-
1
-
-
0030134128
-
DNA-damage, DNA-repair and disease
-
Griffin S: DNA-damage, DNA-repair and disease. Curr Biol 1996, 6:497-499.
-
(1996)
Curr Biol
, vol.6
, pp. 497-499
-
-
Griffin, S.1
-
2
-
-
0029042130
-
Identification of mismatch repair genes and their role in the development of cancer
-
Fishel R, Kolodner RD: Identification of mismatch repair genes and their role in the development of cancer. Curr Opin Genet Dev 1995, 5:382-395.
-
(1995)
Curr Opin Genet Dev
, vol.5
, pp. 382-395
-
-
Fishel, R.1
Kolodner, R.D.2
-
3
-
-
0030038643
-
Mutator genes and mosaicism in colorectal-cancer
-
Dunlop MG: Mutator genes and mosaicism in colorectal-cancer. Curr Opin Genet Dev 1996, 6:76-81.
-
(1996)
Curr Opin Genet Dev
, vol.6
, pp. 76-81
-
-
Dunlop, M.G.1
-
4
-
-
0028576410
-
Mismatch repair and cancer susceptibility
-
Kolodner RD, Alani E: Mismatch repair and cancer susceptibility. Curr Opin Biotechnol 1994, 5:585-594.
-
(1994)
Curr Opin Biotechnol
, vol.5
, pp. 585-594
-
-
Kolodner, R.D.1
Alani, E.2
-
5
-
-
0029384515
-
DNA-mismatch repair. the intricacies of eukaryotic spell-checking
-
Kunkel TA: DNA-mismatch repair. The intricacies of eukaryotic spell-checking. Curr Biol 1995, 5:1091-1094.
-
(1995)
Curr Biol
, vol.5
, pp. 1091-1094
-
-
Kunkel, T.A.1
-
6
-
-
0029943449
-
Mismatch repair in replication fidelity, genetic-recombination, and cancer biology
-
Modrich P, Lahue R: Mismatch repair in replication fidelity, genetic-recombination, and cancer biology. Annu Rev Biochem 1996, 65:101-133.
-
(1996)
Annu Rev Biochem
, vol.65
, pp. 101-133
-
-
Modrich, P.1
Lahue, R.2
-
7
-
-
0030465237
-
HMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6
-
Acharya S, Wilson T, Gradia S, Kane MF, Guerrette S, Marsischky GT, Kolodner R, Fishel R: hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6. Proc Natl Acad Sci USA 1996, 93:13629-13634.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 13629-13634
-
-
Acharya, S.1
Wilson, T.2
Gradia, S.3
Kane, M.F.4
Guerrette, S.5
Marsischky, G.T.6
Kolodner, R.7
Fishel, R.8
-
8
-
-
0029070143
-
Isolation of an hMSH2-P160 heterodimer that restores DNA mismatch repair to tumor cells
-
Drummond JT, Li GM, Longley MJ, Modrich P: Isolation of an hMSH2-P160 heterodimer that restores DNA mismatch repair to tumor cells. Science 1995, 268:1909-1912.
-
(1995)
Science
, vol.268
, pp. 1909-1912
-
-
Drummond, J.T.1
Li, G.M.2
Longley, M.J.3
Modrich, P.4
-
9
-
-
0028941627
-
Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor-cells by a heterodimer of human MutL homologs
-
Li GM, Modrich P: Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor-cells by a heterodimer of human MutL homologs. Proc Natl Acad Sci USA 1995, 92:1950-1954.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 1950-1954
-
-
Li, G.M.1
Modrich, P.2
-
10
-
-
0029008683
-
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human-cells
-
Palombo F, Gallinari P, laccarino I, Lettieri T, Hughes M, Darrigo A, Truong O, Hsuan JJ, Jiricny J: GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human-cells. Science 1995, 268:1912-1914.
-
(1995)
Science
, vol.268
, pp. 1912-1914
-
-
Palombo, F.1
Gallinari, P.2
Laccarino, I.3
Lettieri, T.4
Hughes, M.5
Darrigo, A.6
Truong, O.7
Hsuan, J.J.8
Jiricny, J.9
-
11
-
-
0029659046
-
HMUTS-β, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA
-
Palombo F, Iaccarino I, Nakajima E, Ikejima M, Shimada T, Jiricny J: hMUTS-β, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA. Curr Biol 1996, 6:1181-1184. Using a baculovirus expression system, the authors made highly purified preparations of hMutSα and hMutSβ by cotransfection with hMsh2 and either GTBP or hMSH3 expression vectors, respectively. The authors propose that disregulation of hMSH3 synthesis could effect hMutSα function by competing with GTBP for the formation of complexes with hMSH2.
-
(1996)
Curr Biol
, vol.6
, pp. 1181-1184
-
-
Palombo, F.1
Iaccarino, I.2
Nakajima, E.3
Ikejima, M.4
Shimada, T.5
Jiricny, J.6
-
12
-
-
0027269844
-
Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction
-
Fang WH, Modrich P: Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction. J Biol Chem 1993, 268:11838-11844.
-
(1993)
J Biol Chem
, vol.268
, pp. 11838-11844
-
-
Fang, W.H.1
Modrich, P.2
-
13
-
-
0030271999
-
Requirement for PCNa in DNa mismatch repair at a step preceeding DNA resynthesis
-
Umar A, Buermeyer AB, Simon JA, Thomas DC, Clark AB, Liskay RM, Kunkel TA: Requirement for PCNA in DNA mismatch repair at a step preceeding DNA resynthesis. Cell 1996, 87:65-73.
-
(1996)
Cell
, vol.87
, pp. 65-73
-
-
Umar, A.1
Buermeyer, A.B.2
Simon, J.A.3
Thomas, D.C.4
Clark, A.B.5
Liskay, R.M.6
Kunkel, T.A.7
-
14
-
-
0025773554
-
Mutator phenotype may be required for multistage carcinogenesis
-
Loeb LA: Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 1991, 51:3075-3079.
-
(1991)
Cancer Res
, vol.51
, pp. 3075-3079
-
-
Loeb, L.A.1
-
15
-
-
0027285475
-
Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
-
Ionov Y, Peinado MA, Malkhosyan S, Shibata D, Perucho M: Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 1993, 363:558-561.
-
(1993)
Nature
, vol.363
, pp. 558-561
-
-
Ionov, Y.1
Peinado, M.2
Malkhosyan, S.3
Shibata, D.4
Perucho, M.A.5
-
16
-
-
0026439207
-
Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction
-
Peinado MA, Malkhosyan S, Velazquez A, Perucho M: Isolation and characterization of allelic losses and gains in colorectal tumors by arbitrarily primed polymerase chain reaction. Proc Natl Acad Sci USA 1992, 89:10065-10069.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 10065-10069
-
-
Peinado, M.1
Malkhosyan, S.2
Velazquez, A.3
Perucho, M.A.4
-
17
-
-
0027314411
-
Microsatellite instability in cancer of the proximal colon
-
Thibodeau SN, Bren G, Schaid D: Microsatellite instability in cancer of the proximal colon. Science 1993, 260:816-819.
