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Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
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Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites
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Paech K, Webb P, Kuiper GG, Nilsson S, Gustaffson JA, Kushner PJ, Scanlan TS: Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science 1997, 277:1508-1510. Examines the transactivation potential ERα and ERα bound to estradiol or antiestrogens, and shows that they have opposite effects at the AP1 site, which represents one possible mechanism of tissue specificity.
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Science
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Paech, K.1
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Oestrogen receptor mutants and variants in breast cancer
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Eur J Cancer
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Dowsett, M.1
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Brzozowski AM, Pike AC, Dauter Z, Hubbard RE, Bonn T, Engstrom O, et al.: Molecular basis of agonism and antagonism in the oestrogen receptor. Nature 1997, 389:753-758. This article describes the crystal structure of ERα ligand binding domain bound to estradiol and raloxifene. Altered conformation causes differences in transactivation potential, possibly accounting for tissue-specific effects.
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Nature
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Brzozowski, A.M.1
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Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, et al.: AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 1997, 277:965-968. The identification of an ER co-activator that is frequently overexpressed in primary breast tumors is presented.
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J Clin Oncol
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Kolquist KA, Ellisen LW, Counter CM, Meyerson M, Tan LK, Weinberg RA, et al.: Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. Nat Genet 1998, 19:182-186. This article discusses in situ detection of the catalytic component of telomerase showing limited expression in normal breast tissue and progressively elevated levels with increasing tumorigenicity.
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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
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Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, et al.: Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997, 15:356-362. This paper and the paper below by Li et al. (Science 1997, 275:1943-1947) describe the identification and characterization of the novel tumor suppressor gene PTEN.
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Nat Genet
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Steck, P.A.1
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Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, et al.: PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997, 13:356-362. This paper and the paper above by Steck et al. (Nat Genet 1997, 15:356-362) describe the identification and characterization of the novel tumor suppressor gene PTEN.
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Science
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Li, J.1
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Am J Hum Genet
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Tsou, H.C.1
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Am J Hum Genet
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Lynch, E.D.1
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Tr/Tr mouse, which expresses a truncated BRCA2 protein but is still viable, and the resulting phenotype. These animals, and cells derived from them, exhibit features consistent with defective DNA repair capability.
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Tr/Tr mouse, which expresses a truncated BRCA2 protein but is still viable, and the resulting phenotype. These animals, and cells derived from them, exhibit features consistent with defective DNA repair capability.
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BRCA-associated breast cancer in young women
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Robson M, Gilewski T, Haas B, Levin D, Borgen P, Rajan P, et al.: BRCA-associated breast cancer in young women. J Clin Oncol 1998, 16:1642-1649.
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(1998)
J Clin Oncol
, vol.16
, pp. 1642-1649
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Robson, M.1
Gilewski, T.2
Haas, B.3
Levin, D.4
Borgen, P.5
Rajan, P.6
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