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1
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0029397307
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The p53 gene and its role in human brain tumors
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Bögler O, Huang HJS, Kleihues P, Cavenee WK: The p53 gene and its role in human brain tumors. Glia 1995, 15:308-327. A review article providing comprehensive information on the role of p53 alterations in human brain tumors as well as its biochemical and physiological functions.
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(1995)
Glia
, vol.15
, pp. 308-327
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Bögler, O.1
Huang, H.J.S.2
Kleihues, P.3
Cavenee, W.K.4
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2
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0029913730
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MDM-2 Inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
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Chen J, Wu X, Lin J, Levine AJ: MDM-2 Inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol Cell Biol 1996, 16:2445-2452. An investigation that reveals the ability of the N-terminal domain of MDM-2 to abrogate both p53-mediated cell cycle arrest and apoptosis.
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(1996)
Mol Cell Biol
, vol.16
, pp. 2445-2452
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Chen, J.1
Wu, X.2
Lin, J.3
Levine, A.J.4
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3
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0028220204
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p53-Dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
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Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, Elledge SJ, Reed SI: p53-Dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 1994, 76:1013-1023.
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(1994)
Cell
, vol.76
, pp. 1013-1023
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Dulic, V.1
Kaufmann, W.K.2
Wilson, S.J.3
Tlsty, T.D.4
Lees, E.5
Harper, J.W.6
Elledge, S.J.7
Reed, S.I.8
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4
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0028852067
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Multiple polymorphisms, but no mutations in the WAF1/CIP1 gene in human brain tumours
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Koopmann J, Maintz D, Schild S, Schramm J, Louis DN, Wiestler OD, von Deimling A: Multiple polymorphisms, but no mutations in the WAF1/CIP1 gene in human brain tumours. Br J Cancer 1995, 72:1230-1233. A genetic analysis of P21 gene alterations in 158 human brain tumors.
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(1995)
Br J Cancer
, vol.72
, pp. 1230-1233
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Koopmann, J.1
Maintz, D.2
Schild, S.3
Schramm, J.4
Louis, D.N.5
Wiestler, O.D.6
Von Deimling, A.7
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5
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0028973586
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Increased levels of p21WAF1/Cip1 in human brain tumors
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Jung JM, Bruner JM, Ruan S, Langford LA, Kyritsis AP, Kobayashi T, Levin VA, Zhang W: Increased levels of p21WAF1/Cip1 in human brain tumors. Oncogene 1995, 11:2021-2028. A study demonstrating no p21 gene deletion and rather increased p21 expression levels in human gliomas.
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(1995)
Oncogene
, vol.11
, pp. 2021-2028
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Jung, J.M.1
Bruner, J.M.2
Ruan, S.3
Langford, L.A.4
Kyritsis, A.P.5
Kobayashi, T.6
Levin, V.A.7
Zhang, W.8
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6
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0028928886
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Analysis of the NF2 tumor-suppressor gene and of chromosome 22 deletions in gliomas
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Hoang-Xuan K, Merel P, Vega F, Hugot JP, Cornu P, Delattre JY, Poisson M, Thomas G, Delattre O: Analysis of the NF2 tumor-suppressor gene and of chromosome 22 deletions in gliomas. Int J Cancer 1995, 60:478-481.
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(1995)
Int J Cancer
, vol.60
, pp. 478-481
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Hoang-Xuan, K.1
Merel, P.2
Vega, F.3
Hugot, J.P.4
Cornu, P.5
Delattre, J.Y.6
Poisson, M.7
Thomas, G.8
Delattre, O.9
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7
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0029993450
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Role of the INK4a locus in tumor suppression and cell mortality
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Serrano M, Lee H, Chin L, Cordon CC, Beach D, DePinho RA: Role of the INK4a locus in tumor suppression and cell mortality. Cell 1996, 85:27-37. A study showing that p16 and p19 knockout mice develop spontaneous tumors at an early age and are susceptible to carcinogens, providing direct evidence that p16 functions to suppress neoplastic growth.
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(1996)
Cell
, vol.85
, pp. 27-37
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Serrano, M.1
Lee, H.2
Chin, L.3
Cordon, C.C.4
Beach, D.5
DePinho, R.A.6
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8
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0028929988
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Replacement of the p16/CDKN2 gene suppresses human glioma cell growth
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Arap W, Nishikawa R, Furnari FB, Cavenee WK, Huang HJS: Replacement of the p16/CDKN2 gene suppresses human glioma cell growth. Cancer Res 1995, 55:1351-1354.