-
(1993)
Science
, vol.260
, pp. 816-819
-
-
Thibodeau, S.N.1
Bren, G.2
Schaid, D.3
-
18
-
-
0027158031
-
Clues to the pathogenesis of familial colorectal cancer
-
Aaltonen LA, Peltomaki P, Leach FS, Sistonen P, Pylkkanen L, Mecklin JP, Jarvinen H, Powell SM, Jen J, Hamilton SR et al.: Clues to the pathogenesis of familial colorectal cancer. Science 1993, 260:812-816.
-
(1993)
Science
, vol.260
, pp. 812-816
-
-
Aaltonen, L.A.1
Peltomaki, P.2
Leach, F.S.3
Sistonen, P.4
Pylkkanen, L.5
Mecklin, J.P.6
Jarvinen, H.7
Powell, S.M.8
Jen, J.9
Hamilton, S.R.10
-
19
-
-
0028138341
-
Microsatellite alterations as clonal markers for the detection of human cancer
-
Mao L, Lee DJ, Tockman MS, Erozan YS, Askin F, Sidransky D: Microsatellite alterations as clonal markers for the detection of human cancer. Proc Natl Acad Sci USA 1994, 91:9871-9875.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 9871-9875
-
-
Mao, L.1
Lee, D.J.2
Tockman, M.S.3
Erozan, Y.S.4
Askin, F.5
Sidransky, D.6
-
20
-
-
0027742295
-
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon-cancer
-
Fishel R, Lescoe MK, Rao MRS, Copeland NG, Jenkins NA, Garber J, Kane M, Kolodner R: The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon-cancer. Cell 1993, 75:1027-1038.
-
(1993)
Cell
, vol.75
, pp. 1027-1038
-
-
Fishel, R.1
Lescoe, M.K.2
Rao, M.3
Copeland, N.G.4
Jenkins, N.A.5
Garber, J.6
Kane, M.R.S.7
Kolodner, R.8
-
21
-
-
0030592517
-
Lessons from hereditary colorectal-cancer
-
Kinzler KW, Vogelstein B: Lessons from hereditary colorectal-cancer. Cell 1996, 87:159-170. A comprehensive review of colorectal cancer, contrasting and comparing HNPCC and familial polyposis; an excellent synthesis of the affected pathways and the types and frequencies of germline mutations in these two forms of hereditary colon cancer. Introduces the concept of APC as a 'gatekeeper' gene - inactivation being required for the initiation of net cellular proliferation.
-
(1996)
Cell
, vol.87
, pp. 159-170
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
22
-
-
0027137935
-
Hypermutability and mismatch repair deficiency in RER+ tumor cells
-
Parsons R, Li GM, Longley MJ, Fang WH, Papadopoulos N, Jen J, De la-Chapelle A, Kinzler KW, Vogelstein B, Modrich P: Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell 1993, 75:1227-1236.
-
(1993)
Cell
, vol.75
, pp. 1227-1236
-
-
Parsons, R.1
Li, G.M.2
Longley, M.J.3
Fang, W.H.4
Papadopoulos, N.5
Jen, J.6
De La-Chapelle, A.7
Kinzler, K.W.8
Vogelstein, B.9
Modrich, P.10
-
23
-
-
0028784167
-
Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines
-
Boyer JC, Umar A, Risinger JI, Lipford JR, Kane M, Yin S, Barrett JC, Kolodner RD, Kunkel TA: Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. Cancer Res 1995, 55:6063-6070.
-
(1995)
Cancer Res
, vol.55
, pp. 6063-6070
-
-
Boyer, J.C.1
Umar, A.2
Risinger, J.I.3
Lipford, J.R.4
Kane, M.5
Yin, S.6
Barrett, J.C.7
Kolodner, R.D.8
Kunkel, T.A.9
-
24
-
-
0028862897
-
Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae
-
Strand M, Earley MC, Crouse GF, Petes TD: Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 1995, 92:10418-10421.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 10418-10421
-
-
Strand, M.1
Earley, M.C.2
Crouse, G.F.3
Petes, T.D.4
-
25
-
-
0029870366
-
Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability
-
Johnson RE, Kovvali GK, Prakash L, Prakash S: Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability. J Biol Chem 1996, 271:7285-7288.
-
(1996)
J Biol Chem
, vol.271
, pp. 7285-7288
-
-
Johnson, R.E.1
Kovvali, G.K.2
Prakash, L.3
Prakash, S.4
-
26
-
-
0027306173
-
Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair
-
Strand M, Prolla TA, Liskay RM, Petes TD: Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature 1993, 365:274-276.
-
(1993)
Nature
, vol.365
, pp. 274-276
-
-
Strand, M.1
Prolla, T.A.2
Liskay, R.M.3
Petes, T.D.4
-
27
-
-
0029827630
-
Loss of heterozygosity and base substitution at the Aprt locus in mismatch-repair-proficient and mismatch-repair-deficient colorectal carcinoma cell-lines
-
Phear G, Bhattacharyya NP, Meuth M: Loss of heterozygosity and base substitution at the Aprt locus in mismatch-repair-proficient and mismatch-repair-deficient colorectal carcinoma cell-lines. Mol Cell Biol 1996, 16:6516-6523.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 6516-6523
-
-
Phear, G.1
Bhattacharyya, N.P.2
Meuth, M.3
-
28
-
-
0028847412
-
Molecular analysis of mutations in mutator colorectal carcinoma cell lines
-
Bhattacharyya NP, Ganesh A, Phear G, Richards B, Skandalis A, Meuth M: Molecular analysis of mutations in mutator colorectal carcinoma cell lines. Hum Mol Genet 1995, 4:2057-2064. Different mutational spectra were found in the selectable locus encoding hypoxanthine guanine phosphoribosyl transferase (HPRT) in two cell lines (HCT116 and DLD-1) with different underlying MMR defects. These findings are consistent with known mechanisms of mismatch repair genes and illustrate their effects on single copy human locus. Such studies may help characterize the sequences most likely to be mutated in MSI+ tumors.
-
(1995)
Hum Mol Genet
, vol.4
, pp. 2057-2064
-
-
Bhattacharyya, N.P.1
Ganesh, A.2
Phear, G.3
Richards, B.4
Skandalis, A.5
Meuth, M.6
-
29
-
-
0028887597
-
Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer
-
Eshleman JR, Lang EZ, Bowerfind GK, Parsons R, Vogelstein B, Willson JK, Veigl ML, Sedwick WD, Markowitz SD: Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer. Oncogene 1995, 10:33-37.
