Preclinical testing of recombinant adenoviral herpes simplex virus- thymidine kinase gene therapy for central nervous system malignancies

Neurosurgery

Volumn 41, Issue 2, 1997, Pages 442-452

  Vincent, Arnaud J P E ^a   Esandi, Maria Del C ^b   Avezaat, Cees J J ^a   Vecht, Charles ^a   Smitt, Peter Sillevis ^a   Van Bekkum, Dirk W ^c   Valerio, Dinko ^b,c   Hoogerbrugge, Peter M ^a,c   Bout, Abraham ^b,c  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c CRUCELL HOLLAND BV   (Netherlands)

Author keywords

CNS tumors; Recombinant adenovirus; Suicide gene therapy

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CELL KILLING; CENTRAL NERVOUS SYSTEM TUMOR; CYTOPATHOGENIC EFFECT; CYTOTOXICITY; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; IMMEDIATE EARLY GENE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; SUICIDE GENE; SURVIVAL TIME; TRANSGENE; TUMOR CELL CULTURE; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALS; ANTIVIRAL AGENTS; ARACHNOID; BRAIN NEOPLASMS; CENTRAL NERVOUS SYSTEM NEOPLASMS; CYTOMEGALOVIRUS; GANCICLOVIR; GENE DOSAGE; GENE THERAPY; HUMANS; MENINGEAL NEOPLASMS; PIA MATER; PROMOTER REGIONS (GENETICS); RATS; RECOMBINATION, GENETIC; SIMPLEXVIRUS; SURVIVAL ANALYSIS; THYMIDINE KINASE; TUMOR CELLS, CULTURED;

EID: 0030803888     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006123-199708000-00023     Document Type: Article

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