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(1995)
Cancer Res
, vol.55
, pp. 1351-1354
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Arap, W.1
Nishikawa, R.2
Furnari, F.B.3
Cavenee, W.K.4
Huang, H.J.S.5
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9
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0030033729
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Adenovirus-mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells
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Fueyo J, Gomez-Manzano C, Yung WK, Clayman GL, Liu TJ, Bruner J, Levin VA, Kyritsis AP: Adenovirus-mediated p16/CDKN2 gene transfer induces growth arrest and modifies the transformed phenotype of glioma cells. Oncogene 1996, 12:103-110.
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(1996)
Oncogene
, vol.12
, pp. 103-110
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Fueyo, J.1
Gomez-Manzano, C.2
Yung, W.K.3
Clayman, G.L.4
Liu, T.J.5
Bruner, J.6
Levin, V.A.7
Kyritsis, A.P.8
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10
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0030070484
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CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated
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Ueki K, Ono Y, Henson JW, Efird JT, von Deimling A, Louis DN: CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res 1996, 56:150-153. A genetic investigation of 55 astrocytic gliomas demonstrating that the majority of glioblastomas have alterations of either p16 or Rb, both leading to inactivation of the p16-CDK4-Rb cell cycle regulatory pathway.
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(1996)
Cancer Res
, vol.56
, pp. 150-153
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Ueki, K.1
Ono, Y.2
Henson, J.W.3
Efird, J.T.4
Von Deimling, A.5
Louis, D.N.6
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11
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0029884472
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Infrequent alterations of the p15, p16, CDK4 and cyclin D1 genes in non-astrocytic human brain tumors
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Sato K, Schauble B, Kleihues P, Ohgaki H: Infrequent alterations of the p15, p16, CDK4 and cyclin D1 genes in non-astrocytic human brain tumors. Int J Cancer 1996, 66:305-308. A genetic analysis demonstrating that alterations of the p 15, p16, CDK4, and cyclin D1 genes were rare in 69 nonastrocytic human brain tumors in contrast to those in astrocytic tumors.
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(1996)
Int J Cancer
, vol.66
, pp. 305-308
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Sato, K.1
Schauble, B.2
Kleihues, P.3
Ohgaki, H.4
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12
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0029736653
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Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene
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Ichimura K, Schmidt EE, Goike HM, Collins VP: Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene. Oncogene 1996, 13:1065-1072.
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(1996)
Oncogene
, vol.13
, pp. 1065-1072
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Ichimura, K.1
Schmidt, E.E.2
Goike, H.M.3
Collins, V.P.4
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13
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0028986612
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Loss of P16INK4 expression is frequent in high grade gliomas
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Nishikawa R, Furnari FB, Lin H, Arap W, Berger MS, Cavenee WK, Huang HJS: Loss of P16INK4 expression is frequent in high grade gliomas. Cancer Res 1995, 55:1941-1945.
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(1995)
Cancer Res
, vol.55
, pp. 1941-1945
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Nishikawa, R.1
Furnari, F.B.2
Lin, H.3
Arap, W.4
Berger, M.S.5
Cavenee, W.K.6
Huang, H.J.S.7
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14
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0029967152
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Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation
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Costello JF, Berger MS, Huang HJS, Cavenee WK: Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Res 1996, 56:2405-2410. A study demonstrating hypermethylation of the CpG island in the 5' region of the p16 gene, which causes structural changes of chromatin as an alternative mechanism for p16 inactivation.
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(1996)
Cancer Res
, vol.56
, pp. 2405-2410
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Costello, J.F.1
Berger, M.S.2
Huang, H.J.S.3
Cavenee, W.K.4
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15
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0030046322
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Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B
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Herman JG, Jen J, Merlo A, Baylin SB: Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res 1996, 56:722-727. An investigation showing that inactivation of the p15 gene is commonly associated with hypermethylation of the 5'-CpG island in its promoter region in human gliomas.
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(1996)
Cancer Res
, vol.56
, pp. 722-727
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Herman, J.G.1
Jen, J.2
Merlo, A.3
Baylin, S.B.4
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16
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0028072991
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Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
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Herman JG, Latif F, Weng Y, Lerman MI, Zbar B, Liu S, Samid D, Duan DS, Gnarra JR, Linehan WM, Baylin SB: Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci U S A 1994, 91:9700-9704.