-
(1995)
Oncogene
, vol.10
, pp. 33-37
-
-
Eshleman, J.R.1
Lang, E.Z.2
Bowerfind, G.K.3
Parsons, R.4
Vogelstein, B.5
Willson, J.K.6
Veigl, M.L.7
Sedwick, W.D.8
Markowitz, S.D.9
-
30
-
-
0010945939
-
Apc mutations in colorectal tumors with mismatch repair deficiency
-
Huang J, Papadopoulos N, McKinley AJ, Farrington SM, Curtis LJ, Wyllie AH, Zheng S, Willson JKV, Markowitz SD, Morin P et al.: Apc mutations in colorectal tumors with mismatch repair deficiency. Proc Natl Acad Sci USA 1996, 93:9049-9054.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 9049-9054
-
-
Huang, J.1
Papadopoulos, N.2
McKinley, A.J.3
Farrington, S.M.4
Curtis, L.J.5
Wyllie, A.H.6
Zheng, S.7
Willson, J.K.V.8
Markowitz, S.D.9
Morin, P.10
-
31
-
-
0029951332
-
Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype
-
Malkhosyan S, McCarty A, Sawai H, Perucho M: Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype. Mutat Res 1996, 316:249-259.
-
(1996)
Mutat Res
, vol.316
, pp. 249-259
-
-
Malkhosyan, S.1
McCarty, A.2
Sawai, H.3
Perucho, M.4
-
32
-
-
0028785603
-
Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer
-
Parsons R, Myeroff LL, Liu B, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B: Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res 1995, 55:5548-5550.
-
(1995)
Cancer Res
, vol.55
, pp. 5548-5550
-
-
Parsons, R.1
Myeroff, L.L.2
Liu, B.3
Willson, J.K.4
Markowitz, S.D.5
Kinzler, K.W.6
Vogelstein, B.7
-
33
-
-
0029066689
-
Inactivation of the type-II Tgf-β receptor in colon cancer cells with microsatellite instability
-
Markowitz S, Wang J, Myeroff L, Parsons R, Sun LZ, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW, Vogelstein B et al.: Inactivation of the type-II Tgf-β receptor in colon cancer cells with microsatellite instability. Science 1995, 268:1336-1338. First demonstration of TGF-β RII mutations in colorectal cancers and cell lines with MSI. These mutations were almost exclusively found in RER+ and not RER- tumors. An illustration that genes with short repetitive sequences in their coding regions (10 adenines for TGF-β RII) are susceptible to inactivating frameshift mutations in MMR-deficient tumors. Other genes with short repetitive have been subsequently observed to also have mutations in MMR-deficient tumors.
-
(1995)
Science
, vol.268
, pp. 1336-1338
-
-
Markowitz, S.1
Wang, J.2
Myeroff, L.3
Parsons, R.4
Sun, L.Z.5
Lutterbaugh, J.6
Fan, R.S.7
Zborowska, E.8
Kinzler, K.W.9
Vogelstein, B.10
-
34
-
-
16144368515
-
Microsatellite instability in the insulin-like growth-factor-II receptor gene in gastrointestinal tumors
-
Souza RF, Appel R, Yin J, Wang SN, Smolinski KN, Abraham JM, Zou TT, Shi YQ, Lei JY, Cottrell J et al.: Microsatellite instability in the insulin-like growth-factor-II receptor gene in gastrointestinal tumors. Nat Genet 1996, 14:255-257.
-
(1996)
Nat Genet
, vol.14
, pp. 255-257
-
-
Souza, R.F.1
Appel, R.2
Yin, J.3
Wang, S.N.4
Smolinski, K.N.5
Abraham, J.M.6
Zou, T.T.7
Shi, Y.Q.8
Lei, J.Y.9
Cottrell, J.10
-
35
-
-
0031018674
-
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
-
Rampino N, Yamamoto H, lonov Y, Li Y, Sawai H, Reed JC, Perucho M: Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 1997, 275:967-969.
-
(1997)
Science
, vol.275
, pp. 967-969
-
-
Rampino, N.1
Yamamoto, H.2
Lonov, Y.3
Li, Y.4
Sawai, H.5
Reed, J.C.6
Perucho, M.7
-
36
-
-
0030057131
-
Loss of DNA mismatch repair: Life in the fast lane?
-
Shibata D: Loss of DNA mismatch repair: life in the fast lane? Gastroenterology 1996, 111:519-521.
-
(1996)
Gastroenterology
, vol.111
, pp. 519-521
-
-
Shibata, D.1
-
37
-
-
0028839466
-
Microsatellite instability in colorectal adenocarcinoma cell lines that have full length adenomatous polyposis coli protein
-
Heinen CD, Richardson D, White R, Groden J: Microsatellite instability in colorectal adenocarcinoma cell lines that have full length adenomatous polyposis coli protein. Cancer Res 1995, 55:4797-4799.
-
(1995)
Cancer Res
, vol.55
, pp. 4797-4799
-
-
Heinen, C.D.1
Richardson, D.2
White, R.3
Groden, J.4
-
38
-
-
0030054532
-
Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer
-
Konishi M, Kikuchiyanoshita R, Tanaka K, Muraoka M, Onda A, Okumura Y, Kishi N, Iwama T, Mori T, Koike M et al.: Molecular nature of colon tumors in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer. Gastroenterology 1996, 111:307-317. One of the few studies which document multiple mutations - APC, k-ras, p53, TGF-β RII, hMSH2, MLH1 - within the same group of colon cancers. The mutation spectrum was different between MSI+ and MSI- tumors, suggesting that these two types of tumors may utilize different mutational pathways for multistep tumorigenesis.
-
(1996)
Gastroenterology
, vol.111
, pp. 307-317
-
-
Konishi, M.1
Kikuchiyanoshita, R.2
Tanaka, K.3
Muraoka, M.4
Onda, A.5
Okumura, Y.6
Kishi, N.7
Iwama, T.8
Mori, T.9
Koike, M.10
-
39
-
-
0029267352
-
Immune surveillance in colorectal carcinoma
-
Branch P, Bicknell DC, Rowan A, Bodmer WF, Karran P, Borresen AL, Lothe RA, Meling GI, Lystad S, Morrison P et al.: Immune surveillance in colorectal carcinoma. Nat Genet 1995, 9:231-232.
