1    Coulter, D.M.2    Proffitt, R.T.3
  • 260
    • 84969050488 scopus 로고
    • Tumor targeted liposomes: Implications of liposome (Vescan) imaging of primary and metastatic tumors for liposomal chemotherapy
    • abs 37
    • Presant CA, Turner AF, Nadel H et al. Tumor targeted liposomes: implications of liposome (Vescan) imaging of primary and metastatic tumors for liposomal chemotherapy. Proc Am Soc Clin Oncol 1989; 8: 10 (abs 37).
    • (1989) Proc Am Soc Clin Oncol , vol.8 , pp. 10
    • Presant, C.A.1    Turner, A.F.2    Nadel, H.3
  • 261
    • 0023268886 scopus 로고
    • Influence of lipid composition on the antitumour activity exerted by doxorubicin-containing liposomes in a rat solid tumour model
    • Storm G, Roerdink FH, Steerenberg PA, de Jong WH, Crommelin DJ. Influence of lipid composition on the antitumour activity exerted by doxorubicin-containing liposomes in a rat solid tumour model. Cancer Res 1987; 47: 3366-3372
    • (1987) Cancer Res , vol.47 , pp. 3366-3372
    • Storm, G.1    Roerdink, F.H.2    Steerenberg, P.A.3    De Jong, W.H.4    Crommelin, D.J.5
  • 262
    • 0028349925 scopus 로고
    • Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes
    • Gabizon A, Catane R, Uziely B et al. Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. Cancer Res 1994; 54: 987-992.
    • (1994) Cancer Res , vol.54 , pp. 987-992
    • Gabizon, A.1    Catane, R.2    Uziely, B.3
  • 263
    • 0026733476 scopus 로고
    • Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice
    • Huang SK, Lee K-D, Hong K, Friend DS, Papahadjopoulos D. Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice. Cancer Res 1992; 52: 5135-5143.
    • (1992) Cancer Res , vol.52 , pp. 5135-5143
    • Huang, S.K.1    Lee, K.-D.2    Hong, K.3    Friend, D.S.4    Papahadjopoulos, D.5
  • 264
    • 0005447282 scopus 로고
    • Extravasation and transcytosis of liposomes in Kaposi's sarcoma-like dermal lesions of transgenic mice bearing the HIV tat gene
    • Huang SK, Martin FJ, Jay G et al. Extravasation and transcytosis of liposomes in Kaposi's sarcoma-like dermal lesions of transgenic mice bearing the HIV tat gene. Am J Pathol 1993; 143: 10-14.
    • (1993) Am J Pathol , vol.143 , pp. 10-14
    • Huang, S.K.1    Martin, F.J.2    Jay, G.3
  • 265
    • 0029875698 scopus 로고    scopus 로고
    • Fluroescence imaging studies for the disposition of daunorubicin liposomes (Daunoxome) within tumor tissue
    • Forssen EA, Malé-Brune R, Adler-Moore JP et al. Fluroescence imaging studies for the disposition of daunorubicin liposomes (Daunoxome) within tumor tissue. Cancer Res 1996; 2066-2075.
    • (1996) Cancer Res , pp. 2066-2075
    • Forssen, E.A.1    Malé-Brune, R.2    Adler-Moore, J.P.3
  • 266
    • 23444443192 scopus 로고
    • Antitumour activity of free and liposome-entrapped annamycin, a lipophilic anthracycline antibiotic with non-cross-resistance properties
    • Zou Y, Ling YH, Van NT, Priebe W, Perez Soler R. Antitumour activity of free and liposome-entrapped annamycin, a lipophilic anthracycline antibiotic with non-cross-resistance properties. Cancer Res 1994; 54: 1479-1484.
    • (1994) Cancer Res , vol.54 , pp. 1479-1484
    • Zou, Y.1    Ling, Y.H.2    Van, N.T.3    Priebe, W.4    Perez Soler, R.5
  • 267
    • 0027314129 scopus 로고
    • Comparison of the cardiotoxic effects of liposomal doxorubicin (TLC D-99) versus free oxidation in beagle dogs
    • Kauter PM, Bullard GA, Giusberg RA et al. Comparison of the cardiotoxic effects of liposomal doxorubicin (TLC D-99) versus free oxidation in beagle dogs. In Vivo 1993; 7: 17-26.