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(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 9700-9704
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Herman, J.G.1
Latif, F.2
Weng, Y.3
Lerman, M.I.4
Zbar, B.5
Liu, S.6
Samid, D.7
Duan, D.S.8
Gnarra, J.R.9
Linehan, W.M.10
Baylin, S.B.11
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17
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0029011539
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5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
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Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D: 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1995, 1:686-692.
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(1995)
Nat Med
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, pp. 686-692
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Merlo, A.1
Herman, J.G.2
Mao, L.3
Lee, D.J.4
Gabrielson, E.5
Burger, P.C.6
Baylin, S.B.7
Sidransky, D.8
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18
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0029902618
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The BAX gene maps to the glioma candidate region at 19q13.3, but is not altered in human gliomas
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Chou D, Miyashita T, Mohrenweiser HW, Ueki K, Kastury K, Druck T, von Deimling A, Huebner K, Reed JC, Louis DN: The BAX gene maps to the glioma candidate region at 19q13.3, but is not altered in human gliomas. Cancer Genet Cytogenet 1996, 88:136-140. A study in which alterations of the death promoter bax gene were not detected in 20 gliomas with LOH in chromosome 19q, although by somatic cell hybridization and cosmid mapping it maps to chromosome 19q13.3, where a candidate glioma suppressor gene resides.
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(1996)
Cancer Genet Cytogenet
, vol.88
, pp. 136-140
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Chou, D.1
Miyashita, T.2
Mohrenweiser, H.W.3
Ueki, K.4
Kastury, K.5
Druck, T.6
Von Deimling, A.7
Huebner, K.8
Reed, J.C.9
Louis, D.N.10
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19
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0029024891
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Chromosome 10 deletion mapping in human gliomas: A common deletion region in 10q25
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Rasheed BK, McLendon RE, Friedman HS, Friedman AH, Fuchs HE, Bigner DD, Bigner SH: Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25. Oncogene 1995, 10:2243-2246.
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(1995)
Oncogene
, vol.10
, pp. 2243-2246
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Rasheed, B.K.1
McLendon, R.E.2
Friedman, H.S.3
Friedman, A.H.4
Fuchs, H.E.5
Bigner, D.D.6
Bigner, S.H.7
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20
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0029992049
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Deletion mapping of gliomas suggest the presence of two small regions for candidate tumor-suppressor genes in a 17-cM interval on chromosome 10q
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Albarosa R, Colombo BM, Roz L, Magnani I, Pollo B, Cirenei N, Giani C, Conti AM, DiDonato S, Finocchiaro G: Deletion mapping of gliomas suggest the presence of two small regions for candidate tumor-suppressor genes in a 17-cM interval on chromosome 10q. Am J Hum Genet 1996, 58:1260-1267. An LOH study localizing tumor suppressor gene regions on chromosome 10q, whose deletion is involved in the development of glioblastoma.
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(1996)
Am J Hum Genet
, vol.58
, pp. 1260-1267
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Albarosa, R.1
Colombo, B.M.2
Roz, L.3
Magnani, I.4
Pollo, B.5
Cirenei, N.6
Giani, C.7
Conti, A.M.8
DiDonato, S.9
Finocchiaro, G.10
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21
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0029026344
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Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas
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Albarosa R, DiDonato S, Finocchiaro G: Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas. Hum Genet 1995, 95:709-711.
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(1995)
Hum Genet
, vol.95
, pp. 709-711
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Albarosa, R.1
DiDonato, S.2
Finocchiaro, G.3
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22
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0029398189
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Gene amplification in human gliomas
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Collins VP: Gene amplification in human gliomas. Glia 1995, 15:289-296 A review article providing information about gene amplification that occurs in human gliomas, including EGFR gene and the amplicon in chromosome 12q13-14.
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(1995)
Glia
, vol.15
, pp. 289-296
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Collins, V.P.1
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23
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0028146767
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A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity
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Nishikawa R, Ji XD, Harmon RC, Lazar CS, Gill GN, Cavenee WK, Huang HJS: A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Proc Natl Acad Sci U S A 1994, 91:7727-7731.