-
(1995)
Nat Genet
, vol.9
, pp. 231-232
-
-
Branch, P.1
Bicknell, D.C.2
Rowan, A.3
Bodmer, W.F.4
Karran, P.5
Borresen, A.L.6
Lothe, R.A.7
Meling, G.I.8
Lystad, S.9
Morrison, P.10
-
40
-
-
0031004175
-
Genetic instability in colorectal cancers
-
Langauer C, Kinzler KW, Vogelstein B: Genetic instability in colorectal cancers. Nature 1997, 386:623-627. Chromosomal number exhibited significantly greater variations with time in MSI- cell lines but not in MSI+ cell lines. There may be two different types of genetic instability underlying colorectal carcinogenesis - one manifested by MSI and one by chromosomal instability. A single cell line exhibited both MSI and chromosomal instability, suggesting that instabilities are not mutually exclusive.
-
(1997)
Nature
, vol.386
, pp. 623-627
-
-
Langauer, C.1
Kinzler, K.W.2
Vogelstein, B.3
-
41
-
-
0030983076
-
DNA methylation and genetic instability in colorectal cancer cells
-
Lengauer C, Kinzler KW, Vogelstein B: DNA methylation and genetic instability in colorectal cancer cells. Proc Natl Acad Sci 1997, 94:2545-2550. Retroviral expression was extinguished in MMR-deficient but not in MMR-proficient colorectal cell lines. The lack of retroviral expression was associated with de novo methylation. This de novo methylation was not a specific property of the cell's MMR status as MMR correction by chromosomal transfer did not alter retrovirus methylation. The authors suggest that methylation is normal in MSI+ tumors and abnormal in MSI- tumors.
-
(1997)
Proc Natl Acad Sci
, vol.94
, pp. 2545-2550
-
-
Lengauer, C.1
Kinzler, K.W.2
Vogelstein, B.3
-
42
-
-
0028970197
-
The molecular basis of Turcots syndrome
-
Hamilton SR, Liu B, Parsons RE, Papadopoulos N, Jen J, Powell SM, Krush AJ, Berk T, Cohen Z, Tetu B et al.: The molecular basis of Turcots syndrome. N Engl J Med 1995, 332:839-847.
-
(1995)
N Engl J Med
, vol.332
, pp. 839-847
-
-
Hamilton, S.R.1
Liu, B.2
Parsons, R.E.3
Papadopoulos, N.4
Jen, J.5
Powell, S.M.6
Krush, A.J.7
Berk, T.8
Cohen, Z.9
Tetu, B.10
-
43
-
-
0028215979
-
Microsatellite instability in Muir-Torre syndrome
-
Honchel R, Hailing KC, Schaid DJ, Pittelkow M, Thibodeau SN: Microsatellite instability in Muir-Torre syndrome. Cancer Res 1994, 54:1159-1163.
-
(1994)
Cancer Res
, vol.54
, pp. 1159-1163
-
-
Honchel, R.1
Hailing, K.C.2
Schaid, D.J.3
Pittelkow, M.4
Thibodeau, S.N.5
-
44
-
-
0029915034
-
Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch syndrome)
-
Lynch HT, Smyrk T, Lynch JF: Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch syndrome). Int J Canc 1996, 69:38-43. Recent review of the epidemeology, pathology and clinical features of HN-PCC. Highlights the changing management of HNPCC patients now that specific genetic tests are available.
-
(1996)
Int J Canc
, vol.69
, pp. 38-43
-
-
Lynch, H.T.1
Smyrk, T.2
Lynch, J.F.3
-
45
-
-
0028362325
-
Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation
-
Shibata D, Peinado MA, Ionov Y, Malkhosyan S, Perucho M: Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nat Genet 1994, 6:273-281.
-
(1994)
Nat Genet
, vol.6
, pp. 273-281
-
-
Shibata, D.1
Peinado, M.2
Ionov, Y.3
Malkhosyan, S.4
Perucho, M.A.5
-
46
-
-
0028152314
-
Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer
-
Hemminki A, Peltomaki P, Mecklin JP, Jarvinen H, Salovaara R, Nystrom L-M, De la-Chapelle A, Aaltonen LA: Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer. Nat Genet 1994, 8:405-410.
-
(1994)
Nat Genet
, vol.8
, pp. 405-410
-
-
Hemminki, A.1
Peltomaki, P.2
Mecklin, J.P.3
Jarvinen, H.4
Salovaara, R.5
Nystrom, L.-M.6
De La-Chapelle, A.7
Aaltonen, L.A.8
-
47
-
-
0031017268
-
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
-
Kane MF, Loda M, Gaida GM, Lipman J, Mishra R, Goldman H, Jessup JM, Kolodner R: Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 1997, 57:808-811.
-
(1997)
Cancer Res
, vol.57
, pp. 808-811
-
-
Kane, M.F.1
Loda, M.2
Gaida, G.M.3
Lipman, J.4
Mishra, R.5
Goldman, H.6
Jessup, J.M.7
Kolodner, R.8
-
48
-
-
0029862873
-
Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis
-
Vasen HF, Wijnen JT, Menko FH, Kleibeuker JH, Taal BG, Griffioen G, Nagengast FM, Meijers H-EH, Bertario L, Varesco L et al.: Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis. Gastroenterology 1996, 110:1020-1027.
-
(1996)
Gastroenterology
, vol.110
, pp. 1020-1027
-
-
Vasen, H.F.1
Wijnen, J.T.2
Menko, F.H.3
Kleibeuker, J.H.4
Taal, B.G.5
Griffioen, G.6
Nagengast, F.M.7
Meijers, H.-E.H.8
Bertario, L.9
Varesco, L.10
-
49
-
-
0028915223
-
Genetic instability occurs in the majority of young patients with colorectal cancer
-
Liu B, Farrington SM, Petersen GM, Hamilton SR, Parsons R, Papadopoulos N, Fujiwara T, Jen J, Kinzler KW, Wyllie AH et al.: Genetic instability occurs in the majority of young patients with colorectal cancer. Nat Med 1995, 1:348-352. Patients with MSI+ colorectal cancers but lacking histories consistent with HNPCC were screened for germline mutations in MMR genes. Germline mutations were rare but more common in patients under 35 years of age. These findings demonstrate that, with respect to known MMR genes, most sporadic MSI+ colorectal cancers are non-occult forms of HNPCC. They also illustrate examples of reduced penetrance for some germline mutations.
-
(1995)
Nat Med
, vol.1
, pp. 348-352
-
-
Liu, B.1
Farrington, S.M.2
Petersen, G.M.3
Hamilton, S.R.4
Parsons, R.5
Papadopoulos, N.6
Fujiwara, T.7
Jen, J.8
Kinzler, K.W.9
Wyllie, A.H.10
-
50
-
-
0028859671
-
Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
-
Liu B, Nicolaides NC, Markowitz S, Willson JKV, Parsons RE, Jen J, Papadopolous N, Peltomaki P, De la-Chapelle A, Hamilton SR et al.: Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat Genet 1995, 9:48-55. Sporadic MSI+ cell lines with primary tumors were screened for mutations in MMR genes. MSI was associated with inactivation of both copies of an MMR gene and somatic mutations in MMR genes associated with HNPCC could not be found in most sporadic MSI+ tumors. These findings illustrate that MSI may result from mechanisms other than somatic mutation in known MMR genes.
