Prodrug-activated gene therapy: Involvement of an immunological component in the "bystander effect"

Cancer Gene Therapy

Volumn 3, Issue 2, 1996, Pages 83-88

  Gagandeep, S ^a  

^a ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Bystander effect; Immunological component; Prodrug activated gene therapy

Indexed keywords

GANCICLOVIR; PRODRUG; THYMIDINE KINASE;

ADENOCARCINOMA; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CD4 CD8 RATIO; CELL CULTURE; COLON TUMOR; DOWN REGULATION; DRUG EFFECT; FEMALE; GENE THERAPY; GENE VECTOR; GENETICS; HERPES SIMPLEX VIRUS; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METHODOLOGY; MOUSE; NONPARAMETRIC TEST; NUDE MOUSE; PATHOLOGY; PHENOTYPE; TUMOR ASSOCIATED LEUKOCYTE;

ADENOCARCINOMA; ANIMALS; CD4-CD8 RATIO; COLONIC NEOPLASMS; DOWN-REGULATION; FEMALE; GANCICLOVIR; GENE THERAPY; GENETIC VECTORS; IMMUNE TOLERANCE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTES, TUMOR-INFILTRATING; MICE; MICE, INBRED BALB C; MICE, NUDE; PHENOTYPE; PRODRUGS; SIMPLEXVIRUS; STATISTICS, NONPARAMETRIC; THYMIDINE KINASE; TUMOR CELLS, CULTURED;

EID: 0030100158     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (3)

1. Culver KV, Ram Z, Wallbridge S, Ishii H, Oldfield EH, Blaese RM. In vivo gene transfer with retroviral vectorproducer cells for treatment of experimental brain tumours. Science. 1992;256:1550-1552.
2. Caruso M, Panis Y, Gagandeep S, Houssin D, Salzmann JL, Klatzmann D. Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc Natl Acad Sci USA. 1993;90:7024-7028.
3. Mullen CA, Coale MM, Lowe R, Blaese RM. Tumours expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumour. Cancer Res. 1994;54:1503-1506.