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(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 7727-7731
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Nishikawa, R.1
Ji, X.D.2
Harmon, R.C.3
Lazar, C.S.4
Gill, G.N.5
Cavenee, W.K.6
Huang, H.J.S.7
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24
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14444288522
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The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signalling
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Huang HJS, Nagane M, Klingbeil CK, Lin H, Nishikawa R, Ji XD, Huang CM, Gill GN, Wiley HS, Cavenee WK: The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signalling. J Biol Chem 1997, 272:2927-2935 An investigation indicating that weak and unattenuated constitutive tyrosine kinase activity of a truncated mutant EGFR contributes to its enhanced tumorigenic activity in human glioblastoma cells.
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J Biol Chem
, vol.272
, pp. 2927-2935
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Huang, H.J.S.1
Nagane, M.2
Klingbeil, C.K.3
Lin, H.4
Nishikawa, R.5
Ji, X.D.6
Huang, C.M.7
Gill, G.N.8
Wiley, H.S.9
Cavenee, W.K.10
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26
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0029815093
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Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway
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Prigent SA, Nagane M, Lin H, Huvar I, Boss GR, Feramisco JR, Cavenee WK, Huang HJS: Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway. J Biol Chem 1996, 271:25639-25645. A molecular analysis showing that the constitutively activated mutant EGFR commonly overexpressed in glioblastomas signals through activation and association of She, Grb2 and Ras, thereby mediating its growth advantage.
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(1996)
J Biol Chem
, vol.271
, pp. 25639-25645
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Prigent, S.A.1
Nagane, M.2
Lin, H.3
Huvar, I.4
Boss, G.R.5
Feramisco, J.R.6
Cavenee, W.K.7
Huang, H.J.S.8
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27
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0029025332
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Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas
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Wikstrand CJ, Hale LP, Batra SK, Hill ML, Humphrey PA, Kurpad SN, McLendon RE, Moscatello D, Pegram CN, Reist CJ, Traweek T, Wong AJ, Zalutsky MR, Bigner DD: Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas. Cancer Res 1995, 55:3140-3148.
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(1995)
Cancer Res
, vol.55
, pp. 3140-3148
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Wikstrand, C.J.1
Hale, L.P.2
Batra, S.K.3
Hill, M.L.4
Humphrey, P.A.5
Kurpad, S.N.6
McLendon, R.E.7
Moscatello, D.8
Pegram, C.N.9
Reist, C.J.10
Traweek, T.11
Wong, A.J.12
Zalutsky, M.R.13
Bigner, D.D.14
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28
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0028804246
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Specific targeting of a mutant activated EGF receptor found in glioblastoma using a monoclonal antibody
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Hills D, Rowlinson BG, Gullick WJ: Specific targeting of a mutant activated EGF receptor found in glioblastoma using a monoclonal antibody. Int J Cancer 1995, 63:537-543. A study in which a specific monoclonal antibody against a truncated EGFR was raised and used for targeting of the receptor expressed in tumors in nude mice.
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(1995)
Int J Cancer
, vol.63
, pp. 537-543
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Hills, D.1
Rowlinson, B.G.2
Gullick, W.J.3
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29
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0029837306
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Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors
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Han Y, Caday CG, Nanda A, Cavenee WK, Huang HJS: Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors. Cancer Res 1996, 56:3859-3861. A biological analysis demonstrating that a tyrosine kinase inhibitor, tyrphostin AG 1478. preferentially suppresses the constitutive phosphorylation of a mutant truncated EGFR relative to ligand-dependent autophosphorylation of wild type EGFR, resulting in preferential inhibition of growth and proliferation rate of glioma cells expressing the mutant receptor.
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(1996)
Cancer Res
, vol.56
, pp. 3859-3861
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Han, Y.1
Caday, C.G.2
Nanda, A.3
Cavenee, W.K.4
Huang, H.J.S.5
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30
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9044248587
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Association of loss of heterozygosity on chromosome 17p with high plateletderived growth factor alpha receptor expression in human malignant gliomas
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Hermanson M, Funa K, Koopmann J, Maintz D, Waha A, Westermark B, Heldin CH, Wiestler OD, Louis DN, von Deimling A, Nister M: Association of loss of heterozygosity on chromosome 17p with high plateletderived growth factor alpha receptor expression in human malignant gliomas. Cancer Res 1996, 56:164-171. An investigation that correlates high expression of PDGF receptor-α with LOH on chromosome 17p in low- and high-grade astrocytomas.