-
(1995)
Nat Genet
, vol.9
, pp. 48-55
-
-
Liu, B.1
Nicolaides, N.C.2
Markowitz, S.3
Willson, J.K.V.4
Parsons, R.E.5
Jen, J.6
Papadopolous, N.7
Peltomaki, P.8
De La-Chapelle, A.9
Hamilton, S.R.10
-
51
-
-
2942569549
-
Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients
-
Liu B, Parsons R, Papadopoulos N, Nicolaides NC, Lynch HT, Watson P, Jass JR, Dunlop M, Wyllie A, Peltomaki P et al.: Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med 1996, 2:169-174. A large number of HNPC patients were screened for germline mutations in MMR genes. Germline mutations could be found in 70% of the HNPCC patients, most frequently in hMS2 and hMLH1. This study illustrates the ability to screen for germline mutations in HNPCC and some of the difficulties in mutation identification.
-
(1996)
Nat Med
, vol.2
, pp. 169-174
-
-
Liu, B.1
Parsons, R.2
Papadopoulos, N.3
Nicolaides, N.C.4
Lynch, H.T.5
Watson, P.6
Jass, J.R.7
Dunlop, M.8
Wyllie, A.9
Peltomaki, P.10
-
52
-
-
0028859670
-
Polymerase delta variants in RER colorectal tumours
-
Da Costa LT, Liu B, El Deiry W, Hamilton SR, Kinzler KW, Vogelstein B, Markowitz S, Willson JK, De la-Chapelle A, Downey KM et al.: Polymerase delta variants in RER colorectal tumours. Nat Genet 1995, 9:10-11. First demonstration of mutations in DNA polymerase δ in tumors with MSI. Such 'mutator' polymerases, however, appear to be rare in MSI+ tumors.
-
(1995)
Nat Genet
, vol.9
, pp. 10-11
-
-
Da Costa, L.T.1
Liu, B.2
El Deiry, W.3
Hamilton, S.R.4
Kinzler, K.W.5
Vogelstein, B.6
Markowitz, S.7
Willson, J.K.8
De La-Chapelle, A.9
Downey, K.M.10
-
53
-
-
0029069972
-
Mutations of GTBP in genetically unstable cells
-
Papadopoulos N, Nicolaides NC, Liu B, Parsons R, Lengauer C, Palombo F, Darrigo A, Markowitz S, Willson JK, Kinzler KW et al.: Mutations of GTBP in genetically unstable cells. Science 1995, 268:1915-1917.
-
(1995)
Science
, vol.268
, pp. 1915-1917
-
-
Papadopoulos, N.1
Nicolaides, N.C.2
Liu, B.3
Parsons, R.4
Lengauer, C.5
Palombo, F.6
Darrigo, A.7
Markowitz, S.8
Willson, J.K.9
Kinzler, K.W.10
-
54
-
-
0028844574
-
Differential cellular expression of the human MSH2 repair enzyme in small and large intestine
-
Wilson TM, Ewel A, Duguid JR, Eble JN, Lescoe MK, Fishel R, Kelley MR: Differential cellular expression of the human MSH2 repair enzyme in small and large intestine. Cancer Res 1995, 55:5146-5150.
-
(1995)
Cancer Res
, vol.55
, pp. 5146-5150
-
-
Wilson, T.M.1
Ewel, A.2
Duguid, J.R.3
Eble, J.N.4
Lescoe, M.K.5
Fishel, R.6
Kelley, M.R.7
-
55
-
-
10344228783
-
Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes
-
Thibodeau SN, French AJ, Roche PC, Cunningham JM, Tester DJ, Lindor NM, Moslein G, Baker SM, Liskay RM, Burgart LJ et al.: Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes. Cancer Res 1996, 56:4836-4840.
-
(1996)
Cancer Res
, vol.56
, pp. 4836-4840
-
-
Thibodeau, S.N.1
French, A.J.2
Roche, P.C.3
Cunningham, J.M.4
Tester, D.J.5
Lindor, N.M.6
Moslein, G.7
Baker, S.M.8
Liskay, R.M.9
Burgart, L.J.10
-
56
-
-
9044245700
-
Expression of the human mismatch repair gene hMSH2 in normal and neoplastic tissues
-
Leach FS, Polyak K, Burrell M, Johnson KA, Hill D, Dunlop MG, Wyllie AH, Peltomaki P, De la-Chapelle A, Hamilton SR et al.: Expression of the human mismatch repair gene hMSH2 in normal and neoplastic tissues. Cancer Res 1996, 56:235-240.
-
(1996)
Cancer Res
, vol.56
, pp. 235-240
-
-
Leach, F.S.1
Polyak, K.2
Burrell, M.3
Johnson, K.A.4
Hill, D.5
Dunlop, M.G.6
Wyllie, A.H.7
Peltomaki, P.8
De La-Chapelle, A.9
Hamilton, S.R.10
-
57
-
-
0028226295
-
Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients
-
Aaltonen LA, Peltomaki P, Mecklin JP, Jarvinen H, Jass JR, Green JS, Lynch HT, Watson P, Tallqvist G, Juhola M et al.: Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. Cancer Res 1994, 54:1645-1648.
-
(1994)
Cancer Res
, vol.54
, pp. 1645-1648
-
-
Aaltonen, L.A.1
Peltomaki, P.2
Mecklin, J.P.3
Jarvinen, H.4
Jass, J.R.5
Green, J.S.6
Lynch, H.T.7
Watson, P.8
Tallqvist, G.9
Juhola, M.10
-
58
-
-
0028276666
-
Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences
-
Kim HG, Jen J, Vogelstein B, Hamilton SR: Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 1994, 145:148-156.
-
(1994)
Am J Pathol
, vol.145
, pp. 148-156
-
-
Kim, H.G.1
Jen, J.2
Vogelstein, B.3
Hamilton, S.R.4
-
59
-
-
0030465095
-
Microsatellite instability is associated with the histological features of the tumor in nonfamilial colorectal cancer
-
Risio M, Reato G, Dicelle PF, Fizzotti M, Rossini FP, Foa R: Microsatellite instability is associated with the histological features of the tumor in nonfamilial colorectal cancer. Cancer Res 1996, 56:5470-5474.