    • (1993) In Vivo , vol.7 , pp. 17-26
    • Kauter, P.M.1    Bullard, G.A.2    Giusberg, R.A.3
  • 268
    • 0025642721 scopus 로고
    • Studies on the myelosuppressive activity of doxorubicin entrapped in liposomes
    • Bally MB, Nayar R, Masin D et al. Studies on the myelosuppressive activity of doxorubicin entrapped in liposomes. Cancer Chemother Pharmacol 1990; 27: 13-19
    • (1990) Cancer Chemother Pharmacol , vol.27 , pp. 13-19
    • Bally, M.B.1    Nayar, R.2    Masin, D.3
  • 269
    • 0020080418 scopus 로고
    • Characterization of toxicity and therapeutic efficacy of adriamycin encapsulated in liposomes
    • Olson F, Mayhew E, Maslow D, Rustum Y, Szoka F. Characterization of toxicity and therapeutic efficacy of adriamycin encapsulated in liposomes. Eur J Cancer Clin Oncol 1982; 18: 167-176.
    • (1982) Eur J Cancer Clin Oncol , vol.18 , pp. 167-176
    • Olson, F.1    Mayhew, E.2    Maslow, D.3    Rustum, Y.4    Szoka, F.5
  • 270
    • 0028265875 scopus 로고
    • Liposomal mitoxantrone for the local treatment of peritoneal carcinomatosis induced by colon cancer cells in mice
    • Genne P, Olsson N-O, Gutierrez G, Duchamp O, Chauffert B. Liposomal mitoxantrone for the local treatment of peritoneal carcinomatosis induced by colon cancer cells in mice. Anti-cancer Drug Design 1994; 9: 73-84.
    • (1994) Anti-cancer Drug Design , vol.9 , pp. 73-84
    • Genne, P.1    Olsson, N.-O.2    Gutierrez, G.3    Duchamp, O.4    Chauffert, B.5
  • 271
    • 23444443192 scopus 로고
    • Antitumor activity of free and liposome-entrapped annamycin, a lipophilic anthracycline antibiotic with non-cross-resistance properties
    • Zou Y, Ling Y-H, Van NT, Priebe W, Perez-Solar R. Antitumor activity of free and liposome-entrapped annamycin, a lipophilic anthracycline antibiotic with non-cross-resistance properties. Cancer Res 1994; 54: 1479-1484.
    • (1994) Cancer Res , vol.54 , pp. 1479-1484
    • Zou, Y.1    Ling, Y.-H.2    Van, N.T.3    Priebe, W.4    Perez-Solar, R.5
  • 272
    • 0029006392 scopus 로고
    • Effect of vesicle size and lipid composition on the in vivo tumor selectivity and toxicity of the non-cross-resistant anthracycline annamycin incorporated in liposomes
    • Zou Y Ling Y-H, Reddy S, Priebe W, Perez Soler R. Effect of vesicle size and lipid composition on the in vivo tumor selectivity and toxicity of the non-cross-resistant anthracycline annamycin incorporated in liposomes. Int J Cancer 1995; 61: 666-671.
    • (1995) Int J Cancer , vol.61 , pp. 666-671
    • Zou, Y.1    Ling, Y.-H.2    Reddy, S.3    Priebe, W.4    Perez Soler, R.5
  • 273
    • 0029122889 scopus 로고
    • Distribution of free and liposomal annamycin within human plasma is regulated by plasma triglyceride concentrations but not by lipid transfer protein
    • Wasan KM, Perez Soler R. Distribution of free and liposomal annamycin within human plasma is regulated by plasma triglyceride concentrations but not by lipid transfer protein. J Pharm Sci 1995; 84: 1094-110.
    • (1995) J Pharm Sci , vol.84 , pp. 1094-1110
    • Wasan, K.M.1    Perez Soler, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.