Induction of hematopoietic commitment and erythromyeloid differentiation in embryonal stem cells constitutively expressing c-myb

Blood

Volumn 87, Issue 6, 1996, Pages 2221-2234

  Melotti, Paola ^a   Calabretta, Bruno ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; EMBRYO CELL; GENE ACTIVATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL;

EID: 0029939388     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.6.2221.bloodjournal8762221     Document Type: Article

References (65)

1. Westin EH, Gello RC, Arya SK, Eva A, Souza LM, Baluda MA, Doronson SA, Wong-Staal F: Differential expression of the AMV gene in human hematopoietic cells. Proc Natl Acad Sci USA 79:2194, 1982
2. Duprey SP, Boettinger D: Developmental regulation of c-myb in normal myeloid progenitor cells. Proc Natl Acad Sci USA 82:6937, 1985
3. Clarke MF, Kukowska-Latallo JF, Westin EH, Smith M, Prochownick E: Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation. Mol Cell Biol 8:884, 1988
4. McMahon J, Howe KM, Watson RJ: The induction of Friend erythroleukemia differentiation is markedly affected by expression of a transfected c-myb cDNA oncogene. Oncogene 3:717, 1988
5. Todokoro K, Watson RJ, Higo H, Amanuma H, Kuramochi S, Yanagisawa H, Ikawa Y: Down-regulation of c-myb gene expression is a prerequisite for erythropoietin-induced erythroid differentiation. Proc Natl Acad Sci USA 85:8900, 1988
6. Gewirtz AM, Calabretta B: A c-myb antisense oligodeoxynucleotides inhibits normal human hematopoiesis in vitro. Science 242:1303, 1988
7. Valtieri M, Venturelli D, Care A, Fossati C, Pelosi E, Labbaye C, Mattia G, Gewirtz AM, Calabretta B, Peschle C: Antisense myb inhibition of purified erythroid progenitors in development and differentiation is linked to cycling activity and expression of DNA polymerase-α. Blood 77:1181, 1991
8. Anfossi G, Gewirtz AM, Calabretta B: An oligomer complementary to c-myb mRNA inhibits proliferation of human myeloid leukemic cell lines. Proc Natl Acad Sci USA 86:3379, 1989
9. Calabretta B, Sims RB, Valtieri M, Caracciolo D, Szczylik C, Venturelli D, Ratajczak M, Beran M, Gewirtz AM: Normal and leukemic hematopoietic cells manifest differential sensitivity to inhibitory effects of c-myb antisense oligodeoxynucleotides: An in vitro study with relevance for bone marrow purging. Proc Natl Acad Sci USA 88:2351, 1991
10. Mucenski ML, McLain K, Kier AB, Swerdlow SH, Schreiner CM, Miller TA, Pietryga DW, Scott WJ, Potter SS: A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 65:677, 1991
11. Weston K, Bishop JM: Transcriptional activation by the v-myb oncogene and its cellular progenitor c-myb. Cell 58:85, 1989
12. Sakura H, Kanei-Ishii C, Nagase T, Nakagoshi H, Gonda TJ, Ishii S: Delineation of three functional domains of the transcriptional activator encoded by the c-myb proto-oncogene. Proc Natl Acad Sci USA 86.5758, 1989
13. Ness SA, Marknell A, Graf T: The v-myb oncogene product binds to and activates the promyelocyte-specific MIM-1 gene. Cell 59:1115, 1989
14. Siu G, Wurster AL, Lipsick JS, Hedrick SM: Expression of the CD4 gene requires a Myb transcription factor. Mol Cell Biol 12:1592, 1992
15. Melotti P, Ku D-H, Calabretta B: Regulation of the expression of the hematopoietic stem cell antigen CD34: Role of c-myb. J Exp Med 179:1023, 1994
16. Ku D-H, Wen S-C, Engelhard A, Nicolaides NC, Marino TA, and Calabretta B: c-myb transactivates cdc2 expression via Myb binding sites in the 5′ Ranking region of the human cdc2 gene. J Biol Chem 263:2255, 1993
17. Cogswell JP, Cogswell PC, Kuehl WM, Cuddihy AM, Bender TM, Engelke U, Marcu KB, Ting JP-Y: Mechanism of c-myc regulation by c-myb in different cell lineages. Mol Cell Biol 13:2858, 1993
18. Nicolaides NC, Gualdi R, Casadevall C, Manzella L, Calabretta B: Positive autoregulation of c-myb expression via Myb binding sites in the 5′ flanking region of the human c-myb gene. Mol Cell Biol 11.6166, 1991