-
(1996)
Cancer Res
, vol.56
, pp. 5470-5474
-
-
Risio, M.1
Reato, G.2
Dicelle, P.F.3
Fizzotti, M.4
Rossini, F.P.5
Foa, R.6
-
60
-
-
0027136828
-
Genomic instability in colorectal cancer: Relationship to clinicopathological variables and family history
-
Lothe RA, Peltomaki P, Meling GI, Aaltonen LA, Nystrom L-M, Pylkkanen L, Heimdal K, Andersen TI, Müller P, Rognum TO et al.: Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res 1993, 53:5849-5852.
-
(1993)
Cancer Res
, vol.53
, pp. 5849-5852
-
-
Lothe, R.A.1
Peltomaki, P.2
Meling, G.I.3
Aaltonen, L.A.4
Nystrom, L.-M.5
Pylkkanen, L.6
Heimdal, K.7
Andersen, T.I.8
Müller, P.9
Rognum, T.O.10
-
61
-
-
0028867561
-
Microsatellite instability in human colonic cancer is not a useful clinical indicator of familial colorectal cancer
-
Samowitz WS, Slattery ML, Kerber RA: Microsatellite instability in human colonic cancer is not a useful clinical indicator of familial colorectal cancer. Gastroenterology 1995, 109:1765-1771.
-
(1995)
Gastroenterology
, vol.109
, pp. 1765-1771
-
-
Samowitz, W.S.1
Slattery, M.L.2
Kerber, R.A.3
-
62
-
-
0028845722
-
Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas
-
Borresen AL, Lothe RA, Meling GI, Lystad S, Morrison P, Lipford J, Kane MF, Rognum TO, Kolodner RD: Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas. Hum Mol Genet 1995, 4:2065-2072. Sporadic MSI+ tumors were screened for somatic mutations in hMSH2. A relatively high proportion (26%) were found to have somatic mutations, suggesting that the MSI present in many sporadic tumors may be caused by somatic mutations in known MMR genes.
-
(1995)
Hum Mol Genet
, vol.4
, pp. 2065-2072
-
-
Borresen, A.L.1
Lothe, R.A.2
Meling, G.I.3
Lystad, S.4
Morrison, P.5
Lipford, J.6
Kane, M.F.7
Rognum, T.O.8
Kolodner, R.D.9
-
63
-
-
0029783835
-
Mutation of Msh3 in endometrial cancer and evidence for its functional role in heteroduplex repair
-
Risinger JI, Umar A, Boyd J, Berchuck A, Kunkel TA, Barrett JC: Mutation of Msh3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Nat Genet 1996, 14:102-105. Observation that, unlike HNPCC, endometrial cancers can have hMSH3 and hMSH6 mutations.
-
(1996)
Nat Genet
, vol.14
, pp. 102-105
-
-
Risinger, J.I.1
Umar, A.2
Boyd, J.3
Berchuck, A.4
Kunkel, T.A.5
Barrett, J.C.6
-
64
-
-
0028883556
-
Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas
-
Katabuchi H, Van Rees B, Lambers AR, Ronnett BM, Blazes MS, Leach FS, Cho KR, Hedrick L: Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas. Cancer Res 1995, 55:5556-5560.
-
(1995)
Cancer Res
, vol.55
, pp. 5556-5560
-
-
Katabuchi, H.1
Van Rees, B.2
Lambers, A.R.3
Ronnett, B.M.4
Blazes, M.S.5
Leach, F.S.6
Cho, K.R.7
Hedrick, L.8
-
65
-
-
0030005834
-
Mutational analysis of mismatch repair genes, hMLH1 and hMSH2, in sporadic endometrial carcinomas with microsatellite instability
-
Kobayashi K, Matsushima M, Koi S, Saito H, Sagae S, Kudo R, Nakamura Y: Mutational analysis of mismatch repair genes, hMLH1 and hMSH2, in sporadic endometrial carcinomas with microsatellite instability. Jpn J Cancer Res 1996, 87:141-145.
-
(1996)
Jpn J Cancer Res
, vol.87
, pp. 141-145
-
-
Kobayashi, K.1
Matsushima, M.2
Koi, S.3
Saito, H.4
Sagae, S.5
Kudo, R.6
Nakamura, Y.7
-
66
-
-
0029078288
-
Genetic instability associated with adenoma to carcinoma progression in hereditary nonpolyposis colon cancer
-
Jacoby RF, Marshall DJ, Kailas S, Schlack S, Harms B, Love R: Genetic instability associated with adenoma to carcinoma progression in hereditary nonpolyposis colon cancer. Gastroenterology 1995, 109:73-82.
-
(1995)
Gastroenterology
, vol.109
, pp. 73-82
-
-
Jacoby, R.F.1
Marshall, D.J.2
Kailas, S.3
Schlack, S.4
Harms, B.5
Love, R.6
-
67
-
-
0030466920
-
Microsatellite instability in aberrant crypt foci from human colons
-
Heinen CD, Shivapurkar N, Tang ZC, Gorden J, Alabaster O: Microsatellite instability in aberrant crypt foci from human colons. Cancer Res 1996, 56:5339-5341. MSI was detected in a small proportion of aberrant crypt foci; this finding supports the early loss of MMR in MSI+ tumors and suggests that such aberrant foci my be morphological precursors to MSI+ adenomas or carcinomas.
-
(1996)
Cancer Res
, vol.56
, pp. 5339-5341
-
-
Heinen, C.D.1
Shivapurkar, N.2
Tang, Z.C.3
Gorden, J.4
Alabaster, O.5
-
68
-
-
0029937720
-
Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis
-
Brentnall TA, Crispin DA, Bronner MP, Cherian SP, Hueffed M, Rabinovitch PS, Rubin CE, Haggitt RC, Boland CR: Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis. Cancer Res 1996, 56:1237-1240. Somatic MSI was found in the the normal and dysplastic mucosa of patients with ulcerative colitis. If replicated, this finding suggests that clonal expansions can occur with non-neoplastic cells and that DNA MMR can be overwhelmed in certain physiological conditions.
-
(1996)
Cancer Res
, vol.56
, pp. 1237-1240
-
-
Brentnall, T.A.1
Crispin, D.A.2
Bronner, M.P.3
Cherian, S.P.4
Hueffed, M.5
Rabinovitch, P.S.6
Rubin, C.E.7
Haggitt, R.C.8
Boland, C.R.9
-
69
-
-
0029051552
-
A germline substitution in the human MSH2 gene is associated with high-grade dysplasia and cancer in ulcerative colitis
-
Brentnall TA, Rubin CE, Crispin DA, Stevens A, Batchelor RH, Haggitt RC, Bronner MP, Evans JP, McCahill LE, Bilir N et al.: A germline substitution in the human MSH2 gene is associated with high-grade dysplasia and cancer in ulcerative colitis. Gastroenterology 1995, 109:151-155.
