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Volumn 9, Issue 4, 1998, Pages 295-299

Leptin, the hypothalamus and the regulation of adiposity

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; NEUROTRANSMITTER; PEPTIDE;

EID: 0031686248     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-199808000-00002     Document Type: Review
Times cited : (4)

References (30)
  • 4
    • 14444268971 scopus 로고    scopus 로고
    • Interactions between leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis in the rat
    • Wang Q, Bing C, Al-Barazanji K, Mossakowaska DE, Wang X-M, McBay DL, et al. Interactions between leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis in the rat. Diabetes 1997; 46:335-341. This paper investigates the proposed link between leptin signalling and NPY neurons. It demonstrates that central administration of leptin to fasted rats inhibits food intake and significantly reduces hypothalamic NPY concentrations. Correspondingly, intra cerebral ventricular (ICV) NPY administration was found to significantly increase plasma leptin, induce hyperplagia and weight gain. Thus, leptin and NPY neurons appear to interact as a means of regulating body weight.
    • (1997) Diabetes , vol.46 , pp. 335-341
    • Wang, Q.1    Bing, C.2    Al-Barazanji, K.3    Mossakowaska, D.E.4    Wang, X.-M.5    McBay, D.L.6
  • 5
    • 0031589705 scopus 로고    scopus 로고
    • Central insulin inhibits hypothalamic galanin and neuropeptide Y gene expression and peptide release in intact rats
    • Wang J, Leibowitz KL. Central insulin inhibits hypothalamic galanin and neuropeptide Y gene expression and peptide release in intact rats. Brain Res 1997, 777:231-236.
    • (1997) Brain Res , vol.777 , pp. 231-236
    • Wang, J.1    Leibowitz, K.L.2
  • 6
    • 0030641036 scopus 로고    scopus 로고
    • The new biology of body weight regulation
    • Schwartz MW, Seeley RJ. The new biology of body weight regulation. J Am Diab Assoc 1996; 1997:54-58.
    • (1996) J Am Diab Assoc , vol.1997 , pp. 54-58
    • Schwartz, M.W.1    Seeley, R.J.2
  • 7
    • 0031558626 scopus 로고    scopus 로고
    • Reciprocal regional changes in brain NPY receptor density during dietary restriction and dietary-induced obesity in the rat
    • Widdowson PS, Upton R, Henderson L, Buckingham R, Wilson S, Williams G. Reciprocal regional changes in brain NPY receptor density during dietary restriction and dietary-induced obesity in the rat. Brain Res 1997; 774:1-10. This paper considers changes in the density of NPY receptors during dietary manipulation in the rat. It demonstrates a decrease in binding upon food restriction and an increase upon dietary induced obesity. This suggests that food restriction stimulates NPY release whilst dietary induced obesity inhibits it. Thus, the NPY system does not appear to contribute to the hyperphagia associated with exposure to a palatable diet.
    • (1997) Brain Res , vol.774 , pp. 1-10
    • Widdowson, P.S.1    Upton, R.2    Henderson, L.3    Buckingham, R.4    Wilson, S.5    Williams, G.6
  • 8
    • 0029804743 scopus 로고    scopus 로고
    • Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
    • Erickson JC, Hollopeter G, Palmiter RD. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 1996; 274:1704-1707.
    • (1996) Science , vol.274 , pp. 1704-1707
    • Erickson, J.C.1    Hollopeter, G.2    Palmiter, R.D.3
  • 9
    • 0032489093 scopus 로고    scopus 로고
    • Orexins and orexin receptors. A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour
    • Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, et al. Orexins and orexin receptors. A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 1998; 92:573-585.
    • (1998) Cell , vol.92 , pp. 573-585
    • Sakurai, T.1    Amemiya, A.2    Ishii, M.3    Matsuzaki, I.4    Chemelli, R.M.5    Tanaka, H.6
  • 10
    • 0008390266 scopus 로고    scopus 로고
    • The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
    • de Lecea L, Kilduff TS, Peyron C, Gao XB, Foye PE, Danielson PE, et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A 1998; 95:322-327. This paper describes the identification of another novel factor, hypocretin, which is localized to the dorsal and lateral hypothalamic areas. Hypocretin mRNA encodes two peptides, one of which was found to be excitatory, suggesting they function as neurotransmitters in the CNS. Any role in the control of feeding behaviour remains to be verified.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 322-327
    • De Lecea, L.1    Kilduff, T.S.2    Peyron, C.3    Gao, X.B.4    Foye, P.E.5    Danielson, P.E.6
  • 11
    • 0031949626 scopus 로고    scopus 로고
    • Orexins and appetite: The big picture of energy homeostasis gets a little bigger
    • Schwartz MW. Orexins and appetite: the big picture of energy homeostasis gets a little bigger. Nature Med 1998; 4:385-386.
    • (1998) Nature Med , vol.4 , pp. 385-386
    • Schwartz, M.W.1
  • 12
    • 0030967436 scopus 로고    scopus 로고
    • Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat
    • Larsen PJ, Tang-Christensen M, Jessop DS. Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat. Endocrinology 1997; 138:4445-4455.