19. Gerondakis S, Bishop JM: Structure of the protein encoded by the chicken proto-oncogene c-myb. Mol Cell Biol 6:3677, 1986
20. Dini PW, Lipsick JS: Oncogenic truncation of the first repeat of c-myb decreases DNA binding in vitro and in vivo. Mol Cell Biol 13:7334, 1993
21. Howe KM, Reakers CFL, Watson RJ: Characterization of the sequence-specific interaction of mouse c-myb protein with DNA. EMBO J 8:161, 1990
22. Ramsay R, Ishii S, Gonda TJ: Increase in specific DNA binding by carboxyl truncation suggests a mechanism for activation of Myb. Oncogene 6.1875, 1991
23. Gabrielsen OS, Sentenac A, Fromageot P. Specific DNA binding by c-myb: evidence for a double helix-turn-helix-related motif. Science 253:1140, 1991
24. + marrow cells engraft lethally irradiated baboons. J Clin Invest 81:951, 1988
25. + marrow cells in patients with breast cancer or neuroblastoma. Blood 77:1717, 1992
26. Simmons PJ, Torok-Storb B: CD34 expression by normal precursors in normal human adult bone marrow Blood 72:2848, 1991
27. Geissler EN, Ryan MA, Housman DE: The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 55:185, 1988
28. Rosnet O, Marchetto S, deLapeyriere O, Birnbaum D: Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGF/ CSFIR family. Oncogene 6:1641, 1991
29. Matthews W, Jordan CT, Wiegand GW, Pardoll D, Lemischka IR: A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Cell 65:1143, 1991
30. Orkin SH: GATA-binding transcription factors in hematopoietic cells. Blood 80.575, 1992
31. Weiss MJ, Keller G, Orkin SH: Novel insights into erythroid development revealed through in vitro differentiation of GATA-1-embryonic stem cells. Genes Dev 8:1184, 1994
32. He X-Y, Antao VP, Basila D, Marx JC, Davis BR: Isolation and molecular characterization of the human CD34 gene. Blood 79:2296, 1992
33. Burn TC, Satterthwaite AB, Tenen DG: The human CD34 hematopoietic stem cell antigen promoter and a 3′ enhancer direct hematopoietic expression in tissue culture. Blood 80:3051, 1992
34. Sala A, Bellon T, Melotti P, Peschle C, Calabretta B: Inhibition of erythromyeloid differentiation by constitutive expression of a DNA binding deficient c-myb mutant: Implication for c-myb function. Blood 86:3404, 1995
35. Nicolis S, Bertini C, Ronchi A, Crotta S, Lanfranco L, Moroni E, Giglioni B, Ottolenghi S: An erythroid specific enhancer upstream to the gene encoding the cell-type specific transcription factor GATA-1. Nucleic Acids Res 19:5285, 1991
36. Huttner KM, Barbosa JA, Scangos GA, Pratcheva DD, Ruddle FH: DNA-mediated gene transfer without carrier DNA. J Cell Biol 91:153, 1981
37. Doetschman TC, Eistetter H, Katz M, Schmidt W, Kemler R: The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J Embryol Exp Morphol 87:27, 1985
38. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidium thiocyanate-phenol chloroform extraction. Anal Biochem 162:156, 1987
39. Skorski T, Nieborowska-Skorska M, Barletta C, Malaguernera L, Szczylik C, Chen S-T, Lange B, Calabretta B: Highly efficient elimination of Philadelphia' leukemic cells by exposure to bcr/ abl antisense oligodeoxynucleotide combined with mafosfamide. J Clin Invest 92:194, 1993
40. Bender TP, Kuehl M: Murine myb protooncogene mRNA: cDNA sequence and evidence, for 5′ heterogeneity. Proc Natl Acad Sci USA 83:3204, 1986
41. Venturelli D, Shirsat N, Gemperlein I, Bittenbender S, Hudson S, Rovera G: Nucleotide sequence of cDNA for murine myeloperoxidase. Nucleic Acids Res 17:5852, 1989
42. Qiu FRP, Brown K, Barker PE, Jhanwar S, Ruddle FH: Primary structure of c-kit: Relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of c-kit involves deletion of extracellular domain and C terminus. EMBO J 7:1003, 1988
43. Rothwell VM, Rohrschneider LR: Murine c-fms DNA: Cloning, sequence analysis and retroviral expression. Oncogene Res 1:311, 1987
44. Tsai S-F, Martin DIK, Zon LI, D'Andrea AD, Wong GG, Orkin SH: Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cell. Nature 339:446, 1989