-
(1995)
Gastroenterology
, vol.109
, pp. 151-155
-
-
Brentnall, T.A.1
Rubin, C.E.2
Crispin, D.A.3
Stevens, A.4
Batchelor, R.H.5
Haggitt, R.C.6
Bronner, M.P.7
Evans, J.P.8
McCahill, L.E.9
Bilir, N.10
-
70
-
-
0030061148
-
Better survival rates in patients with MLH1-associated hereditary colorectal cancer
-
Sankila R, Aaltonen LA, Jarvinen HJ, Mecklin JP: Better survival rates in patients with MLH1-associated hereditary colorectal cancer. Gastroenterology 1996, 110:682-687.
-
(1996)
Gastroenterology
, vol.110
, pp. 682-687
-
-
Sankila, R.1
Aaltonen, L.A.2
Jarvinen, H.J.3
Mecklin, J.P.4
-
71
-
-
0029665878
-
Human MutSa recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine or the cisplatin-d(GpG) adduct
-
Duckett DR, Drummond JT, Murchie AIH, Reardon JT, Sancar A, Lilley DMJ, Modrich P: Human MutSa recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine or the cisplatin-d(GpG) adduct Proc Natl Acad Sci USA 1996, 93:6443-6447.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 6443-6447
-
-
Duckett, D.R.1
Drummond, J.T.2
Murchie, A.I.H.3
Reardon, J.T.4
Sancar, A.5
Lilley, D.M.J.6
Modrich, P.7
-
72
-
-
0030015770
-
Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N′-nitro-N-nitrosoguanidine
-
Carethers JM, Hawn MT, Chauhan DP, Luce MC, Marra G, Koi M, Boland CR: Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N′-nitro-N-nitrosoguanidine. J Clin Invest 1996, 98:199-206.
-
(1996)
J Clin Invest
, vol.98
, pp. 199-206
-
-
Carethers, J.M.1
Hawn, M.T.2
Chauhan, D.P.3
Luce, M.C.4
Marra, G.5
Koi, M.6
Boland, C.R.7
-
73
-
-
0029812676
-
Cisplatin and adriamycin resistance are associated with MutLa and mismatch repair deficiency in an ovarian tumor cell line
-
Drummond JT, Anthoney A, Brown R, Modrich P: Cisplatin and adriamycin resistance are associated with MutLa and mismatch repair deficiency in an ovarian tumor cell line. J Biol Chem 1996, 271:19645-19648.
-
(1996)
J Biol Chem
, vol.271
, pp. 19645-19648
-
-
Drummond, J.T.1
Anthoney, A.2
Brown, R.3
Modrich, P.4
-
74
-
-
8944230189
-
Loss of DNA mismatch repair in acquired resistance to cisplatin
-
Aebi S, Kurdi H-B, Gordon R, Cenni B, Zheng H, Fink D, Christen RD, Boland CR, Koi M, Fishel R et al.: Loss of DNA mismatch repair in acquired resistance to cisplatin. Cancer Res 1996, 56:3087-3090.
-
(1996)
Cancer Res
, vol.56
, pp. 3087-3090
-
-
Aebi, S.1
Kurdi, H.-B.2
Gordon, R.3
Cenni, B.4
Zheng, H.5
Fink, D.6
Christen, R.D.7
Boland, C.R.8
Koi, M.9
Fishel, R.10
-
75
-
-
0029061638
-
Mismatch repair deficiency in phenotypically normal human cells
-
Parsons R, Li GM, Longley M, Modrich P, Liu B, Berk T, Hamilton SR, Kinzler KW, Vogelstein B: Mismatch repair deficiency in phenotypically normal human cells. Science 1995, 268:738-740. Although the normal tissues of most HNPCC individuals are repair-proficient and lack evidence of elevated mutation rates, this was not the case with two specific HNPCC individuals. A high level of somatic MS mutations were observed in normal tissues and in cell lines from these two rare examples; however, they did not have markedly elevated frequencies or earlier onsets of tumorigenesis compared to the majority of HNPCC individuals with repair-proficient normal tissues. This is a provocative observation which suggests that a general increase in mutation rates alone is insufficient to initiate tumorigenesis.
-
(1995)
Science
, vol.268
, pp. 738-740
-
-
Parsons, R.1
Li, G.M.2
Longley, M.3
Modrich, P.4
Liu, B.5
Berk, T.6
Hamilton, S.R.7
Kinzler, K.W.8
Vogelstein, B.9
-
76
-
-
0029887819
-
Transcription-coupled repair deficiency and mutations in human mismatch repair genes
-
Mellon I, Rajpal DK, Koi M, Boland CR, Champe GN: Transcription-coupled repair deficiency and mutations in human mismatch repair genes. Science 1996, 272:557-560.
-
(1996)
Science
, vol.272
, pp. 557-560
-
-
Mellon, I.1
Rajpal, D.K.2
Koi, M.3
Boland, C.R.4
Champe, G.N.5
-
77
-
-
0029101616
-
Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer
-
De Wind N, Dekker M, Berns A, Radman M, Te Riele H: Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell 1995, 82:321-330.
-
(1995)
Cell
, vol.82
, pp. 321-330
-
-
De Wind, N.1
Dekker, M.2
Berns, A.3
Radman, M.4
Te Riele, H.5
-
78
-
-
0029111463
-
MSH2 deficient mice are viable and susceptible to lymphoid tumours
-
Reitmair AH, Schmits R, Ewel A, Bapat B, Redston M, Mitri A, Waterhouse P, Mittrucker HW, Wakeham A, Liu B et al.: MSH2 deficient mice are viable and susceptible to lymphoid tumours. Nat Genet 1995, 11:64-70.
-
(1995)
Nat Genet
, vol.11
, pp. 64-70
-
-
Reitmair, A.H.1
Schmits, R.2
Ewel, A.3
Bapat, B.4
Redston, M.5
Mitri, A.6
Waterhouse, P.7
Mittrucker, H.W.8
Wakeham, A.9
Liu, B.10
-
79
-
-
8944232867
-
Involvement of mouse MIh1 in DNA mismatch repair and meiotic crossing over
-
-/- males is reduced 10-100 fold.
-
(1996)
Nat Genet
, vol.13
, pp. 336-342
-
-
Baker, S.M.1
Plug, A.W.2
Prolla, T.A.3
Bronner, C.E.4
Harris, A.C.5
Yao, X.6
Christie, D.M.7
Monell, C.8
Arnheim, N.9
Bradley, A.10
-
80
-
-
15844367099
-
Meiotic pachytene arrest in MLH1-deficient mice
-
Edelmann W, Cohen PE, Kane M, Lau K, Morrow B, Bennett S, Umar A, Kunkel T, Cattoretti G, Chaganti R et al.: Meiotic pachytene arrest in MLH1-deficient mice. Cell 1996, 85:1125-1134. An observation of the same sterility phenotype as [79••]. The authors report that in vitro fertilized oocytes recovered from superovulated Mini-'- females never completed meiosis II or developed to 4-8 cell stage compared to wildtype females.