    • (1997) Endocrinology , vol.138 , pp. 4445-4455
    • Larsen, P.J.1    Tang-Christensen, M.2    Jessop, D.S.3
  • 13
  • 14
    • 0031590319 scopus 로고    scopus 로고
    • Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodents
    • Goldstone AP, Mercer JG, Gunn I, Moar KM, Mark C, Edwards B, et al. Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodents. FEBS Lett 1997; 415:134-138. A novel approach utilizing orphan G-protein-coupled receptors to screen brain extracts led to the purification and cloning of two related peptides, orexin A and B. These were found to demonstrate a limited distribution in the hypothalamus. Additionally they increase upon starvation and their central administration induces hyperphagia. Their potential interactions with other neuropeptides remain to be determined.
    • (1997) FEBS Lett , vol.415 , pp. 134-138
    • Goldstone, A.P.1    Mercer, J.G.2    Gunn, I.3    Moar, K.M.4    Mark, C.5    Edwards, B.6
  • 15
    • 0030770640 scopus 로고    scopus 로고
    • Influence of fasting and neuropeptide Y on the suppressive food intake introduced by intracerebroventricular injection of glucagon-like peptide-1 in the neonatal chick
    • Furuse M, Matsumuto M, Mori R, Sugahara K, Kano K, Hasegawa S. Influence of fasting and neuropeptide Y on the suppressive food intake introduced by intracerebroventricular injection of glucagon-like peptide-1 in the neonatal chick. Brain Res 1997; 764:289-292. This paper further investigates the role of GLP-1 injection in the control of feeding behaviour by considering the effects of the appetite stimulant NPY on ICV GLP-1 injection. GLP-1 was found to inhibit the effects of NPY indicating an interaction between the two systems, with the GLP-1 system offering the more potent control of food intake.
    • (1997) Brain Res , vol.764 , pp. 289-292
    • Furuse, M.1    Matsumuto, M.2    Mori, R.3    Sugahara, K.4    Kano, K.5    Hasegawa, S.6
  • 16
    • 0028112970 scopus 로고
    • Agouti protein is an antagonist of the melanocyte-stimulating hormone receptor
    • Lu D, Willard D, Patel IR, Kadwell S, Overton L, Kost T, et al. Agouti protein is an antagonist of the melanocyte-stimulating hormone receptor. Nature 1994; 371:799-802.
    • (1994) Nature , vol.371 , pp. 799-802
    • Lu, D.1    Willard, D.2    Patel, I.R.3    Kadwell, S.4    Overton, L.5    Kost, T.6
  • 17
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    • Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997; 88:131-141. Inactivation of the melanocortin-4 receptor by gene targetting is reported to result in a maturity onset obesity syndrome which mimics characteristic features of the agouti obesity by antagonism of the receptor, thus identifying it as a key player in the control of feeding behaviour.
    • (1997) Cell , vol.88 , pp. 131-141
    • Huszar, D.1    Lynch, C.A.2    Fairchild-Huntress, V.3    Dunmore, J.H.4    Fang, Q.5    Berkemeier, L.R.6
  • 18
    • 0030614331 scopus 로고    scopus 로고
    • Role of the melanocortinergic neurons in feeding and the agouti obesity syndrome
    • Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of the melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 1997, 385:165-168. This paper addresses the hypothesis that agouti causes obesity by antagonism of melanocortin-4 receptors by identifying cyclic melanocortin analogues which demonstrate potent agonist or antagonist activity at neural melanocortin receptors (MC3-R and MC4-R). It finds that melanocortinergic neurons function to inhibit feeding behaviour, with antagonism of the inhibitory signal being the probable explanation of the agouti obesity syndrome. In addition it is shown that the antagonist agouti is selective for the mouse MC4-R over the rat MC3-R, thus supporting the suggested central role of MC4-R in the control of feeding behaviour.
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 19
    • 0031042075 scopus 로고    scopus 로고
    • Mutations in the carboxyl terminus of the agouti protein decreases agouti inhibition of ligand binding to the melanocortin receptors
    • Kiefer LL, Ittoop ORR, Bunce K, Ruesdale AT, Willard DH, Nichols JS, et al. Mutations in the carboxyl terminus of the agouti protein decreases agouti inhibition of ligand binding to the melanocortin receptors. Biochemistry 1997; 36:2084-2090. This paper considers the actions of recombinant agouti protein on both MC3-R and MC4-R. Unlike the previous paper it reports similar affinities of the protein at both receptors, in mouse and human, suggesting that MC3-R is also a potential candidate for mediating the effects of ectopic agouti expression.
    • (1997) Biochemistry , vol.36 , pp. 2084-2090
    • Kiefer, L.L.1    Ittoop, O.R.R.2    Bunce, K.3    Ruesdale, A.T.4    Willard, D.H.5    Nichols, J.S.6
  • 20
    • 0031888157 scopus 로고    scopus 로고
    • Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin
    • Mizuno TM, Kleopoulos SP, Bergen HT, Roberts JL, Priest CA, Mobbs CV. Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 1998; 47:294-297.