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(1996)
Cancer Res
, vol.56
, pp. 164-171
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Hermanson, M.1
Funa, K.2
Koopmann, J.3
Maintz, D.4
Waha, A.5
Westermark, B.6
Heldin, C.H.7
Wiestler, O.D.8
Louis, D.N.9
Von Deimling, A.10
Nister, M.11
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31
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0029054187
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Molecular cytogenetic quantitation of gains and losses of genetic material from human gliomas
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Feuerstein BG, Mohapatra G: Molecular cytogenetic quantitation of gains and losses of genetic material from human gliomas. J Neurooncol 1995, 24:47-55.
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J Neurooncol
, vol.24
, pp. 47-55
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Feuerstein, B.G.1
Mohapatra, G.2
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0029736825
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Characterization of genomic alterations associated with glioma progression by comparative genomic hybridization
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Weber RG, Sabel M, Reifenberger J, Sommer C: Characterization of genomic alterations associated with glioma progression by comparative genomic hybridization. Oncogene 1996, 13:983-994. An analysis of 30 human primary and recurrent gliomas from 15 patients by comparative genomic hybridization providing a comprehensive overview of the genomic alterations associated with the progression of individual gliomas.
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Oncogene
, vol.13
, pp. 983-994
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Weber, R.G.1
Sabel, M.2
Reifenberger, J.3
Sommer, C.4
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33
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0028970955
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Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of CDK4 is observed in distinct subsets of malignant glial tumors and cell lines
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He J, Olson JJ, James CD: Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of CDK4 is observed in distinct subsets of malignant glial tumors and cell lines. Cancer Res 1995, 55:4833-4836. An investigation showing alternative mechanisms leading to the functional inactivation of retinoblastoma protein in the majority of human gliomas.
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(1995)
Cancer Res
, vol.55
, pp. 4833-4836
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He, J.1
Olson, J.J.2
James, C.D.3
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34
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0030982897
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Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA
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Costello JF, Plass C, Arap W, Chapman VM, Held WA, Berger MS, Huang HJS, Cavenee WK: Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA. Cancer Res 1997, 57:1250-1254.
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Cancer Res
, vol.57
, pp. 1250-1254
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Costello, J.F.1
Plass, C.2
Arap, W.3
Chapman, V.M.4
Held, W.A.5
Berger, M.S.6
Huang, H.J.S.7
Cavenee, W.K.8
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35
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0030046508
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Life, death, and the pursuit of apoptosis
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White E: Life, death, and the pursuit of apoptosis. Genes Dev 1996, 10:1-15. An outstanding review of apoptosis that provides comprehensive understanding of the roles of apoptosis regulators in process of cell death at the biochemical level.
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Genes Dev
, vol.10
, pp. 1-15
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White, E.1
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36
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0030020689
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Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis
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Gomez MC, Fueyo J, Kyritsis AP, Steck PA, Roth JA, McDonnell TJ, Steck KD, Levin VA, Yung WK: Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis. Cancer Res 1996, 56:694-699. A functional analysis of the wild-type p53 gene delivered by an adenovirus vector, demonstrating that apoptosis is induced in the glioma cells expressing endogenous mutant p53, while cell proliferation is inhibited in cells with wild-type p53 genotype.
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(1996)
Cancer Res
, vol.56
, pp. 694-699
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Gomez, M.C.1
Fueyo, J.2
Kyritsis, A.P.3
Steck, P.A.4
Roth, J.A.5
McDonnell, T.J.6
Steck, K.D.7
Levin, V.A.8
Yung, W.K.9
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37
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0030023848
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Cell cycle synchrony unmasks the influence of p53 function on radiosensitivity of human glioblastoma cells
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Yount GL, Haas KD, Vidair CA, Haas M, Dewey WC, Israel MA: Cell cycle synchrony unmasks the influence of p53 function on radiosensitivity of human glioblastoma cells. Cancer Res 1996, 56:500-506. An investigation revealing that p53-dependent G1 arrest, but not apoptosis, is induced by ionizing radiation, contributing to radiosensitivity of glioma cells.
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(1996)
Cancer Res
, vol.56
, pp. 500-506
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Yount, G.L.1
Haas, K.D.2
Vidair, C.A.3
Haas, M.4
Dewey, W.C.5
Israel, M.A.6
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