45. Citro G, Perrotti D, Cucco C, D'Agnano I, Sacchi A, Zupi G, Calabretta B: Inhibition of leukemia cell proliferation by receptor-mediated uptake of c-myb antisense oligodeoxynucleotides. Proc Natl Acad Sci USA 89:7031, 1992
46. Harlow E, Lane D: Antibodies: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1988
47. Yaswen P, Stampfer MR, Ghosh K, Cohen JS: Effects of sequence of thioated oligonucleotides on cultured human mammary epithelial cells. Antisense Res Dev 3:67, 1993
48. Burgess TL, Fischer EF, Ross SL, Bready JV, Qian Y-X, Bayewitch LA, Cohen AM, Henere CJ, Hu SS-F, Kramer TB, Lott FD, Martin FH, Pierce GF, Simonet L, Farrell CL: The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism. Proc Natl Acad Sci USA 92:4051, 1995
49. Melotti P, Calabretta B. c-myb and ets-2 act independently in regulating CD34 expression. J Biol Chem 269:25303, 1994
50. Talavera A, Basilico C: Temperature sensitive mutants of BHK cells affected in cell cycle progression. J Cell Physiol 92:425, 1977
51. Sanchez-Madrid F, Simon P, Thompson S, Springer TA: Mapping of antigenic and functional epitopes on the α-and β-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1. J Exp Med 158:586, 1983
52. Unkeless JC: Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J Exp Med 150:580, 1979
53. Calabretta B, Nicolaides NC: c-myb and growth control. Crit Rev Eukaryot Gene Expr 2:225, 1992
54. Wiles MV, Keller G: Multiple hematopoietic lineages develop from embryonic stem (ES) cells in colture. Development 111:259, 1991
55. Keller G, Kennedy M, Papayannopoulou T, Wiles MV: Hematopoietic commitment during embryonic stem cell differentiation in culture. Mol Cell Biol 13:473, 1993
56. McClanahan T, Dalrymple S, Barkett M, Lee F: Hematopoietic growth factor receptor genes as markers of lineage commitment during in vitro development of hematopoietic cells. Blood 81:2903, 1993
57. Lyman SD, James L, Vanden Bos T, de Vues P, Brasel K, Gliniak B, Hollingsworth LT, Picha KS, McKenna HJ, Splett RR, Fletcher FA, Maraskovsky E, Farrah T, Foxworthe D, Williams DE, Beckmann MP: Molecular cloning of a ligand for the FLT3/FLK2 tyrosine kinase receptor: A proliferative factor for primitive hematopoietic cells. Cell 75:1152, 1993
58. Hannum C, Culpepper J, Campbell D, McClanahan T, Zurawski S, Bazan JF, Kastelein R, Hudak S, Wagner J, Mattson J, Luh J, Duda G, Martina N, Peterson D, Menon S, Shenfeld A, Muench M, Kelner G, Namikawa R, Rennick D, Roncarolo M-G, Zlotnik A, Rosnet O, Dubreull P, Birnbaum P, Lee F: Ligand for FLT3/FLK2 receptor tyrosyne kinase regulates growth of hematopoietic stem cells and is encoded by variants RNAs. Nature 368:643, 1994
59. Brandt J, Briddel RA, Srour EF, Leemhuis TB, Hoffman R: Role of c-kit in the expansion of human hematopoietic progenitor cells. Blood 79:634, 1992
60. DiGiusto D, Chen S, Combs J, Webb S, Namikawa R, Tsukamoto A, Chen B, Galy AHM: Human fetal bone marrow early progenitors for T, B, and myeloid cells are found exclusively in the population expressing high levels of CD34. Blood 84:421, 1994
61. Tsai F-Y, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH: An early hematopoietic defect in mice lacking the transcription factor GATA-2. Nature 371:221, 1994
62. Shivdasani RA, Mayer EL, Orkin SH: Absence of blood formation in mice lacking the T-cell leukemia oncoprotein tal-1/SCL. Nature 373:432, 1994
63. Aurigemma RE, Blair DG, Ruscetti SK: Transactivaction of erythroid transcription factor GATA1 by a myb-ets-containing retrovirus. J Virol 66:3056, 1992
64. Dudek H, Tantravahi RV, Rao VN, Reddy ESP, Reddy EP: Myb and ets proteins cooperate in transcriptional activation of the mim-1 promoter. Proc Natl Acad Sci USA 89:1291, 1992
65. Yasuda H, Galli GJ, Geissler EN: Cloning and functional analysis of the mouse c-kit promoter. Biochem Biophys Res Commun 191:893, 1993