-
(1996)
Cell
, vol.85
, pp. 1125-1134
-
-
Edelmann, W.1
Cohen, P.E.2
Kane, M.3
Lau, K.4
Morrow, B.5
Bennett, S.6
Umar, A.7
Kunkel, T.8
Cattoretti, G.9
Chaganti, R.10
-
81
-
-
0029099989
-
Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis
-
Baker SM, Bronner CE, Zhang L, Plug AW, Robatzek M, Warren G, Elliott EA, Yu J, Ashley T, Arnheim N et al.: Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell 1995, 82:309-319. First demonstration that an MMR protein is involved in chromosome synapsis. The authors report unusual associations of the XY body with chromosome aberrations.
-
(1995)
Cell
, vol.82
, pp. 309-319
-
-
Baker, S.M.1
Bronner, C.E.2
Zhang, L.3
Plug, A.W.4
Robatzek, M.5
Warren, G.6
Elliott, E.A.7
Yu, J.8
Ashley, T.9
Arnheim, N.10
-
82
-
-
9444271133
-
Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice
-
Reitmair AH, Redston M, Cai JC, Chuang TC, Bjerknes M, Cheng H, Hay K, Gallinger S, Bapat B, Mak TW: Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice. Cancer Res 1996, 56:3842-3849.
-
(1996)
Cancer Res
, vol.56
, pp. 3842-3849
-
-
Reitmair, A.H.1
Redston, M.2
Cai, J.C.3
Chuang, T.C.4
Bjerknes, M.5
Cheng, H.6
Hay, K.7
Gallinger, S.8
Bapat, B.9
Mak, T.W.10
-
83
-
-
0024469392
-
The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants
-
Rayssiguier C, Thaler DS, Radman M: The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants. Nature 1989, 342:396-401.
-
(1989)
Nature
, vol.342
, pp. 396-401
-
-
Rayssiguier, C.1
Thaler, D.S.2
Radman, M.3
-
84
-
-
0029860724
-
High mutation frequencies among Escherichia coli and Salmonella pathogens
-
Leclerc JE, Li BG, Payne WL, Cebula TA: High mutation frequencies among Escherichia coli and Salmonella pathogens. Science 1996, 274:1208-1211.
-
(1996)
Science
, vol.274
, pp. 1208-1211
-
-
Leclerc, J.E.1
Li, B.G.2
Payne, W.L.3
Cebula, T.A.4
-
85
-
-
0343002304
-
The mismatch repair system reduces meiotic homeologous recombination and stimulates recombination-dependent chromosome loss
-
Chambers SR, Hunter N, Louis EJ, Borts RH: The mismatch repair system reduces meiotic homeologous recombination and stimulates recombination-dependent chromosome loss. Mutation Res DNAging Genet Instab Aging 1996, 316:249-259.
-
(1996)
Mutation Res DNAging Genet Instab Aging
, vol.316
, pp. 249-259
-
-
Chambers, S.R.1
Hunter, N.2
Louis, E.J.3
Borts, R.H.4
-
86
-
-
0030051527
-
Mitotic crossovers between diverged sequences are regulated by mismatch repair proteins in Saccaromyces cerevisiae
-
Datta A, Adjiri A, New L, Crouse GF, Jinks R-S: Mitotic crossovers between diverged sequences are regulated by mismatch repair proteins in Saccaromyces cerevisiae. Mol Cell Biol 1996, 16:1085-1093.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 1085-1093
-
-
Datta, A.1
Adjiri, A.2
New, L.3
Crouse, G.F.4
Jinks, R.-S.5
-
87
-
-
0029802538
-
The mismatch repair system contributes to meiotic sterility in an interspecific yeast hybrid
-
Hunter N, Chambers SR, Louis EJ, Borts RH: The mismatch repair system contributes to meiotic sterility in an interspecific yeast hybrid. Mol Cell Biol 1996, 16:6110-6120.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 6110-6120
-
-
Hunter, N.1
Chambers, S.R.2
Louis, E.J.3
Borts, R.H.4
-
88
-
-
0028918202
-
Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces cerevisiae
-
Selva EM, New L, Crouse GF, Lahue RS: Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces cerevisiae. Genetics 1995, 139:1175-1188.
-
(1995)
Genetics
, vol.139
, pp. 1175-1188
-
-
Selva, E.M.1
New, L.2
Crouse, G.F.3
Lahue, R.S.4
-
89
-
-
0029930699
-
Extrachromosomal recombination occurs efficiently in cells defective in various DNA repair systems
-
Morrison C, Wagner E: Extrachromosomal recombination occurs efficiently in cells defective in various DNA repair systems. Nucleic Acids Res 1996, 24:2053-2058.
-
(1996)
Nucleic Acids Res
, vol.24
, pp. 2053-2058
-
-
Morrison, C.1
Wagner, E.2
-
90
-
-
0027988576
-
DNA loop repair by human cell extracts
-
Umar A, Boyer JC, Kunkel TA: DNA loop repair by human cell extracts. Science 1994, 266:814-816.
-
(1994)
Science
, vol.266
, pp. 814-816
-
-
Umar, A.1
Boyer, J.C.2
Kunkel, T.A.3
-
91
-
-
0029994532
-
Somatic microsatellite mutations as molecular tumor clocks
-
Shibata D, Navidi W, Salovaara R, Li ZH, Aaltonen LA: Somatic microsatellite mutations as molecular tumor clocks. Nat Med 1996, 2:676-681. Introduces the concept of MS loci as molecular tumor 'clocks' in cancers with MSI. Microdissection of MMR-deficient human tumors reveal high genetic diversity (many different sized MS alleles) present in even small 200-400 cell tumor regions. This genetic diversity is related to tumor age using a phylogenetic approach, providing objective evidence of the likely number of divisions since clonal expansion. Thus type of phylogenetic application, similar to its use in many other biological problems, may reveal patterns of tumor evolution.
-
(1996)
Nat Med
, vol.2
, pp. 676-681
-
-
Shibata, D.1
Navidi, W.2
Salovaara, R.3
Li, Z.H.4
Aaltonen, L.A.5
-
92
-
-
8944262831
-
MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis
-
+/- mice.
-
(1996)
Cancer Res
, vol.56
, pp. 2922-2926
-
-
Reitmair, A.H.1
Cai, J.C.2
Bjerknes, M.3
Redston, M.4
Cheng, H.5
Pind, M.T.6
Hay, K.7
Mitri, A.8
Bapat, B.V.9
Mak, T.W.10
|