    • (1998) Diabetes , vol.47 , pp. 294-297
    • Mizuno, T.M.1    Kleopoulos, S.P.2    Bergen, H.T.3    Roberts, J.L.4    Priest, C.A.5    Mobbs, C.V.6
  • 22
    • 0030928715 scopus 로고    scopus 로고
    • Proopiomelanocorlin neurons are direct targets for leptin in the hypothalamus
    • Cheung CC, Clifton DK, Steiner RA. Proopiomelanocorlin neurons are direct targets for leptin in the hypothalamus. Endocrinology 1997; 138:4489-4492.
    • (1997) Endocrinology , vol.138 , pp. 4489-4492
    • Cheung, C.C.1    Clifton, D.K.2    Steiner, R.A.3
  • 23
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
    • Ollmann MM, Wilson BD, Yang Y-K, Kerns JA, Chen Y, Gantz I, Barsh GS. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 1997; 278:135-138. This paper reports the isolation of a gene which encodes the protein termed agouti-related protein (AGRP) because of its similarity to agouti. Unlike agouti, the RNA for AGRP is normally expressed in the hypothalamus Recombinant AGRP was shown to be a potent and selective antagonist ot MC3-R and MC4-R, the receptor subtypes associated with control of body weight, thus implicating AGRP in the normal control of body weight.
    • (1997) Science , vol.278 , pp. 135-138
    • Ollmann, M.M.1    Wilson, B.D.2    Yang, Y.-K.3    Kerns, J.A.4    Chen, Y.5    Gantz, I.6    Barsh, G.S.7
  • 24
    • 0030893647 scopus 로고    scopus 로고
    • Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice
    • •]. In situ hybridization showed agouti related transcript to be expressed in the arcuate nucleus where its levels were found to be elevated in ob/ob and db/db mice, identifying it as a potential mediator of the hypothalamic control of feeding.
    • (1997) Genes Dev , vol.11 , pp. 593-602
    • Shutter, J.R.1    Graham, M.2    Kinsey, A.C.3    Scully, S.4    Lüthy, R.5    Stark, K.L.6
  • 25
    • 0030894709 scopus 로고    scopus 로고
    • Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome
    • Kesterson RA, Huszar D, Lynch CA, Simerly RB, Cone RD. Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome. Mol Endocrinol 1997; 11:630-637. This study considers the potential roles of NPY, POMC and galanin in the melanocortinergic obesity syndrome. Whilst no significant changes in POMC, galanin and arcuate nucleus NPY were detected, higher NPY levels in the dorsal medial hypothalamic nucleus of agouti mice were identified indicating a potential role for NPY in the obesity syndrome.
    • (1997) Mol Endocrinol , vol.11 , pp. 630-637
    • Kesterson, R.A.1    Huszar, D.2    Lynch, C.A.3    Simerly, R.B.4    Cone, R.D.5
  • 28
    • 0030678119 scopus 로고    scopus 로고
    • Independent and additive effects of central POMC and leptin pathways on murine obesity
    • Boston BA, Blaydon KM, Varnerin J, Cone RD. Independent and additive effects of central POMC and leptin pathways on murine obesity. Science 1997; 278:1641-1644. Previously, it was assumed that POMC neurons lie within the central control pathway transmitting the regulatory effects of leptin on feeding. However, the production of double mutant mice, with both defective POMC signalling and the absence of leptin, found the effects of the mutations to be independent and additive. Thus, a pathway of obesity dependent on defective POMC signalling but independent of leptin appears to exist.
    • (1997) Science , vol.278 , pp. 1641-1644
    • Boston, B.A.1    Blaydon, K.M.2    Varnerin, J.3    Cone, R.D.4
  • 29
    • 13344279395 scopus 로고    scopus 로고
    • A role for melanin-concentrating hormone in the central regulation of feeding behaviour
    • Qu D, Ludwig DS, Gammeltoft S, Piper M, Pelleymounter MA, Cullen MJ, et al. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 1996; 380:243-247.
    • (1996) Nature , vol.380 , pp. 243-247
    • Qu, D.1    Ludwig, D.S.2    Gammeltoft, S.3    Piper, M.4    Pelleymounter, M.A.5    Cullen, M.J.6
  • 30
    • 0031023301 scopus 로고    scopus 로고
    • Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight
    • Rossi M, Choi SJ, O'Shea D, Miyoshi T, Ghatei MA, Bloom SR. Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology 1997; 138:351-355. This paper further investigates the effects of melanin-concentrating hormone on feeding. When injected ICV a dose dependent increase in feeding was observed. This effect was found to be acute, with tolerance developed after 6 days. The findings indicate that melanin-concentrating hormone provides some immediate control over feeding behaviour, but does not appear to contribute to the long term control of body weight.
    • (1997) Endocrinology , vol.138 , pp. 351-355
    • Rossi, M.1    Choi, S.J.2    O'Shea, D.3    Miyoshi, T.4    Ghatei, M.A.5    Bloom, S.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.